Anti-MAdCAM antibody (PF-00547659) for ulcerative colitis (TURANDOT): a phase 2, randomised, double-blind, placebo-controlled trial.
Identifieur interne : 001181 ( Main/Exploration ); précédent : 001180; suivant : 001182Anti-MAdCAM antibody (PF-00547659) for ulcerative colitis (TURANDOT): a phase 2, randomised, double-blind, placebo-controlled trial.
Auteurs : Séverine Vermeire [Belgique] ; William J. Sandborn [États-Unis] ; Silvio Danese [Italie] ; Xavier Hébuterne [France] ; Bruce A. Salzberg [États-Unis] ; Maria Klopocka [Pologne] ; Dino Tarabar [Serbie] ; Tomas Vanasek [République tchèque] ; Miloš Greguš [Slovaquie] ; Paul A. Hellstern [États-Unis] ; Joo Sung Kim [Corée du Sud] ; Miles P. Sparrow [Australie] ; Kenneth J. Gorelick [États-Unis] ; Michelle Hinz [États-Unis] ; Alaa Ahmad [États-Unis] ; Vivek Pradhan [États-Unis] ; Mina Hassan-Zahraee [États-Unis] ; Robert Clare [États-Unis] ; Fabio Cataldi [États-Unis] ; Walter Reinisch [Canada]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
PF-00547659 is a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to selectively reduce lymphocyte homing to the intestinal tract. We aimed to assess the efficacy and safety of PF-00547659 in patients with moderate to severe ulcerative colitis.
DOI: 10.1016/S0140-6736(17)30930-3
PubMed: 28527704
Affiliations:
- Australie, Belgique, Canada, Corée du Sud, France, Italie, Pologne, République tchèque, Serbie, Slovaquie, États-Unis
- Californie, Floride, Géorgie (États-Unis), Lombardie, Massachusetts, Provence-Alpes-Côte d'Azur, Région capitale de Séoul
- Milan, Nice, Séoul
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Sandborn</name><affiliation wicri:level="2"><nlm:affiliation>University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Danese, Silvio" sort="Danese, Silvio" uniqKey="Danese S" first="Silvio" last="Danese">Silvio Danese</name><affiliation wicri:level="3"><nlm:affiliation>Humanitas University, Clinical and Research Center, Humanitas Research Hospital, Rozzano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Humanitas University, Clinical and Research Center, Humanitas Research Hospital, Rozzano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Hebuterne, Xavier" sort="Hebuterne, Xavier" uniqKey="Hebuterne X" first="Xavier" last="Hébuterne">Xavier Hébuterne</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire de Nice Sophia Antipolis, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Nice Sophia Antipolis, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Salzberg, Bruce A" sort="Salzberg, Bruce A" uniqKey="Salzberg B" first="Bruce A" last="Salzberg">Bruce A. 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Electronic address: severine.vermeire@uzleuven.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Leuven University Hospital and University of Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sandborn, William J" sort="Sandborn, William J" uniqKey="Sandborn W" first="William J" last="Sandborn">William J. Sandborn</name><affiliation wicri:level="2"><nlm:affiliation>University of California San Diego, La Jolla, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of California San Diego, La Jolla, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Danese, Silvio" sort="Danese, Silvio" uniqKey="Danese S" first="Silvio" last="Danese">Silvio Danese</name><affiliation wicri:level="3"><nlm:affiliation>Humanitas University, Clinical and Research Center, Humanitas Research Hospital, Rozzano, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Humanitas University, Clinical and Research Center, Humanitas Research Hospital, Rozzano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Hebuterne, Xavier" sort="Hebuterne, Xavier" uniqKey="Hebuterne X" first="Xavier" last="Hébuterne">Xavier Hébuterne</name><affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier Universitaire de Nice Sophia Antipolis, Nice, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Universitaire de Nice Sophia Antipolis, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="Salzberg, Bruce A" sort="Salzberg, Bruce A" uniqKey="Salzberg B" first="Bruce A" last="Salzberg">Bruce A. Salzberg</name><affiliation wicri:level="2"><nlm:affiliation>Atlanta Gastroenterology Specialists PC, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Atlanta Gastroenterology Specialists PC, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Klopocka, Maria" sort="Klopocka, Maria" uniqKey="Klopocka M" first="Maria" last="Klopocka">Maria Klopocka</name><affiliation wicri:level="1"><nlm:affiliation>Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Nicolaus Copernicus University in Toruń, Bydgoszcz</wicri:regionArea><wicri:noRegion>Bydgoszcz</wicri:noRegion></affiliation></author><author><name sortKey="Tarabar, Dino" sort="Tarabar, Dino" uniqKey="Tarabar D" first="Dino" last="Tarabar">Dino Tarabar</name><affiliation wicri:level="1"><nlm:affiliation>Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade, Serbia.</nlm:affiliation><country xml:lang="fr">Serbie</country><wicri:regionArea>Military Medical Academy, Clinic for Gastroenterology and Hepatology, Belgrade</wicri:regionArea><wicri:noRegion>Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Vanasek, Tomas" sort="Vanasek, Tomas" uniqKey="Vanasek T" first="Tomas" last="Vanasek">Tomas Vanasek</name><affiliation wicri:level="1"><nlm:affiliation>Charles University Hospital, Hradec Kralove, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Charles University Hospital, Hradec Kralove</wicri:regionArea><wicri:noRegion>Hradec Kralove</wicri:noRegion></affiliation></author><author><name sortKey="Gregus, Milos" sort="Gregus, Milos" uniqKey="Gregus M" first="Miloš" last="Greguš">Miloš Greguš</name><affiliation wicri:level="1"><nlm:affiliation>Gastroenterology Center, Nitra, Slovakia.</nlm:affiliation><country xml:lang="fr">Slovaquie</country><wicri:regionArea>Gastroenterology Center, Nitra</wicri:regionArea><wicri:noRegion>Nitra</wicri:noRegion></affiliation></author><author><name sortKey="Hellstern, Paul A" sort="Hellstern, Paul A" uniqKey="Hellstern P" first="Paul A" last="Hellstern">Paul A. Hellstern</name><affiliation wicri:level="2"><nlm:affiliation>Nature Coast Clinical Research, Inverness, FL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nature Coast Clinical Research, Inverness, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Kim, Joo Sung" sort="Kim, Joo Sung" uniqKey="Kim J" first="Joo Sung" last="Kim">Joo Sung Kim</name><affiliation wicri:level="3"><nlm:affiliation>Seoul National University College of Medicine, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sparrow, Miles P" sort="Sparrow, Miles P" uniqKey="Sparrow M" first="Miles P" last="Sparrow">Miles P. Sparrow</name><affiliation wicri:level="1"><nlm:affiliation>Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Alfred Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Gorelick, Kenneth J" sort="Gorelick, Kenneth J" uniqKey="Gorelick K" first="Kenneth J" last="Gorelick">Kenneth J. Gorelick</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hinz, Michelle" sort="Hinz, Michelle" uniqKey="Hinz M" first="Michelle" last="Hinz">Michelle Hinz</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ahmad, Alaa" sort="Ahmad, Alaa" uniqKey="Ahmad A" first="Alaa" last="Ahmad">Alaa Ahmad</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pradhan, Vivek" sort="Pradhan, Vivek" uniqKey="Pradhan V" first="Vivek" last="Pradhan">Vivek Pradhan</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Hassan Zahraee, Mina" sort="Hassan Zahraee, Mina" uniqKey="Hassan Zahraee M" first="Mina" last="Hassan-Zahraee">Mina Hassan-Zahraee</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Clare, Robert" sort="Clare, Robert" uniqKey="Clare R" first="Robert" last="Clare">Robert Clare</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Cataldi, Fabio" sort="Cataldi, Fabio" uniqKey="Cataldi F" first="Fabio" last="Cataldi">Fabio Cataldi</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Reinisch, Walter" sort="Reinisch, Walter" uniqKey="Reinisch W" first="Walter" last="Reinisch">Walter Reinisch</name><affiliation wicri:level="1"><nlm:affiliation>Medical University of Vienna, Vienna, Austria; McMaster University, Hamilton, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medical University of Vienna, Vienna, Austria; McMaster University, Hamilton, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">PF-00547659 is a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to selectively reduce lymphocyte homing to the intestinal tract. We aimed to assess the efficacy and safety of PF-00547659 in patients with moderate to severe ulcerative colitis.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>Italie</li><li>Pologne</li><li>République tchèque</li><li>Serbie</li><li>Slovaquie</li><li>États-Unis</li></country><region><li>Californie</li><li>Floride</li><li>Géorgie (États-Unis)</li><li>Lombardie</li><li>Massachusetts</li><li>Provence-Alpes-Côte d'Azur</li><li>Région capitale de Séoul</li></region><settlement><li>Milan</li><li>Nice</li><li>Séoul</li></settlement></list><tree><country name="Belgique"><noRegion><name sortKey="Vermeire, Severine" sort="Vermeire, Severine" uniqKey="Vermeire S" first="Séverine" last="Vermeire">Séverine Vermeire</name></noRegion></country><country name="États-Unis"><region name="Californie"><name sortKey="Sandborn, William J" sort="Sandborn, William J" uniqKey="Sandborn W" first="William J" last="Sandborn">William J. Sandborn</name></region><name sortKey="Ahmad, Alaa" sort="Ahmad, Alaa" uniqKey="Ahmad A" first="Alaa" last="Ahmad">Alaa Ahmad</name><name sortKey="Cataldi, Fabio" sort="Cataldi, Fabio" uniqKey="Cataldi F" first="Fabio" last="Cataldi">Fabio Cataldi</name><name sortKey="Clare, Robert" sort="Clare, Robert" uniqKey="Clare R" first="Robert" last="Clare">Robert Clare</name><name sortKey="Gorelick, Kenneth J" sort="Gorelick, Kenneth J" uniqKey="Gorelick K" first="Kenneth J" last="Gorelick">Kenneth J. Gorelick</name><name sortKey="Hassan Zahraee, Mina" sort="Hassan Zahraee, Mina" uniqKey="Hassan Zahraee M" first="Mina" last="Hassan-Zahraee">Mina Hassan-Zahraee</name><name sortKey="Hellstern, Paul A" sort="Hellstern, Paul A" uniqKey="Hellstern P" first="Paul A" last="Hellstern">Paul A. Hellstern</name><name sortKey="Hinz, Michelle" sort="Hinz, Michelle" uniqKey="Hinz M" first="Michelle" last="Hinz">Michelle Hinz</name><name sortKey="Pradhan, Vivek" sort="Pradhan, Vivek" uniqKey="Pradhan V" first="Vivek" last="Pradhan">Vivek Pradhan</name><name sortKey="Salzberg, Bruce A" sort="Salzberg, Bruce A" uniqKey="Salzberg B" first="Bruce A" last="Salzberg">Bruce A. Salzberg</name></country><country name="Italie"><region name="Lombardie"><name sortKey="Danese, Silvio" sort="Danese, Silvio" uniqKey="Danese S" first="Silvio" last="Danese">Silvio Danese</name></region></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Hebuterne, Xavier" sort="Hebuterne, Xavier" uniqKey="Hebuterne X" first="Xavier" last="Hébuterne">Xavier Hébuterne</name></region></country><country name="Pologne"><noRegion><name sortKey="Klopocka, Maria" sort="Klopocka, Maria" uniqKey="Klopocka M" first="Maria" last="Klopocka">Maria Klopocka</name></noRegion></country><country name="Serbie"><noRegion><name sortKey="Tarabar, Dino" sort="Tarabar, Dino" uniqKey="Tarabar D" first="Dino" last="Tarabar">Dino Tarabar</name></noRegion></country><country name="République tchèque"><noRegion><name sortKey="Vanasek, Tomas" sort="Vanasek, Tomas" uniqKey="Vanasek T" first="Tomas" last="Vanasek">Tomas Vanasek</name></noRegion></country><country name="Slovaquie"><noRegion><name sortKey="Gregus, Milos" sort="Gregus, Milos" uniqKey="Gregus M" first="Miloš" last="Greguš">Miloš Greguš</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Kim, Joo Sung" sort="Kim, Joo Sung" uniqKey="Kim J" first="Joo Sung" last="Kim">Joo Sung Kim</name></region></country><country name="Australie"><noRegion><name sortKey="Sparrow, Miles P" sort="Sparrow, Miles P" uniqKey="Sparrow M" first="Miles P" last="Sparrow">Miles P. Sparrow</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Reinisch, Walter" sort="Reinisch, Walter" uniqKey="Reinisch W" first="Walter" last="Reinisch">Walter Reinisch</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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