AustralieFrV1, Main, Exploration, bibRecord, 001145

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Identifieur interne : 001145 ( Main/Exploration ); précédent : 001144; suivant : 001146

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Auteurs : Tom Parks [Royaume-Uni] ; Mariana M. Mirabel [France] ; Joseph Kado [Fidji] ; Kathryn Auckland [Royaume-Uni] ; Jaroslaw Nowak [Royaume-Uni] ; Anna Rautanen [Royaume-Uni] ; Alexander J. Mentzer [Royaume-Uni] ; Eloi Marijon [France] ; Xavier Jouven [France] ; Mai Ling Perman [Fidji] ; Tuliana Cua [Fidji] ; John K. Kauwe [États-Unis] ; John B. Allen [États-Unis] ; Henry Taylor [Samoa] ; Kathryn J. Robson [Royaume-Uni] ; Charlotte M. Deane [Royaume-Uni] ; Andrew C. Steer [Australie] ; Adrian V. S. Hill [Royaume-Uni]

Source :

Nature Communications [ 2041-1723 ] ; 2017.

RBID : PMC:5437274

Abstract

The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the IGHV4-61 gene segment corresponding to the IGHV4-61*02 allele. We show each copy of IGHV4-61*02 is associated with a 1.4-fold increase in the risk of RHD (odds ratio 1.43, 95% confidence intervals 1.27–1.61, P=4.1 × 10⁻⁹). These findings provide new insight into the role of germline variation in the IGH locus in disease susceptibility.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437274

DOI: 10.1038/ncomms14946
PubMed: 28492228
PubMed Central: 5437274

Affiliations:

Australie, Fidji, France, Royaume-Uni, Samoa, États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania</title>
<author><name sortKey="Parks, Tom" sort="Parks, Tom" uniqKey="Parks T" first="Tom" last="Parks">Tom Parks</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mirabel, Mariana M" sort="Mirabel, Mariana M" uniqKey="Mirabel M" first="Mariana M." last="Mirabel">Mariana M. Mirabel</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>College of Medicine, Nursing & Health Sciences, Fiji National University</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auckland, Kathryn" sort="Auckland, Kathryn" uniqKey="Auckland K" first="Kathryn" last="Auckland">Kathryn Auckland</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nowak, Jaroslaw" sort="Nowak, Jaroslaw" uniqKey="Nowak J" first="Jaroslaw" last="Nowak">Jaroslaw Nowak</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Statistics, University of Oxford</institution>
, Peter Medawar Building for Pathogen Research, Oxford OX1 3S,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rautanen, Anna" sort="Rautanen, Anna" uniqKey="Rautanen A" first="Anna" last="Rautanen">Anna Rautanen</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mentzer, Alexander J" sort="Mentzer, Alexander J" uniqKey="Mentzer A" first="Alexander J." last="Mentzer">Alexander J. Mentzer</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>Faculté de Médecine Paris Descartes, Université Paris Descartes</institution>
, 15, rue de l'école de medicine, 75006 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>Faculté de Médecine Paris Descartes, Université Paris Descartes</institution>
, 15, rue de l'école de medicine, 75006 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perman, Mai Ling" sort="Perman, Mai Ling" uniqKey="Perman M" first="Mai Ling" last="Perman">Mai Ling Perman</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>College of Medicine, Nursing & Health Sciences, Fiji National University</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cua, Tuliana" sort="Cua, Tuliana" uniqKey="Cua T" first="Tuliana" last="Cua">Tuliana Cua</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kauwe, John K" sort="Kauwe, John K" uniqKey="Kauwe J" first="John K." last="Kauwe">John K. Kauwe</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Life Sciences, Brigham Young University</institution>
, 4146 Life Sciences Building, Provo, Utah 84602,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allen, John B" sort="Allen, John B" uniqKey="Allen J" first="John B." last="Allen">John B. Allen</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Life Sciences, Brigham Young University</institution>
, 4146 Life Sciences Building, Provo, Utah 84602,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taylor, Henry" sort="Taylor, Henry" uniqKey="Taylor H" first="Henry" last="Taylor">Henry Taylor</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Rheumatic Heart Disease Control Programme, Samoa Ministry of Health</institution>
, Moto'otua, Ifiifi Street, Apia,<country>Samoa</country>
</nlm:aff>
<country xml:lang="fr">Samoa</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robson, Kathryn J" sort="Robson, Kathryn J" uniqKey="Robson K" first="Kathryn J." last="Robson">Kathryn J. Robson</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington</institution>
, Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deane, Charlotte M" sort="Deane, Charlotte M" uniqKey="Deane C" first="Charlotte M." last="Deane">Charlotte M. Deane</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Statistics, University of Oxford</institution>
, Peter Medawar Building for Pathogen Research, Oxford OX1 3S,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C." last="Steer">Andrew C. Steer</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Centre for International Child Health, University of Melbourne</institution>
, 50 Flemington Road, Parkville, Melbourne Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Murdoch Children's Research Institute</institution>
, 50 Flemington Road, Parkville, Melbourne, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28492228</idno>
<idno type="pmc">5437274</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437274</idno>
<idno type="RBID">PMC:5437274</idno>
<idno type="doi">10.1038/ncomms14946</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">000792</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000792</idno>
<idno type="wicri:Area/Pmc/Curation">000791</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000791</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000420</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000420</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000B99</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B99</idno>
<idno type="wicri:Area/PubMed/Curation">000B96</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B96</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000B96</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B96</idno>
<idno type="wicri:Area/Ncbi/Merge">004795</idno>
<idno type="wicri:Area/Ncbi/Curation">004795</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004795</idno>
<idno type="wicri:Area/Main/Merge">001140</idno>
<idno type="wicri:Area/Main/Curation">001145</idno>
<idno type="wicri:Area/Main/Exploration">001145</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania</title>
<author><name sortKey="Parks, Tom" sort="Parks, Tom" uniqKey="Parks T" first="Tom" last="Parks">Tom Parks</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mirabel, Mariana M" sort="Mirabel, Mariana M" uniqKey="Mirabel M" first="Mariana M." last="Mirabel">Mariana M. Mirabel</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>College of Medicine, Nursing & Health Sciences, Fiji National University</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Auckland, Kathryn" sort="Auckland, Kathryn" uniqKey="Auckland K" first="Kathryn" last="Auckland">Kathryn Auckland</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nowak, Jaroslaw" sort="Nowak, Jaroslaw" uniqKey="Nowak J" first="Jaroslaw" last="Nowak">Jaroslaw Nowak</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Statistics, University of Oxford</institution>
, Peter Medawar Building for Pathogen Research, Oxford OX1 3S,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rautanen, Anna" sort="Rautanen, Anna" uniqKey="Rautanen A" first="Anna" last="Rautanen">Anna Rautanen</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mentzer, Alexander J" sort="Mentzer, Alexander J" uniqKey="Mentzer A" first="Alexander J." last="Mentzer">Alexander J. Mentzer</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>Faculté de Médecine Paris Descartes, Université Paris Descartes</institution>
, 15, rue de l'école de medicine, 75006 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name>
<affiliation wicri:level="1"><nlm:aff id="a2"><institution>Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou</institution>
, 56, rue Leblanc, 75908 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>Faculté de Médecine Paris Descartes, Université Paris Descartes</institution>
, 15, rue de l'école de medicine, 75006 Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Perman, Mai Ling" sort="Perman, Mai Ling" uniqKey="Perman M" first="Mai Ling" last="Perman">Mai Ling Perman</name>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>College of Medicine, Nursing & Health Sciences, Fiji National University</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cua, Tuliana" sort="Cua, Tuliana" uniqKey="Cua T" first="Tuliana" last="Cua">Tuliana Cua</name>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital</institution>
, Brown Street, Suva,<country>Fiji</country>
</nlm:aff>
<country xml:lang="fr">Fidji</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kauwe, John K" sort="Kauwe, John K" uniqKey="Kauwe J" first="John K." last="Kauwe">John K. Kauwe</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Life Sciences, Brigham Young University</institution>
, 4146 Life Sciences Building, Provo, Utah 84602,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Allen, John B" sort="Allen, John B" uniqKey="Allen J" first="John B." last="Allen">John B. Allen</name>
<affiliation wicri:level="1"><nlm:aff id="a8"><institution>College of Life Sciences, Brigham Young University</institution>
, 4146 Life Sciences Building, Provo, Utah 84602,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taylor, Henry" sort="Taylor, Henry" uniqKey="Taylor H" first="Henry" last="Taylor">Henry Taylor</name>
<affiliation wicri:level="1"><nlm:aff id="a9"><institution>Rheumatic Heart Disease Control Programme, Samoa Ministry of Health</institution>
, Moto'otua, Ifiifi Street, Apia,<country>Samoa</country>
</nlm:aff>
<country xml:lang="fr">Samoa</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Robson, Kathryn J" sort="Robson, Kathryn J" uniqKey="Robson K" first="Kathryn J." last="Robson">Kathryn J. Robson</name>
<affiliation wicri:level="1"><nlm:aff id="a10"><institution>MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington</institution>
, Oxford OX3 9DS,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deane, Charlotte M" sort="Deane, Charlotte M" uniqKey="Deane C" first="Charlotte M." last="Deane">Charlotte M. Deane</name>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Statistics, University of Oxford</institution>
, Peter Medawar Building for Pathogen Research, Oxford OX1 3S,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C." last="Steer">Andrew C. Steer</name>
<affiliation wicri:level="1"><nlm:aff id="a11"><institution>Centre for International Child Health, University of Melbourne</institution>
, 50 Flemington Road, Parkville, Melbourne Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a12"><institution>Murdoch Children's Research Institute</institution>
, 50 Flemington Road, Parkville, Melbourne, Victoria 3052,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Wellcome Trust Centre for Human Genetics, University of Oxford</institution>
, Roosevelt Drive, Oxford OX3 7BN,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The indigenous populations of the South Pacific experience a high burden of rheumatic heart disease (RHD). Here we report a genome-wide association study (GWAS) of RHD susceptibility in 2,852 individuals recruited in eight Oceanian countries. Stratifying by ancestry, we analysed genotyped and imputed variants in Melanesians (607 cases and 1,229 controls) before follow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or other populations (totalling 399 cases and 617 controls). We identify a novel susceptibility signal in the immunoglobulin heavy chain (IGH) locus centring on a haplotype of nonsynonymous variants in the <italic>IGHV4-61</italic>
 gene segment corresponding to the <italic>IGHV4-61</italic>
*02 allele. We show each copy of <italic>IGHV4-61</italic>
*02 is associated with a 1.4-fold increase in the risk of RHD (odds ratio 1.43, 95% confidence intervals 1.27–1.61, <italic>P</italic>
=4.1 × 10<sup>−9</sup>
). These findings provide new insight into the role of germline variation in the IGH locus in disease susceptibility.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Steer, A C" uniqKey="Steer A">A. C. Steer</name>
</author>
<author><name sortKey="Carapetis, J R" uniqKey="Carapetis J">J. R. Carapetis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carapetis, J R" uniqKey="Carapetis J">J. R. Carapetis</name>
</author>
<author><name sortKey="Steer, A C" uniqKey="Steer A">A. C. Steer</name>
</author>
<author><name sortKey="Mulholland, E K" uniqKey="Mulholland E">E. K. Mulholland</name>
</author>
<author><name sortKey="Weber, M" uniqKey="Weber M">M. Weber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Remenyi, B" uniqKey="Remenyi B">B. Reményi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carapetis, J R" uniqKey="Carapetis J">J. R. Carapetis</name>
</author>
<author><name sortKey="Zuhlke, L J" uniqKey="Zuhlke L">L. J. Zühlke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheadle, W B" uniqKey="Cheadle W">W. B. Cheadle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Engel, M E" uniqKey="Engel M">M. E. Engel</name>
</author>
<author><name sortKey="Stander, R" uniqKey="Stander R">R. Stander</name>
</author>
<author><name sortKey="Vogel, J" uniqKey="Vogel J">J. Vogel</name>
</author>
<author><name sortKey="Adeyemo, A A" uniqKey="Adeyemo A">A. A. Adeyemo</name>
</author>
<author><name sortKey="Mayosi, B M" uniqKey="Mayosi B">B. M. Mayosi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carapetis, J R" uniqKey="Carapetis J">J. R. Carapetis</name>
</author>
<author><name sortKey="Currie, B J" uniqKey="Currie B">B. J. Currie</name>
</author>
<author><name sortKey="Mathews, J D" uniqKey="Mathews J">J. D. Mathews</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, W J" uniqKey="Martin W">W. J. Martin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parks, T" uniqKey="Parks T">T. Parks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delaneau, O" uniqKey="Delaneau O">O. Delaneau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morris, A P" uniqKey="Morris A">A. P. Morris</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Evangelou, E" uniqKey="Evangelou E">E. Evangelou</name>
</author>
<author><name sortKey="Ioannidis, J P A" uniqKey="Ioannidis J">J. P. A. Ioannidis</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
<author><name sortKey="Jackson, K J" uniqKey="Jackson K">K. J. Jackson</name>
</author>
<author><name sortKey="Sewell, W A" uniqKey="Sewell W">W. A. Sewell</name>
</author>
<author><name sortKey="Collins, A M" uniqKey="Collins A">A. M. Collins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Remenyi, B" uniqKey="Remenyi B">B. Reményi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adzhubei, I A" uniqKey="Adzhubei I">I. A. Adzhubei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dunbar, J" uniqKey="Dunbar J">J. Dunbar</name>
</author>
<author><name sortKey="Fuchs, A" uniqKey="Fuchs A">A. Fuchs</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name>
</author>
<author><name sortKey="Deane, C M" uniqKey="Deane C">C. M. Deane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bujotzek, A" uniqKey="Bujotzek A">A. Bujotzek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="North, B" uniqKey="North B">B. North</name>
</author>
<author><name sortKey="Lehmann, A" uniqKey="Lehmann A">A. Lehmann</name>
</author>
<author><name sortKey="Dunbrack, R L" uniqKey="Dunbrack R">R. L. Dunbrack</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nowak, J" uniqKey="Nowak J">J. Nowak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krawczyk, K" uniqKey="Krawczyk K">K. Krawczyk</name>
</author>
<author><name sortKey="Baker, T" uniqKey="Baker T">T. Baker</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name>
</author>
<author><name sortKey="Deane, C M" uniqKey="Deane C">C. M. Deane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stave, J W" uniqKey="Stave J">J. W. Stave</name>
</author>
<author><name sortKey="Lindpaintner, K" uniqKey="Lindpaintner K">K. Lindpaintner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honegger, A" uniqKey="Honegger A">A. Honegger</name>
</author>
<author><name sortKey="Pluckthun, A" uniqKey="Pluckthun A">A. Plückthun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watson, C T" uniqKey="Watson C">C. T. Watson</name>
</author>
<author><name sortKey="Breden, F" uniqKey="Breden F">F. Breden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robinson, W H" uniqKey="Robinson W">W. H. Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Watson, C T" uniqKey="Watson C">C. T. Watson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matsuda, F" uniqKey="Matsuda F">F. Matsuda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, J C" uniqKey="Lambert J">J. C. Lambert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsai, F J" uniqKey="Tsai F">F.-J. Tsai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaplan, M H" uniqKey="Kaplan M">M. H. Kaplan</name>
</author>
<author><name sortKey="Bolande, R" uniqKey="Bolande R">R. Bolande</name>
</author>
<author><name sortKey="Rakita, L" uniqKey="Rakita L">L. Rakita</name>
</author>
<author><name sortKey="Blair, J" uniqKey="Blair J">J. Blair</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adderson, E E" uniqKey="Adderson E">E. E. Adderson</name>
</author>
<author><name sortKey="Shikhman, A R" uniqKey="Shikhman A">A. R. Shikhman</name>
</author>
<author><name sortKey="Ward, K E" uniqKey="Ward K">K. E. Ward</name>
</author>
<author><name sortKey="Cunningham, M W" uniqKey="Cunningham M">M. W. Cunningham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Towers, R J" uniqKey="Towers R">R. J. Towers</name>
</author>
<author><name sortKey="Bolm, M" uniqKey="Bolm M">M. Bolm</name>
</author>
<author><name sortKey="Currie, B J" uniqKey="Currie B">B. J. Currie</name>
</author>
<author><name sortKey="Chhatwal, G S" uniqKey="Chhatwal G">G. S. Chhatwal</name>
</author>
<author><name sortKey="Fagan, P K" uniqKey="Fagan P">P. K. Fagan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steer, A C" uniqKey="Steer A">A. C. Steer</name>
</author>
<author><name sortKey="Batzloff, M R" uniqKey="Batzloff M">M. R. Batzloff</name>
</author>
<author><name sortKey="Mulholland, K" uniqKey="Mulholland K">K. Mulholland</name>
</author>
<author><name sortKey="Carapetis, J R" uniqKey="Carapetis J">J. R. Carapetis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seldin, M F" uniqKey="Seldin M">M. F. Seldin</name>
</author>
<author><name sortKey="Pasaniuc, B" uniqKey="Pasaniuc B">B. Pasaniuc</name>
</author>
<author><name sortKey="Price, A L" uniqKey="Price A">A. L. Price</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonow, R O" uniqKey="Bonow R">R. O. Bonow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wellcome Trust" uniqKey="Wellcome Trust">Wellcome Trust</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Old, J M" uniqKey="Old J">J. M. Old</name>
</author>
<author><name sortKey="Clegg, J B" uniqKey="Clegg J">J. B. Clegg</name>
</author>
<author><name sortKey="Weatherall, D J" uniqKey="Weatherall D">D. J. Weatherall</name>
</author>
<author><name sortKey="Booth, P B" uniqKey="Booth P">P. B. Booth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hill, A V S" uniqKey="Hill A">A. V. S. Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hill, A V S" uniqKey="Hill A">A. V. S. Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flint, J" uniqKey="Flint J">J. Flint</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Shaughnessy, D F" uniqKey="O Shaughnessy D">D. F. O'Shaughnessy</name>
</author>
<author><name sortKey="Hill, A V S" uniqKey="Hill A">A. V. S. Hill</name>
</author>
<author><name sortKey="Bowden, D K" uniqKey="Bowden D">D. K. Bowden</name>
</author>
<author><name sortKey="Weatherall, D J" uniqKey="Weatherall D">D. J. Weatherall</name>
</author>
<author><name sortKey="Clegg, J B" uniqKey="Clegg J">J. B. Clegg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Philippon, G" uniqKey="Philippon G">G. Philippon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ganczakowski, M" uniqKey="Ganczakowski M">M. Ganczakowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barnardo, M C" uniqKey="Barnardo M">M. C. Barnardo</name>
</author>
<author><name sortKey="Welsh, K I" uniqKey="Welsh K">K. I. Welsh</name>
</author>
<author><name sortKey="Vilches, C" uniqKey="Vilches C">C. Vilches</name>
</author>
<author><name sortKey="Maitland, K" uniqKey="Maitland K">K. Maitland</name>
</author>
<author><name sortKey="Bunce, M" uniqKey="Bunce M">M. Bunce</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maitland, K" uniqKey="Maitland K">K. Maitland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinson, J J" uniqKey="Martinson J">J. J. Martinson</name>
</author>
<author><name sortKey="Chapman, N H" uniqKey="Chapman N">N. H. Chapman</name>
</author>
<author><name sortKey="Rees, D C" uniqKey="Rees D">D. C. Rees</name>
</author>
<author><name sortKey="Liu, Y T" uniqKey="Liu Y">Y. T. Liu</name>
</author>
<author><name sortKey="Clegg, J B" uniqKey="Clegg J">J. B. Clegg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Merryweather Clarke, A T" uniqKey="Merryweather Clarke A">A. T. Merryweather-Clarke</name>
</author>
<author><name sortKey="Pointon, J J" uniqKey="Pointon J">J. J. Pointon</name>
</author>
<author><name sortKey="Shearman, J D" uniqKey="Shearman J">J. D. Shearman</name>
</author>
<author><name sortKey="Robson, K J" uniqKey="Robson K">K. J. Robson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anderson, C A" uniqKey="Anderson C">C. A. Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, C C" uniqKey="Chang C">C. C. Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lunter, G" uniqKey="Lunter G">G. Lunter</name>
</author>
<author><name sortKey="Goodson, M" uniqKey="Goodson M">M. Goodson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckenna, A" uniqKey="Mckenna A">A. McKenna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Auwera, G A" uniqKey="Van Der Auwera G">G. A. Van der Auwera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delaneau, O" uniqKey="Delaneau O">O. Delaneau</name>
</author>
<author><name sortKey="Marchini, J" uniqKey="Marchini J">J. Marchini</name>
</author>
<author><name sortKey="Zagury, J F" uniqKey="Zagury J">J.-F. Zagury</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howie, B N" uniqKey="Howie B">B. N. Howie</name>
</author>
<author><name sortKey="Donnelly, P J" uniqKey="Donnelly P">P. J. Donnelly</name>
</author>
<author><name sortKey="Marchini, J" uniqKey="Marchini J">J. Marchini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howie, B" uniqKey="Howie B">B. Howie</name>
</author>
<author><name sortKey="Marchini, J" uniqKey="Marchini J">J. Marchini</name>
</author>
<author><name sortKey="Stephens, M" uniqKey="Stephens M">M. Stephens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moltke, I" uniqKey="Moltke I">I. Moltke</name>
</author>
<author><name sortKey="Albrechtsen, A" uniqKey="Albrechtsen A">A. Albrechtsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, A" uniqKey="Raj A">A. Raj</name>
</author>
<author><name sortKey="Stephens, M" uniqKey="Stephens M">M. Stephens</name>
</author>
<author><name sortKey="Pritchard, J K" uniqKey="Pritchard J">J. K. Pritchard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Lee, S H" uniqKey="Lee S">S. H. Lee</name>
</author>
<author><name sortKey="Goddard, M E" uniqKey="Goddard M">M. E. Goddard</name>
</author>
<author><name sortKey="Visscher, P M" uniqKey="Visscher P">P. M. Visscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, J Z" uniqKey="Li J">J. Z. Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Devlin, B" uniqKey="Devlin B">B. Devlin</name>
</author>
<author><name sortKey="Roeder, K" uniqKey="Roeder K">K. Roeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayeck, T J" uniqKey="Hayeck T">T. J. Hayeck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, B B" uniqKey="Hansen B">B. B. Hansen</name>
</author>
<author><name sortKey="Klopfer, S O" uniqKey="Klopfer S">S. O. Klopfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Zaitlen, N A" uniqKey="Zaitlen N">N. A. Zaitlen</name>
</author>
<author><name sortKey="Goddard, M E" uniqKey="Goddard M">M. E. Goddard</name>
</author>
<author><name sortKey="Visscher, P M" uniqKey="Visscher P">P. M. Visscher</name>
</author>
<author><name sortKey="Price, A L" uniqKey="Price A">A. L. Price</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchini, J" uniqKey="Marchini J">J. Marchini</name>
</author>
<author><name sortKey="Howie, B" uniqKey="Howie B">B. Howie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sham, P C" uniqKey="Sham P">P. C. Sham</name>
</author>
<author><name sortKey="Purcell, S M" uniqKey="Purcell S">S. M. Purcell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Han, B" uniqKey="Han B">B. Han</name>
</author>
<author><name sortKey="Eskin, E" uniqKey="Eskin E">E. Eskin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mahajan, A" uniqKey="Mahajan A">A. Mahajan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, J" uniqKey="Ye J">J. Ye</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Fidji</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>Samoa</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Parks, Tom" sort="Parks, Tom" uniqKey="Parks T" first="Tom" last="Parks">Tom Parks</name>
</noRegion>
<name sortKey="Auckland, Kathryn" sort="Auckland, Kathryn" uniqKey="Auckland K" first="Kathryn" last="Auckland">Kathryn Auckland</name>
<name sortKey="Deane, Charlotte M" sort="Deane, Charlotte M" uniqKey="Deane C" first="Charlotte M." last="Deane">Charlotte M. Deane</name>
<name sortKey="Hill, Adrian V S" sort="Hill, Adrian V S" uniqKey="Hill A" first="Adrian V. S." last="Hill">Adrian V. S. Hill</name>
<name sortKey="Mentzer, Alexander J" sort="Mentzer, Alexander J" uniqKey="Mentzer A" first="Alexander J." last="Mentzer">Alexander J. Mentzer</name>
<name sortKey="Nowak, Jaroslaw" sort="Nowak, Jaroslaw" uniqKey="Nowak J" first="Jaroslaw" last="Nowak">Jaroslaw Nowak</name>
<name sortKey="Rautanen, Anna" sort="Rautanen, Anna" uniqKey="Rautanen A" first="Anna" last="Rautanen">Anna Rautanen</name>
<name sortKey="Robson, Kathryn J" sort="Robson, Kathryn J" uniqKey="Robson K" first="Kathryn J." last="Robson">Kathryn J. Robson</name>
</country>
<country name="France"><noRegion><name sortKey="Mirabel, Mariana M" sort="Mirabel, Mariana M" uniqKey="Mirabel M" first="Mariana M." last="Mirabel">Mariana M. Mirabel</name>
</noRegion>
<name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name>
<name sortKey="Jouven, Xavier" sort="Jouven, Xavier" uniqKey="Jouven X" first="Xavier" last="Jouven">Xavier Jouven</name>
<name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name>
<name sortKey="Marijon, Eloi" sort="Marijon, Eloi" uniqKey="Marijon E" first="Eloi" last="Marijon">Eloi Marijon</name>
</country>
<country name="Fidji"><noRegion><name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name>
</noRegion>
<name sortKey="Cua, Tuliana" sort="Cua, Tuliana" uniqKey="Cua T" first="Tuliana" last="Cua">Tuliana Cua</name>
<name sortKey="Kado, Joseph" sort="Kado, Joseph" uniqKey="Kado J" first="Joseph" last="Kado">Joseph Kado</name>
<name sortKey="Perman, Mai Ling" sort="Perman, Mai Ling" uniqKey="Perman M" first="Mai Ling" last="Perman">Mai Ling Perman</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Kauwe, John K" sort="Kauwe, John K" uniqKey="Kauwe J" first="John K." last="Kauwe">John K. Kauwe</name>
</noRegion>
<name sortKey="Allen, John B" sort="Allen, John B" uniqKey="Allen J" first="John B." last="Allen">John B. Allen</name>
</country>
<country name="Samoa"><noRegion><name sortKey="Taylor, Henry" sort="Taylor, Henry" uniqKey="Taylor H" first="Henry" last="Taylor">Henry Taylor</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C." last="Steer">Andrew C. Steer</name>
</noRegion>
<name sortKey="Steer, Andrew C" sort="Steer, Andrew C" uniqKey="Steer A" first="Andrew C." last="Steer">Andrew C. Steer</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001145 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001145 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:5437274
   |texte=   Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28492228" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.