Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors.
Identifieur interne : 000D90 ( Main/Exploration ); précédent : 000D89; suivant : 000D91Dual-Action Cancer Therapy with Targeted Porous Silicon Nanovectors.
Auteurs : Anna Cifuentes-Rius [Australie] ; Angela Ivask [Australie] ; Ester Sporleder [Australie] ; Ishdeep Kaur [Australie] ; Yasmin Assan [Australie] ; Shasha Rao [Australie] ; David Warther [France] ; Clive A. Prestidge [Australie] ; Jean-Olivier Durand [France] ; Nicolas H. Voelcker [Australie]Source :
- Small (Weinheim an der Bergstrasse, Germany) [ 1613-6829 ] ; 2017.
Abstract
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.
DOI: 10.1002/smll.201701201
PubMed: 28570785
Affiliations:
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Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Ivask, Angela" sort="Ivask, Angela" uniqKey="Ivask A" first="Angela" last="Ivask">Angela Ivask</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Sporleder, Ester" sort="Sporleder, Ester" uniqKey="Sporleder E" first="Ester" last="Sporleder">Ester Sporleder</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Kaur, Ishdeep" sort="Kaur, Ishdeep" uniqKey="Kaur I" first="Ishdeep" last="Kaur">Ishdeep Kaur</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Assan, Yasmin" sort="Assan, Yasmin" uniqKey="Assan Y" first="Yasmin" last="Assan">Yasmin Assan</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author><author><name sortKey="Rao, Shasha" sort="Rao, Shasha" uniqKey="Rao S" first="Shasha" last="Rao">Shasha Rao</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000</wicri:regionArea><wicri:noRegion>5000</wicri:noRegion></affiliation></author><author><name sortKey="Warther, David" sort="Warther, David" uniqKey="Warther D" first="David" last="Warther">David Warther</name><affiliation wicri:level="1"><nlm:affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05</wicri:regionArea><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Prestidge, Clive A" sort="Prestidge, Clive A" uniqKey="Prestidge C" first="Clive A" last="Prestidge">Clive A. Prestidge</name><affiliation wicri:level="1"><nlm:affiliation>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pharmacy and Medical Sciences, University of South Australia, City East Campus, Adelaide, SA, 5000</wicri:regionArea><wicri:noRegion>5000</wicri:noRegion></affiliation></author><author><name sortKey="Durand, Jean Olivier" sort="Durand, Jean Olivier" uniqKey="Durand J" first="Jean-Olivier" last="Durand">Jean-Olivier Durand</name><affiliation wicri:level="1"><nlm:affiliation>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM-ENSCM-UM1cc, 1701, Place Eugène Bataillon, F-34095, Montpelliercedex 05</wicri:regionArea><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion><wicri:noRegion>34095, Montpelliercedex 05</wicri:noRegion></affiliation></author><author><name sortKey="Voelcker, Nicolas H" sort="Voelcker, Nicolas H" uniqKey="Voelcker N" first="Nicolas H" last="Voelcker">Nicolas H. Voelcker</name><affiliation wicri:level="1"><nlm:affiliation>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute, University of South Australia, Mawson Lakes, SA, 5095</wicri:regionArea><wicri:noRegion>5095</wicri:noRegion></affiliation></author></analytic><series><title level="j">Small (Weinheim an der Bergstrasse, Germany)</title><idno type="eISSN">1613-6829</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two-stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Cifuentes Rius, Anna" sort="Cifuentes Rius, Anna" uniqKey="Cifuentes Rius A" first="Anna" last="Cifuentes-Rius">Anna Cifuentes-Rius</name></noRegion><name sortKey="Assan, Yasmin" sort="Assan, Yasmin" uniqKey="Assan Y" first="Yasmin" last="Assan">Yasmin Assan</name><name sortKey="Ivask, Angela" sort="Ivask, Angela" uniqKey="Ivask A" first="Angela" last="Ivask">Angela Ivask</name><name sortKey="Kaur, Ishdeep" sort="Kaur, Ishdeep" uniqKey="Kaur I" first="Ishdeep" last="Kaur">Ishdeep Kaur</name><name sortKey="Prestidge, Clive A" sort="Prestidge, Clive A" uniqKey="Prestidge C" first="Clive A" last="Prestidge">Clive A. Prestidge</name><name sortKey="Rao, Shasha" sort="Rao, Shasha" uniqKey="Rao S" first="Shasha" last="Rao">Shasha Rao</name><name sortKey="Sporleder, Ester" sort="Sporleder, Ester" uniqKey="Sporleder E" first="Ester" last="Sporleder">Ester Sporleder</name><name sortKey="Voelcker, Nicolas H" sort="Voelcker, Nicolas H" uniqKey="Voelcker N" first="Nicolas H" last="Voelcker">Nicolas H. Voelcker</name></country><country name="France"><noRegion><name sortKey="Warther, David" sort="Warther, David" uniqKey="Warther D" first="David" last="Warther">David Warther</name></noRegion><name sortKey="Durand, Jean Olivier" sort="Durand, Jean Olivier" uniqKey="Durand J" first="Jean-Olivier" last="Durand">Jean-Olivier Durand</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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