Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.
Identifieur interne : 000A46 ( Main/Exploration ); précédent : 000A45; suivant : 000A47Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.
Auteurs : Michele Simonato [Italie] ; Sloka Iyengar [États-Unis] ; Amy Brooks-Kayal [États-Unis] ; Stephen Collins [États-Unis] ; Antoine Depaulis [France] ; David W. Howells [Australie] ; Frances Jensen [États-Unis] ; Jing Liao [Royaume-Uni] ; Malcolm R. Macleod [Royaume-Uni] ; Manisha Patel [États-Unis] ; Heidrun Potschka [Allemagne] ; Matthew Walker [Royaume-Uni] ; Vicky Whittemore [États-Unis] ; Emily S. Sena [Royaume-Uni]Source :
- Epilepsia [ 1528-1167 ] ; 2017.
Abstract
Current antiseizure therapy is ineffective in approximately one third of people with epilepsy and is often associated with substantial side effects. In addition, most current therapeutic paradigms offer treatment, but not cure, and no therapies are able to modify the underlying disease, that is, can prevent or halt the process of epileptogenesis or alleviate the cognitive and psychiatric comorbidities. Preclinical research in the field of epilepsy has been extensive, but unfortunately, not all the animal models being used have been validated for their predictive value. The overall goal of TASK2 of the AES/ILAE Translational Task Force is to organize and coordinate systematic reviews on selected topics regarding animal research in epilepsy. Herein we describe our strategy. In the first part of the paper we provide an overview of the usefulness of systematic reviews and meta-analysis for preclinical research and explain the essentials for their conduct. Then we describe in detail the protocol for a first systematic review, which will focus on the identification and characterization of outcome measures reported in animal models of epilepsy. The specific goals of this study are to define systematically the phenotypic characteristics of the most commonly used animal models, and to effectively compare these with the manifestations of human epilepsy. This will provide epilepsy researchers with detailed information on the strengths and weaknesses of epilepsy models, facilitating their refinement and future research. Ultimately, this could lead to a refined use of relevant models for understanding the mechanism(s) of the epilepsies and developing novel therapies.
DOI: 10.1111/epi.13908
PubMed: 29105071
Affiliations:
- Allemagne, Australie, France, Italie, Royaume-Uni, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Bavière, Colorado, District de Haute-Bavière, Floride, Grand Londres, Maryland, Pennsylvanie, Rhône-Alpes, Écosse, État de New York
- Grenoble, Londres, Munich, Édimbourg
- Université Louis-et-Maximilien de Munich, Université d'Édimbourg
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Le document en format XML
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Howells</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, University of Tasmania, Hobart, Tasmania</wicri:regionArea><wicri:noRegion>Tasmania</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Frances" sort="Jensen, Frances" uniqKey="Jensen F" first="Frances" last="Jensen">Frances Jensen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Liao, Jing" sort="Liao, Jing" uniqKey="Liao J" first="Jing" last="Liao">Jing Liao</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Macleod, Malcolm R" sort="Macleod, Malcolm R" uniqKey="Macleod M" first="Malcolm R" last="Macleod">Malcolm R. Macleod</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Patel, Manisha" sort="Patel, Manisha" uniqKey="Patel M" first="Manisha" last="Patel">Manisha Patel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmaceutical Sciences, University of Colorado, Aurora, Colorado</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Potschka, Heidrun" sort="Potschka, Heidrun" uniqKey="Potschka H" first="Heidrun" last="Potschka">Heidrun Potschka</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University (LMU), Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Walker, Matthew" sort="Walker, Matthew" uniqKey="Walker M" first="Matthew" last="Walker">Matthew Walker</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neurology, University College of London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, University College of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Whittemore, Vicky" sort="Whittemore, Vicky" uniqKey="Whittemore V" first="Vicky" last="Whittemore">Vicky Whittemore</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Sena, Emily S" sort="Sena, Emily S" uniqKey="Sena E" first="Emily S" last="Sena">Emily S. Sena</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author></analytic><series><title level="j">Epilepsia</title><idno type="eISSN">1528-1167</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current antiseizure therapy is ineffective in approximately one third of people with epilepsy and is often associated with substantial side effects. In addition, most current therapeutic paradigms offer treatment, but not cure, and no therapies are able to modify the underlying disease, that is, can prevent or halt the process of epileptogenesis or alleviate the cognitive and psychiatric comorbidities. Preclinical research in the field of epilepsy has been extensive, but unfortunately, not all the animal models being used have been validated for their predictive value. The overall goal of TASK2 of the AES/ILAE Translational Task Force is to organize and coordinate systematic reviews on selected topics regarding animal research in epilepsy. Herein we describe our strategy. In the first part of the paper we provide an overview of the usefulness of systematic reviews and meta-analysis for preclinical research and explain the essentials for their conduct. Then we describe in detail the protocol for a first systematic review, which will focus on the identification and characterization of outcome measures reported in animal models of epilepsy. The specific goals of this study are to define systematically the phenotypic characteristics of the most commonly used animal models, and to effectively compare these with the manifestations of human epilepsy. This will provide epilepsy researchers with detailed information on the strengths and weaknesses of epilepsy models, facilitating their refinement and future research. Ultimately, this could lead to a refined use of relevant models for understanding the mechanism(s) of the epilepsies and developing novel therapies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bavière</li><li>Colorado</li><li>District de Haute-Bavière</li><li>Floride</li><li>Grand Londres</li><li>Maryland</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Grenoble</li><li>Londres</li><li>Munich</li><li>Édimbourg</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Édimbourg</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Simonato, Michele" sort="Simonato, Michele" uniqKey="Simonato M" first="Michele" last="Simonato">Michele Simonato</name></noRegion></country><country name="États-Unis"><region name="État de New York"><name sortKey="Iyengar, Sloka" sort="Iyengar, Sloka" uniqKey="Iyengar S" first="Sloka" last="Iyengar">Sloka Iyengar</name></region><name sortKey="Brooks Kayal, Amy" sort="Brooks Kayal, Amy" uniqKey="Brooks Kayal A" first="Amy" last="Brooks-Kayal">Amy Brooks-Kayal</name><name sortKey="Collins, Stephen" sort="Collins, Stephen" uniqKey="Collins S" first="Stephen" last="Collins">Stephen Collins</name><name sortKey="Jensen, Frances" sort="Jensen, Frances" uniqKey="Jensen F" first="Frances" last="Jensen">Frances Jensen</name><name sortKey="Patel, Manisha" sort="Patel, Manisha" uniqKey="Patel M" first="Manisha" last="Patel">Manisha Patel</name><name sortKey="Whittemore, Vicky" sort="Whittemore, Vicky" uniqKey="Whittemore V" first="Vicky" last="Whittemore">Vicky Whittemore</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Depaulis, Antoine" sort="Depaulis, Antoine" uniqKey="Depaulis A" first="Antoine" last="Depaulis">Antoine Depaulis</name></region></country><country name="Australie"><noRegion><name sortKey="Howells, David W" sort="Howells, David W" uniqKey="Howells D" first="David W" last="Howells">David W. Howells</name></noRegion></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Liao, Jing" sort="Liao, Jing" uniqKey="Liao J" first="Jing" last="Liao">Jing Liao</name></region><name sortKey="Macleod, Malcolm R" sort="Macleod, Malcolm R" uniqKey="Macleod M" first="Malcolm R" last="Macleod">Malcolm R. Macleod</name><name sortKey="Sena, Emily S" sort="Sena, Emily S" uniqKey="Sena E" first="Emily S" last="Sena">Emily S. Sena</name><name sortKey="Walker, Matthew" sort="Walker, Matthew" uniqKey="Walker M" first="Matthew" last="Walker">Matthew Walker</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Potschka, Heidrun" sort="Potschka, Heidrun" uniqKey="Potschka H" first="Heidrun" last="Potschka">Heidrun Potschka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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