Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation
Identifieur interne : 000995 ( Main/Exploration ); précédent : 000994; suivant : 000996Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation
Auteurs : Boris Novakovic [Australie] ; Thierry Fournier [France] ; Lynda K. Harris [Royaume-Uni] ; Joanna James [Nouvelle-Zélande] ; Claire T. Roberts ; Hannah E. J. Yong [Australie] ; Bill Kalionis [Australie] ; Danièle Evain-Brion [France] ; Peter R. Ebeling [Australie] ; Euan M. Wallace [Australie] ; Richard Saffery [Australie] ; Padma Murthi [Australie]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Homeobox genes regulate embryonic and placental development, and are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear. DNA methylation analysis was performed on human placentae from first, second and third trimesters to determine methylation patterns of homeobox gene promoters across gestation. Most homeobox genes were hypo-methylated throughout gestation, suggesting that DNA methylation is not the primary mechanism involved in regulating HOX genes expression in the placenta. Nevertheless, several genes showed variable methylation patterns across gestation, with a general trend towards an increase in methylation over gestation. Three genes (
Url:
DOI: 10.1038/s41598-017-04776-5
PubMed: 28674422
PubMed Central: 5495813
Affiliations:
- Australie, France, Nouvelle-Zélande, Royaume-Uni
- Victoria (État), Île-de-France
- Melbourne, Paris
- Université de Melbourne
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Le document en format XML
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in human placenta are associated with trophoblast differentiation</title>
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</author>
<author><name sortKey="Ebeling, Peter R" sort="Ebeling, Peter R" uniqKey="Ebeling P" first="Peter R." last="Ebeling">Peter R. Ebeling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id>
<institution-id institution-id-type="GRID">grid.1002.3</institution-id>
<institution>Department of Medicine,</institution>
<institution>School of Clinical Sciences, Monash University,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wallace, Euan M" sort="Wallace, Euan M" uniqKey="Wallace E" first="Euan M." last="Wallace">Euan M. Wallace</name>
<affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.452824.d</institution-id>
<institution>The Ritchie Centre,</institution>
<institution>Hudson Institute of Medical Research,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff11"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id>
<institution-id institution-id-type="GRID">grid.1002.3</institution-id>
<institution>Department of Obstetrics and Gynaecology,</institution>
<institution>Monash University,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0614 0346</institution-id>
<institution-id institution-id-type="GRID">grid.416107.5</institution-id>
<institution>Cancer and Disease Epigenetics, Murdoch Childrens Research Institute,</institution>
<institution>Royal Children’s Hospital,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2179 088X</institution-id>
<institution-id institution-id-type="GRID">grid.1008.9</institution-id>
<institution>Department of Paediatrics,</institution>
<institution>University of Melbourne,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murthi, Padma" sort="Murthi, Padma" uniqKey="Murthi P" first="Padma" last="Murthi">Padma Murthi</name>
<affiliation wicri:level="4"><nlm:aff id="Aff8">Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women’s Hospital, and Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Maternal-Fetal Medicine Pregnancy Research Centre, The Royal Women’s Hospital, and Department of Obstetrics and Gynaecology, University of Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7857</institution-id>
<institution-id institution-id-type="GRID">grid.1002.3</institution-id>
<institution>Department of Medicine,</institution>
<institution>School of Clinical Sciences, Monash University,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff10"><institution-wrap><institution-id institution-id-type="GRID">grid.452824.d</institution-id>
<institution>The Ritchie Centre,</institution>
<institution>Hudson Institute of Medical Research,</institution>
</institution-wrap>
Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Victoria</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Homeobox genes regulate embryonic and placental development, and are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear. DNA methylation analysis was performed on human placentae from first, second and third trimesters to determine methylation patterns of homeobox gene promoters across gestation. Most homeobox genes were hypo-methylated throughout gestation, suggesting that DNA methylation is not the primary mechanism involved in regulating HOX genes expression in the placenta. Nevertheless, several genes showed variable methylation patterns across gestation, with a general trend towards an increase in methylation over gestation. Three genes (<italic>TLX1, HOXA10</italic>
and <italic>DLX5</italic>
) showed inverse gains of methylation with decreasing mRNA expression throughout pregnancy, supporting a role for DNA methylation in their regulation. Proteins encoded by these genes were primarily localised to the syncytiotrophoblast layer, and showed decreased expression later in gestation. siRNA mediated downregulation of <italic>DLX5</italic>
, <italic>TLX1</italic>
and <italic>HOXA10</italic>
in primary term villous cytotrophoblast resulted in decreased proliferation and increased expression of differentiation markers, including <italic>ERVW-1</italic>
. Our data suggest that loss of <italic>DLX5, TLX1</italic>
and <italic>HOXA10</italic>
expression in late gestation is required for proper placental differentiation and function.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morrish, Dw" uniqKey="Morrish D">DW Morrish</name>
</author>
<author><name sortKey="Dakour, J" uniqKey="Dakour J">J Dakour</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knofler, M" uniqKey="Knofler M">M Knofler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knofler, M" uniqKey="Knofler M">M Knofler</name>
</author>
<author><name sortKey="Vasicek, R" uniqKey="Vasicek R">R Vasicek</name>
</author>
<author><name sortKey="Schreiber, M" uniqKey="Schreiber M">M Schreiber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knofler, M" uniqKey="Knofler M">M Knofler</name>
</author>
<author><name sortKey="Pollheimer, J" uniqKey="Pollheimer J">J Pollheimer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cross, Jc" uniqKey="Cross J">JC Cross</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Latos, Pa" uniqKey="Latos P">PA Latos</name>
</author>
<author><name sortKey="Hemberger, M" uniqKey="Hemberger M">M Hemberger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boncinelli, E" uniqKey="Boncinelli E">E Boncinelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gehring, Wj" uniqKey="Gehring W">WJ Gehring</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunes, Fd" uniqKey="Nunes F">FD Nunes</name>
</author>
<author><name sortKey="De Almeida, Fc" uniqKey="De Almeida F">FC de Almeida</name>
</author>
<author><name sortKey="Tucci, R" uniqKey="Tucci R">R Tucci</name>
</author>
<author><name sortKey="De Sousa, Sc" uniqKey="De Sousa S">SC de Sousa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boncinelli, E" uniqKey="Boncinelli E">E Boncinelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gehring, Wj" uniqKey="Gehring W">WJ Gehring</name>
</author>
<author><name sortKey="Hiromi, Y" uniqKey="Hiromi Y">Y Hiromi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Akam, M" uniqKey="Akam M">M Akam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lohmann, I" uniqKey="Lohmann I">I Lohmann</name>
</author>
<author><name sortKey="Mcginnis, W" uniqKey="Mcginnis W">W McGinnis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mann, Rs" uniqKey="Mann R">RS Mann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Acampora, D" uniqKey="Acampora D">D Acampora</name>
</author>
<author><name sortKey="Pannese, M" uniqKey="Pannese M">M Pannese</name>
</author>
<author><name sortKey="D Sposito, M" uniqKey="D Sposito M">M D’Esposito</name>
</author>
<author><name sortKey="Simeone, A" uniqKey="Simeone A">A Simeone</name>
</author>
<author><name sortKey="Boncinelli, E" uniqKey="Boncinelli E">E Boncinelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oudejans, Cb" uniqKey="Oudejans C">CB Oudejans</name>
</author>
<author><name sortKey="Pannese, M" uniqKey="Pannese M">M Pannese</name>
</author>
<author><name sortKey="Simeone, A" uniqKey="Simeone A">A Simeone</name>
</author>
<author><name sortKey="Meijer, Cj" uniqKey="Meijer C">CJ Meijer</name>
</author>
<author><name sortKey="Boncinelli, E" uniqKey="Boncinelli E">E Boncinelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chui, A" uniqKey="Chui A">A Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chui, A" uniqKey="Chui A">A Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grati, Fr" uniqKey="Grati F">FR Grati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Quinn, Lm" uniqKey="Quinn L">LM Quinn</name>
</author>
<author><name sortKey="Johnson, Bv" uniqKey="Johnson B">BV Johnson</name>
</author>
<author><name sortKey="Nicholl, J" uniqKey="Nicholl J">J Nicholl</name>
</author>
<author><name sortKey="Sutherland, Gr" uniqKey="Sutherland G">GR Sutherland</name>
</author>
<author><name sortKey="Kalionis, B" uniqKey="Kalionis B">B Kalionis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rajaraman, G" uniqKey="Rajaraman G">G Rajaraman</name>
</author>
<author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
<author><name sortKey="Quinn, L" uniqKey="Quinn L">L Quinn</name>
</author>
<author><name sortKey="Brennecke, Sp" uniqKey="Brennecke S">SP Brennecke</name>
</author>
<author><name sortKey="Kalionis, B" uniqKey="Kalionis B">B Kalionis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Yy" uniqKey="Sun Y">YY Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rajaraman, G" uniqKey="Rajaraman G">G Rajaraman</name>
</author>
<author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
<author><name sortKey="Brennecke, Sp" uniqKey="Brennecke S">SP Brennecke</name>
</author>
<author><name sortKey="Kalionis, B" uniqKey="Kalionis B">B Kalionis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rajaraman, G" uniqKey="Rajaraman G">G Rajaraman</name>
</author>
<author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
<author><name sortKey="Pathirage, N" uniqKey="Pathirage N">N Pathirage</name>
</author>
<author><name sortKey="Brennecke, Sp" uniqKey="Brennecke S">SP Brennecke</name>
</author>
<author><name sortKey="Kalionis, B" uniqKey="Kalionis B">B Kalionis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Yin, L" uniqKey="Yin L">L Yin</name>
</author>
<author><name sortKey="Zhao, F" uniqKey="Zhao F">F Zhao</name>
</author>
<author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chui, A" uniqKey="Chui A">A Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chui, A" uniqKey="Chui A">A Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murthi, P" uniqKey="Murthi P">P Murthi</name>
</author>
<author><name sortKey="Abumaree, M" uniqKey="Abumaree M">M Abumaree</name>
</author>
<author><name sortKey="Kalionis, B" uniqKey="Kalionis B">B Kalionis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Novakovic, B" uniqKey="Novakovic B">B Novakovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Januar, V" uniqKey="Januar V">V Januar</name>
</author>
<author><name sortKey="Desoye, G" uniqKey="Desoye G">G Desoye</name>
</author>
<author><name sortKey="Novakovic, B" uniqKey="Novakovic B">B Novakovic</name>
</author>
<author><name sortKey="Cvitic, S" uniqKey="Cvitic S">S Cvitic</name>
</author>
<author><name sortKey="Saffery, R" uniqKey="Saffery R">R Saffery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsumagari, K" uniqKey="Tsumagari K">K Tsumagari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avraham, A" uniqKey="Avraham A">A Avraham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Illingworth, R" uniqKey="Illingworth R">R Illingworth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blair, Jd" uniqKey="Blair J">JD Blair</name>
</author>
<author><name sortKey="Langlois, S" uniqKey="Langlois S">S Langlois</name>
</author>
<author><name sortKey="Mcfadden, De" uniqKey="Mcfadden D">DE McFadden</name>
</author>
<author><name sortKey="Robinson, Wp" uniqKey="Robinson W">WP Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Green, Bb" uniqKey="Green B">BB Green</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baek, K" uniqKey="Baek K">K Baek</name>
</author>
<author><name sortKey="Baek, Jh" uniqKey="Baek J">JH Baek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farshdousti Hagh, M" uniqKey="Farshdousti Hagh M">M Farshdousti Hagh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Cp" uniqKey="Chen C">CP Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Novakovic, B" uniqKey="Novakovic B">B Novakovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Novakovic, B" uniqKey="Novakovic B">B Novakovic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ollikainen, M" uniqKey="Ollikainen M">M Ollikainen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name>
</author>
<author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
<li>Royaume-Uni</li>
</country>
<region><li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Melbourne</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Roberts, Claire T" sort="Roberts, Claire T" uniqKey="Roberts C" first="Claire T." last="Roberts">Claire T. Roberts</name>
</noCountry>
<country name="Australie"><noRegion><name sortKey="Novakovic, Boris" sort="Novakovic, Boris" uniqKey="Novakovic B" first="Boris" last="Novakovic">Boris Novakovic</name>
</noRegion>
<name sortKey="Ebeling, Peter R" sort="Ebeling, Peter R" uniqKey="Ebeling P" first="Peter R." last="Ebeling">Peter R. Ebeling</name>
<name sortKey="Kalionis, Bill" sort="Kalionis, Bill" uniqKey="Kalionis B" first="Bill" last="Kalionis">Bill Kalionis</name>
<name sortKey="Murthi, Padma" sort="Murthi, Padma" uniqKey="Murthi P" first="Padma" last="Murthi">Padma Murthi</name>
<name sortKey="Murthi, Padma" sort="Murthi, Padma" uniqKey="Murthi P" first="Padma" last="Murthi">Padma Murthi</name>
<name sortKey="Murthi, Padma" sort="Murthi, Padma" uniqKey="Murthi P" first="Padma" last="Murthi">Padma Murthi</name>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name>
<name sortKey="Wallace, Euan M" sort="Wallace, Euan M" uniqKey="Wallace E" first="Euan M." last="Wallace">Euan M. Wallace</name>
<name sortKey="Wallace, Euan M" sort="Wallace, Euan M" uniqKey="Wallace E" first="Euan M." last="Wallace">Euan M. Wallace</name>
<name sortKey="Yong, Hannah E J" sort="Yong, Hannah E J" uniqKey="Yong H" first="Hannah E. J." last="Yong">Hannah E. J. Yong</name>
</country>
<country name="France"><noRegion><name sortKey="Fournier, Thierry" sort="Fournier, Thierry" uniqKey="Fournier T" first="Thierry" last="Fournier">Thierry Fournier</name>
</noRegion>
<name sortKey="Evain Brion, Daniele" sort="Evain Brion, Daniele" uniqKey="Evain Brion D" first="Danièle" last="Evain-Brion">Danièle Evain-Brion</name>
<name sortKey="Evain Brion, Daniele" sort="Evain Brion, Daniele" uniqKey="Evain Brion D" first="Danièle" last="Evain-Brion">Danièle Evain-Brion</name>
<name sortKey="Evain Brion, Daniele" sort="Evain Brion, Daniele" uniqKey="Evain Brion D" first="Danièle" last="Evain-Brion">Danièle Evain-Brion</name>
<name sortKey="Fournier, Thierry" sort="Fournier, Thierry" uniqKey="Fournier T" first="Thierry" last="Fournier">Thierry Fournier</name>
<name sortKey="Fournier, Thierry" sort="Fournier, Thierry" uniqKey="Fournier T" first="Thierry" last="Fournier">Thierry Fournier</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Harris, Lynda K" sort="Harris, Lynda K" uniqKey="Harris L" first="Lynda K." last="Harris">Lynda K. Harris</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="James, Joanna" sort="James, Joanna" uniqKey="James J" first="Joanna" last="James">Joanna James</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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