Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health.
Identifieur interne : 000968 ( Main/Exploration ); précédent : 000967; suivant : 000969Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health.
Auteurs : François Leulier [France] ; Lesley T. Macneil [Canada] ; Won-Jae Lee [Corée du Sud] ; John F. Rawls [États-Unis] ; Patrice D. Cani [Belgique] ; Martin Schwarzer [France] ; Liping Zhao [République populaire de Chine] ; Stephen J. Simpson [Australie]Source :
- Cell metabolism [ 1932-7420 ] ; 2017.
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English descriptors
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Abstract
Nutrition is paramount in shaping all aspects of animal biology. In addition, the influence of the intestinal microbiota on physiology is now widely recognized. Given that diet also shapes the intestinal microbiota, this raises the question of how the nutritional environment and microbial assemblages together influence animal physiology. This research field constitutes a new frontier in the field of organismal biology that needs to be addressed. Here we review recent studies using animal models and humans and propose an integrative framework within which to define the study of the diet-physiology-microbiota systems and ultimately link it to human health. Nutritional Geometry sits centrally in the proposed framework and offers means to define diet compositions that are optimal for individuals and populations.
DOI: 10.1016/j.cmet.2017.02.001
PubMed: 28273475
Affiliations:
- Australie, Belgique, Canada, Corée du Sud, France, République populaire de Chine, États-Unis
- Auvergne-Rhône-Alpes, Caroline du Nord, Nouvelle-Galles du Sud, Ontario, Province du Brabant wallon, Rhône-Alpes, Région capitale de Séoul, Région wallonne
- Hamilton (Ontario), Louvain-la-Neuve, Lyon, Sydney, Séoul
- Université McMaster, Université catholique de Louvain, Université de Sydney, Université nationale de Séoul
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Electronic address: francois.leulier@ens-lyon.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon 1, F-69364 Lyon Cedex 07</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Macneil, Lesley T" sort="Macneil, Lesley T" uniqKey="Macneil L" first="Lesley T" last="Macneil">Lesley T. Macneil</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S4K1, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S4K1, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S4K1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S4K1, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S4K1, Canada; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S4K1</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Lee, Won Jae" sort="Lee, Won Jae" uniqKey="Lee W" first="Won-Jae" last="Lee">Won-Jae Lee</name><affiliation wicri:level="4"><nlm:affiliation>School of Biological Science, Institute of Molecular Biology and Genetics, National Creative Research Initiative Center for Hologenomics, Seoul National University, Seoul 151-742, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>School of Biological Science, Institute of Molecular Biology and Genetics, National Creative Research Initiative Center for Hologenomics, Seoul National University, Seoul 151-742</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Rawls, John F" sort="Rawls, John F" uniqKey="Rawls J" first="John F" last="Rawls">John F. Rawls</name><affiliation wicri:level="2"><nlm:affiliation>Department of Molecular Genetics and Microbiology, Center for the Genomics of Microbial Systems, Duke University School of Medicine, Durham, NC 27710, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Genetics and Microbiology, Center for the Genomics of Microbial Systems, Duke University School of Medicine, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Cani, Patrice D" sort="Cani, Patrice D" uniqKey="Cani P" first="Patrice D" last="Cani">Patrice D. Cani</name><affiliation wicri:level="4"><nlm:affiliation>Université Catholique de Louvain, Louvain Drug Research Institute, WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Metabolism and Nutrition Research Group, B-1200 Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Université Catholique de Louvain, Louvain Drug Research Institute, WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Metabolism and Nutrition Research Group, B-1200 Brussels</wicri:regionArea><orgName type="university">Université catholique de Louvain</orgName><placeName><settlement type="city">Louvain-la-Neuve</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province du Brabant wallon</region></placeName></affiliation></author><author><name sortKey="Schwarzer, Martin" sort="Schwarzer, Martin" uniqKey="Schwarzer M" first="Martin" last="Schwarzer">Martin Schwarzer</name><affiliation wicri:level="1"><nlm:affiliation>Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon 1, F-69364 Lyon Cedex 07, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Génomique Fonctionnelle de Lyon (IGFL), Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5242, Université Claude Bernard Lyon 1, F-69364 Lyon Cedex 07</wicri:regionArea><wicri:noRegion>69364 Lyon Cedex 07</wicri:noRegion><wicri:noRegion>69364 Lyon Cedex 07</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Liping" sort="Zhao, Liping" uniqKey="Zhao L" first="Liping" last="Zhao">Liping Zhao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Microbial Metabolism and Ministry of Education Key Laboratory of Systems Biomedicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240</wicri:regionArea><wicri:noRegion>Shanghai 200240</wicri:noRegion></affiliation></author><author><name sortKey="Simpson, Stephen J" sort="Simpson, Stephen J" uniqKey="Simpson S" first="Stephen J" last="Simpson">Stephen J. Simpson</name><affiliation wicri:level="4"><nlm:affiliation>Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author></analytic><series><title level="j">Cell metabolism</title><idno type="eISSN">1932-7420</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Gastrointestinal Microbiome (physiology)</term><term>Health</term><term>Humans</term><term>Models, Animal</term><term>Nutritional Physiological Phenomena</term><term>Phenotype</term><term>Systems Biology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biologie des systèmes</term><term>Humains</term><term>Microbiome gastro-intestinal (physiologie)</term><term>Modèles animaux</term><term>Phénomènes physiologiques nutritionnels</term><term>Phénotype</term><term>Santé</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Microbiome gastro-intestinal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gastrointestinal Microbiome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Health</term><term>Humans</term><term>Models, Animal</term><term>Nutritional Physiological Phenomena</term><term>Phenotype</term><term>Systems Biology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie des systèmes</term><term>Humains</term><term>Modèles animaux</term><term>Phénomènes physiologiques nutritionnels</term><term>Phénotype</term><term>Santé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nutrition is paramount in shaping all aspects of animal biology. In addition, the influence of the intestinal microbiota on physiology is now widely recognized. Given that diet also shapes the intestinal microbiota, this raises the question of how the nutritional environment and microbial assemblages together influence animal physiology. This research field constitutes a new frontier in the field of organismal biology that needs to be addressed. Here we review recent studies using animal models and humans and propose an integrative framework within which to define the study of the diet-physiology-microbiota systems and ultimately link it to human health. Nutritional Geometry sits centrally in the proposed framework and offers means to define diet compositions that are optimal for individuals and populations.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>France</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Caroline du Nord</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Province du Brabant wallon</li><li>Rhône-Alpes</li><li>Région capitale de Séoul</li><li>Région wallonne</li></region><settlement><li>Hamilton (Ontario)</li><li>Louvain-la-Neuve</li><li>Lyon</li><li>Sydney</li><li>Séoul</li></settlement><orgName><li>Université McMaster</li><li>Université catholique de Louvain</li><li>Université de Sydney</li><li>Université nationale de Séoul</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Leulier, Francois" sort="Leulier, Francois" uniqKey="Leulier F" first="François" last="Leulier">François Leulier</name></region><name sortKey="Schwarzer, Martin" sort="Schwarzer, Martin" uniqKey="Schwarzer M" first="Martin" last="Schwarzer">Martin Schwarzer</name></country><country name="Canada"><region name="Ontario"><name sortKey="Macneil, Lesley T" sort="Macneil, Lesley T" uniqKey="Macneil L" first="Lesley T" last="Macneil">Lesley T. Macneil</name></region></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Won Jae" sort="Lee, Won Jae" uniqKey="Lee W" first="Won-Jae" last="Lee">Won-Jae Lee</name></region></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Rawls, John F" sort="Rawls, John F" uniqKey="Rawls J" first="John F" last="Rawls">John F. Rawls</name></region></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Cani, Patrice D" sort="Cani, Patrice D" uniqKey="Cani P" first="Patrice D" last="Cani">Patrice D. Cani</name></region></country><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Liping" sort="Zhao, Liping" uniqKey="Zhao L" first="Liping" last="Zhao">Liping Zhao</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Simpson, Stephen J" sort="Simpson, Stephen J" uniqKey="Simpson S" first="Stephen J" last="Simpson">Stephen J. Simpson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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