Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
Identifieur interne : 000912 ( Main/Exploration ); précédent : 000911; suivant : 000913Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
Auteurs : Chai K. Lim [Australie] ; Ayse Bilgin [Australie] ; David B. Lovejoy [Australie] ; Vanessa Tan [Australie] ; Sonia Bustamante [Australie] ; Bruce V. Taylor [Australie] ; Alban Bessede [France] ; Bruce J. Brew [Australie] ; Gilles J. Guillemin [Australie]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain insights into the links between inflammation, the KP and multiple sclerosis (MS) pathogenesis, we investigated the KP metabolomics profile of MS patients. Most significantly, we found aberrant levels of two key KP metabolites, kynurenic acid (KA) and quinolinic acid (QA). The balance between these metabolites is important as it determines overall excitotoxic activity at the N-methyl-D-Aspartate (NMDA) receptor. We also identified that serum KP metabolic signatures in patients can discriminate clinical MS subtypes with high sensitivity and specificity. A C5.0 Decision Tree classification model discriminated the clinical subtypes of MS with a sensitivity of 91%. After validation in another independent cohort, sensitivity was maintained at 85%. Collectively, our studies suggest that abnormalities in the KP may be associated with the switch from early-mild stage MS to debilitating progressive forms of MS and that analysis of KP metabolites in MS patient serum may have application as MS disease biomarkers.
Url:
DOI: 10.1038/srep41473
PubMed: 28155867
PubMed Central: 5290739
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000867
- to stream Pmc, to step Curation: 000866
- to stream Pmc, to step Checkpoint: 000227
- to stream PubMed, to step Corpus: 001080
- to stream PubMed, to step Curation: 001077
- to stream PubMed, to step Checkpoint: 001077
- to stream Ncbi, to step Merge: 004263
- to stream Ncbi, to step Curation: 004263
- to stream Ncbi, to step Checkpoint: 004263
- to stream Main, to step Merge: 000907
- to stream Main, to step Curation: 000912
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression</title><author><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pharmacology, School of Medical Sciences, University of New South Wales</institution>, NSW 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bilgin, Ayse" sort="Bilgin, Ayse" uniqKey="Bilgin A" first="Ayse" last="Bilgin">Ayse Bilgin</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Statistics, Faculty of Science and Engineering, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lovejoy, David B" sort="Lovejoy, David B" uniqKey="Lovejoy D" first="David B." last="Lovejoy">David B. Lovejoy</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Vanessa" sort="Tan, Vanessa" uniqKey="Tan V" first="Vanessa" last="Tan">Vanessa Tan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bustamante, Sonia" sort="Bustamante, Sonia" uniqKey="Bustamante S" first="Sonia" last="Bustamante">Sonia Bustamante</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioanalytical Mass Spectrometry Facility, University of New South Wales</institution>, NSW 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Bruce V" sort="Taylor, Bruce V" uniqKey="Taylor B" first="Bruce V." last="Taylor">Bruce V. Taylor</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, TAS 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>ImmuSmol</institution>, Pessac,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Neurology, St Vincent’s Hospital</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28155867</idno><idno type="pmc">5290739</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290739</idno><idno type="RBID">PMC:5290739</idno><idno type="doi">10.1038/srep41473</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000867</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000867</idno><idno type="wicri:Area/Pmc/Curation">000866</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000866</idno><idno type="wicri:Area/Pmc/Checkpoint">000227</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000227</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001080</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001080</idno><idno type="wicri:Area/PubMed/Curation">001077</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001077</idno><idno type="wicri:Area/PubMed/Checkpoint">001077</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001077</idno><idno type="wicri:Area/Ncbi/Merge">004263</idno><idno type="wicri:Area/Ncbi/Curation">004263</idno><idno type="wicri:Area/Ncbi/Checkpoint">004263</idno><idno type="wicri:Area/Main/Merge">000907</idno><idno type="wicri:Area/Main/Curation">000912</idno><idno type="wicri:Area/Main/Exploration">000912</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression</title><author><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Pharmacology, School of Medical Sciences, University of New South Wales</institution>, NSW 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bilgin, Ayse" sort="Bilgin, Ayse" uniqKey="Bilgin A" first="Ayse" last="Bilgin">Ayse Bilgin</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Statistics, Faculty of Science and Engineering, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lovejoy, David B" sort="Lovejoy, David B" uniqKey="Lovejoy D" first="David B." last="Lovejoy">David B. Lovejoy</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Vanessa" sort="Tan, Vanessa" uniqKey="Tan V" first="Vanessa" last="Tan">Vanessa Tan</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bustamante, Sonia" sort="Bustamante, Sonia" uniqKey="Bustamante S" first="Sonia" last="Bustamante">Sonia Bustamante</name><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioanalytical Mass Spectrometry Facility, University of New South Wales</institution>, NSW 2052,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Taylor, Bruce V" sort="Taylor, Bruce V" uniqKey="Taylor B" first="Bruce V." last="Taylor">Bruce V. Taylor</name><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Menzies Research Institute Tasmania, University of Tasmania</institution>, TAS 7000,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name><affiliation wicri:level="1"><nlm:aff id="a6"><institution>ImmuSmol</institution>, Pessac,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a8"><institution>Department of Neurology, St Vincent’s Hospital</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University</institution>, NSW 2109,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a7"><institution>Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research</institution>, Sydney,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Activation of the kynurenine pathway (KP) of tryptophan metabolism results from chronic inflammation and is known to exacerbate progression of neurodegenerative disease. To gain insights into the links between inflammation, the KP and multiple sclerosis (MS) pathogenesis, we investigated the KP metabolomics profile of MS patients. Most significantly, we found aberrant levels of two key KP metabolites, kynurenic acid (KA) and quinolinic acid (QA). The balance between these metabolites is important as it determines overall excitotoxic activity at the N-methyl-D-Aspartate (NMDA) receptor. We also identified that serum KP metabolic signatures in patients can discriminate clinical MS subtypes with high sensitivity and specificity. A C5.0 Decision Tree classification model discriminated the clinical subtypes of MS with a sensitivity of 91%. After validation in another independent cohort, sensitivity was maintained at 85%. Collectively, our studies suggest that abnormalities in the KP may be associated with the switch from early-mild stage MS to debilitating progressive forms of MS and that analysis of KP metabolites in MS patient serum may have application as MS disease biomarkers.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Trapp, B D" uniqKey="Trapp B">B. D. Trapp</name></author><author><name sortKey="Nave, K A" uniqKey="Nave K">K. A. Nave</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiner, H L" uniqKey="Weiner H">H. L. Weiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Onnor, J C" uniqKey="O Onnor J">J. C. O’Connor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author><author><name sortKey="Smythe, G" uniqKey="Smythe G">G. Smythe</name></author><author><name sortKey="Takikawa, O" uniqKey="Takikawa O">O. Takikawa</name></author><author><name sortKey="Brew, B J" uniqKey="Brew B">B. J. Brew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miranda, A F" uniqKey="Miranda A">A. F. Miranda</name></author><author><name sortKey="Boegman, R J" uniqKey="Boegman R">R. J. Boegman</name></author><author><name sortKey="Beninger, R J" uniqKey="Beninger R">R. J. Beninger</name></author><author><name sortKey="Jhamandas, K" uniqKey="Jhamandas K">K. Jhamandas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foster, A C" uniqKey="Foster A">A. C. Foster</name></author><author><name sortKey="Vezzani, A" uniqKey="Vezzani A">A. Vezzani</name></author><author><name sortKey="French, E D" uniqKey="French E">E. D. French</name></author><author><name sortKey="Schwarcz, R" uniqKey="Schwarcz R">R. Schwarcz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bessede, A" uniqKey="Bessede A">A. Bessede</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pitt, D" uniqKey="Pitt D">D. Pitt</name></author><author><name sortKey="Werner, P" uniqKey="Werner P">P. Werner</name></author><author><name sortKey="Raine, C S" uniqKey="Raine C">C. S. Raine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salter, M G" uniqKey="Salter M">M. G. Salter</name></author><author><name sortKey="Fern, R" uniqKey="Fern R">R. Fern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, C K" uniqKey="Lim C">C. K. Lim</name></author><author><name sortKey="Bruce, B J" uniqKey="Bruce B">B. J. Bruce</name></author><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teunissen, C E" uniqKey="Teunissen C">C. E. Teunissen</name></author><author><name sortKey="Malekzadeh, A" uniqKey="Malekzadeh A">A. Malekzadeh</name></author><author><name sortKey="Leurs, C" uniqKey="Leurs C">C. Leurs</name></author><author><name sortKey="Bridel, C" uniqKey="Bridel C">C. Bridel</name></author><author><name sortKey="Killestein, J" uniqKey="Killestein J">J. Killestein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, C K" uniqKey="Lim C">C. K. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, S P" uniqKey="Jones S">S. P. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smythe, G A" uniqKey="Smythe G">G. A. Smythe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braidy, N" uniqKey="Braidy N">N. Braidy</name></author><author><name sortKey="Lim, C K" uniqKey="Lim C">C. K. Lim</name></author><author><name sortKey="Grant, R" uniqKey="Grant R">R. Grant</name></author><author><name sortKey="Brew, B J" uniqKey="Brew B">B. J. Brew</name></author><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, A" uniqKey="Khan A">A. Khan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hastie, T" uniqKey="Hastie T">T. Hastie</name></author><author><name sortKey="Tibshirani, R" uniqKey="Tibshirani R">R. Tibshirani</name></author><author><name sortKey="Friedman, J" uniqKey="Friedman J">J. Friedman</name></author><author><name sortKey="Franklin, J" uniqKey="Franklin J">J. Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, J" uniqKey="Han J">J. Han</name></author><author><name sortKey="Kamber, M" uniqKey="Kamber M">M. Kamber</name></author><author><name sortKey="Pei, J" uniqKey="Pei J">J. Pei</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Venables, W" uniqKey="Venables W">W. Venables</name></author><author><name sortKey="Ripley, B" uniqKey="Ripley B">B. Ripley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grant, R S" uniqKey="Grant R">R. S. Grant</name></author><author><name sortKey="Coggan, S E" uniqKey="Coggan S">S. E. Coggan</name></author><author><name sortKey="Smythe, G A" uniqKey="Smythe G">G. A. Smythe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mancuso, R" uniqKey="Mancuso R">R. Mancuso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aeinehband, S" uniqKey="Aeinehband S">S. Aeinehband</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mellor, A L" uniqKey="Mellor A">A. L. Mellor</name></author><author><name sortKey="Munn, D H" uniqKey="Munn D">D. H. Munn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quintana, F J" uniqKey="Quintana F">F. J. Quintana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kwidzinski, E" uniqKey="Kwidzinski E">E. Kwidzinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Correale, J" uniqKey="Correale J">J. Correale</name></author><author><name sortKey="Ysrraelit, M C" uniqKey="Ysrraelit M">M. C. Ysrraelit</name></author><author><name sortKey="Gaitan, M I" uniqKey="Gaitan M">M. I. Gaitan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohr, D C" uniqKey="Mohr D">D. C. Mohr</name></author><author><name sortKey="Goodkin, D E" uniqKey="Goodkin D">D. E. Goodkin</name></author><author><name sortKey="Islar, J" uniqKey="Islar J">J. Islar</name></author><author><name sortKey="Hauser, S L" uniqKey="Hauser S">S. L. Hauser</name></author><author><name sortKey="Genain, C P" uniqKey="Genain C">C. P. Genain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farez Mauricio, F" uniqKey="Farez Mauricio F">F. Farez Mauricio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steiner, J" uniqKey="Steiner J">J. Steiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author><author><name sortKey="Smythe, G" uniqKey="Smythe G">G. Smythe</name></author><author><name sortKey="Takikawa, O" uniqKey="Takikawa O">O. Takikawa</name></author><author><name sortKey="Brew, B J" uniqKey="Brew B">B. J. Brew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sundaram, G" uniqKey="Sundaram G">G. Sundaram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stone, T W" uniqKey="Stone T">T. W. Stone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guidetti, P" uniqKey="Guidetti P">P. Guidetti</name></author><author><name sortKey="Schwarcz, R" uniqKey="Schwarcz R">R. Schwarcz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiarugi, A" uniqKey="Chiarugi A">A. Chiarugi</name></author><author><name sortKey="Cozzi, A" uniqKey="Cozzi A">A. Cozzi</name></author><author><name sortKey="Ballerini, C" uniqKey="Ballerini C">C. Ballerini</name></author><author><name sortKey="Massacesi, L" uniqKey="Massacesi L">L. Massacesi</name></author><author><name sortKey="Moroni, F" uniqKey="Moroni F">F. Moroni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cocco, E" uniqKey="Cocco E">E. Cocco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raison, C L" uniqKey="Raison C">C. L. Raison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Midttun, O" uniqKey="Midttun O">O. Midttun</name></author><author><name sortKey="Hustad, S" uniqKey="Hustad S">S. Hustad</name></author><author><name sortKey="Ueland, P M" uniqKey="Ueland P">P. M. Ueland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name></author><author><name sortKey="Guillemin, G J" uniqKey="Guillemin G">G. J. Guillemin</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name></noRegion><name sortKey="Bilgin, Ayse" sort="Bilgin, Ayse" uniqKey="Bilgin A" first="Ayse" last="Bilgin">Ayse Bilgin</name><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="Bustamante, Sonia" sort="Bustamante, Sonia" uniqKey="Bustamante S" first="Sonia" last="Bustamante">Sonia Bustamante</name><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name><name sortKey="Lovejoy, David B" sort="Lovejoy, David B" uniqKey="Lovejoy D" first="David B." last="Lovejoy">David B. Lovejoy</name><name sortKey="Tan, Vanessa" sort="Tan, Vanessa" uniqKey="Tan V" first="Vanessa" last="Tan">Vanessa Tan</name><name sortKey="Taylor, Bruce V" sort="Taylor, Bruce V" uniqKey="Taylor B" first="Bruce V." last="Taylor">Bruce V. Taylor</name></country><country name="France"><noRegion><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000912 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000912 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5290739
|texte= Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28155867" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |