AustralieFrV1, Main, Exploration, bibRecord, 000869

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial.

Identifieur interne : 000869 ( Main/Exploration ); précédent : 000868; suivant : 000870

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial.

Auteurs : Alice T. Shaw [États-Unis] ; Enriqueta Felip [Espagne] ; Todd M. Bauer [États-Unis] ; Benjamin Besse [France] ; Alejandro Navarro [Espagne] ; Sophie Postel-Vinay [France] ; Justin F. Gainor [États-Unis] ; Melissa Johnson [États-Unis] ; Jorg Dietrich [États-Unis] ; Leonard P. James [États-Unis] ; Jill S. Clancy [États-Unis] ; Joseph Chen [États-Unis] ; Jean-François Martini [États-Unis] ; Antonello Abbattista [Italie] ; Benjamin J. Solomon [Australie]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2017.

RBID : pubmed:29074098

Abstract

Most patients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops, commonly within the CNS. This study aimed to analyse the safety, efficacy, and pharmacokinetic properties of lorlatinib, a novel, highly potent, selective, and brain-penetrant ALK and ROS1 TKI with preclinical activity against most known resistance mutations, in patients with advanced ALK-positive or ROS1-positive NSCLC.

DOI: 10.1016/S1470-2045(17)30680-0
PubMed: 29074098

Affiliations:

Australie, Espagne, France, Italie, États-Unis
Californie, Catalogne, Lombardie, Massachusetts, New Jersey, Tennessee, Victoria (État), État de New York
Barcelone, Melbourne, Milan, Orsay

Le document en format XML

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<front><div type="abstract" xml:lang="en">Most patients with anaplastic lymphoma kinase (ALK)-rearranged or ROS proto-oncogene 1 (ROS1)-rearranged non-small-cell lung cancer (NSCLC) are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops, commonly within the CNS. This study aimed to analyse the safety, efficacy, and pharmacokinetic properties of lorlatinib, a novel, highly potent, selective, and brain-penetrant ALK and ROS1 TKI with preclinical activity against most known resistance mutations, in patients with advanced ALK-positive or ROS1-positive NSCLC.</div>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Solomon, Benjamin J" sort="Solomon, Benjamin J" uniqKey="Solomon B" first="Benjamin J" last="Solomon">Benjamin J. Solomon</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial.

Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial.

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	Serveur d'exploration sur les relations entre la France et l'Australie
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