Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions.
Identifieur interne : 000842 ( Main/Exploration ); précédent : 000841; suivant : 000843Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions.
Auteurs : Yannick Wirz [Suisse] ; Angela Branche [États-Unis] ; Michel Wolff [France] ; Tobias Welte [Allemagne] ; Vandack Nobre [Brésil] ; Konrad Reinhart [Allemagne] ; Ann R. Falsey [États-Unis] ; Pierre Damas [Belgique] ; Albertus Beishuizen [Pays-Bas] ; Rodrigo O. Deliberato [Brésil] ; Yahya Shehabi [Australie] ; Jens-Ulrik S. Jensen [Danemark] ; Beat Mueller [Suisse] ; Philipp Schuetz [Suisse]Source :
- ACS infectious diseases [ 2373-8227 ] ; 2017.
Abstract
Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis.
DOI: 10.1021/acsinfecdis.7b00199
PubMed: 29120606
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Danemark, France, Pays-Bas, Suisse, États-Unis
- Basse-Saxe, Hovedstaden, Province de Liège, État de São Paulo, Île-de-France
- Copenhague, Hanovre, Liège, Paris, São Paulo
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Kantonsspital Aarau , Tellstrasse, 5000 Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau , Tellstrasse, 5000 Aarau</wicri:regionArea><wicri:noRegion>5000 Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Allergy and Infectious Diseases Respiratory Pathogen Research Center, University of Rochester Medical Center , 601 Elmwood Ave., Rochester, New York 14642, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Allergy and Infectious Diseases Respiratory Pathogen Research Center, University of Rochester Medical Center , 601 Elmwood Ave., Rochester, New York 14642</wicri:regionArea><wicri:noRegion>New York 14642</wicri:noRegion></affiliation></author><author><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot , 5 Rue Thomas Mann, 75013 Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Réanimation Médicale, Université Paris 7-Denis-Diderot , 5 Rue Thomas Mann, 75013 Paris</wicri:regionArea><wicri:noRegion>75013 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Medicine, Medizinische Hochschule Hannover , Carl-Neuberg-Straße 1, 30625 Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pulmonary Medicine, Medizinische Hochschule Hannover , Carl-Neuberg-Straße 1, 30625 Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name><affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais , 110 Santa Efigênia, Belo Horizonte, Minas Gerais 30130-100, Brasil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Intensive Care, Hospital das Clinicas da Universidade Federal de Minas Gerais , 110 Santa Efigênia, Belo Horizonte, Minas Gerais 30130-100</wicri:regionArea><wicri:noRegion>Minas Gerais 30130-100</wicri:noRegion></affiliation></author><author><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital , Am Klinikum 1, 07747 Jena, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital , Am Klinikum 1, 07747 Jena</wicri:regionArea><wicri:noRegion>07747 Jena</wicri:noRegion><wicri:noRegion>07747 Jena</wicri:noRegion><wicri:noRegion>07747 Jena</wicri:noRegion></affiliation></author><author><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Allergy and Infectious Diseases Respiratory Pathogen Research Center, University of Rochester Medical Center , 601 Elmwood Ave., Rochester, New York 14642, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Institute of Allergy and Infectious Diseases Respiratory Pathogen Research Center, University of Rochester Medical Center , 601 Elmwood Ave., Rochester, New York 14642</wicri:regionArea><wicri:noRegion>New York 14642</wicri:noRegion></affiliation></author><author><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name><affiliation wicri:level="3"><nlm:affiliation>Department of General Intensive Care, University Hospital of Liege, domaine universitaire du Sart Tilman, , 4000 Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of General Intensive Care, University Hospital of Liege, domaine universitaire du Sart Tilman, , 4000 Liège</wicri:regionArea><placeName><region type="province" nuts="2">Province de Liège</region><settlement type="city">Liège</settlement></placeName></affiliation></author><author><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name><affiliation wicri:level="1"><nlm:affiliation>Intensive Care Center, Medisch Spectrum Twente, Koningsplein 1, 7512KZ, Enschede, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Intensive Care Center, Medisch Spectrum Twente, Koningsplein 1, 7512KZ, Enschede</wicri:regionArea><wicri:noRegion>Enschede</wicri:noRegion></affiliation></author><author><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care Unit, Hospital Israelita Albert Einstein , Av. Albert Einstein, 627/701, Morumbi, São Paulo, São Paulo 05652-900, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Critical Care Unit, Hospital Israelita Albert Einstein , Av. Albert Einstein, 627/701, Morumbi, São Paulo, São Paulo 05652-900</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name><affiliation wicri:level="1"><nlm:affiliation>Critical Care and Peri-operative Medicine, Monash Health , Clayton Rd., Clayton, Victoria 3171, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Critical Care and Peri-operative Medicine, Monash Health , Clayton Rd., Clayton, Victoria 3171</wicri:regionArea><wicri:noRegion>Victoria 3171</wicri:noRegion></affiliation></author><author><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name><affiliation wicri:level="1"><nlm:affiliation>CHIP & PERSIMUNE, Department of Infectious Diseases, Finsencentret, Rigshospitalet, University of Copenhagen , Blegdamsvej 9, 2100 København, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>CHIP & PERSIMUNE, Department of Infectious Diseases, Finsencentret, Rigshospitalet, University of Copenhagen , Blegdamsvej 9, 2100 København</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau , Tellstrasse, 5000 Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau , Tellstrasse, 5000 Aarau</wicri:regionArea><wicri:noRegion>5000 Aarau</wicri:noRegion></affiliation></author><author><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name><affiliation wicri:level="1"><nlm:affiliation>Medical University Department, Kantonsspital Aarau , Tellstrasse, 5000 Aarau, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Medical University Department, Kantonsspital Aarau , Tellstrasse, 5000 Aarau</wicri:regionArea><wicri:noRegion>5000 Aarau</wicri:noRegion></affiliation></author></analytic><series><title level="j">ACS infectious diseases</title><idno type="eISSN">2373-8227</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Due to overlap of clinical findings and low sensitivity of bacterial diagnostic tests, differentiation between bacterial and viral respiratory tract infections remains challenging, ultimately leading to antibiotic overuse in this population of patients. Addition of procalcitonin, a blood biomarker expressed by epithelial cells in response to bacterial infections, to the clinical assessment leads to a reduction in inappropriate antibiotic initiation. Procalcitonin also provides prognostic information about the resolution of illness, and significant decreases over time are a strong signal for the discontinuation of antibiotics. Current evidence from randomized trials indicates that procalcitonin-guided antibiotic stewardship results in a reduction in antibiotic use and antibiotic side effects, which importantly translates into improved survival of patients with respiratory infections. Inclusion of procalcitonin into antibiotic stewardship algorithms thus improves the diagnostic and therapeutic management of patients presenting with respiratory illnesses and holds great promise to mitigate the global bacterial resistance crisis.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Danemark</li><li>France</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Hovedstaden</li><li>Province de Liège</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Copenhague</li><li>Hanovre</li><li>Liège</li><li>Paris</li><li>São Paulo</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Wirz, Yannick" sort="Wirz, Yannick" uniqKey="Wirz Y" first="Yannick" last="Wirz">Yannick Wirz</name></noRegion><name sortKey="Mueller, Beat" sort="Mueller, Beat" uniqKey="Mueller B" first="Beat" last="Mueller">Beat Mueller</name><name sortKey="Schuetz, Philipp" sort="Schuetz, Philipp" uniqKey="Schuetz P" first="Philipp" last="Schuetz">Philipp Schuetz</name></country><country name="États-Unis"><noRegion><name sortKey="Branche, Angela" sort="Branche, Angela" uniqKey="Branche A" first="Angela" last="Branche">Angela Branche</name></noRegion><name sortKey="Falsey, Ann R" sort="Falsey, Ann R" uniqKey="Falsey A" first="Ann R" last="Falsey">Ann R. Falsey</name></country><country name="France"><region name="Île-de-France"><name sortKey="Wolff, Michel" sort="Wolff, Michel" uniqKey="Wolff M" first="Michel" last="Wolff">Michel Wolff</name></region></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Welte, Tobias" sort="Welte, Tobias" uniqKey="Welte T" first="Tobias" last="Welte">Tobias Welte</name></region><name sortKey="Reinhart, Konrad" sort="Reinhart, Konrad" uniqKey="Reinhart K" first="Konrad" last="Reinhart">Konrad Reinhart</name></country><country name="Brésil"><noRegion><name sortKey="Nobre, Vandack" sort="Nobre, Vandack" uniqKey="Nobre V" first="Vandack" last="Nobre">Vandack Nobre</name></noRegion><name sortKey="Deliberato, Rodrigo O" sort="Deliberato, Rodrigo O" uniqKey="Deliberato R" first="Rodrigo O" last="Deliberato">Rodrigo O. Deliberato</name></country><country name="Belgique"><region name="Province de Liège"><name sortKey="Damas, Pierre" sort="Damas, Pierre" uniqKey="Damas P" first="Pierre" last="Damas">Pierre Damas</name></region></country><country name="Pays-Bas"><noRegion><name sortKey="Beishuizen, Albertus" sort="Beishuizen, Albertus" uniqKey="Beishuizen A" first="Albertus" last="Beishuizen">Albertus Beishuizen</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Shehabi, Yahya" sort="Shehabi, Yahya" uniqKey="Shehabi Y" first="Yahya" last="Shehabi">Yahya Shehabi</name></noRegion></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Jensen, Jens Ulrik S" sort="Jensen, Jens Ulrik S" uniqKey="Jensen J" first="Jens-Ulrik S" last="Jensen">Jens-Ulrik S. Jensen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |