No evidence for toxicity after long-term photobiomodulation in normal non-human primates.
Identifieur interne : 000723 ( Main/Exploration ); précédent : 000722; suivant : 000724No evidence for toxicity after long-term photobiomodulation in normal non-human primates.
Auteurs : Cécile Moro [France] ; Napoleon Torres [France] ; Katerina Arvanitakis [Australie] ; Karen Cullen [Australie] ; Claude Chabrol [France] ; Diane Agay [France] ; Fannie Darlot [France] ; Alim-Louis Benabid [France] ; John Mitrofanis [Australie]Source :
- Experimental brain research [ 1432-1106 ] ; 2017.
Abstract
In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (red light, 670 nm) to a midline midbrain region. Animals were then aldehyde-fixed and their brains were processed for immunohistochemistry. In general, our results showed that longer term intracranial application of photobiomodulation had no adverse effects on the surrounding brain parenchyma or on the nearby dopaminergic cell system. We found no evidence for photobiomodulation generating an inflammatory glial response or neuronal degeneration near the implant site; further, photobiomodulation did not induce an abnormal activation or mitochondrial stress in nearby cells, nor did it cause an abnormal arrangement of the surrounding vasculature (endothelial basement membrane). Finally, because of our interest in Parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. In summary, we found no histological basis for any major biosafety concerns associated with photobiomodulation delivered by our intracranial approach and our findings set a key template for progress onto clinical trial on patients with Parkinson's disease.
DOI: 10.1007/s00221-017-5048-7
PubMed: 28744621
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Grenoble, Sydney
- Université de Sydney
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Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name><affiliation wicri:level="3"><nlm:affiliation>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement><region type="region" 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Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Grenoble Alpes, CEA, LETI, CLINATEC, MINATEC Campus, 38000, Grenoble</wicri:regionArea><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy F13, University of Sydney, Camperdown, 2006, Australia. john.mitrofanis@sydney.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomy F13, University of Sydney, Camperdown, 2006</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">Experimental brain research</title><idno type="eISSN">1432-1106</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, we explored the effects of a longer term application, up to 12 weeks, of photobiomodulation in normal, naïve macaque monkeys. Monkeys (n = 5) were implanted intracranially with an optical fibre device delivering photobiomodulation (red light, 670 nm) to a midline midbrain region. Animals were then aldehyde-fixed and their brains were processed for immunohistochemistry. In general, our results showed that longer term intracranial application of photobiomodulation had no adverse effects on the surrounding brain parenchyma or on the nearby dopaminergic cell system. We found no evidence for photobiomodulation generating an inflammatory glial response or neuronal degeneration near the implant site; further, photobiomodulation did not induce an abnormal activation or mitochondrial stress in nearby cells, nor did it cause an abnormal arrangement of the surrounding vasculature (endothelial basement membrane). Finally, because of our interest in Parkinson's disease, we noted that photobiomodulation had no impact on the number of midbrain dopaminergic cells and the density of their terminations in the striatum. In summary, we found no histological basis for any major biosafety concerns associated with photobiomodulation delivered by our intracranial approach and our findings set a key template for progress onto clinical trial on patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name></region><name sortKey="Agay, Diane" sort="Agay, Diane" uniqKey="Agay D" first="Diane" last="Agay">Diane Agay</name><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Chabrol, Claude" sort="Chabrol, Claude" uniqKey="Chabrol C" first="Claude" last="Chabrol">Claude Chabrol</name><name sortKey="Darlot, Fannie" sort="Darlot, Fannie" uniqKey="Darlot F" first="Fannie" last="Darlot">Fannie Darlot</name><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Arvanitakis, Katerina" sort="Arvanitakis, Katerina" uniqKey="Arvanitakis K" first="Katerina" last="Arvanitakis">Katerina Arvanitakis</name></region><name sortKey="Cullen, Karen" sort="Cullen, Karen" uniqKey="Cullen K" first="Karen" last="Cullen">Karen Cullen</name><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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