AustralieFrV1, Main, Exploration, bibRecord, 000470

Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Identifieur interne : 000470 ( Main/Exploration ); précédent : 000469; suivant : 000471

Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Auteurs : Paul Leong ; Pierre-Yves Le Roux ; Jason Callahan ; Shankar Siva ; Michael S. Hofman ; Daniel P. Steinfort

Source :

Respirology Case Reports [ 2051-3380 ] ; 2017.

RBID : PMC:5550810

Abstract

Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV₁). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium‐68 ventilation–perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q‐PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6‐min walk distance (6MWD) without change in spirometry. Post‐EBV V/Q‐PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post‐EBV V/Q‐PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550810

DOI: 10.1002/rcr2.253
PubMed: 28808575
PubMed Central: 5550810

Affiliations:

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Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

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Abstract

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