Reprint of Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT).
Identifieur interne : 000445 ( Main/Exploration ); précédent : 000444; suivant : 000446Reprint of Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT).
Auteurs : Anders Helander [Suède] ; Jos Wielders [Pays-Bas] ; Raymond Anton [États-Unis] ; Torsten Arndt [Allemagne] ; Vincenza Bianchi [Italie] ; Jean Deenmamode [Royaume-Uni] ; Jan-Olof Jeppsson [Suède] ; John B. Whitfield [Australie] ; Cas Weykamp [Pays-Bas] ; François Schellenberg [France]Source :
- Clinica chimica acta; international journal of clinical chemistry [ 1873-3492 ] ; 2017.
Abstract
Carbohydrate-deficient transferrin (CDT) is a glycoform profile of serum transferrin that increases in response to sustained high alcohol intake and over the last decades has become an important alcohol biomarker with clinical and forensic applications. However, the wide range of CDT measurement procedures has resulted in lack of uniform results and reference limits, and hampered comparison of results. In 2005, the IFCC therefore founded a special working group (WG) aiming for standardisation of CDT measurement. This review summarises the history of CDT and the actions taken by the WG-CDT. Initial steps included the definition of the measurand (serum disialotransferrin to total transferrin fraction expressed in %), and the determination of a well-defined anion-exchange HPLC procedure as the candidate reference measurement procedure (cRMP). Subsequent achievements were the establishment of a network of reference laboratories to perform the cRMP, setting a reference interval, and development of a reference material based on human serum for which the laboratory network assign values. Using a set of reference materials for calibration allowed for achieving equivalence of results of all present CDT measurement procedures. The final steps of the WG-CDT have been a full validation of the cRMP to make it an IFCC approved RMP, and providing guidance for international standardisation of all CDT measurement procedures.
DOI: 10.1016/j.cca.2017.03.018
PubMed: 28322729
Affiliations:
- Allemagne, Australie, France, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Caroline du Sud, Centre-Val de Loire, Grand Londres, Région Centre, Svealand
- Londres, Stockholm, Tours
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Antonio e Biagio Hospital, Alessandria, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>SS. Antonio e Biagio Hospital, Alessandria</wicri:regionArea><wicri:noRegion>Alessandria</wicri:noRegion></affiliation></author><author><name sortKey="Deenmamode, Jean" sort="Deenmamode, Jean" uniqKey="Deenmamode J" first="Jean" last="Deenmamode">Jean Deenmamode</name><affiliation wicri:level="3"><nlm:affiliation>Homerton University Hospital, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Homerton University Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jeppsson, Jan Olof" sort="Jeppsson, Jan Olof" uniqKey="Jeppsson J" first="Jan-Olof" last="Jeppsson">Jan-Olof Jeppsson</name><affiliation wicri:level="1"><nlm:affiliation>Skåne University Hospital, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Skåne University Hospital, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name><affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea><wicri:noRegion>Brisbane</wicri:noRegion></affiliation></author><author><name sortKey="Weykamp, Cas" sort="Weykamp, Cas" uniqKey="Weykamp C" first="Cas" last="Weykamp">Cas Weykamp</name><affiliation wicri:level="1"><nlm:affiliation>Queen Beatrix Hospital, Winterswijk, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Queen Beatrix Hospital, Winterswijk</wicri:regionArea><wicri:noRegion>Winterswijk</wicri:noRegion></affiliation></author><author><name sortKey="Schellenberg, Francois" sort="Schellenberg, Francois" uniqKey="Schellenberg F" first="François" last="Schellenberg">François Schellenberg</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Trousseau, CHRU, Tours, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Trousseau, CHRU, Tours</wicri:regionArea><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Tours</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinica chimica acta; international journal of clinical chemistry</title><idno type="eISSN">1873-3492</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Carbohydrate-deficient transferrin (CDT) is a glycoform profile of serum transferrin that increases in response to sustained high alcohol intake and over the last decades has become an important alcohol biomarker with clinical and forensic applications. However, the wide range of CDT measurement procedures has resulted in lack of uniform results and reference limits, and hampered comparison of results. In 2005, the IFCC therefore founded a special working group (WG) aiming for standardisation of CDT measurement. This review summarises the history of CDT and the actions taken by the WG-CDT. Initial steps included the definition of the measurand (serum disialotransferrin to total transferrin fraction expressed in %), and the determination of a well-defined anion-exchange HPLC procedure as the candidate reference measurement procedure (cRMP). Subsequent achievements were the establishment of a network of reference laboratories to perform the cRMP, setting a reference interval, and development of a reference material based on human serum for which the laboratory network assign values. Using a set of reference materials for calibration allowed for achieving equivalence of results of all present CDT measurement procedures. The final steps of the WG-CDT have been a full validation of the cRMP to make it an IFCC approved RMP, and providing guidance for international standardisation of all CDT measurement procedures.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Caroline du Sud</li><li>Centre-Val de Loire</li><li>Grand Londres</li><li>Région Centre</li><li>Svealand</li></region><settlement><li>Londres</li><li>Stockholm</li><li>Tours</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Helander, Anders" sort="Helander, Anders" uniqKey="Helander A" first="Anders" last="Helander">Anders Helander</name></region><name sortKey="Jeppsson, Jan Olof" sort="Jeppsson, Jan Olof" uniqKey="Jeppsson J" first="Jan-Olof" last="Jeppsson">Jan-Olof Jeppsson</name></country><country name="Pays-Bas"><noRegion><name sortKey="Wielders, Jos" sort="Wielders, Jos" uniqKey="Wielders J" first="Jos" last="Wielders">Jos Wielders</name></noRegion><name sortKey="Weykamp, Cas" sort="Weykamp, Cas" uniqKey="Weykamp C" first="Cas" last="Weykamp">Cas Weykamp</name></country><country name="États-Unis"><region name="Caroline du Sud"><name sortKey="Anton, Raymond" sort="Anton, Raymond" uniqKey="Anton R" first="Raymond" last="Anton">Raymond Anton</name></region></country><country name="Allemagne"><noRegion><name sortKey="Arndt, Torsten" sort="Arndt, Torsten" uniqKey="Arndt T" first="Torsten" last="Arndt">Torsten Arndt</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Bianchi, Vincenza" sort="Bianchi, Vincenza" uniqKey="Bianchi V" first="Vincenza" last="Bianchi">Vincenza Bianchi</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Deenmamode, Jean" sort="Deenmamode, Jean" uniqKey="Deenmamode J" first="Jean" last="Deenmamode">Jean Deenmamode</name></region></country><country name="Australie"><noRegion><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name></noRegion></country><country name="France"><region name="Centre-Val de Loire"><name sortKey="Schellenberg, Francois" sort="Schellenberg, Francois" uniqKey="Schellenberg F" first="François" last="Schellenberg">François Schellenberg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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