The intensive care medicine research agenda in nutrition and metabolism
Identifieur interne : 000199 ( Main/Exploration ); précédent : 000198; suivant : 000200The intensive care medicine research agenda in nutrition and metabolism
Auteurs : Yaseen M. Arabi ; Michael P. Casaer [Belgique] ; Marianne Chapman [Australie] ; Daren K. Heyland ; Carole Ichai [France] ; Paul E. Marik [États-Unis] ; Robert G. Martindale [États-Unis] ; Stephen A. Mcclave [États-Unis] ; Jean-Charles Preiser [Belgique] ; Jean Reignier [France] ; Todd W. Rice [États-Unis] ; Greet Van Den Berghe [Belgique] ; Arthur R. H. Van Zanten [Pays-Bas] ; Peter J. M. Weijs [Pays-Bas]Source :
- Intensive Care Medicine [ 0342-4642 ] ; 2017.
Abstract
The objectives of this review are to summarize the current practices and major recent advances in critical care nutrition and metabolism, review common beliefs that have been contradicted by recent trials, highlight key remaining areas of uncertainty, and suggest recommendations for the top 10 studies/trials to be done in the next 10 years.
Recent literature was reviewed and developments and knowledge gaps were summarized. The panel identified candidate topics for future trials in critical care nutrition and metabolism. Then, members of the panel rated each one of the topics using a grading system (0–4). Potential studies were ranked on the basis of average score.
Recent randomized controlled trials (RCTs) have challenged several concepts, including the notion that energy expenditure must be met universally in all critically ill patients during the acute phase of critical illness, the routine monitoring of gastric residual volume, and the value of immune-modulating nutrition. The optimal protein dose combined with standardized active and passive mobilization during the acute phase and post-acute phase of critical illness were the top ranked studies for the next 10 years. Nutritional assessment, nutritional strategies in critically obese patients, and the effects of continuous versus intermittent enteral nutrition were also among the highest-ranking studies.
Priorities for clinical research in the field of nutritional management of critically ill patients were suggested, with the prospect that different nutritional interventions targeted to the appropriate patient population will be examined for their effect on facilitating recovery and improving survival in adequately powered and properly designed studies, probably in conjunction with physical activity.
The online version of this article (doi:10.1007/s00134-017-4711-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00134-017-4711-6
PubMed: 28374096
PubMed Central: 5569654
Affiliations:
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Arabi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0608 0662</institution-id><institution-id institution-id-type="GRID">grid.412149.b</institution-id><institution>Intensive Care Department, MC 1425, College of Medicine,</institution><institution>King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Center (KAIMRC),</institution></institution-wrap>P.O. Box 22490, Riyadh, 11426 Kingdom of Saudi Arabia</nlm:aff><wicri:noCountry code="subfield">11426 Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Casaer, Michael P" sort="Casaer, Michael P" uniqKey="Casaer M" first="Michael P." last="Casaer">Michael P. 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Heyland</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8331</institution-id><institution-id institution-id-type="GRID">grid.410356.5</institution-id><institution>Department of Critical Care Medicine,</institution><institution>Queen’s University,</institution></institution-wrap>Kingston, ON Canada</nlm:aff><wicri:noCountry code="subfield">ON Canada</wicri:noCountry></affiliation></author><author><name sortKey="Ichai, Carole" sort="Ichai, Carole" uniqKey="Ichai C" first="Carole" last="Ichai">Carole Ichai</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2322 4179</institution-id><institution-id institution-id-type="GRID">grid.410528.a</institution-id><institution>Anesthesiology and Intensive Care Medicine, Intensive Care Unit,</institution><institution>Pasteur 2 Hospital, University Hospital of Nice,</institution></institution-wrap>Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Nice</wicri:regionArea></affiliation></author><author><name sortKey="Marik, Paul E" sort="Marik, Paul E" uniqKey="Marik P" first="Paul E." last="Marik">Paul E. 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Rice</name><affiliation wicri:level="2"><nlm:aff id="Aff12"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2264 7217</institution-id><institution-id institution-id-type="GRID">grid.152326.1</institution-id><institution>Division of Allergy, Pulmonary, and Critical Care Medicine,</institution><institution>Vanderbilt University School of Medicine,</institution></institution-wrap>Nashville, TN USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Van Den Berghe, Greet" sort="Van Den Berghe, Greet" uniqKey="Van Den Berghe G" first="Greet" last="Van Den Berghe">Greet Van Den Berghe</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0668 7884</institution-id><institution-id institution-id-type="GRID">grid.5596.f</institution-id><institution>Laboratory and Clinical Department of Intensive Care Medicine,</institution><institution>Catholic University Leuven,</institution></institution-wrap>Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Van Zanten, Arthur R H" sort="Van Zanten, Arthur R H" uniqKey="Van Zanten A" first="Arthur R. H." last="Van Zanten">Arthur R. H. Van Zanten</name><affiliation wicri:level="1"><nlm:aff id="Aff13"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0398 026X</institution-id><institution-id institution-id-type="GRID">grid.415351.7</institution-id><institution>Department of Intensive Care Medicine,</institution><institution>Gelderse Vallei Hospital,</institution></institution-wrap>Willy Brandtlaan, Ede, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Willy Brandtlaan, Ede</wicri:regionArea><wicri:noRegion>Ede</wicri:noRegion></affiliation></author><author><name sortKey="Weijs, Peter J M" sort="Weijs, Peter J M" uniqKey="Weijs P" first="Peter J. M." last="Weijs">Peter J. M. Weijs</name><affiliation wicri:level="1"><nlm:aff id="Aff14"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0435 165X</institution-id><institution-id institution-id-type="GRID">grid.16872.3a</institution-id><institution>Nutrition and Dietetics, Department of Internal Medicine, and Department of Intensive Care Medicine,</institution><institution>VU University Medical Center,</institution></institution-wrap>Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff15"><institution-wrap><institution-id institution-id-type="GRID">grid.431204.0</institution-id><institution>Department of Nutrition and Dietetics, School of Sports and Nutrition,</institution><institution>Amsterdam University of Applied Sciences,</institution></institution-wrap>Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Amsterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Intensive Care Medicine</title><idno type="ISSN">0342-4642</idno><idno type="eISSN">1432-1238</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p id="Par1">The objectives of this review are to summarize the current practices and major recent advances in critical care nutrition and metabolism, review common beliefs that have been contradicted by recent trials, highlight key remaining areas of uncertainty, and suggest recommendations for the top 10 studies/trials to be done in the next 10 years.</p></sec><sec><title>Methods</title><p id="Par2">Recent literature was reviewed and developments and knowledge gaps were summarized. The panel identified candidate topics for future trials in critical care nutrition and metabolism. Then, members of the panel rated each one of the topics using a grading system (0–4). Potential studies were ranked on the basis of average score.</p></sec><sec><title>Results</title><p id="Par3">Recent randomized controlled trials (RCTs) have challenged several concepts, including the notion that energy expenditure must be met universally in all critically ill patients during the acute phase of critical illness, the routine monitoring of gastric residual volume, and the value of immune-modulating nutrition. The optimal protein dose combined with standardized active and passive mobilization during the acute phase and post-acute phase of critical illness were the top ranked studies for the next 10 years. Nutritional assessment, nutritional strategies in critically obese patients, and the effects of continuous versus intermittent enteral nutrition were also among the highest-ranking studies.</p></sec><sec><title>Conclusions</title><p id="Par4">Priorities for clinical research in the field of nutritional management of critically ill patients were suggested, with the prospect that different nutritional interventions targeted to the appropriate patient population will be examined for their effect on facilitating recovery and improving survival in adequately powered and properly designed studies, probably in conjunction with physical activity.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1007/s00134-017-4711-6) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Preiser, Jc" uniqKey="Preiser J">JC 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Stapleton</name></author><author><name sortKey="Mourtzakis, M" uniqKey="Mourtzakis M">M Mourtzakis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hiesmayr, M" uniqKey="Hiesmayr M">M Hiesmayr</name></author><author><name sortKey="Schindler, K" uniqKey="Schindler K">K Schindler</name></author><author><name sortKey="Pernicka, E" uniqKey="Pernicka E">E Pernicka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deane, Am" uniqKey="Deane A">AM Deane</name></author><author><name sortKey="Dhaliwal, R" uniqKey="Dhaliwal R">R Dhaliwal</name></author><author><name sortKey="Day, Ag" uniqKey="Day A">AG Day</name></author><author><name sortKey="Ridley, Ej" uniqKey="Ridley E">EJ Ridley</name></author><author><name sortKey="Davies, Ar" uniqKey="Davies A">AR Davies</name></author><author><name sortKey="Heyland, Dk" uniqKey="Heyland D">DK Heyland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Summers, Mj" uniqKey="Summers M">MJ Summers</name></author><author><name sortKey="Chapple, La" uniqKey="Chapple L">LA Chapple</name></author><author><name sortKey="Mcclave, Sa" uniqKey="Mcclave S">SA McClave</name></author><author><name sortKey="Deane, Am" uniqKey="Deane A">AM Deane</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>France</li><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Kentucky</li><li>Oregon</li><li>Tennessee</li><li>Virginie</li></region></list><tree><noCountry><name sortKey="Arabi, Yaseen M" sort="Arabi, Yaseen M" uniqKey="Arabi Y" first="Yaseen M." last="Arabi">Yaseen M. Arabi</name><name sortKey="Heyland, Daren K" sort="Heyland, Daren K" uniqKey="Heyland D" first="Daren K." last="Heyland">Daren K. Heyland</name></noCountry><country name="Belgique"><noRegion><name sortKey="Casaer, Michael P" sort="Casaer, Michael P" uniqKey="Casaer M" first="Michael P." last="Casaer">Michael P. Casaer</name></noRegion><name sortKey="Preiser, Jean Charles" sort="Preiser, Jean Charles" uniqKey="Preiser J" first="Jean-Charles" last="Preiser">Jean-Charles Preiser</name><name sortKey="Van Den Berghe, Greet" sort="Van Den Berghe, Greet" uniqKey="Van Den Berghe G" first="Greet" last="Van Den Berghe">Greet Van Den Berghe</name></country><country name="Australie"><noRegion><name sortKey="Chapman, Marianne" sort="Chapman, Marianne" uniqKey="Chapman M" first="Marianne" last="Chapman">Marianne Chapman</name></noRegion></country><country name="France"><noRegion><name sortKey="Ichai, Carole" sort="Ichai, Carole" uniqKey="Ichai C" first="Carole" last="Ichai">Carole Ichai</name></noRegion><name sortKey="Reignier, Jean" sort="Reignier, Jean" uniqKey="Reignier J" first="Jean" last="Reignier">Jean Reignier</name><name sortKey="Reignier, Jean" sort="Reignier, Jean" uniqKey="Reignier J" first="Jean" last="Reignier">Jean Reignier</name></country><country name="États-Unis"><region name="Virginie"><name sortKey="Marik, Paul E" sort="Marik, Paul E" uniqKey="Marik P" first="Paul E." last="Marik">Paul E. Marik</name></region><name sortKey="Martindale, Robert G" sort="Martindale, Robert G" uniqKey="Martindale R" first="Robert G." last="Martindale">Robert G. Martindale</name><name sortKey="Mcclave, Stephen A" sort="Mcclave, Stephen A" uniqKey="Mcclave S" first="Stephen A." last="Mcclave">Stephen A. Mcclave</name><name sortKey="Rice, Todd W" sort="Rice, Todd W" uniqKey="Rice T" first="Todd W." last="Rice">Todd W. Rice</name></country><country name="Pays-Bas"><noRegion><name sortKey="Van Zanten, Arthur R H" sort="Van Zanten, Arthur R H" uniqKey="Van Zanten A" first="Arthur R. H." last="Van Zanten">Arthur R. H. Van Zanten</name></noRegion><name sortKey="Weijs, Peter J M" sort="Weijs, Peter J M" uniqKey="Weijs P" first="Peter J. M." last="Weijs">Peter J. M. Weijs</name><name sortKey="Weijs, Peter J M" sort="Weijs, Peter J M" uniqKey="Weijs P" first="Peter J. M." last="Weijs">Peter J. M. Weijs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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