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Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene

Identifieur interne : 00AE43 ( Main/Curation ); précédent : 00AE42; suivant : 00AE44

Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene

Auteurs : Paul A. Dawson [Australie] ; Laurent Beck [France] ; Daniel Markovich [Australie]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2003.

RBID : PMC:263877

Abstract

Inorganic sulfate is required for numerous functions in mammalian physiology, and its circulating levels are proposed to be maintained by the Na⁺-SO₄^2- cotransporter, (NaS_i-1). To determine the role of NaS_i-1 in sulfate homeostasis and the physiological consequences in its absence, we have generated a mouse lacking a functional NaS_i-1 gene, Nas1. Serum sulfate concentration was reduced by >75% in Nas1^-/- mice when compared with Nas1^+/+ mice. Nas1^-/- mice exhibit increased urinary sulfate excretion, reduced renal and intestinal Na⁺-SO₄^2- cotransport, and a general growth retardation. Nas1^-/- mouse body weight was reduced by >20% when compared with Nas1^+/+ and Nas1^+/- littermates at 2 weeks of age and remained so throughout adulthood. Nas1^-/- females had a lowered fertility, with a 60% reduction in litter size. Spontaneous clonic seizures were observed in Nas1^-/- mice from 8 months of age. These data demonstrate NaS_i-1 is essential for maintaining sulfate homeostasis, and its expression is necessary for a wide range of physiological functions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC263877

DOI: 10.1073/pnas.2231298100
PubMed: 14578452
PubMed Central: 263877

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-SO<sub>4</sub>
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<sup>-/-</sup>
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<sup>-/-</sup>
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<sup>-/-</sup>
 mice from 8 months of age. These data demonstrate NaS<sub>i</sub>
-1 is essential for maintaining sulfate homeostasis, and its expression is necessary for a wide range of physiological functions.</p>
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Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene

Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene

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Abstract

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