AustralieFrV1, Main, Curation, bibRecord, 008235

Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

Identifieur interne : 008235 ( Main/Curation ); précédent : 008234; suivant : 008236

Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

Auteurs : Bastiaan E. De Galan [Australie, Pays-Bas] ; Vlado Perkovic [Australie] ; Toshiharu Ninomiya [Australie] ; Avinesh Pillai [Australie] ; Anushka Patel [Australie] ; Alan Cass [Australie] ; Bruce Neal [Australie] ; Neil Poulter [Royaume-Uni] ; Stephen Harrap [Australie] ; Carl-Erik Mogensen [Danemark] ; Mark Cooper [Australie] ; Michel Marre [France] ; Bryan Williams [Royaume-Uni] ; Pavel Hamet [Canada] ; Giuseppe Mancia [Italie] ; Mark Woodward [Australie] ; Paul Glasziou [Royaume-Uni] ; Diederick E. Grobbee [Pays-Bas] ; Stephen Macmahon [Australie] ; John Chalmers [Australie]

Source :

Journal of the American Society of Nephrology [ 1046-6673 ] ; 2009.

RBID : Pascal:09-0193729

Descripteurs français

Pascal (Inist)
- Diabète de type 2, Pression sanguine, Pression artérielle, Rein, Néphrologie, Urologie.

English descriptors

KwdEn :
- Arterial pressure, Blood pressure, Kidney, Nephrology, Type 2 diabetes, Urology.

Abstract

BP is an important determinant of kidney disease among patients with diabetes. The recommended thresholds to initiate treatment to lower BP are 130/80 and 125/75 mmHg for people with diabetes and nephropathy, respectively. We sought to determine the effects of lowering BP below these currently recommended thresholds on renal outcomes among 11,140 patients who had type 2 diabetes and participated in the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study. Patients were randomly assigned to fixed combination perindopril-indapamide or placebo, regardless of their BP at entry. During a mean follow-up of 4.3 yr, active treatment reduced the risk for renal events by 21% (P < 0.0001), which was driven by reduced risks for developing microalbuminuria and macroalbuminuria (both P < 0.003). Effects of active treatment were consistent across subgroups defined by baseline systolic or diastolic BP. Lower systolic BP levels during follow-up, even to <110 mmHg, was associated with progressively lower rates of renal events. In conclusion, BP-lowering treatment with perindopril-indapamide administered routinely to individuals with type 2 diabetes provides important renoprotection, even among those with initial BP <120/70 mmHg. We could not identify a BP threshold below which renal benefit is lost.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663832

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Le document en format XML

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<author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Ninomiya, Toshiharu" sort="Ninomiya, Toshiharu" uniqKey="Ninomiya T" first="Toshiharu" last="Ninomiya">Toshiharu Ninomiya</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cass, Alan" sort="Cass, Alan" uniqKey="Cass A" first="Alan" last="Cass">Alan Cass</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Physiology, University of Melbourne</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Mogensen, Carl Erik" sort="Mogensen, Carl Erik" uniqKey="Mogensen C" first="Carl-Erik" last="Mogensen">Carl-Erik Mogensen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medical Department M, Aarhus University Hospital, Aarhus Sygehus</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Mark" sort="Cooper, Mark" uniqKey="Cooper M" first="Mark" last="Cooper">Mark Cooper</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat-Claude Bernard</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Cardiovascular Sciences, University of Leicester School of Medicine</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)</s1>
<s2>Montreal, Québec</s2>
<s3>CAN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Clinical Medicine and Prevention, University of Milano-Bicocca</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the American Society of Nephrology</title>
<title level="j" type="abbreviated">J. Am. Soc. Nephrol.</title>
<idno type="ISSN">1046-6673</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the American Society of Nephrology</title>
<title level="j" type="abbreviated">J. Am. Soc. Nephrol.</title>
<idno type="ISSN">1046-6673</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arterial pressure</term>
<term>Blood pressure</term>
<term>Kidney</term>
<term>Nephrology</term>
<term>Type 2 diabetes</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Diabète de type 2</term>
<term>Pression sanguine</term>
<term>Pression artérielle</term>
<term>Rein</term>
<term>Néphrologie</term>
<term>Urologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BP is an important determinant of kidney disease among patients with diabetes. The recommended thresholds to initiate treatment to lower BP are 130/80 and 125/75 mmHg for people with diabetes and nephropathy, respectively. We sought to determine the effects of lowering BP below these currently recommended thresholds on renal outcomes among 11,140 patients who had type 2 diabetes and participated in the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study. Patients were randomly assigned to fixed combination perindopril-indapamide or placebo, regardless of their BP at entry. During a mean follow-up of 4.3 yr, active treatment reduced the risk for renal events by 21% (P < 0.0001), which was driven by reduced risks for developing microalbuminuria and macroalbuminuria (both P < 0.003). Effects of active treatment were consistent across subgroups defined by baseline systolic or diastolic BP. Lower systolic BP levels during follow-up, even to <110 mmHg, was associated with progressively lower rates of renal events. In conclusion, BP-lowering treatment with perindopril-indapamide administered routinely to individuals with type 2 diabetes provides important renoprotection, even among those with initial BP <120/70 mmHg. We could not identify a BP threshold below which renal benefit is lost.</div>
</front>
</TEI>
<double idat="1046-6673:2009:De Galan B:lowering:blood:pressure"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes</title>
<author><name sortKey="De Galan, Bastiaan E" sort="De Galan, Bastiaan E" uniqKey="De Galan B" first="Bastiaan E." last="De Galan">Bastiaan E. De Galan</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of General Internal Medicine, Radboud University Nijmegen Medical Centre</s1>
<s2>Nijmegen</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Ninomiya, Toshiharu" sort="Ninomiya, Toshiharu" uniqKey="Ninomiya T" first="Toshiharu" last="Ninomiya">Toshiharu Ninomiya</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cass, Alan" sort="Cass, Alan" uniqKey="Cass A" first="Alan" last="Cass">Alan Cass</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Physiology, University of Melbourne</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Mogensen, Carl Erik" sort="Mogensen, Carl Erik" uniqKey="Mogensen C" first="Carl-Erik" last="Mogensen">Carl-Erik Mogensen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medical Department M, Aarhus University Hospital, Aarhus Sygehus</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Mark" sort="Cooper, Mark" uniqKey="Cooper M" first="Mark" last="Cooper">Mark Cooper</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat-Claude Bernard</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Cardiovascular Sciences, University of Leicester School of Medicine</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)</s1>
<s2>Montreal, Québec</s2>
<s3>CAN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Clinical Medicine and Prevention, University of Milano-Bicocca</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">09-0193729</idno>
<date when="2009">2009</date>
<idno type="stanalyst">PASCAL 09-0193729 INIST</idno>
<idno type="RBID">Pascal:09-0193729</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">002E47</idno>
<idno type="wicri:Area/PascalFrancis/Curation">003173</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">002A19</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002A19</idno>
<idno type="wicri:doubleKey">1046-6673:2009:De Galan B:lowering:blood:pressure</idno>
<idno type="wicri:Area/Main/Merge">008988</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes</title>
<author><name sortKey="De Galan, Bastiaan E" sort="De Galan, Bastiaan E" uniqKey="De Galan B" first="Bastiaan E." last="De Galan">Bastiaan E. De Galan</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of General Internal Medicine, Radboud University Nijmegen Medical Centre</s1>
<s2>Nijmegen</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Ninomiya, Toshiharu" sort="Ninomiya, Toshiharu" uniqKey="Ninomiya T" first="Toshiharu" last="Ninomiya">Toshiharu Ninomiya</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cass, Alan" sort="Cass, Alan" uniqKey="Cass A" first="Alan" last="Cass">Alan Cass</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Physiology, University of Melbourne</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Mogensen, Carl Erik" sort="Mogensen, Carl Erik" uniqKey="Mogensen C" first="Carl-Erik" last="Mogensen">Carl-Erik Mogensen</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Medical Department M, Aarhus University Hospital, Aarhus Sygehus</s1>
<s2>Aarhus</s2>
<s3>DNK</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>Aarhus</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Mark" sort="Cooper, Mark" uniqKey="Cooper M" first="Mark" last="Cooper">Mark Cooper</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute</s1>
<s2>Melbourne</s2>
<s3>AUS</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat-Claude Bernard</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Cardiovascular Sciences, University of Leicester School of Medicine</s1>
<s2>Leicester</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)</s1>
<s2>Montreal, Québec</s2>
<s3>CAN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Montreal, Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Clinical Medicine and Prevention, University of Milano-Bicocca</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
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</placeName>
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</author>
<author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht</s1>
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</inist:fA14>
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<placeName><settlement type="city">Utrecht</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
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<s3>AUS</s3>
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<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>George Institute For International Health, University of Sydney</s1>
<s2>Sydney</s2>
<s3>AUS</s3>
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<sZ>2 aut.</sZ>
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</inist:fA14>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the American Society of Nephrology</title>
<title level="j" type="abbreviated">J. Am. Soc. Nephrol.</title>
<idno type="ISSN">1046-6673</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the American Society of Nephrology</title>
<title level="j" type="abbreviated">J. Am. Soc. Nephrol.</title>
<idno type="ISSN">1046-6673</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arterial pressure</term>
<term>Blood pressure</term>
<term>Kidney</term>
<term>Nephrology</term>
<term>Type 2 diabetes</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Diabète de type 2</term>
<term>Pression sanguine</term>
<term>Pression artérielle</term>
<term>Rein</term>
<term>Néphrologie</term>
<term>Urologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BP is an important determinant of kidney disease among patients with diabetes. The recommended thresholds to initiate treatment to lower BP are 130/80 and 125/75 mmHg for people with diabetes and nephropathy, respectively. We sought to determine the effects of lowering BP below these currently recommended thresholds on renal outcomes among 11,140 patients who had type 2 diabetes and participated in the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study. Patients were randomly assigned to fixed combination perindopril-indapamide or placebo, regardless of their BP at entry. During a mean follow-up of 4.3 yr, active treatment reduced the risk for renal events by 21% (P < 0.0001), which was driven by reduced risks for developing microalbuminuria and macroalbuminuria (both P < 0.003). Effects of active treatment were consistent across subgroups defined by baseline systolic or diastolic BP. Lower systolic BP levels during follow-up, even to <110 mmHg, was associated with progressively lower rates of renal events. In conclusion, BP-lowering treatment with perindopril-indapamide administered routinely to individuals with type 2 diabetes provides important renoprotection, even among those with initial BP <120/70 mmHg. We could not identify a BP threshold below which renal benefit is lost.</div>
</front>
</TEI>
</INIST>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes</title>
<author><name sortKey="De Galan, Bastiaan E" sort="De Galan, Bastiaan E" uniqKey="De Galan B" first="Bastiaan E." last="De Galan">Bastiaan E. De Galan</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Ninomiya, Toshiharu" sort="Ninomiya, Toshiharu" uniqKey="Ninomiya T" first="Toshiharu" last="Ninomiya">Toshiharu Ninomiya</name>
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<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name>
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<country xml:lang="fr">Australie</country>
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<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
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</author>
<author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
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</author>
<author><name sortKey="Cass, Alan" sort="Cass, Alan" uniqKey="Cass A" first="Alan" last="Cass">Alan Cass</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
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</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
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<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mogensen, Carl Erik" sort="Mogensen, Carl Erik" uniqKey="Mogensen C" first="Carl-Erik" last="Mogensen">Carl-Erik Mogensen</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus C</wicri:regionArea>
<wicri:noRegion>Aarhus C</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Mark" sort="Cooper, Mark" uniqKey="Cooper M" first="Mark" last="Cooper">Mark Cooper</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat–Claude Bernard, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Québec, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="N0x1a54b90N0x1f05e28">Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University, Oxford, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19225038</idno>
<idno type="pmc">2663832</idno>
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<idno type="RBID">PMC:2663832</idno>
<idno type="doi">10.1681/ASN.2008070667</idno>
<date when="2009">2009</date>
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<idno type="wicri:Area/Pmc/Checkpoint">002771</idno>
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<idno type="wicri:Area/Ncbi/Checkpoint">000535</idno>
<idno type="wicri:doubleKey">1046-6673:2009:De Galan B:lowering:blood:pressure</idno>
<idno type="wicri:Area/Main/Merge">008259</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes</title>
<author><name sortKey="De Galan, Bastiaan E" sort="De Galan, Bastiaan E" uniqKey="De Galan B" first="Bastiaan E." last="De Galan">Bastiaan E. De Galan</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands;</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perkovic, Vlado" sort="Perkovic, Vlado" uniqKey="Perkovic V" first="Vlado" last="Perkovic">Vlado Perkovic</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
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<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Ninomiya, Toshiharu" sort="Ninomiya, Toshiharu" uniqKey="Ninomiya T" first="Toshiharu" last="Ninomiya">Toshiharu Ninomiya</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Pillai, Avinesh" sort="Pillai, Avinesh" uniqKey="Pillai A" first="Avinesh" last="Pillai">Avinesh Pillai</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Patel, Anushka" sort="Patel, Anushka" uniqKey="Patel A" first="Anushka" last="Patel">Anushka Patel</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Cass, Alan" sort="Cass, Alan" uniqKey="Cass A" first="Alan" last="Cass">Alan Cass</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Neal, Bruce" sort="Neal, Bruce" uniqKey="Neal B" first="Bruce" last="Neal">Bruce Neal</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Poulter, Neil" sort="Poulter, Neil" uniqKey="Poulter N" first="Neil" last="Poulter">Neil Poulter</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harrap, Stephen" sort="Harrap, Stephen" uniqKey="Harrap S" first="Stephen" last="Harrap">Stephen Harrap</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of Physiology, University of Melbourne, Melbourne Australia;</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mogensen, Carl Erik" sort="Mogensen, Carl Erik" uniqKey="Mogensen C" first="Carl-Erik" last="Mogensen">Carl-Erik Mogensen</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus C, Denmark;</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus C</wicri:regionArea>
<wicri:noRegion>Aarhus C</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cooper, Mark" sort="Cooper, Mark" uniqKey="Cooper M" first="Mark" last="Cooper">Mark Cooper</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Danielle Alberti Memorial Centre for Diabetes Complications, Baker Heart Research Institute, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marre, Michel" sort="Marre, Michel" uniqKey="Marre M" first="Michel" last="Marre">Michel Marre</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat–Claude Bernard, Paris, France;</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Endocrinologie Diabétologie Nutrition, Groupe Hospitalier Bichat–Claude Bernard, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Bryan" sort="Williams, Bryan" uniqKey="Williams B" first="Bryan" last="Williams">Bryan Williams</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester School of Medicine, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hamet, Pavel" sort="Hamet, Pavel" uniqKey="Hamet P" first="Pavel" last="Hamet">Pavel Hamet</name>
<affiliation wicri:level="1"><nlm:aff id="N0x1a54b90N0x1f05e28">Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Québec, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Research Centre, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mancia, Giuseppe" sort="Mancia, Giuseppe" uniqKey="Mancia G" first="Giuseppe" last="Mancia">Giuseppe Mancia</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woodward, Mark" sort="Woodward, Mark" uniqKey="Woodward M" first="Mark" last="Woodward">Mark Woodward</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="N0x1a54b90N0x1f05e28">Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University, Oxford, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Evidence-Based Practice, Institute of Health Sciences, Oxford University, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E." last="Grobbee">Diederick E. Grobbee</name>
<affiliation wicri:level="3"><nlm:aff id="N0x1a54b90N0x1f05e28">Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht</wicri:regionArea>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macmahon, Stephen" sort="Macmahon, Stephen" uniqKey="Macmahon S" first="Stephen" last="Macmahon">Stephen Macmahon</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name>
<affiliation wicri:level="4"><nlm:aff id="N0x1a54b90N0x1f05e28">George Institute For International Health, University of Sydney, Sydney, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>George Institute For International Health, University of Sydney, Sydney</wicri:regionArea>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
<settlement type="city">Sydney</settlement>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the American Society of Nephrology : JASN</title>
<idno type="ISSN">1046-6673</idno>
<idno type="eISSN">1533-3450</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>BP is an important determinant of kidney disease among patients with diabetes. The recommended thresholds to initiate treatment to lower BP are 130/80 and 125/75 mmHg for people with diabetes and nephropathy, respectively. We sought to determine the effects of lowering BP below these currently recommended thresholds on renal outcomes among 11,140 patients who had type 2 diabetes and participated in the Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE) study. Patients were randomly assigned to fixed combination perindopril-indapamide or placebo, regardless of their BP at entry. During a mean follow-up of 4.3 yr, active treatment reduced the risk for renal events by 21% (<italic>P</italic>
 < 0.0001), which was driven by reduced risks for developing microalbuminuria and macroalbuminuria (both <italic>P</italic>
 < 0.003). Effects of active treatment were consistent across subgroups defined by baseline systolic or diastolic BP. Lower systolic BP levels during follow-up, even to <110 mmHg, was associated with progressively lower rates of renal events. In conclusion, BP-lowering treatment with perindopril-indapamide administered routinely to individuals with type 2 diabetes provides important renoprotection, even among those with initial BP <120/70 mmHg. We could not identify a BP threshold below which renal benefit is lost.</p>
</div>
</front>
</TEI>
</PMC>
</double>
</record>

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Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

Lowering Blood Pressure Reduces Renal Events in Type 2 Diabetes

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