Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions
Identifieur interne : 007034 ( Main/Curation ); précédent : 007033; suivant : 007035Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions
Auteurs : Ronan Jambou [Australie, France] ; Valery Combes [Australie] ; Marie-Jose Jambou [Australie] ; Babeth B. Weksler [France, États-Unis] ; Pierre-Olivier Couraud [France] ; Georges E. Grau [Australie]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2010.
Abstract
Cerebral malaria, a major cause of death during malaria infection, is characterised by the sequestration of infected red blood cells (IRBC) in brain microvessels. Most of the molecules implicated in the adhesion of IRBC on endothelial cells (EC) are already described; however, the structure of the IRBC/EC junction and the impact of this adhesion on the EC are poorly understood. We analysed this interaction using human brain microvascular EC monolayers co-cultured with IRBC. Our study demonstrates the transfer of material from the IRBC to the brain EC plasma membrane in a trogocytosis-like process, followed by a TNF-enhanced IRBC engulfing process. Upon IRBC/EC binding, parasite antigens are transferred to early endosomes in the EC, in a cytoskeleton-dependent process. This is associated with the opening of the intercellular junctions. The transfer of IRBC antigens can thus transform EC into a target for the immune response and contribute to the profound EC alterations, including peri-vascular oedema, associated with cerebral malaria.
Url:
DOI: 10.1371/journal.ppat.1001021
PubMed: 20686652
PubMed Central: 2912387
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Weksler</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Institut Cochin, CNRS UMR 8104, INSERM U567, Université Paris Descartes, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Cochin, CNRS UMR 8104, INSERM U567, Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Cornell University Medical College, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cornell University Medical College, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Couraud, Pierre Olivier" sort="Couraud, Pierre Olivier" uniqKey="Couraud P" first="Pierre-Olivier" last="Couraud">Pierre-Olivier Couraud</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Institut Cochin, CNRS UMR 8104, INSERM U567, Université Paris Descartes, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Cochin, CNRS UMR 8104, INSERM U567, Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation></author><author><name sortKey="Grau, Georges E" sort="Grau, Georges E" uniqKey="Grau G" first="Georges E." last="Grau">Georges E. Grau</name><affiliation wicri:level="4"><nlm:aff id="aff1"><addr-line>Vascular Immunology Unit, Department of Pathology and Bosch Institute, Sydney Medical School, The University of Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vascular Immunology Unit, Department of Pathology and Bosch Institute, Sydney Medical School, The University of Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cerebral malaria, a major cause of death during malaria infection, is characterised by the sequestration of infected red blood cells (IRBC) in brain microvessels. Most of the molecules implicated in the adhesion of IRBC on endothelial cells (EC) are already described; however, the structure of the IRBC/EC junction and the impact of this adhesion on the EC are poorly understood. We analysed this interaction using human brain microvascular EC monolayers co-cultured with IRBC. Our study demonstrates the transfer of material from the IRBC to the brain EC plasma membrane in a trogocytosis-like process, followed by a TNF-enhanced IRBC engulfing process. Upon IRBC/EC binding, parasite antigens are transferred to early endosomes in the EC, in a cytoskeleton-dependent process. This is associated with the opening of the intercellular junctions. The transfer of IRBC antigens can thus transform EC into a target for the immune response and contribute to the profound EC alterations, including peri-vascular oedema, associated with cerebral malaria.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Newton, Cr" uniqKey="Newton C">CR Newton</name></author><author><name sortKey="Warn, Pa" uniqKey="Warn P">PA Warn</name></author><author><name sortKey="Winstanley, Pa" uniqKey="Winstanley P">PA Winstanley</name></author><author><name sortKey="Peshu, N" uniqKey="Peshu N">N Peshu</name></author><author><name sortKey="Snow, Rw" uniqKey="Snow R">RW Snow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adibhatla, Rm" uniqKey="Adibhatla R">RM Adibhatla</name></author><author><name sortKey="Hatcher, Jf" uniqKey="Hatcher J">JF Hatcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deininger, Mh" 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Lepidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Daubeuf, S" uniqKey="Daubeuf S">S Daubeuf</name></author><author><name sortKey="Puaux, Al" uniqKey="Puaux A">AL Puaux</name></author><author><name sortKey="Joly, E" uniqKey="Joly E">E Joly</name></author><author><name sortKey="Hudrisier, D" uniqKey="Hudrisier D">D Hudrisier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ambroise Thomas, P" uniqKey="Ambroise Thomas P">P Ambroise-Thomas</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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