Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab.
Identifieur interne : 003C02 ( Main/Curation ); précédent : 003C01; suivant : 003C03Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab.
Auteurs : Erik Stroes [Pays-Bas] ; David Colquhoun [Australie] ; David Sullivan [Australie] ; Fernando Civeira [Espagne] ; Robert S. Rosenson [États-Unis] ; Gerald F. Watts [Australie] ; Eric Bruckert [France] ; Leslie Cho [États-Unis] ; Ricardo Dent [États-Unis] ; Beat Knusel [États-Unis] ; Allen Xue [États-Unis] ; Rob Scott [États-Unis] ; Scott M. Wasserman [États-Unis] ; Michael Rocco [États-Unis]Source :
- Journal of the American College of Cardiology [ 1558-3597 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Anticorps monoclonaux (), Anticorps monoclonaux (administration et posologie), Anticorps monoclonaux (immunologie), Anticorps monoclonaux (sang), Apoptose, Association de médicaments, Calendrier d'administration des médicaments, Cholestérol (sang), Femelle, Humains, Hypercholestérolémie (immunologie), Hypercholestérolémie (sang), Hypercholestérolémie (traitement médicamenteux), Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (administration et posologie), Jeune adulte, Mâle, Méthode en double aveugle, Proprotein convertases (antagonistes et inhibiteurs), Proprotein convertases (immunologie), Proprotéine convertase 9, Résultat thérapeutique, Serine endopeptidases (immunologie), Sujet âgé, Tolérance aux médicaments, Études de suivi.
- MESH :
- administration et posologie : Anticorps monoclonaux, Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase.
- antagonistes et inhibiteurs : Proprotein convertases.
- immunologie : Anticorps monoclonaux, Hypercholestérolémie, Proprotein convertases, Serine endopeptidases.
- sang : Anticorps monoclonaux, Cholestérol, Hypercholestérolémie.
- traitement médicamenteux : Hypercholestérolémie.
- Adolescent, Adulte, Anticorps monoclonaux, Apoptose, Association de médicaments, Calendrier d'administration des médicaments, Femelle, Humains, Jeune adulte, Mâle, Méthode en double aveugle, Proprotéine convertase 9, Résultat thérapeutique, Sujet âgé, Tolérance aux médicaments, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antibodies, Monoclonal (administration & dosage), Antibodies, Monoclonal (blood), Antibodies, Monoclonal (drug effects), Antibodies, Monoclonal (immunology), Apoptosis, Cholesterol (blood), Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Drug Tolerance, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage), Hypercholesterolemia (blood), Hypercholesterolemia (drug therapy), Hypercholesterolemia (immunology), Male, Proprotein Convertase 9, Proprotein Convertases (antagonists & inhibitors), Proprotein Convertases (immunology), Serine Endopeptidases (immunology), Treatment Outcome, Young Adult.
- MESH :
- chemical , administration & dosage : Antibodies, Monoclonal, Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemical , antagonists & inhibitors : Proprotein Convertases.
- chemical , blood : Antibodies, Monoclonal, Cholesterol.
- chemical , drug effects : Antibodies, Monoclonal.
- chemical , immunology : Antibodies, Monoclonal, Proprotein Convertases, Serine Endopeptidases.
- blood : Hypercholesterolemia.
- drug therapy : Hypercholesterolemia.
- immunology : Hypercholesterolemia.
- Adolescent, Adult, Aged, Apoptosis, Double-Blind Method, Drug Administration Schedule, Drug Therapy, Combination, Drug Tolerance, Female, Follow-Up Studies, Humans, Male, Proprotein Convertase 9, Treatment Outcome, Young Adult.
Abstract
This study sought to evaluate the efficacy and safety of subcutaneous evolocumab compared with oral ezetimibe in hypercholesterolemic patients who are unable to tolerate effective statin doses.
DOI: 10.1016/j.jacc.2014.03.019
PubMed: 24694531
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pubmed:24694531Le document en format XML
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<author><name sortKey="Wasserman, Scott M" sort="Wasserman, Scott M" uniqKey="Wasserman S" first="Scott M" last="Wasserman">Scott M. Wasserman</name>
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<term>Adult</term>
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<term>Antibodies, Monoclonal (blood)</term>
<term>Antibodies, Monoclonal (drug effects)</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Apoptosis</term>
<term>Cholesterol (blood)</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Drug Therapy, Combination</term>
<term>Drug Tolerance</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (administration & dosage)</term>
<term>Hypercholesterolemia (blood)</term>
<term>Hypercholesterolemia (drug therapy)</term>
<term>Hypercholesterolemia (immunology)</term>
<term>Male</term>
<term>Proprotein Convertase 9</term>
<term>Proprotein Convertases (antagonists & inhibitors)</term>
<term>Proprotein Convertases (immunology)</term>
<term>Serine Endopeptidases (immunology)</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Anticorps monoclonaux ()</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Anticorps monoclonaux (sang)</term>
<term>Apoptose</term>
<term>Association de médicaments</term>
<term>Calendrier d'administration des médicaments</term>
<term>Cholestérol (sang)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypercholestérolémie (immunologie)</term>
<term>Hypercholestérolémie (sang)</term>
<term>Hypercholestérolémie (traitement médicamenteux)</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase (administration et posologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Proprotein convertases (antagonistes et inhibiteurs)</term>
<term>Proprotein convertases (immunologie)</term>
<term>Proprotéine convertase 9</term>
<term>Résultat thérapeutique</term>
<term>Serine endopeptidases (immunologie)</term>
<term>Sujet âgé</term>
<term>Tolérance aux médicaments</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term>
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</keywords>
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<term>Cholesterol</term>
</keywords>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Proprotein Convertases</term>
<term>Serine Endopeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticorps monoclonaux</term>
<term>Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Proprotein convertases</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hypercholesterolemia</term>
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</keywords>
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<term>Hypercholestérolémie</term>
<term>Proprotein convertases</term>
<term>Serine endopeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Hypercholesterolemia</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps monoclonaux</term>
<term>Cholestérol</term>
<term>Hypercholestérolémie</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hypercholestérolémie</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Apoptosis</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Drug Therapy, Combination</term>
<term>Drug Tolerance</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Proprotein Convertase 9</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Anticorps monoclonaux</term>
<term>Apoptose</term>
<term>Association de médicaments</term>
<term>Calendrier d'administration des médicaments</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Proprotéine convertase 9</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tolérance aux médicaments</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">This study sought to evaluate the efficacy and safety of subcutaneous evolocumab compared with oral ezetimibe in hypercholesterolemic patients who are unable to tolerate effective statin doses.</div>
</front>
</TEI>
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