A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.
Identifieur interne : 003234 ( Main/Curation ); précédent : 003233; suivant : 003235A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.
Auteurs : Maria E. Cabanillas [États-Unis] ; Martin Schlumberger [France] ; Barbara Jarzab [Pologne] ; Renato G. Martins [États-Unis] ; Furio Pacini [Italie] ; Bruce Robinson [Australie] ; Judith C. Mccaffrey [États-Unis] ; Manisha H. Shah [États-Unis] ; Donald L. Bodenner [États-Unis] ; Duncan Topliss [Australie] ; Corina Andresen [États-Unis] ; James P. O'Brien [États-Unis] ; Min Ren [États-Unis] ; Yasuhiro Funahashi [États-Unis] ; Roger Allison [Australie] ; Rossella Elisei [Italie] ; Kate Newbold [Royaume-Uni] ; Lisa F. Licitra [Italie] ; Steven I. Sherman [États-Unis] ; Douglas W. Ball [États-Unis]Source :
- Cancer [ 1097-0142 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antinéoplasiques (usage thérapeutique), Femelle, Humains, Inhibiteurs de protéines kinases (effets indésirables), Inhibiteurs de protéines kinases (usage thérapeutique), Marqueurs biologiques tumoraux (analyse), Mâle, Phénylurées (effets indésirables), Phénylurées (usage thérapeutique), Quinoléines (effets indésirables), Quinoléines (usage thérapeutique), Radio-isotopes de l'iode (effets indésirables), Radio-isotopes de l'iode (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Tumeurs de la thyroïde (mortalité), Tumeurs de la thyroïde (traitement médicamenteux), Évolution de la maladie.
- MESH :
- analyse : Marqueurs biologiques tumoraux.
- effets indésirables : Inhibiteurs de protéines kinases, Phénylurées, Quinoléines, Radio-isotopes de l'iode.
- mortalité : Tumeurs de la thyroïde.
- traitement médicamenteux : Tumeurs de la thyroïde.
- usage thérapeutique : Antinéoplasiques, Inhibiteurs de protéines kinases, Phénylurées, Quinoléines, Radio-isotopes de l'iode.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Résultat thérapeutique, Sujet âgé, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Antineoplastic Agents (therapeutic use), Biomarkers, Tumor (analysis), Disease Progression, Female, Humans, Iodine Radioisotopes (adverse effects), Iodine Radioisotopes (therapeutic use), Male, Middle Aged, Phenylurea Compounds (adverse effects), Phenylurea Compounds (therapeutic use), Protein Kinase Inhibitors (adverse effects), Protein Kinase Inhibitors (therapeutic use), Quinolines (adverse effects), Quinolines (therapeutic use), Thyroid Neoplasms (drug therapy), Thyroid Neoplasms (mortality), Treatment Outcome.
- MESH :
- chemical , adverse effects : Iodine Radioisotopes, Phenylurea Compounds, Protein Kinase Inhibitors, Quinolines.
- chemical , analysis : Biomarkers, Tumor.
- chemical , therapeutic use : Antineoplastic Agents, Iodine Radioisotopes, Phenylurea Compounds, Protein Kinase Inhibitors, Quinolines.
- drug therapy : Thyroid Neoplasms.
- mortality : Thyroid Neoplasms.
- Adult, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Treatment Outcome.
Abstract
Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1 through 3 (VEGFR1-VEGFR3), fibroblast growth factor receptors 1 through 4 (FGFR1-FGFR4), platelet-derived growth factor receptor α (PDGFRα), ret proto-oncogene (RET), and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) signaling networks implicated in tumor angiogenesis. Positive phase 1 results in solid tumors prompted a phase 2 trial in patients with advanced, radioiodine-refractory, differentiated thyroid cancer (RR-DTC).
DOI: 10.1002/cncr.29395
PubMed: 25913680
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pubmed:25913680Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A phase 2 trial of lenvatinib (E7080) in advanced, progressive, radioiodine-refractory, differentiated thyroid cancer: A clinical outcomes and biomarker assessment.</title>
<author><name sortKey="Cabanillas, Maria E" sort="Cabanillas, Maria E" uniqKey="Cabanillas M" first="Maria E" last="Cabanillas">Maria E. Cabanillas</name>
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<author><name sortKey="Bodenner, Donald L" sort="Bodenner, Donald L" uniqKey="Bodenner D" first="Donald L" last="Bodenner">Donald L. Bodenner</name>
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<author><name sortKey="Topliss, Duncan" sort="Topliss, Duncan" uniqKey="Topliss D" first="Duncan" last="Topliss">Duncan Topliss</name>
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<author><name sortKey="O Brien, James P" sort="O Brien, James P" uniqKey="O Brien J" first="James P" last="O'Brien">James P. O'Brien</name>
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<author><name sortKey="Ren, Min" sort="Ren, Min" uniqKey="Ren M" first="Min" last="Ren">Min Ren</name>
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<author><name sortKey="Allison, Roger" sort="Allison, Roger" uniqKey="Allison R" first="Roger" last="Allison">Roger Allison</name>
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<author><name sortKey="Newbold, Kate" sort="Newbold, Kate" uniqKey="Newbold K" first="Kate" last="Newbold">Kate Newbold</name>
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<author><name sortKey="Licitra, Lisa F" sort="Licitra, Lisa F" uniqKey="Licitra L" first="Lisa F" last="Licitra">Lisa F. Licitra</name>
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<author><name sortKey="Sherman, Steven I" sort="Sherman, Steven I" uniqKey="Sherman S" first="Steven I" last="Sherman">Steven I. Sherman</name>
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<author><name sortKey="Ball, Douglas W" sort="Ball, Douglas W" uniqKey="Ball D" first="Douglas W" last="Ball">Douglas W. Ball</name>
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<series><title level="j">Cancer</title>
<idno type="eISSN">1097-0142</idno>
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<front><div type="abstract" xml:lang="en">Lenvatinib is an oral, multitargeted tyrosine kinase inhibitor of the vascular endothelial growth factor receptors 1 through 3 (VEGFR1-VEGFR3), fibroblast growth factor receptors 1 through 4 (FGFR1-FGFR4), platelet-derived growth factor receptor α (PDGFRα), ret proto-oncogene (RET), and v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) signaling networks implicated in tumor angiogenesis. Positive phase 1 results in solid tumors prompted a phase 2 trial in patients with advanced, radioiodine-refractory, differentiated thyroid cancer (RR-DTC).</div>
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