Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials.
Identifieur interne : 002015 ( Main/Curation ); précédent : 002014; suivant : 002016Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials.
Auteurs : Jason Grebely [Australie] ; Stefan Mauss [Allemagne] ; Ashley Brown [Royaume-Uni] ; Jean-Pierre Bronowicki [France] ; Massimo Puoti [Italie] ; David Wyles [États-Unis] ; Macky Natha [États-Unis] ; Yanni Zhu [États-Unis] ; Junming Yang [États-Unis] ; Bruce Kreter [États-Unis] ; Diana M. Brainard [États-Unis] ; Chohee Yun [États-Unis] ; Val Carr [Royaume-Uni] ; Gregory J. Dore [Australie]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Association de médicaments (effets indésirables), Benzimidazoles (administration et posologie), Benzimidazoles (effets indésirables), Benzimidazoles (usage thérapeutique), Charge virale (), Femelle, Fluorènes (administration et posologie), Fluorènes (effets indésirables), Fluorènes (usage thérapeutique), Génotype, Hepacivirus (), Hepacivirus (génétique), Humains, Hépatite C chronique (génétique), Hépatite C chronique (sang), Hépatite C chronique (traitement médicamenteux), Interprétation statistique de données, Mâle, Ribavirine (administration et posologie), Ribavirine (effets indésirables), Ribavirine (usage thérapeutique), Réponse virologique soutenue, Sofosbuvir (administration et posologie), Sofosbuvir (effets indésirables), Sofosbuvir (usage thérapeutique), Test ELISA, Traitement de substitution aux opiacés, Usagers de drogues, Études rétrospectives.
- MESH :
- administration et posologie : Benzimidazoles, Fluorènes, Ribavirine, Sofosbuvir.
- effets indésirables : Association de médicaments, Benzimidazoles, Fluorènes, Ribavirine, Sofosbuvir.
- génétique : Hepacivirus, Hépatite C chronique.
- sang : Hépatite C chronique.
- traitement médicamenteux : Hépatite C chronique.
- usage thérapeutique : Antiviraux, Benzimidazoles, Fluorènes, Ribavirine, Sofosbuvir.
- Adulte, Adulte d'âge moyen, Charge virale, Femelle, Génotype, Hepacivirus, Humains, Interprétation statistique de données, Mâle, Réponse virologique soutenue, Test ELISA, Traitement de substitution aux opiacés, Usagers de drogues, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Antiviral Agents (therapeutic use), Benzimidazoles (administration & dosage), Benzimidazoles (adverse effects), Benzimidazoles (therapeutic use), Data Interpretation, Statistical, Drug Therapy, Combination (adverse effects), Drug Users, Enzyme-Linked Immunosorbent Assay, Female, Fluorenes (administration & dosage), Fluorenes (adverse effects), Fluorenes (therapeutic use), Genotype, Hepacivirus (drug effects), Hepacivirus (genetics), Hepatitis C, Chronic (blood), Hepatitis C, Chronic (drug therapy), Hepatitis C, Chronic (genetics), Humans, Male, Middle Aged, Opiate Substitution Treatment, Retrospective Studies, Ribavirin (administration & dosage), Ribavirin (adverse effects), Ribavirin (therapeutic use), Sofosbuvir (administration & dosage), Sofosbuvir (adverse effects), Sofosbuvir (therapeutic use), Sustained Virologic Response, Viral Load (drug effects).
- MESH :
- chemical , administration & dosage : Benzimidazoles, Fluorenes, Ribavirin, Sofosbuvir.
- chemical , adverse effects : Benzimidazoles, Fluorenes, Ribavirin, Sofosbuvir.
- chemical , therapeutic use : Antiviral Agents, Benzimidazoles, Fluorenes, Ribavirin, Sofosbuvir.
- adverse effects : Drug Therapy, Combination.
- blood : Hepatitis C, Chronic.
- drug effects : Hepacivirus, Viral Load.
- drug therapy : Hepatitis C, Chronic.
- genetics : Hepacivirus, Hepatitis C, Chronic.
- Adult, Data Interpretation, Statistical, Drug Users, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Humans, Male, Middle Aged, Opiate Substitution Treatment, Retrospective Studies, Sustained Virologic Response.
Abstract
Interferon-based hepatitis C virus (HCV) therapy is safe and effective among people receiving opioid substitution therapy (OST), but treatment uptake remains low. Our aim was to evaluate the impact of OST and drug use during therapy on completion, adherence, sustained virologic response (SVR12), and safety of ledipasvir/sofosbuvir ± ribavirin.
DOI: 10.1093/cid/ciw580
PubMed: 27553375
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001457
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001435
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001435
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003A27
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003A27
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003A27
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002014
Links to Exploration step
pubmed:27553375Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials.</title>
<author><name sortKey="Grebely, Jason" sort="Grebely, Jason" uniqKey="Grebely J" first="Jason" last="Grebely">Jason Grebely</name>
<affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney.</nlm:affiliation>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:orgArea>The Kirby Institute, UNSW Australia</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Mauss, Stefan" sort="Mauss, Stefan" uniqKey="Mauss S" first="Stefan" last="Mauss">Stefan Mauss</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for HIV and Hepatogastroenterology, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for HIV and Hepatogastroenterology, Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Ashley" sort="Brown, Ashley" uniqKey="Brown A" first="Ashley" last="Brown">Ashley Brown</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Department of Medicine, St Mary's Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liver Unit, Department of Medicine, St Mary's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U954, Universitary Hospital of Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U954, Universitary Hospital of Nancy, University of Lorraine, Vandoeuvre-les-Nancy</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
<settlement type="city">Vandœuvre-lès-Nancy</settlement>
<settlement type="city" wicri:auto="agglo">Nancy</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puoti, Massimo" sort="Puoti, Massimo" uniqKey="Puoti M" first="Massimo" last="Puoti">Massimo Puoti</name>
<affiliation wicri:level="3"><nlm:affiliation>Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyles, David" sort="Wyles, David" uniqKey="Wyles D" first="David" last="Wyles">David Wyles</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases, University of California, San Diego.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Diego</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Division of Infectious Diseases, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Natha, Macky" sort="Natha, Macky" uniqKey="Natha M" first="Macky" last="Natha">Macky Natha</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhu, Yanni" sort="Zhu, Yanni" uniqKey="Zhu Y" first="Yanni" last="Zhu">Yanni Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Junming" sort="Yang, Junming" uniqKey="Yang J" first="Junming" last="Yang">Junming Yang</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kreter, Bruce" sort="Kreter, Bruce" uniqKey="Kreter B" first="Bruce" last="Kreter">Bruce Kreter</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M" last="Brainard">Diana M. Brainard</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yun, Chohee" sort="Yun, Chohee" uniqKey="Yun C" first="Chohee" last="Yun">Chohee Yun</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carr, Val" sort="Carr, Val" uniqKey="Carr V" first="Val" last="Carr">Val Carr</name>
<affiliation wicri:level="1"><nlm:affiliation>Gilead Sciences, Stockley Park, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Gilead Sciences, Stockley Park</wicri:regionArea>
<wicri:noRegion>Stockley Park</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
<affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney.</nlm:affiliation>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:orgArea>The Kirby Institute, UNSW Australia</wicri:orgArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27553375</idno>
<idno type="pmid">27553375</idno>
<idno type="doi">10.1093/cid/ciw580</idno>
<idno type="wicri:Area/PubMed/Corpus">001457</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001457</idno>
<idno type="wicri:Area/PubMed/Curation">001435</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001435</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001435</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001435</idno>
<idno type="wicri:Area/Ncbi/Merge">003A27</idno>
<idno type="wicri:Area/Ncbi/Curation">003A27</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003A27</idno>
<idno type="wicri:Area/Main/Merge">002014</idno>
<idno type="wicri:Area/Main/Curation">002015</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials.</title>
<author><name sortKey="Grebely, Jason" sort="Grebely, Jason" uniqKey="Grebely J" first="Jason" last="Grebely">Jason Grebely</name>
<affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney.</nlm:affiliation>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:orgArea>The Kirby Institute, UNSW Australia</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Mauss, Stefan" sort="Mauss, Stefan" uniqKey="Mauss S" first="Stefan" last="Mauss">Stefan Mauss</name>
<affiliation wicri:level="3"><nlm:affiliation>Center for HIV and Hepatogastroenterology, Düsseldorf, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for HIV and Hepatogastroenterology, Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Ashley" sort="Brown, Ashley" uniqKey="Brown A" first="Ashley" last="Brown">Ashley Brown</name>
<affiliation wicri:level="3"><nlm:affiliation>Liver Unit, Department of Medicine, St Mary's Hospital, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Liver Unit, Department of Medicine, St Mary's Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bronowicki, Jean Pierre" sort="Bronowicki, Jean Pierre" uniqKey="Bronowicki J" first="Jean-Pierre" last="Bronowicki">Jean-Pierre Bronowicki</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U954, Universitary Hospital of Nancy, University of Lorraine, Vandoeuvre-les-Nancy, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U954, Universitary Hospital of Nancy, University of Lorraine, Vandoeuvre-les-Nancy</wicri:regionArea>
<placeName><region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
<settlement type="city">Vandœuvre-lès-Nancy</settlement>
<settlement type="city" wicri:auto="agglo">Nancy</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puoti, Massimo" sort="Puoti, Massimo" uniqKey="Puoti M" first="Massimo" last="Puoti">Massimo Puoti</name>
<affiliation wicri:level="3"><nlm:affiliation>Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Azienda Ospedaliera Ospedale Niguarda Ca' Granda, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyles, David" sort="Wyles, David" uniqKey="Wyles D" first="David" last="Wyles">David Wyles</name>
<affiliation wicri:level="3"><nlm:affiliation>Division of Infectious Diseases, University of California, San Diego.</nlm:affiliation>
<country>États-Unis</country>
<placeName><settlement type="city">San Diego</settlement>
<region type="state">Californie</region>
</placeName>
<wicri:orgArea>Division of Infectious Diseases, University of California</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Natha, Macky" sort="Natha, Macky" uniqKey="Natha M" first="Macky" last="Natha">Macky Natha</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zhu, Yanni" sort="Zhu, Yanni" uniqKey="Zhu Y" first="Yanni" last="Zhu">Yanni Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Junming" sort="Yang, Junming" uniqKey="Yang J" first="Junming" last="Yang">Junming Yang</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kreter, Bruce" sort="Kreter, Bruce" uniqKey="Kreter B" first="Bruce" last="Kreter">Bruce Kreter</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Brainard, Diana M" sort="Brainard, Diana M" uniqKey="Brainard D" first="Diana M" last="Brainard">Diana M. Brainard</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yun, Chohee" sort="Yun, Chohee" uniqKey="Yun C" first="Chohee" last="Yun">Chohee Yun</name>
<affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Foster City, California.</nlm:affiliation>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Gilead Sciences, Foster City</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Carr, Val" sort="Carr, Val" uniqKey="Carr V" first="Val" last="Carr">Val Carr</name>
<affiliation wicri:level="1"><nlm:affiliation>Gilead Sciences, Stockley Park, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Gilead Sciences, Stockley Park</wicri:regionArea>
<wicri:noRegion>Stockley Park</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dore, Gregory J" sort="Dore, Gregory J" uniqKey="Dore G" first="Gregory J" last="Dore">Gregory J. Dore</name>
<affiliation wicri:level="3"><nlm:affiliation>The Kirby Institute, UNSW Australia, Sydney.</nlm:affiliation>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<wicri:orgArea>The Kirby Institute, UNSW Australia</wicri:orgArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Benzimidazoles (administration & dosage)</term>
<term>Benzimidazoles (adverse effects)</term>
<term>Benzimidazoles (therapeutic use)</term>
<term>Data Interpretation, Statistical</term>
<term>Drug Therapy, Combination (adverse effects)</term>
<term>Drug Users</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Fluorenes (administration & dosage)</term>
<term>Fluorenes (adverse effects)</term>
<term>Fluorenes (therapeutic use)</term>
<term>Genotype</term>
<term>Hepacivirus (drug effects)</term>
<term>Hepacivirus (genetics)</term>
<term>Hepatitis C, Chronic (blood)</term>
<term>Hepatitis C, Chronic (drug therapy)</term>
<term>Hepatitis C, Chronic (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Opiate Substitution Treatment</term>
<term>Retrospective Studies</term>
<term>Ribavirin (administration & dosage)</term>
<term>Ribavirin (adverse effects)</term>
<term>Ribavirin (therapeutic use)</term>
<term>Sofosbuvir (administration & dosage)</term>
<term>Sofosbuvir (adverse effects)</term>
<term>Sofosbuvir (therapeutic use)</term>
<term>Sustained Virologic Response</term>
<term>Viral Load (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Association de médicaments (effets indésirables)</term>
<term>Benzimidazoles (administration et posologie)</term>
<term>Benzimidazoles (effets indésirables)</term>
<term>Benzimidazoles (usage thérapeutique)</term>
<term>Charge virale ()</term>
<term>Femelle</term>
<term>Fluorènes (administration et posologie)</term>
<term>Fluorènes (effets indésirables)</term>
<term>Fluorènes (usage thérapeutique)</term>
<term>Génotype</term>
<term>Hepacivirus ()</term>
<term>Hepacivirus (génétique)</term>
<term>Humains</term>
<term>Hépatite C chronique (génétique)</term>
<term>Hépatite C chronique (sang)</term>
<term>Hépatite C chronique (traitement médicamenteux)</term>
<term>Interprétation statistique de données</term>
<term>Mâle</term>
<term>Ribavirine (administration et posologie)</term>
<term>Ribavirine (effets indésirables)</term>
<term>Ribavirine (usage thérapeutique)</term>
<term>Réponse virologique soutenue</term>
<term>Sofosbuvir (administration et posologie)</term>
<term>Sofosbuvir (effets indésirables)</term>
<term>Sofosbuvir (usage thérapeutique)</term>
<term>Test ELISA</term>
<term>Traitement de substitution aux opiacés</term>
<term>Usagers de drogues</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Benzimidazoles</term>
<term>Fluorenes</term>
<term>Ribavirin</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Benzimidazoles</term>
<term>Fluorenes</term>
<term>Ribavirin</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Benzimidazoles</term>
<term>Fluorenes</term>
<term>Ribavirin</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Benzimidazoles</term>
<term>Fluorènes</term>
<term>Ribavirine</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Drug Therapy, Combination</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepacivirus</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Association de médicaments</term>
<term>Benzimidazoles</term>
<term>Fluorènes</term>
<term>Ribavirine</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepacivirus</term>
<term>Hepatitis C, Chronic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hepacivirus</term>
<term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite C chronique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Benzimidazoles</term>
<term>Fluorènes</term>
<term>Ribavirine</term>
<term>Sofosbuvir</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Data Interpretation, Statistical</term>
<term>Drug Users</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Opiate Substitution Treatment</term>
<term>Retrospective Studies</term>
<term>Sustained Virologic Response</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge virale</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Hepacivirus</term>
<term>Humains</term>
<term>Interprétation statistique de données</term>
<term>Mâle</term>
<term>Réponse virologique soutenue</term>
<term>Test ELISA</term>
<term>Traitement de substitution aux opiacés</term>
<term>Usagers de drogues</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> Interferon-based hepatitis C virus (HCV) therapy is safe and effective among people receiving opioid substitution therapy (OST), but treatment uptake remains low. Our aim was to evaluate the impact of OST and drug use during therapy on completion, adherence, sustained virologic response (SVR12), and safety of ledipasvir/sofosbuvir ± ribavirin.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002015 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002015 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:27553375 |texte= Efficacy and Safety of Ledipasvir/Sofosbuvir With and Without Ribavirin in Patients With Chronic HCV Genotype 1 Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ION Trials. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:27553375" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |