European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND.
Identifieur interne : 001F59 ( Main/Curation ); précédent : 001F58; suivant : 001F60European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND.
Auteurs : Hemasse Amiri [Allemagne] ; Erich Bluhmki [Allemagne] ; Martin Bendszus [Allemagne] ; Christoph C. Eschenfelder [Allemagne] ; Geoffrey A. Donnan [Australie] ; Didier Leys [France] ; Carlos Molina [Espagne] ; Peter A. Ringleb [Allemagne] ; Peter D. Schellinger [Allemagne] ; Stefan Schwab [Allemagne] ; Danilo Toni [Italie] ; Nils Wahlgren [Suède] ; Werner Hacke [Allemagne]Source :
- International journal of stroke : official journal of the International Stroke Society [ 1747-4949 ] ; 2016.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (traitement médicamenteux), Activateur tissulaire du plasminogène (administration et posologie), Activateur tissulaire du plasminogène (usage thérapeutique), Administration par voie intraveineuse, Facteurs temps, Humains, Imagerie par résonance magnétique, Méthode en double aveugle, Neuroimagerie, Protocoles cliniques (normes), Résultat thérapeutique, Traitement thrombolytique ().
- MESH :
- administration et posologie : Activateur tissulaire du plasminogène.
- normes : Protocoles cliniques.
- traitement médicamenteux : Accident vasculaire cérébral.
- usage thérapeutique : Activateur tissulaire du plasminogène.
- Administration par voie intraveineuse, Facteurs temps, Humains, Imagerie par résonance magnétique, Méthode en double aveugle, Neuroimagerie, Résultat thérapeutique, Traitement thrombolytique.
English descriptors
- KwdEn :
- Administration, Intravenous, Clinical Protocols (standards), Double-Blind Method, Humans, Magnetic Resonance Imaging, Neuroimaging, Stroke (drug therapy), Thrombolytic Therapy (methods), Time Factors, Tissue Plasminogen Activator (administration & dosage), Tissue Plasminogen Activator (therapeutic use), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Tissue Plasminogen Activator.
- drug therapy : Stroke.
- methods : Thrombolytic Therapy.
- standards : Clinical Protocols.
- chemical , therapeutic use : Tissue Plasminogen Activator.
- Administration, Intravenous, Double-Blind Method, Humans, Magnetic Resonance Imaging, Neuroimaging, Time Factors, Treatment Outcome.
Abstract
Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is an effective and approved therapy for acute ischemic stroke within 4.5 h of onset except for USA, Canada, Croatia, and Moldovia with a current 3 h label. We hypothesized that ischemic stroke patients selected with significant penumbral mismatch on magnetic resonance imaging (MRI) at 4.5-9 h after onset of stroke will have improved clinical outcomes when given intravenous rt-PA (alteplase) compared to placebo.
DOI: 10.1177/1747493015620805
PubMed: 26783318
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pubmed:26783318Le document en format XML
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<front><div type="abstract" xml:lang="en">Thrombolytic therapy with recombinant tissue plasminogen activator (rt-PA) is an effective and approved therapy for acute ischemic stroke within 4.5 h of onset except for USA, Canada, Croatia, and Moldovia with a current 3 h label. We hypothesized that ischemic stroke patients selected with significant penumbral mismatch on magnetic resonance imaging (MRI) at 4.5-9 h after onset of stroke will have improved clinical outcomes when given intravenous rt-PA (alteplase) compared to placebo.</div>
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