Global strategies are required to cure and eliminate HBV infection.
Identifieur interne : 001E06 ( Main/Curation ); précédent : 001E05; suivant : 001E07Global strategies are required to cure and eliminate HBV infection.
Auteurs : Peter Revill [Australie] ; Barbara Testoni [France] ; Stephen Locarnini [Australie] ; Fabien Zoulim [France]Source :
- Nature reviews. Gastroenterology & hepatology [ 1759-5053 ] ; 2016.
Descripteurs français
- KwdFr :
- Antiviraux (usage thérapeutique), Coopération internationale, Découverte de médicament (organisation et administration), Découverte de médicament (économie), Essais cliniques comme sujet (économie), Humains, Hépatite B chronique (), Hépatite B chronique (immunologie), Hépatite B chronique (traitement médicamenteux), Hépatite B chronique (virologie), Politique de santé, Promotion de la santé (organisation et administration), Promotion de la santé (économie), Santé mondiale, Soutien financier à la recherche comme sujet.
- MESH :
- immunologie : Hépatite B chronique.
- organisation et administration : Découverte de médicament, Promotion de la santé.
- traitement médicamenteux : Hépatite B chronique.
- usage thérapeutique : Antiviraux.
- virologie : Hépatite B chronique.
- économie : Découverte de médicament, Essais cliniques comme sujet, Promotion de la santé.
- Coopération internationale, Humains, Hépatite B chronique, Politique de santé, Santé mondiale, Soutien financier à la recherche comme sujet.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Clinical Trials as Topic (economics), Drug Discovery (economics), Drug Discovery (organization & administration), Global Health, Health Policy, Health Promotion (economics), Health Promotion (organization & administration), Hepatitis B, Chronic (drug therapy), Hepatitis B, Chronic (immunology), Hepatitis B, Chronic (prevention & control), Hepatitis B, Chronic (virology), Humans, International Cooperation, Research Support as Topic.
- MESH :
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Hepatitis B, Chronic.
- economics : Clinical Trials as Topic, Drug Discovery, Health Promotion.
- immunology : Hepatitis B, Chronic.
- organization & administration : Drug Discovery, Health Promotion.
- prevention & control : Hepatitis B, Chronic.
- virology : Hepatitis B, Chronic.
- Global Health, Health Policy, Humans, International Cooperation, Research Support as Topic.
Abstract
Chronic HBV infection results in >1 million deaths per year from cirrhosis and liver cancer. No known cure for chronic HBV exists, due in part to the continued presence of transcriptionally active DNA in the nucleus that is not directly targeted by current antiviral therapies. A coordinated approach is urgently needed to advance an HBV cure worldwide, such as those established in the HIV field. We propose the establishment of an International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) to facilitate the formation of international working groups on HBV virology, immunology, innovative tools and clinical trials: to promote awareness and education as well as to drive changes in government policy and ensure funds are channelled to HBV cure research and drug development. With the ICE-HBV in place, it should be possible to enable a HBV cure within the next decade.
DOI: 10.1038/nrgastro.2016.7
PubMed: 26907881
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No known cure for chronic HBV exists, due in part to the continued presence of transcriptionally active DNA in the nucleus that is not directly targeted by current antiviral therapies. A coordinated approach is urgently needed to advance an HBV cure worldwide, such as those established in the HIV field. We propose the establishment of an International Coalition to Eliminate Hepatitis B Virus (ICE-HBV) to facilitate the formation of international working groups on HBV virology, immunology, innovative tools and clinical trials: to promote awareness and education as well as to drive changes in government policy and ensure funds are channelled to HBV cure research and drug development. With the ICE-HBV in place, it should be possible to enable a HBV cure within the next decade.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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