In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat.
Identifieur interne : 001C92 ( Main/Curation ); précédent : 001C91; suivant : 001C93In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat.
Auteurs : Marie Médoc [France] ; Martine Dhilly [France] ; Lidia Matesic [Australie] ; Jérôme Toutain [France] ; Anwen M. Krause-Heuer [Australie] ; Jérôme Delamare [France] ; Benjamin H. Fraser [Australie] ; Omar Touzani [France] ; Louisa Barré [France] ; Ivan Greguric [Australie] ; Franck Sobrio [France]Source :
- Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging [ 1860-2002 ] ; 2016.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (anatomopathologie), Accident vasculaire cérébral (imagerie diagnostique), Acide méthyl-malonique (analogues et dérivés), Acide méthyl-malonique (pharmacocinétique), Acide méthyl-malonique (pharmacologie), Animaux, Apoptose (), Caspase-3 (métabolisme), Caspase-7 (métabolisme), Imagerie moléculaire (), Inhibiteurs des caspases (pharmacocinétique), Inhibiteurs des caspases (pharmacologie), Inhibiteurs des caspases (sang), Isatine (), Isatine (pharmacologie), Modèles animaux de maladie humaine, Mâle, Radiopharmaceutiques (pharmacocinétique), Radiopharmaceutiques (pharmacologie), Radiopharmaceutiques (sang), Rat Sprague-Dawley, Répartition dans les tissus (), Scintigraphie.
- MESH :
- analogues et dérivés : Acide méthyl-malonique.
- anatomopathologie : Accident vasculaire cérébral.
- imagerie diagnostique : Accident vasculaire cérébral.
- métabolisme : Caspase-3, Caspase-7.
- pharmacocinétique : Acide méthyl-malonique, Inhibiteurs des caspases, Radiopharmaceutiques.
- pharmacologie : Acide méthyl-malonique, Inhibiteurs des caspases, Isatine, Radiopharmaceutiques.
- sang : Inhibiteurs des caspases, Radiopharmaceutiques.
- Animaux, Apoptose, Imagerie moléculaire, Isatine, Modèles animaux de maladie humaine, Mâle, Rat Sprague-Dawley, Répartition dans les tissus, Scintigraphie.
English descriptors
- KwdEn :
- Animals, Apoptosis (drug effects), Caspase 3 (metabolism), Caspase 7 (metabolism), Caspase Inhibitors (blood), Caspase Inhibitors (pharmacokinetics), Caspase Inhibitors (pharmacology), Disease Models, Animal, Isatin (chemistry), Isatin (pharmacology), Male, Methylmalonic Acid (analogs & derivatives), Methylmalonic Acid (pharmacokinetics), Methylmalonic Acid (pharmacology), Molecular Imaging (methods), Radionuclide Imaging, Radiopharmaceuticals (blood), Radiopharmaceuticals (pharmacokinetics), Radiopharmaceuticals (pharmacology), Rats, Sprague-Dawley, Stroke (diagnostic imaging), Stroke (pathology), Tissue Distribution (drug effects).
- MESH :
- chemical , analogs & derivatives : Methylmalonic Acid.
- chemical , blood : Caspase Inhibitors, Radiopharmaceuticals.
- chemical , chemistry : Isatin.
- chemical , metabolism : Caspase 3, Caspase 7.
- diagnostic imaging : Stroke.
- drug effects : Apoptosis, Tissue Distribution.
- methods : Molecular Imaging.
- pathology : Stroke.
- chemical , pharmacokinetics : Caspase Inhibitors, Methylmalonic Acid, Radiopharmaceuticals.
- chemical , pharmacology : Caspase Inhibitors, Isatin, Methylmalonic Acid, Radiopharmaceuticals.
- Animals, Disease Models, Animal, Male, Radionuclide Imaging, Rats, Sprague-Dawley.
Abstract
The first biological evaluation of two potent fluorine-18 radiolabelled inhibitors of caspase-3/7 was achieved in a cerebral stroke rat model to visualize apoptosis.
DOI: 10.1007/s11307-015-0865-1
PubMed: 26013478
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Krause-Heuer</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Delamare, Jerome" sort="Delamare, Jerome" uniqKey="Delamare J" first="Jérôme" last="Delamare">Jérôme Delamare</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Fraser, Benjamin H" sort="Fraser, Benjamin H" uniqKey="Fraser B" first="Benjamin H" last="Fraser">Benjamin H. 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first="Louisa" last="Barré">Louisa Barré</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Greguric, Ivan" sort="Greguric, Ivan" uniqKey="Greguric I" first="Ivan" last="Greguric">Ivan Greguric</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Sobrio, Franck" sort="Sobrio, Franck" uniqKey="Sobrio F" first="Franck" last="Sobrio">Franck Sobrio</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France. sobrio@cyceron.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26013478</idno><idno type="pmid">26013478</idno><idno type="doi">10.1007/s11307-015-0865-1</idno><idno type="wicri:Area/PubMed/Corpus">002277</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002277</idno><idno type="wicri:Area/PubMed/Curation">002251</idno><idno type="wicri:explorRef" wicri:stream="PubMed" 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LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Dhilly, Martine" sort="Dhilly, Martine" uniqKey="Dhilly M" first="Martine" last="Dhilly">Martine Dhilly</name><affiliation wicri:level="3"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Matesic, Lidia" sort="Matesic, Lidia" uniqKey="Matesic L" first="Lidia" last="Matesic">Lidia Matesic</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Toutain, Jerome" sort="Toutain, Jerome" uniqKey="Toutain J" first="Jérôme" last="Toutain">Jérôme Toutain</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Krause Heuer, Anwen M" sort="Krause Heuer, Anwen M" uniqKey="Krause Heuer A" first="Anwen M" last="Krause-Heuer">Anwen M. Krause-Heuer</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Delamare, Jerome" sort="Delamare, Jerome" uniqKey="Delamare J" first="Jérôme" last="Delamare">Jérôme Delamare</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Fraser, Benjamin H" sort="Fraser, Benjamin H" uniqKey="Fraser B" first="Benjamin H" last="Fraser">Benjamin H. Fraser</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Touzani, Omar" sort="Touzani, Omar" uniqKey="Touzani O" first="Omar" last="Touzani">Omar Touzani</name><affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Barre, Louisa" sort="Barre, Louisa" uniqKey="Barre L" first="Louisa" last="Barré">Louisa Barré</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author><author><name sortKey="Greguric, Ivan" sort="Greguric, Ivan" uniqKey="Greguric I" first="Ivan" last="Greguric">Ivan Greguric</name><affiliation wicri:level="1"><nlm:affiliation>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Life Sciences Division, Australian Nuclear Science and Technology Organisation, Kirrawee DC, NSW, 2232</wicri:regionArea><wicri:noRegion>2232</wicri:noRegion></affiliation></author><author><name sortKey="Sobrio, Franck" sort="Sobrio, Franck" uniqKey="Sobrio F" first="Franck" last="Sobrio">Franck Sobrio</name><affiliation wicri:level="1"><nlm:affiliation>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen, France. sobrio@cyceron.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, F-14074, Caen</wicri:regionArea><wicri:noRegion>14074, Caen</wicri:noRegion><wicri:noRegion>14074, Caen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging</title><idno type="eISSN">1860-2002</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis (drug effects)</term><term>Caspase 3 (metabolism)</term><term>Caspase 7 (metabolism)</term><term>Caspase Inhibitors (blood)</term><term>Caspase Inhibitors (pharmacokinetics)</term><term>Caspase Inhibitors (pharmacology)</term><term>Disease Models, Animal</term><term>Isatin (chemistry)</term><term>Isatin (pharmacology)</term><term>Male</term><term>Methylmalonic Acid (analogs & derivatives)</term><term>Methylmalonic Acid (pharmacokinetics)</term><term>Methylmalonic Acid (pharmacology)</term><term>Molecular Imaging (methods)</term><term>Radionuclide Imaging</term><term>Radiopharmaceuticals (blood)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Radiopharmaceuticals (pharmacology)</term><term>Rats, Sprague-Dawley</term><term>Stroke (diagnostic imaging)</term><term>Stroke (pathology)</term><term>Tissue Distribution (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (anatomopathologie)</term><term>Accident vasculaire cérébral (imagerie diagnostique)</term><term>Acide méthyl-malonique (analogues et dérivés)</term><term>Acide méthyl-malonique (pharmacocinétique)</term><term>Acide méthyl-malonique (pharmacologie)</term><term>Animaux</term><term>Apoptose ()</term><term>Caspase-3 (métabolisme)</term><term>Caspase-7 (métabolisme)</term><term>Imagerie moléculaire ()</term><term>Inhibiteurs des caspases (pharmacocinétique)</term><term>Inhibiteurs des caspases (pharmacologie)</term><term>Inhibiteurs des caspases (sang)</term><term>Isatine ()</term><term>Isatine (pharmacologie)</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Radiopharmaceutiques (pharmacocinétique)</term><term>Radiopharmaceutiques (pharmacologie)</term><term>Radiopharmaceutiques (sang)</term><term>Rat Sprague-Dawley</term><term>Répartition dans les tissus ()</term><term>Scintigraphie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Methylmalonic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Caspase Inhibitors</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Isatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspase 3</term><term>Caspase 7</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide méthyl-malonique</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Apoptosis</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Accident vasculaire cérébral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspase-3</term><term>Caspase-7</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Acide méthyl-malonique</term><term>Inhibiteurs des caspases</term><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Caspase Inhibitors</term><term>Methylmalonic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acide méthyl-malonique</term><term>Inhibiteurs des caspases</term><term>Isatine</term><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Caspase Inhibitors</term><term>Isatin</term><term>Methylmalonic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Inhibiteurs des caspases</term><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Radionuclide Imaging</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Imagerie moléculaire</term><term>Isatine</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Répartition dans les tissus</term><term>Scintigraphie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first biological evaluation of two potent fluorine-18 radiolabelled inhibitors of caspase-3/7 was achieved in a cerebral stroke rat model to visualize apoptosis.</div></front></TEI></record>Pour manipuler ce document sous Unix 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