A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.
Identifieur interne : 001316 ( Main/Curation ); précédent : 001315; suivant : 001317A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.
Auteurs : Pauline Floch [France] ; Julien Izotte [France] ; Julien Guillemaud [France] ; Elodie Sifré [France] ; Pierre Costet [France] ; Benoit Rousseau [France] ; Amandine Marine Laur [France] ; Alban Giese [France] ; Victoria Korolik [Australie] ; Francis Mégraud [France] ; Pierre Dubus [France] ; Michael Hahne [France] ; Philippe Lehours [France]Source :
- The American journal of pathology [ 1525-2191 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Charge bactérienne, Estomac (anatomopathologie), Estomac (microbiologie), Femelle, Helicobacter pylori (immunologie), Humains, Immunohistochimie, Infections à Helicobacter (anatomopathologie), Infections à Helicobacter (immunologie), Infections à Helicobacter (microbiologie), Inflammation, Lymphocytes B (anatomopathologie), Lymphocytes B (microbiologie), Lymphocytes T CD4+ (anatomopathologie), Lymphocytes T CD4+ (microbiologie), Lymphome B de la zone marginale (anatomopathologie), Lymphome B de la zone marginale (immunologie), Lymphome B de la zone marginale (microbiologie), Lymphome malin non hodgkinien (anatomopathologie), Lymphome malin non hodgkinien (immunologie), Lymphome malin non hodgkinien (microbiologie), Membre-13 de la superfamille du facteur de nécrose tumorale (génétique), Membre-13 de la superfamille du facteur de nécrose tumorale (immunologie), Modèles animaux de maladie humaine, Souris, Souris de lignée C57BL, Souris transgéniques, Tissu lymphoïde (anatomopathologie), Tissu lymphoïde (microbiologie), Tumeurs de l'estomac (anatomopathologie), Tumeurs de l'estomac (immunologie), Tumeurs de l'estomac (microbiologie).
- MESH :
- anatomopathologie : Estomac, Infections à Helicobacter, Lymphocytes B, Lymphocytes T CD4+, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Tissu lymphoïde, Tumeurs de l'estomac.
- génétique : Membre-13 de la superfamille du facteur de nécrose tumorale.
- immunologie : Helicobacter pylori, Infections à Helicobacter, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Membre-13 de la superfamille du facteur de nécrose tumorale, Tumeurs de l'estomac.
- microbiologie : Estomac, Infections à Helicobacter, Lymphocytes B, Lymphocytes T CD4+, Lymphome B de la zone marginale, Lymphome malin non hodgkinien, Tissu lymphoïde, Tumeurs de l'estomac.
- Animaux, Charge bactérienne, Femelle, Humains, Immunohistochimie, Inflammation, Modèles animaux de maladie humaine, Souris, Souris de lignée C57BL, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, B-Lymphocytes (microbiology), B-Lymphocytes (pathology), Bacterial Load, CD4-Positive T-Lymphocytes (microbiology), CD4-Positive T-Lymphocytes (pathology), Disease Models, Animal, Female, Helicobacter Infections (immunology), Helicobacter Infections (microbiology), Helicobacter Infections (pathology), Helicobacter pylori (immunology), Humans, Immunohistochemistry, Inflammation, Lymphoid Tissue (microbiology), Lymphoid Tissue (pathology), Lymphoma, B-Cell, Marginal Zone (immunology), Lymphoma, B-Cell, Marginal Zone (microbiology), Lymphoma, B-Cell, Marginal Zone (pathology), Lymphoma, Non-Hodgkin (immunology), Lymphoma, Non-Hodgkin (microbiology), Lymphoma, Non-Hodgkin (pathology), Mice, Mice, Inbred C57BL, Mice, Transgenic, Stomach (microbiology), Stomach (pathology), Stomach Neoplasms (immunology), Stomach Neoplasms (microbiology), Stomach Neoplasms (pathology), Tumor Necrosis Factor Ligand Superfamily Member 13 (genetics), Tumor Necrosis Factor Ligand Superfamily Member 13 (immunology).
- MESH :
- chemical , genetics : Tumor Necrosis Factor Ligand Superfamily Member 13.
- immunology : Helicobacter Infections, Helicobacter pylori, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach Neoplasms, Tumor Necrosis Factor Ligand Superfamily Member 13.
- microbiology : B-Lymphocytes, CD4-Positive T-Lymphocytes, Helicobacter Infections, Lymphoid Tissue, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach, Stomach Neoplasms.
- pathology : B-Lymphocytes, CD4-Positive T-Lymphocytes, Helicobacter Infections, Lymphoid Tissue, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Non-Hodgkin, Stomach, Stomach Neoplasms.
- Animals, Bacterial Load, Disease Models, Animal, Female, Humans, Immunohistochemistry, Inflammation, Mice, Mice, Inbred C57BL, Mice, Transgenic.
Abstract
APRIL is a member of the tumor necrosis factor cytokine family involved in the regulation of B-cell immunity. We present a study of the infection by Helicobacter species of transgenic (Tg) C57BL6 mice, ectopically expressing the human form of APRIL. Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helicobacter pylori and compared with noninfected animals. Mice were euthanized 18 months after infection, and inflammatory responses and histologic alterations were analyzed. Flow cytometry results revealed that WT-infected mice had less leukocyte infiltration than APRIL Tg-infected mice. In WT-infected mice, infiltrates in gastric tissues were predominantly composed of T cells, mainly CD4(+) for H. pylori and CD8(+) for H. felis. In APRIL Tg-infected mice, leukocyte infiltrates were composed of B cells with few CD4(+) T cells for both species. B cells expressed B surface markers compatible with a marginal zone origin. These results were confirmed by immunohistochemistry. B cells in particular were involved in lymphoepithelial lesions, a hallmark of gastric MALT lymphoma. Monoclonality was observed in a few infiltrates in the presence of lymphoepithelial lesions. These results confirm the importance of APRIL in the development of gastric lymphoid infiltrates induced by Helicobacter species in vivo. We believe that APRIL Tg mice infected by Helicobacter species may represent a novel animal model of gastric lymphomagenesis.
DOI: 10.1016/j.ajpath.2017.03.004
PubMed: 28460208
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pubmed:28460208Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.</title>
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<author><name sortKey="Rousseau, Benoit" sort="Rousseau, Benoit" uniqKey="Rousseau B" first="Benoit" last="Rousseau">Benoit Rousseau</name>
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<author><name sortKey="Laur, Amandine Marine" sort="Laur, Amandine Marine" uniqKey="Laur A" first="Amandine Marine" last="Laur">Amandine Marine Laur</name>
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<author><name sortKey="Korolik, Victoria" sort="Korolik, Victoria" uniqKey="Korolik V" first="Victoria" last="Korolik">Victoria Korolik</name>
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<author><name sortKey="Hahne, Michael" sort="Hahne, Michael" uniqKey="Hahne M" first="Michael" last="Hahne">Michael Hahne</name>
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<term>Bacterial Load</term>
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<term>CD4-Positive T-Lymphocytes (pathology)</term>
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<term>Female</term>
<term>Helicobacter Infections (immunology)</term>
<term>Helicobacter Infections (microbiology)</term>
<term>Helicobacter Infections (pathology)</term>
<term>Helicobacter pylori (immunology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Inflammation</term>
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<term>Lymphoid Tissue (pathology)</term>
<term>Lymphoma, B-Cell, Marginal Zone (immunology)</term>
<term>Lymphoma, B-Cell, Marginal Zone (microbiology)</term>
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<term>Infections à Helicobacter (microbiologie)</term>
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<front><div type="abstract" xml:lang="en">APRIL is a member of the tumor necrosis factor cytokine family involved in the regulation of B-cell immunity. We present a study of the infection by Helicobacter species of transgenic (Tg) C57BL6 mice, ectopically expressing the human form of APRIL. Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helicobacter pylori and compared with noninfected animals. Mice were euthanized 18 months after infection, and inflammatory responses and histologic alterations were analyzed. Flow cytometry results revealed that WT-infected mice had less leukocyte infiltration than APRIL Tg-infected mice. In WT-infected mice, infiltrates in gastric tissues were predominantly composed of T cells, mainly CD4(+) for H. pylori and CD8(+) for H. felis. In APRIL Tg-infected mice, leukocyte infiltrates were composed of B cells with few CD4(+) T cells for both species. B cells expressed B surface markers compatible with a marginal zone origin. These results were confirmed by immunohistochemistry. B cells in particular were involved in lymphoepithelial lesions, a hallmark of gastric MALT lymphoma. Monoclonality was observed in a few infiltrates in the presence of lymphoepithelial lesions. These results confirm the importance of APRIL in the development of gastric lymphoid infiltrates induced by Helicobacter species in vivo. We believe that APRIL Tg mice infected by Helicobacter species may represent a novel animal model of gastric lymphomagenesis.</div>
</front>
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