Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.
Identifieur interne : 000E64 ( Main/Curation ); précédent : 000E63; suivant : 000E65Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.
Auteurs : Marita Cross [Australie] ; Ludovic Dubouis [Australie] ; Matthieu Mangin [Australie] ; David J. Hunter [Australie] ; Lyn March [Australie] ; Gillian Hawker [Australie] ; Francis Guillemin [Australie]Source :
- The Journal of rheumatology [ 0315-162X ] ; 2017.
Abstract
Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.
DOI: 10.3899/jrheum.161107
PubMed: 28668808
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<author><name sortKey="Cross, Marita" sort="Cross, Marita" uniqKey="Cross M" first="Marita" last="Cross">Marita Cross</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
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<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
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<author><name sortKey="Mangin, Matthieu" sort="Mangin, Matthieu" uniqKey="Mangin M" first="Matthieu" last="Mangin">Matthieu Mangin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
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<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
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<author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
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<orgName type="university">Université de Sydney</orgName>
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<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<placeName><settlement type="city">Sydney</settlement>
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<author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Defining Flare in Osteoarthritis of the Hip and Knee: A Systematic Literature Review - OMERACT Virtual Special Interest Group.</title>
<author><name sortKey="Cross, Marita" sort="Cross, Marita" uniqKey="Cross M" first="Marita" last="Cross">Marita Cross</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="Dubouis, Ludovic" sort="Dubouis, Ludovic" uniqKey="Dubouis L" first="Ludovic" last="Dubouis">Ludovic Dubouis</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
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<author><name sortKey="Mangin, Matthieu" sort="Mangin, Matthieu" uniqKey="Mangin M" first="Matthieu" last="Mangin">Matthieu Mangin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J" last="Hunter">David J. Hunter</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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<author><name sortKey="March, Lyn" sort="March, Lyn" uniqKey="March L" first="Lyn" last="March">Lyn March</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
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<author><name sortKey="Hawker, Gillian" sort="Hawker, Gillian" uniqKey="Hawker G" first="Gillian" last="Hawker">Gillian Hawker</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
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</author>
<author><name sortKey="Guillemin, Francis" sort="Guillemin, Francis" uniqKey="Guillemin F" first="Francis" last="Guillemin">Francis Guillemin</name>
<affiliation wicri:level="4"><nlm:affiliation>From the Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, Australia; Inserm, CIC 1433 Clinical Epidemiology; University of Lorraine, EA 4360 APEMAC, Nancy, France; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. M. Cross, Research Fellow, PhD, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. Dubouis, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; M. Mangin, Medical Resident, Inserm, CIC 1433 Clinical Epidemiology; D.J. Hunter, PhD, Professor of Medicine, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; L. March, PhD, FRACP, FAFPHM, Professor of Rheumatology and Musculoskeletal Epidemiology, Institute of Bone and Joint Research-Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital; G. Hawker, MD, PhD, Chair and Professor of Medicine, Department of Medicine, University of Toronto; F. Guillemin, MD, PhD, Professor of Epidemiology and Public Health, Inserm, CIC 1433 Clinical Epidemiology, and University of Lorraine, EA 4360 APEMAC. Address correspondence to M. Cross, Institute of Bone and Joint Research, Department of Rheumatology, Royal North Shore Hospital, St. Leonards, New South Wales, 2065 Australia. E-mail: maritac@med.usyd.edu.au. Accepted for publication May 12, 2017.</nlm:affiliation>
<orgName type="university">Université de Sydney</orgName>
<country>Australie</country>
<placeName><settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of rheumatology</title>
<idno type="ISSN">0315-162X</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Beyond the exacerbation of pain in describing a flare in osteoarthritis (OA), patients and health professionals add other elements that deserve to be fully elucidated, such as effusion, swelling, and mobility limitation. To define and conceptualize the construct flare in OA, the objective was to identify the key variables, or symptoms, that worsen, and to clarify how these variables are described in the literature by patients and clinicians.</div>
</front>
</TEI>
</record>
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