New Approaches to Investigate Drug-Induced Hypersensitivity.
Identifieur interne : 000740 ( Main/Curation ); précédent : 000739; suivant : 000741New Approaches to Investigate Drug-Induced Hypersensitivity.
Auteurs : Monday O. Ogese [Royaume-Uni] ; Shaheda Ahmed [Royaume-Uni] ; Ana Alferivic [Royaume-Uni] ; Catherine J. Betts [Royaume-Uni] ; Anne Dickinson [Royaume-Uni] ; Lee Faulkner [Royaume-Uni] ; Neil French [Royaume-Uni] ; Andrew Gibson [Royaume-Uni] ; Gideon M. Hirschfield [Royaume-Uni] ; Michael Kammüller [Suisse] ; Xiaoli Meng [Royaume-Uni] ; Stefan F. Martin [Allemagne] ; Philippe Musette [France] ; Alan Norris [Royaume-Uni] ; Munir Pirmohamed [Royaume-Uni] ; B Kevin Park [Royaume-Uni] ; Anthony W. Purcell [Australie] ; Colin F. Spraggs [Royaume-Uni] ; Jessica Whritenour [États-Unis] ; Dean J. Naisbitt [Royaume-Uni]Source :
- Chemical research in toxicology [ 1520-5010 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : Drug Hypersensitivity.
- immunology : Drug Hypersensitivity, Major Histocompatibility Complex.
- Animals, Biological Assay, Drug Industry, Genetic Predisposition to Disease, Humans, Phenotype, Risk Factors.
Abstract
The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.
DOI: 10.1021/acs.chemrestox.6b00333
PubMed: 27806199
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pubmed:27806199Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and INSERM, University of Rouen , 905 Rouen, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Dermatology and INSERM, University of Rouen , 905 Rouen</wicri:regionArea>
<wicri:noRegion>905 Rouen</wicri:noRegion>
<wicri:noRegion>905 Rouen</wicri:noRegion>
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<author><name sortKey="Norris, Alan" sort="Norris, Alan" uniqKey="Norris A" first="Alan" last="Norris">Alan Norris</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea>
<wicri:noRegion>Liverpool L69 3GE</wicri:noRegion>
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</author>
<author><name sortKey="Pirmohamed, Munir" sort="Pirmohamed, Munir" uniqKey="Pirmohamed M" first="Munir" last="Pirmohamed">Munir Pirmohamed</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea>
<wicri:noRegion>Liverpool L69 3GE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, B Kevin" sort="Park, B Kevin" uniqKey="Park B" first="B Kevin" last="Park">B Kevin Park</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea>
<wicri:noRegion>Liverpool L69 3GE</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purcell, Anthony W" sort="Purcell, Anthony W" uniqKey="Purcell A" first="Anthony W" last="Purcell">Anthony W. Purcell</name>
<affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University , Clayton, Victoria 3800</wicri:regionArea>
<wicri:noRegion>Victoria 3800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spraggs, Colin F" sort="Spraggs, Colin F" uniqKey="Spraggs C" first="Colin F" last="Spraggs">Colin F. Spraggs</name>
<affiliation wicri:level="1"><nlm:affiliation>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY, U.K.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medicines Research Centre, GlaxoSmithKline , Gunnels Wood Road, Stevenage SG1 2NY</wicri:regionArea>
<wicri:noRegion>Stevenage SG1 2NY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whritenour, Jessica" sort="Whritenour, Jessica" uniqKey="Whritenour J" first="Jessica" last="Whritenour">Jessica Whritenour</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Drug Safety Research and Development, Pfizer , Eastern Point Road, Groton, Connecticut 06340</wicri:regionArea>
<wicri:noRegion>Connecticut 06340</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Naisbitt, Dean J" sort="Naisbitt, Dean J" uniqKey="Naisbitt D" first="Dean J" last="Naisbitt">Dean J. Naisbitt</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE, U.K.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool , Ashton Street, Liverpool L69 3GE</wicri:regionArea>
<wicri:noRegion>Liverpool L69 3GE</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Chemical research in toxicology</title>
<idno type="eISSN">1520-5010</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biological Assay</term>
<term>Drug Hypersensitivity (genetics)</term>
<term>Drug Hypersensitivity (immunology)</term>
<term>Drug Industry</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Major Histocompatibility Complex (immunology)</term>
<term>Phenotype</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Complexe majeur d'histocompatibilité (immunologie)</term>
<term>Dosage biologique</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Hypersensibilité médicamenteuse (génétique)</term>
<term>Hypersensibilité médicamenteuse (immunologie)</term>
<term>Industrie pharmaceutique</term>
<term>Phénotype</term>
<term>Prédisposition génétique à une maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Hypersensitivity</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Hypersensibilité médicamenteuse</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Complexe majeur d'histocompatibilité</term>
<term>Hypersensibilité médicamenteuse</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Drug Hypersensitivity</term>
<term>Major Histocompatibility Complex</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biological Assay</term>
<term>Drug Industry</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Phenotype</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Dosage biologique</term>
<term>Facteurs de risque</term>
<term>Humains</term>
<term>Industrie pharmaceutique</term>
<term>Phénotype</term>
<term>Prédisposition génétique à une maladie</term>
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<front><div type="abstract" xml:lang="en">The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.</div>
</front>
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