The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.
Identifieur interne : 000229 ( Main/Curation ); précédent : 000228; suivant : 000230The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea.
Auteurs : Natalie E. Hofmann [Suisse] ; Stephan Karl [Australie] ; Rahel Wampfler [Suisse] ; Benson Kiniboro [Papouasie-Nouvelle-Guinée] ; Albina Teliki [Papouasie-Nouvelle-Guinée] ; Jonah Iga [Papouasie-Nouvelle-Guinée] ; Andreea Waltmann [Australie] ; Inoni Betuela [Papouasie-Nouvelle-Guinée] ; Ingrid Felger [Suisse] ; Leanne J. Robinson [Australie] ; Ivo Mueller [Australie]Source :
- eLife [ 2050-084X ] ; 2017.
Abstract
The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.
DOI: 10.7554/eLife.23708
PubMed: 28862132
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<front><div type="abstract" xml:lang="en">The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses.</div>
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