Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice
Identifieur interne : 002E39 ( Istex/Curation ); précédent : 002E38; suivant : 002E40Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice
Auteurs : Gaëlle Gottrand [France] ; Kahina Taleb [France] ; Isabelle Ragon [France] ; Anne-Sophie Bergot [Australie] ; Jérémie D. Goldstein [France] ; Gilles Marodon [France]Source :
- The Journal of Gene Medicine [ 1099-498X ] ; 2012-02.
Descripteurs français
- Wicri :
- topic : Droit d'auteur.
English descriptors
- KwdEn :
- Bioscience, Caliper life sciences, Cfse, Clonal deletion, Control mice, Copyright, Factor viii, Female mice, Gene therapy, Gene transfer, Hemophilia, Ifng, Immune, Immune response, Immune responses, Immune tolerance, Immunization, Intrathymic, Intrathymic gene transfer, John wiley sons, Lentiviral, Lentiviral vector, Lentiviral vectors, Luciferase, Luciferase activity, Lvha, Lvha vector, Mouse, Negative selection, Normal mice, Peptide, Present study, Results show, Same antigen, Single experiment, Single mouse, Soluble form, Splenocytes, Thymic, Thymus, Tolerance induction, Transgene, Transgenic, Transgenic mice, Treg, Treg cells, Tumor growth, Vector, Viii, Vivo.
- Teeft :
- Bioscience, Caliper life sciences, Cfse, Clonal deletion, Control mice, Copyright, Factor viii, Female mice, Gene therapy, Gene transfer, Hemophilia, Ifng, Immune, Immune response, Immune responses, Immune tolerance, Immunization, Intrathymic, Intrathymic gene transfer, John wiley sons, Lentiviral, Lentiviral vector, Lentiviral vectors, Luciferase, Luciferase activity, Lvha, Lvha vector, Mouse, Negative selection, Normal mice, Peptide, Present study, Results show, Same antigen, Single experiment, Single mouse, Soluble form, Splenocytes, Thymic, Thymus, Tolerance induction, Transgene, Transgenic, Transgenic mice, Treg, Treg cells, Tumor growth, Vector, Viii, Vivo.
Abstract
Gene transfer in the thymus, based on HIV‐derived lentiviral vectors, is a promising avenue for modulation of T cell selection and autoimmunity. However, the impact of intrathymic (IT) injections on an antigen‐specific immune response elicited in the periphery of normal mice has not been investigated yet.
Url:
DOI: 10.1002/jgm.1650
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Goldstein</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Marodon, Gilles" sort="Marodon, Gilles" uniqKey="Marodon G" first="Gilles" last="Marodon">Gilles Marodon</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation><affiliation><mods:affiliation>G. Marodon, CNRS UMR 7211, INSERM U959, Bât CERVI, 83 Bd de l'Hôpital, 75651 Paris, Cedex 13, France.E‐mail:</mods:affiliation><wicri:noCountry code="subField">France.E‐mail:</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: gilles.marodon@upmc.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F6324CF41A8DA7376596D8C3AE199CC8424D3B2C</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1002/jgm.1650</idno><idno type="url">https://api.istex.fr/document/F6324CF41A8DA7376596D8C3AE199CC8424D3B2C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002E39</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002E39</idno><idno type="wicri:Area/Istex/Curation">002E39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Intrathymic injection of lentiviral vector curtails the immune response in the periphery of normal mice</title><author><name sortKey="Gottrand, Gaelle" sort="Gottrand, Gaelle" uniqKey="Gottrand G" first="Gaëlle" last="Gottrand">Gaëlle Gottrand</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Taleb, Kahina" sort="Taleb, Kahina" uniqKey="Taleb K" first="Kahina" last="Taleb">Kahina Taleb</name><affiliation wicri:level="1"><mods:affiliation>CNRS UMR 8104, INSERM U1016, Institut Cochin, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 8104, INSERM U1016, Institut Cochin, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Current Address: CNRS UMR 8104, INSERM U1016, Institut Cochin, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Current Address: CNRS UMR 8104, INSERM U1016, Institut Cochin, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Ragon, Isabelle" sort="Ragon, Isabelle" uniqKey="Ragon I" first="Isabelle" last="Ragon">Isabelle Ragon</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Bergot, Anne Ophie" sort="Bergot, Anne Ophie" uniqKey="Bergot A" first="Anne-Sophie" last="Bergot">Anne-Sophie Bergot</name><affiliation wicri:level="1"><mods:affiliation>The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland, Brisbane, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland, Brisbane</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Current Address: The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland, Brisbane, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Current Address: The University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Goldstein, Jeremie D" sort="Goldstein, Jeremie D" uniqKey="Goldstein J" first="Jérémie D." last="Goldstein">Jérémie D. Goldstein</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Marodon, Gilles" sort="Marodon, Gilles" uniqKey="Marodon G" first="Gilles" last="Marodon">Gilles Marodon</name><affiliation wicri:level="1"><mods:affiliation>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Pierre et Marie Curie, UPMC University of Paris 06, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique CNRS, UMR 7211, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, INSERM, U959, Paris</wicri:regionArea></affiliation><affiliation><mods:affiliation>G. Marodon, CNRS UMR 7211, INSERM U959, Bât CERVI, 83 Bd de l'Hôpital, 75651 Paris, Cedex 13, France.E‐mail:</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: gilles.marodon@upmc.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Gene Medicine</title><title level="j" type="alt">THE JOURNAL OF GENE MEDICINE</title><idno type="ISSN">1099-498X</idno><idno type="eISSN">1521-2254</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="90">90</biblScope><biblScope unit="page" to="99">99</biblScope><biblScope unit="page-count">10</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2012-02">2012-02</date></imprint><idno type="ISSN">1099-498X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1099-498X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bioscience</term><term>Caliper life sciences</term><term>Cfse</term><term>Clonal deletion</term><term>Control mice</term><term>Copyright</term><term>Factor viii</term><term>Female mice</term><term>Gene therapy</term><term>Gene transfer</term><term>Hemophilia</term><term>Ifng</term><term>Immune</term><term>Immune response</term><term>Immune responses</term><term>Immune tolerance</term><term>Immunization</term><term>Intrathymic</term><term>Intrathymic gene transfer</term><term>John wiley sons</term><term>Lentiviral</term><term>Lentiviral vector</term><term>Lentiviral vectors</term><term>Luciferase</term><term>Luciferase activity</term><term>Lvha</term><term>Lvha vector</term><term>Mouse</term><term>Negative selection</term><term>Normal mice</term><term>Peptide</term><term>Present study</term><term>Results show</term><term>Same antigen</term><term>Single experiment</term><term>Single mouse</term><term>Soluble form</term><term>Splenocytes</term><term>Thymic</term><term>Thymus</term><term>Tolerance induction</term><term>Transgene</term><term>Transgenic</term><term>Transgenic mice</term><term>Treg</term><term>Treg cells</term><term>Tumor growth</term><term>Vector</term><term>Viii</term><term>Vivo</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bioscience</term><term>Caliper life sciences</term><term>Cfse</term><term>Clonal deletion</term><term>Control mice</term><term>Copyright</term><term>Factor viii</term><term>Female mice</term><term>Gene therapy</term><term>Gene transfer</term><term>Hemophilia</term><term>Ifng</term><term>Immune</term><term>Immune response</term><term>Immune responses</term><term>Immune tolerance</term><term>Immunization</term><term>Intrathymic</term><term>Intrathymic gene transfer</term><term>John wiley sons</term><term>Lentiviral</term><term>Lentiviral vector</term><term>Lentiviral vectors</term><term>Luciferase</term><term>Luciferase activity</term><term>Lvha</term><term>Lvha vector</term><term>Mouse</term><term>Negative selection</term><term>Normal mice</term><term>Peptide</term><term>Present study</term><term>Results show</term><term>Same antigen</term><term>Single experiment</term><term>Single mouse</term><term>Soluble form</term><term>Splenocytes</term><term>Thymic</term><term>Thymus</term><term>Tolerance induction</term><term>Transgene</term><term>Transgenic</term><term>Transgenic mice</term><term>Treg</term><term>Treg cells</term><term>Tumor growth</term><term>Vector</term><term>Viii</term><term>Vivo</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Droit d'auteur</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Gene transfer in the thymus, based on HIV‐derived lentiviral vectors, is a promising avenue for modulation of T cell selection and autoimmunity. However, the impact of intrathymic (IT) injections on an antigen‐specific immune response elicited in the periphery of normal mice has not been investigated yet.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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