The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
Identifieur interne : 002C11 ( Istex/Curation ); précédent : 002C10; suivant : 002C12The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
Auteurs : Lyndon Da Cruz [Royaume-Uni] ; Brian F. Coley [Suisse] ; Jessy Dorn [États-Unis] ; Francesco Merlini [Suisse] ; Eugene Filley [États-Unis] ; Punita Christopher [États-Unis] ; Fred K. Chen [Royaume-Uni, Australie] ; Varalakshmi Wuyyuru [États-Unis] ; Jose Sahel [France] ; Paulo Stanga [Royaume-Uni] ; Mark Humayun [États-Unis] ; Robert J. Greenberg [États-Unis] ; Gislin Dagnelie [États-Unis]Source :
- British Journal of Ophthalmology [ 0007-1161 ] ; 2013-05.
Descripteurs français
- Wicri :
- topic : étude de faisabilité.
English descriptors
- KwdEn :
- Argus, Average time, Black background, Blind subjects, Clinical science, Correct answers, Correct letter, Correct letters, Daily life, Electrical stimulation, Electrode, Eyes unpatched, Feasibility study, Head scanning, Implant, Implantation, Letter height, Letter size, Letter size reduction, Light detection, Light perception, Nancial interest, Ophthalmol, Profound vision loss, Prosthesis, Random order, Rank test, Research centre, Residual light perception, Retina, Retinal, Retinal detachment, Retinal prosthesis, Retinal prosthesis system, Retinal stimulation, Retinal tack, Retinitis pigmentosa, Second sight, Small sample size, Spatial information, Spatial resolution, Standard mode, Statistical analysis, Study group, Subretinal implant, Substantial contributions, Time limit, Total number, Unit steps, Unpatched, Video processing unit, Visual performance, Western australia, Word reading, Word recognition.
- Teeft :
- Argus, Average time, Black background, Blind subjects, Clinical science, Correct answers, Correct letter, Correct letters, Daily life, Electrical stimulation, Electrode, Eyes unpatched, Feasibility study, Head scanning, Implant, Implantation, Letter height, Letter size, Letter size reduction, Light detection, Light perception, Nancial interest, Ophthalmol, Profound vision loss, Prosthesis, Random order, Rank test, Research centre, Residual light perception, Retina, Retinal, Retinal detachment, Retinal prosthesis, Retinal prosthesis system, Retinal stimulation, Retinal tack, Retinitis pigmentosa, Second sight, Small sample size, Spatial information, Spatial resolution, Standard mode, Statistical analysis, Study group, Subretinal implant, Substantial contributions, Time limit, Total number, Unit steps, Unpatched, Video processing unit, Visual performance, Western australia, Word reading, Word recognition.
Abstract
Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months. Conclusions Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.
Url:
DOI: 10.1136/bjophthalmol-2012-301525
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Coley</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Lausanne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Second Sight Medical Products, Inc, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Dorn, Jessy" sort="Dorn, Jessy" uniqKey="Dorn J" first="Jessy" last="Dorn">Jessy Dorn</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Merlini, Francesco" sort="Merlini, Francesco" uniqKey="Merlini F" first="Francesco" last="Merlini">Francesco Merlini</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Lausanne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Second Sight Medical Products, Inc, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Filley, Eugene" sort="Filley, Eugene" uniqKey="Filley E" first="Eugene" last="Filley">Eugene Filley</name><affiliation wicri:level="1"><mods:affiliation>Retina Foundation of the Southwest, Dallas, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Retina Foundation of the Southwest, Dallas</wicri:regionArea></affiliation></author><author><name sortKey="Christopher, Punita" sort="Christopher, Punita" uniqKey="Christopher P" first="Punita" last="Christopher">Punita Christopher</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Fred K" sort="Chen, Fred K" uniqKey="Chen F" first="Fred K" last="Chen">Fred K. 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Coley</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Lausanne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Second Sight Medical Products, Inc, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Dorn, Jessy" sort="Dorn, Jessy" uniqKey="Dorn J" first="Jessy" last="Dorn">Jessy Dorn</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Merlini, Francesco" sort="Merlini, Francesco" uniqKey="Merlini F" first="Francesco" last="Merlini">Francesco Merlini</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Lausanne, Switzerland</mods:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Second Sight Medical Products, Inc, Lausanne</wicri:regionArea></affiliation></author><author><name sortKey="Filley, Eugene" sort="Filley, Eugene" uniqKey="Filley E" first="Eugene" last="Filley">Eugene Filley</name><affiliation wicri:level="1"><mods:affiliation>Retina Foundation of the Southwest, Dallas, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Retina Foundation of the Southwest, Dallas</wicri:regionArea></affiliation></author><author><name sortKey="Christopher, Punita" sort="Christopher, Punita" uniqKey="Christopher P" first="Punita" last="Christopher">Punita Christopher</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Fred K" sort="Chen, Fred K" uniqKey="Chen F" first="Fred K" last="Chen">Fred K. Chen</name><affiliation wicri:level="1"><mods:affiliation>NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London</wicri:regionArea></affiliation><affiliation wicri:level="2"><mods:affiliation>Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Nedlands, Western Australia</mods:affiliation><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Nedlands</wicri:cityArea></affiliation></author><author><name sortKey="Wuyyuru, Varalakshmi" sort="Wuyyuru, Varalakshmi" uniqKey="Wuyyuru V" first="Varalakshmi" last="Wuyyuru">Varalakshmi Wuyyuru</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Sahel, Jose" sort="Sahel, Jose" uniqKey="Sahel J" first="Jose" last="Sahel">Jose Sahel</name><affiliation wicri:level="1"><mods:affiliation>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Stanga, Paulo" sort="Stanga, Paulo" uniqKey="Stanga P" first="Paulo" last="Stanga">Paulo Stanga</name><affiliation wicri:level="1"><mods:affiliation>Manchester Biomedical Research Centre, Manchester Royal Eye Hospital, University of Manchester, Manchester, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Manchester Biomedical Research Centre, Manchester Royal Eye Hospital, University of Manchester, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Humayun, Mark" sort="Humayun, Mark" uniqKey="Humayun M" first="Mark" last="Humayun">Mark Humayun</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Doheny Eye Institute, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Doheny Eye Institute, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Greenberg, Robert J" sort="Greenberg, Robert J" uniqKey="Greenberg R" first="Robert J" last="Greenberg">Robert J. Greenberg</name><affiliation wicri:level="1"><mods:affiliation>Second Sight Medical Products, Inc, Sylmar, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Second Sight Medical Products, Inc, Sylmar, California</wicri:regionArea></affiliation></author><author><name sortKey="Dagnelie, Gislin" sort="Dagnelie, Gislin" uniqKey="Dagnelie G" first="Gislin" last="Dagnelie">Gislin Dagnelie</name><affiliation wicri:level="1"><mods:affiliation>Johns Hopkins Hospital, Lions Vision Center, Baltimore, Maryland, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins Hospital, Lions Vision Center, Baltimore, Maryland</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Ophthalmology</title><title level="j" type="abbrev">Br J Ophthalmol</title><idno type="ISSN">0007-1161</idno><idno type="eISSN">1468-2079</idno><imprint><publisher>BMJ Publishing Group Ltd.</publisher><pubPlace>BMA House, Tavistock Square, London, WC1H 9JR</pubPlace><date type="published" when="2013-05">2013-05</date><biblScope unit="volume">97</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="632">632</biblScope></imprint><idno type="ISSN">0007-1161</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1161</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Argus</term><term>Average time</term><term>Black background</term><term>Blind subjects</term><term>Clinical science</term><term>Correct answers</term><term>Correct letter</term><term>Correct letters</term><term>Daily life</term><term>Electrical stimulation</term><term>Electrode</term><term>Eyes unpatched</term><term>Feasibility study</term><term>Head scanning</term><term>Implant</term><term>Implantation</term><term>Letter height</term><term>Letter size</term><term>Letter size reduction</term><term>Light detection</term><term>Light perception</term><term>Nancial interest</term><term>Ophthalmol</term><term>Profound vision loss</term><term>Prosthesis</term><term>Random order</term><term>Rank test</term><term>Research centre</term><term>Residual light perception</term><term>Retina</term><term>Retinal</term><term>Retinal detachment</term><term>Retinal prosthesis</term><term>Retinal prosthesis system</term><term>Retinal stimulation</term><term>Retinal tack</term><term>Retinitis pigmentosa</term><term>Second sight</term><term>Small sample size</term><term>Spatial information</term><term>Spatial resolution</term><term>Standard mode</term><term>Statistical analysis</term><term>Study group</term><term>Subretinal implant</term><term>Substantial contributions</term><term>Time limit</term><term>Total number</term><term>Unit steps</term><term>Unpatched</term><term>Video processing unit</term><term>Visual performance</term><term>Western australia</term><term>Word reading</term><term>Word recognition</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Argus</term><term>Average time</term><term>Black background</term><term>Blind subjects</term><term>Clinical science</term><term>Correct answers</term><term>Correct letter</term><term>Correct letters</term><term>Daily life</term><term>Electrical stimulation</term><term>Electrode</term><term>Eyes unpatched</term><term>Feasibility study</term><term>Head scanning</term><term>Implant</term><term>Implantation</term><term>Letter height</term><term>Letter size</term><term>Letter size reduction</term><term>Light detection</term><term>Light perception</term><term>Nancial interest</term><term>Ophthalmol</term><term>Profound vision loss</term><term>Prosthesis</term><term>Random order</term><term>Rank test</term><term>Research centre</term><term>Residual light perception</term><term>Retina</term><term>Retinal</term><term>Retinal detachment</term><term>Retinal prosthesis</term><term>Retinal prosthesis system</term><term>Retinal stimulation</term><term>Retinal tack</term><term>Retinitis pigmentosa</term><term>Second sight</term><term>Small sample size</term><term>Spatial information</term><term>Spatial resolution</term><term>Standard mode</term><term>Statistical analysis</term><term>Study group</term><term>Subretinal implant</term><term>Substantial contributions</term><term>Time limit</term><term>Total number</term><term>Unit steps</term><term>Unpatched</term><term>Video processing unit</term><term>Visual performance</term><term>Western australia</term><term>Word reading</term><term>Word recognition</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>étude de faisabilité</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, long-term retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and four-letter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months. Conclusions Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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