Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors
Identifieur interne : 002B54 ( Istex/Corpus ); précédent : 002B53; suivant : 002B55Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors
Auteurs : Florence Netzer ; Nathalie Mandjee ; Anthony J. Verberne ; Jean-François Bernard ; Michel Hamon ; Raul Laguzzi ; Caroline Sévoz-CoucheSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2009-05.
English descriptors
- KwdEn :
- Activation, Afferent, Baroreceptor, Baseline, Bezold, Bicuculline, Bilateral microinjections, Blackwell publishing, Blood pressure, Bradycardia, Bradycardic, Bradycardic component, Bradycardic response, Bradycardic responses, Cardiac, Cardiac responses, Cardiopulmonary, Cardiovagal, Cardiovascular, Carotid, Carotid chemoreceptor, Central microinjections, Chemical stimulation, Chemoreceptor, Defence, Defence reaction, Dlpag, Dlpag activation, Dlpag stimulation, Electrical stimulation, European journal, European neuroscience societies, Experimental responses, Gabaa, Gabaa receptors, Gabaergic, Granisetron, Hamon, Inhibition, Inhibitory, Inhibitory effect, Inhibitory effects, Jarisch, Journal compilation federation, Laguzzi, Lateral, Medullary, Microinjection, Microinjections, Muscimol, Netzer, Neuron, Neuroscience, Nucleus tractus solitarii, Nucleus tractus solitarius, Paton, Periaqueductal, Phenylbiguanide, Physiol, Pmol, Receptor, Receptor antagonist, Receptor antagonists, Region neurons, Same rats, Separate groups, Serotonergic, Serotonergic neurons, Sevoz, Solitarii, Solitary tract, Tractus, Vagal.
- Teeft :
- Activation, Afferent, Baroreceptor, Baseline, Bezold, Bicuculline, Bilateral microinjections, Blackwell publishing, Blood pressure, Bradycardia, Bradycardic, Bradycardic component, Bradycardic response, Bradycardic responses, Cardiac, Cardiac responses, Cardiopulmonary, Cardiovagal, Cardiovascular, Carotid, Carotid chemoreceptor, Central microinjections, Chemical stimulation, Chemoreceptor, Defence, Defence reaction, Dlpag, Dlpag activation, Dlpag stimulation, Electrical stimulation, European journal, European neuroscience societies, Experimental responses, Gabaa, Gabaa receptors, Gabaergic, Granisetron, Hamon, Inhibition, Inhibitory, Inhibitory effect, Inhibitory effects, Jarisch, Journal compilation federation, Laguzzi, Lateral, Medullary, Microinjection, Microinjections, Muscimol, Netzer, Neuron, Neuroscience, Nucleus tractus solitarii, Nucleus tractus solitarius, Paton, Periaqueductal, Phenylbiguanide, Physiol, Pmol, Receptor, Receptor antagonist, Receptor antagonists, Region neurons, Same rats, Separate groups, Serotonergic, Serotonergic neurons, Sevoz, Solitarii, Solitary tract, Tractus, Vagal.
Abstract
Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.
Url:
DOI: 10.1111/j.1460-9568.2009.06758.x
Links to Exploration step
ISTEX:E74A09295241189012A76074C57829DEB3126CBELe document en format XML
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tract</term><term>Tractus</term><term>Vagal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>dlpag</json:string><json:string>receptor</json:string><json:string>carotid</json:string><json:string>bradycardia</json:string><json:string>chemoreceptor</json:string><json:string>bradycardic</json:string><json:string>microinjection</json:string><json:string>neuroscience</json:string><json:string>granisetron</json:string><json:string>microinjections</json:string><json:string>pmol</json:string><json:string>bicuculline</json:string><json:string>defence reaction</json:string><json:string>phenylbiguanide</json:string><json:string>bradycardic responses</json:string><json:string>neuron</json:string><json:string>carotid chemoreceptor</json:string><json:string>gabaa</json:string><json:string>tractus</json:string><json:string>sevoz</json:string><json:string>physiol</json:string><json:string>paton</json:string><json:string>dlpag stimulation</json:string><json:string>defence</json:string><json:string>muscimol</json:string><json:string>serotonergic</json:string><json:string>blackwell publishing</json:string><json:string>european neuroscience societies</json:string><json:string>journal compilation federation</json:string><json:string>european journal</json:string><json:string>periaqueductal</json:string><json:string>inhibitory effects</json:string><json:string>bradycardic response</json:string><json:string>vagal</json:string><json:string>cardiovagal</json:string><json:string>inhibitory effect</json:string><json:string>bezold</json:string><json:string>jarisch</json:string><json:string>electrical stimulation</json:string><json:string>solitarii</json:string><json:string>cardiac</json:string><json:string>medullary</json:string><json:string>cardiopulmonary</json:string><json:string>dlpag activation</json:string><json:string>cardiac responses</json:string><json:string>netzer</json:string><json:string>chemical stimulation</json:string><json:string>hamon</json:string><json:string>serotonergic neurons</json:string><json:string>receptor antagonist</json:string><json:string>bilateral microinjections</json:string><json:string>gabaergic</json:string><json:string>laguzzi</json:string><json:string>experimental responses</json:string><json:string>nucleus tractus solitarii</json:string><json:string>cardiovascular</json:string><json:string>afferent</json:string><json:string>nucleus tractus solitarius</json:string><json:string>receptor antagonists</json:string><json:string>separate groups</json:string><json:string>solitary tract</json:string><json:string>inhibitory</json:string><json:string>lateral</json:string><json:string>baroreceptor</json:string><json:string>central microinjections</json:string><json:string>blood pressure</json:string><json:string>gabaa receptors</json:string><json:string>region neurons</json:string><json:string>same rats</json:string><json:string>bradycardic component</json:string><json:string>baseline</json:string><json:string>activation</json:string><json:string>inhibition</json:string></teeft></keywords><author><json:item><name>Florence Netzer</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string><json:string>Université Paris Descartes, 12 Rue de l'Ecole de Médecine, Paris</json:string></affiliations></json:item><json:item><name>Nathalie Mandjee</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Anthony J. Verberne</name><affiliations><json:string>Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, University of Melbourne, Heidelberg,Victoria, Australia</json:string></affiliations></json:item><json:item><name>Jean‐François Bernard</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Michel Hamon</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Raul Laguzzi</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Caroline Sévoz‐Couche</name><affiliations><json:string>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>defence reaction</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nucleus of the solitary tract</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parasympathetic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rat</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>serotonin</value></json:item></subject><articleId><json:string>EJN6758</json:string></articleId><arkIstex>ark:/67375/WNG-JDXLMPT7-2</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</abstract><qualityIndicators><score>9.916</score><pdfWordCount>8074</pdfWordCount><pdfCharCount>50593</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>595.276 x 810.709 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>243</abstractWordCount><abstractCharCount>1675</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors</title><pmid><json:string>19453625</json:string></pmid><genre><json:string>article</json:string></genre><host><title>European Journal of Neuroscience</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1460-9568</json:string></doi><issn><json:string>0953-816X</json:string></issn><eissn><json:string>1460-9568</json:string></eissn><publisherId><json:string>EJN</json:string></publisherId><volume>29</volume><issue>10</issue><pages><first>2017</first><last>2028</last><total>12</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2009</json:string><json:string>2020</json:string></date><geogName></geogName><orgName><json:string>Glaxo–Smith–Kline</json:string><json:string>Glaxo-Smith-Kline</json:string><json:string>Blackwell Publishing Ltd</json:string><json:string>University of Melbourne</json:string><json:string>Calbiochem</json:string><json:string>Aldrich Chemical</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Paris Cedex</json:string><json:string>Austin Health</json:string><json:string>Alexa Fluor</json:string><json:string>Nathalie Mandjee</json:string><json:string>Caroline Sevoz-Couche</json:string><json:string>Marie Curie</json:string><json:string>Dr Julian</json:string><json:string>Michel Hamon</json:string><json:string>Raul Laguzzi</json:string><json:string>Jean-Francois Bernard</json:string><json:string>Von Bezold</json:string><json:string>F. Netzer</json:string><json:string>Paris Descartes</json:string><json:string>La Jolla</json:string><json:string>Anthony J. Verberne</json:string></persName><placeName><json:string>Germany</json:string><json:string>Australia</json:string><json:string>Heidelberg</json:string><json:string>UK</json:string><json:string>Harlow</json:string><json:string>Victoria</json:string><json:string>France</json:string><json:string>Cambridge</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Sevoz et al., 1996, 1997</json:string><json:string>Jordan & Spyer, 1986</json:string><json:string>Pickering et al., 2003</json:string><json:string>Le Brun et al., 2007</json:string><json:string>Comet et al., 2004, 2005</json:string><json:string>Rupniak et al., 2000</json:string><json:string>Anderson & Mitchell, 1986</json:string><json:string>Palkovits & Zaborszky, 1977</json:string><json:string>Geis et al., 1981</json:string><json:string>Chianca Junior & Machado, 1994</json:string><json:string>Bonham & Joad, 1991</json:string><json:string>Marshall, 1981</json:string><json:string>Depaulis et al., 1992</json:string><json:string>Boscan & Paton, 2002</json:string><json:string>Paton, 1998b</json:string><json:string>Finley & Katz, 1992</json:string><json:string>Sevoz et al., 1997</json:string><json:string>Cohen et al., 1989</json:string><json:string>Verberne & Guyenet, 1992</json:string><json:string>Carrive et al., 1987</json:string><json:string>Nosaka, 1996</json:string><json:string>Paton, 1998a</json:string><json:string>Kalia & Sullivan, 1982</json:string><json:string>Sevoz et al., 1996</json:string><json:string>Hoyer et al., 2002</json:string><json:string>Vardhan et al., 1993b</json:string><json:string>Coleridge & Coleridge, 1980</json:string><json:string>Pratt & Bowery, 1989</json:string><json:string>Edwards & Paton, 1999</json:string><json:string>Evans et al., 1990</json:string><json:string>Mancia & Zancchetti, 1981</json:string><json:string>Bernard et al., 2008</json:string><json:string>Comet et al., 2005</json:string><json:string>Vardhan et al., 1993a</json:string><json:string>Bandler et al., 2000</json:string><json:string>Zhang et al., 2000</json:string><json:string>F. 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Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</licence></availability><date type="published" when="2009-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors</title><title level="a" type="short">Chemoreflex inhibition during the defence reaction</title><author xml:id="author-0000"><persName><forename type="first">Florence</forename><surname>Netzer</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation><affiliation>Université Paris Descartes, 12 Rue de l'Ecole de Médecine, Paris</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Nathalie</forename><surname>Mandjee</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Anthony J.</forename><surname>Verberne</surname></persName><affiliation>Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, University of Melbourne, Heidelberg,
Victoria, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Jean‐François</forename><surname>Bernard</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Michel</forename><surname>Hamon</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Raul</forename><surname>Laguzzi</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Caroline</forename><surname>Sévoz‐Couche</surname></persName><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France<address><country key="FR"></country></address></affiliation></author><idno type="istex">E74A09295241189012A76074C57829DEB3126CBE</idno><idno type="ark">ark:/67375/WNG-JDXLMPT7-2</idno><idno type="DOI">10.1111/j.1460-9568.2009.06758.x</idno><idno type="unit">EJN6758</idno><idno type="toTypesetVersion">file:EJN.EJN6758.pdf</idno></analytic><monogr><title level="j" type="main">European Journal of Neuroscience</title><title level="j" type="alt">EUROPEAN JOURNAL OF NEUROSCIENCE</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="book-DOI">10.1111/(ISSN)1460-9568</idno><idno type="book-part-DOI">10.1111/ejn.2009.29.issue-10</idno><idno type="product">EJN</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="2017">2017</biblScope><biblScope unit="page" to="2028">2028</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2009-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT<hi rend="subscript">3</hi>, NK<hi rend="subscript">1</hi> and GABA<hi rend="subscript">A</hi> receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT<hi rend="subscript">3</hi> receptor antagonist), bicuculline (a GABA<hi rend="subscript">A</hi> receptor antagonist) and GR‐205171 (an NK<hi rend="subscript">1</hi> receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT<hi rend="subscript">3</hi> receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT<hi rend="subscript">3</hi>, GABA<hi rend="subscript">A</hi> and NK<hi rend="subscript">1</hi> receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">defence reaction</term><term xml:id="k2">nucleus of the solitary tract</term><term xml:id="k3">parasympathetic</term><term xml:id="k4">rat</term><term xml:id="k5">serotonin</term></keywords><keywords rend="tocHeading1"><term>NEUROSYSTEMS</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E74A09295241189012A76074C57829DEB3126CBE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="05010"><doi origin="wiley">10.1111/ejn.2009.29.issue-10</doi><numberingGroup><numbering type="journalVolume" number="29">29</numbering><numbering type="journalIssue" number="10">10</numbering></numberingGroup><coverDate startDate="2009-05">May 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="8" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2009.06758.x</doi><idGroup><id type="unit" value="EJN6758"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="tocHeading1">NEUROSYSTEMS</title></titleGroup><copyright>© The Authors (2009). 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E‐mail: <email>fnetzer@hotmail.com</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN6758.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 18 September 2008, revised 11 March 2009, accepted 20 March 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="7"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors</title><title type="shortAuthors">F. Netzer <i>et al.</i></title><title type="short">Chemoreflex inhibition during the defence reaction</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Florence</givenNames><familyName>Netzer</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Nathalie</givenNames><familyName>Mandjee</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>Anthony J.</givenNames><familyName>Verberne</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Jean‐François</givenNames><familyName>Bernard</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Michel</givenNames><familyName>Hamon</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Raul</givenNames><familyName>Laguzzi</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>Caroline</givenNames><familyName>Sévoz‐Couche</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Université Paris Descartes, 12 Rue de l'Ecole de Médecine, Paris</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="AU"><unparsedAffiliation>
Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, University of Melbourne, Heidelberg,
Victoria, Australia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">defence reaction</keyword><keyword xml:id="k2">nucleus of the solitary tract</keyword><keyword xml:id="k3">parasympathetic</keyword><keyword xml:id="k4">rat</keyword><keyword xml:id="k5">serotonin</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT<sub>3</sub>, NK<sub>1</sub> and GABA<sub>A</sub> receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT<sub>3</sub> receptor antagonist), bicuculline (a GABA<sub>A</sub> receptor antagonist) and GR‐205171 (an NK<sub>1</sub> receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT<sub>3</sub> receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT<sub>3</sub>, GABA<sub>A</sub> and NK<sub>1</sub> receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Chemoreflex inhibition during the defence reaction</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Inhibition of the bradycardic component of the von Bezold–Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors</title></titleInfo><name type="personal"><namePart type="given">Florence</namePart><namePart type="family">Netzer</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><affiliation>Université Paris Descartes, 12 Rue de l'Ecole de Médecine, Paris</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nathalie</namePart><namePart type="family">Mandjee</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony J.</namePart><namePart type="family">Verberne</namePart><affiliation>Department of Medicine, Clinical Pharmacology and Therapeutics Unit, Austin Health, University of Melbourne, Heidelberg,Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐François</namePart><namePart type="family">Bernard</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Hamon</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Raul</namePart><namePart type="family">Laguzzi</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Caroline</namePart><namePart type="family">Sévoz‐Couche</namePart><affiliation>UMR 677 INSERM/UMPC, C.H.U. Pitié‐Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2009-05</dateIssued><edition>Received 18 September 2008, revised 11 March 2009, accepted 20 March 2009</edition><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">7</extent><extent unit="tables">2</extent></physicalDescription><abstract lang="en">Stimulation of the dorsolateral periaqueductal gray matter (dlPAG) and the B3 cell group inhibits the cardiovagal component of the baroreflex in rats. Our aim was to determine whether the defence reaction induces similar modulatory effects on the cardiac response of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex. We examined the effects of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components of the von Bezold–Jarisch and the carotid chemoreceptor reflexes. In addition, as 5‐HT3, NK1 and GABAA receptor activation blocks cardiac reflex responses, we studied whether these receptors were involved in the dlPAG‐induced inhibitory effects. We found that, after microinjection of granisetron (a 5‐HT3 receptor antagonist), bicuculline (a GABAA receptor antagonist) and GR‐205171 (an NK1 receptor antagonist) into the nucleus of the solitary tract (NTS), reflex bradycardic responses were preserved during dlPAG stimulation. Finally, activation of the B3 region also inhibited both reflex bradycardic responses, and these effects were prevented by prior blockade of 5‐HT3 receptors in the NTS. The inhibitory effect of dlPAG stimulation on the cardiac reflex responses was prevented by inhibition of neurons in the medullary B3 region. In conclusion, 5‐HT3, GABAA and NK1 receptors in the NTS appear to be involved in the inhibition of the von Bezold–Jarisch reflex and the carotid chemoreceptor reflex bradycardia evoked by activation of neurons in the dlPAG and the raphé magnus.</abstract><subject lang="en"><genre>keywords</genre><topic>defence reaction</topic><topic>nucleus of the solitary tract</topic><topic>parasympathetic</topic><topic>rat</topic><topic>serotonin</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>2017</start><end>2028</end><total>12</total></extent></part></relatedItem><identifier type="istex">E74A09295241189012A76074C57829DEB3126CBE</identifier><identifier type="ark">ark:/67375/WNG-JDXLMPT7-2</identifier><identifier type="DOI">10.1111/j.1460-9568.2009.06758.x</identifier><identifier type="ArticleID">EJN6758</identifier><accessCondition type="use and reproduction" contentType="copyright">© The Authors (2009). Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/E74A09295241189012A76074C57829DEB3126CBE/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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