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One‐Year Clinical Outcomes after Sirolimus‐Eluting Coronary Stent Implantation for Acute Myocardial Infarction in the Worldwide e‐SELECT Registry

Identifieur interne : 001E39 ( Istex/Corpus ); précédent : 001E38; suivant : 001E40

One‐Year Clinical Outcomes after Sirolimus‐Eluting Coronary Stent Implantation for Acute Myocardial Infarction in the Worldwide e‐SELECT Registry

Auteurs : Stephen G. Worthley ; Alexandre Abizaid ; Adrian Banning ; Antonio Bartorelli ; Vladimír Džavík ; Stephen Ellis ; Runlin Gao ; Victor Legrand ; Philip Urban ; Christian Spaulding

Source :

RBID : ISTEX:A09720F7BE584B7AFD83AE6E1BCBC59F73728977

English descriptors

Abstract

Background: The aim was to ascertain the 1‐year clinical outcomes of 1,234 patients who underwent implantations of sirolimus‐eluting stents (SES) for acute myocardial infarction (MI) in the multinational e‐SELECT registry.

Url:
DOI: 10.1111/j.1540-8183.2011.00705.x

Links to Exploration step

ISTEX:A09720F7BE584B7AFD83AE6E1BCBC59F73728977

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<div type="abstract">Background: The aim was to ascertain the 1‐year clinical outcomes of 1,234 patients who underwent implantations of sirolimus‐eluting stents (SES) for acute myocardial infarction (MI) in the multinational e‐SELECT registry.</div>
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In the e‐SELECT registry which included 15,147 patients treated with sirolimus‐eluting stent (SES), we ascertained the 1‐year clinical outcomes of 1,234 patients who presented within <24 hours of acute MI onset. In acute MI patients SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients (MACE: 5.5% vs. 4.8%; P = 0.28; ST: 2.1 vs. 0.88%, P < 0.001). (J Interven Cardiol 2012;25:253–261)</p>
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<i>Background:</i>
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<b>
<i>Methods:</i>
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<i>Results:</i>
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<i>At 1 year, the rates of major adverse cardiac events (MACE) (5.5% vs. 4.8%; P = 0.28) were similarly low in the acute and no acute MI groups. The rates of definite/probable stent thrombosis (ST) were higher in the acute MI group (2.1%vs; 0.88%, P < 0.001). ST was a strong independent predictor of death at 1 year (HR 13.4; 95% CI 5.0, 36.0; P < 0.001) and MI (HR 58.9; 95% CI 26.9, 129.1; P < 0.001). Dual antiplatelet therapy (DAPT) compliance at 6 months was 96.0% in the acute MI versus 94.5% in the no acute MI group (P = 0.03).</i>
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<p>
<b>Condensed abstract </b>
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<namePart type="given">VICTOR</namePart>
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<namePart>for the e‐SELECT investigators</namePart>
<description>Cardiovascular Investigation Unit, Royal Adelaide Hospital, Adelaide, AustraliaInstituto Dante Pazzanese de Cardiologia, Sao Paolo, BrazilJohn Radcliffe Hospital, Oxford, United KingdomCentro Cardiologico Monzino, IRCCS, University of Milan, Milan, ItalyPeter Munk Cardiac Centre, University Health Network, Toronto, CanadaCleveland Clinic Foundation, Cleveland, Ohio, USACardiovascular Institute and Fu Wai Hospital, Beijing, ChinaCentre Hospitalier Universitaire, Liège, BelgiumEuropean Hospital Georges Pompidou, Assistance Publique‐Hôpitaux de Paris, and INSERM U 970, Paris Descartes University, Paris, FranceLa Tour Hospital, Geneva, SwitzerlandList available as online‐supplement</description>
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<abstract>Background: The aim was to ascertain the 1‐year clinical outcomes of 1,234 patients who underwent implantations of sirolimus‐eluting stents (SES) for acute myocardial infarction (MI) in the multinational e‐SELECT registry.</abstract>
<abstract>Methods: Fifteen thousand and one hundred and forty‐seven patients treated with SES were entered in the e‐SELECT registry, of whom 1,234 presented within <24 hours of onset of acute MI.</abstract>
<abstract>Results: At 1 year, the rates of major adverse cardiac events (MACE) (5.5% vs. 4.8%; P = 0.28) were similarly low in the acute and no acute MI groups. The rates of definite/probable stent thrombosis (ST) were higher in the acute MI group (2.1%vs; 0.88%, P < 0.001). ST was a strong independent predictor of death at 1 year (HR 13.4; 95% CI 5.0, 36.0; P < 0.001) and MI (HR 58.9; 95% CI 26.9, 129.1; P < 0.001). Dual antiplatelet therapy (DAPT) compliance at 6 months was 96.0% in the acute MI versus 94.5% in the no acute MI group (P = 0.03).</abstract>
<abstract>Conclusion: In selected patients presenting within <24 hours of acute MI onset and highly compliant with DAPT, SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients.</abstract>
<abstract>Condensed abstract  In the e‐SELECT registry which included 15,147 patients treated with sirolimus‐eluting stent (SES), we ascertained the 1‐year clinical outcomes of 1,234 patients who presented within <24 hours of acute MI onset. In acute MI patients SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients (MACE: 5.5% vs. 4.8%; P = 0.28; ST: 2.1 vs. 0.88%, P < 0.001). (J Interven Cardiol 2012;25:253–261)</abstract>
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<note type="content"> Appendix A: Steering committee and Clinical event committeeSupporting Info Item: Supporting info item - </note>
<identifier type="ISSN">0896-4327</identifier>
<identifier type="eISSN">1540-8183</identifier>
<identifier type="DOI">10.1111/(ISSN)1540-8183</identifier>
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<number>25</number>
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<accessCondition type="use and reproduction" contentType="copyright">©2012, Wiley Periodicals, Inc.</accessCondition>
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