Proteases and proteomics: Cutting to the core of human skin pathologies
Identifieur interne : 001B04 ( Istex/Corpus ); précédent : 001B03; suivant : 001B05Proteases and proteomics: Cutting to the core of human skin pathologies
Auteurs : Simon J. De Veer ; Laetitia Furio ; Jonathan M. Harris ; Alain HovnanianSource :
- PROTEOMICS – Clinical Applications [ 1862-8346 ] ; 2014-06.
Abstract
Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.
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DOI: 10.1002/prca.201300081
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ISTEX:8F58DCC8457926A416193B4F5E5198A3D1D65D54Le document en format XML
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De Veer</name><affiliation><mods:affiliation>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia</mods:affiliation></affiliation></author><author><name sortKey="Furio, Laetitia" sort="Furio, Laetitia" uniqKey="Furio L" first="Laetitia" last="Furio">Laetitia Furio</name><affiliation><mods:affiliation>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Harris, Jonathan M" sort="Harris, Jonathan M" uniqKey="Harris J" first="Jonathan M." last="Harris">Jonathan M. 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Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Simon J. de Veer</name><affiliations><json:string>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</json:string><json:string>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</json:string><json:string>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia</json:string></affiliations></json:item><json:item><name>Laetitia Furio</name><affiliations><json:string>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</json:string><json:string>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</json:string></affiliations></json:item><json:item><name>Jonathan M. 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J. de Veer et al.</title></titleGroup><creators><creator xml:id="prca1534-cr-0001" creatorRole="author" affiliationRef="#prca1534-aff-0001 #prca1534-aff-0002 #prca1534-aff-0003"><personName><givenNames>Simon J.</givenNames><familyNamePrefix>de</familyNamePrefix><familyName>Veer</familyName></personName></creator><creator xml:id="prca1534-cr-0002" creatorRole="author" affiliationRef="#prca1534-aff-0001 #prca1534-aff-0002"><personName><givenNames>Laetitia</givenNames><familyName>Furio</familyName></personName></creator><creator xml:id="prca1534-cr-0003" creatorRole="author" affiliationRef="#prca1534-aff-0003"><personName><givenNames>Jonathan M.</givenNames><familyName>Harris</familyName></personName></creator><creator xml:id="prca1534-cr-0004" creatorRole="author" affiliationRef="#prca1534-aff-0001 #prca1534-aff-0002 #prca1534-aff-0004" corresponding="yes"><personName><givenNames>Alain</givenNames><familyName>Hovnanian</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="prca1534-aff-0001" countryCode="FR"><orgName>Université Paris Descartes – Sorbonne Paris Cité</orgName><address><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="prca1534-aff-0002" countryCode="FR"><orgName>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, <i>Imagine</i> Institute</orgName><address><city>Paris</city><country>France</country></address></affiliation><affiliation xml:id="prca1534-aff-0003" countryCode="AU"><orgDiv>Institute of Health and Biomedical Innovation</orgDiv><orgName>Queensland University of Technology</orgName><address><city>Brisbane</city><country>Australia</country></address></affiliation><affiliation xml:id="prca1534-aff-0004" countryCode="FR"><orgDiv>Department of Genetics</orgDiv><orgName>Necker Hospital for Sick Children</orgName><address><city>Paris</city><country>France</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="prca1534-kwd-0001">Epidermis</keyword><keyword xml:id="prca1534-kwd-0002">Inflammation</keyword><keyword xml:id="prca1534-kwd-0003">Keratinocyte</keyword><keyword xml:id="prca1534-kwd-0004">Permeability barrier</keyword><keyword xml:id="prca1534-kwd-0005">Therapeutic target</keyword></keywordGroup><fundingInfo><fundingAgency>French Ministry of Health</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Agence Nationale de la Recherche</fundingAgency><fundingNumber>ANR‐08‐GENO‐033</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><p>Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Proteases and proteomics: Cutting to the core of human skin pathologies</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Proteases and proteomics: Cutting to the core of human skin pathologies</title></titleInfo><name type="personal"><namePart type="given">Simon J.</namePart><namePart type="family">de Veer</namePart><affiliation>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</affiliation><affiliation>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</affiliation><affiliation>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laetitia</namePart><namePart type="family">Furio</namePart><affiliation>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</affiliation><affiliation>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jonathan M.</namePart><namePart type="family">Harris</namePart><affiliation>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alain</namePart><namePart type="family">Hovnanian</namePart><affiliation>Université Paris Descartes – Sorbonne Paris Cité, Paris, France</affiliation><affiliation>INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France</affiliation><affiliation>Department of Genetics, Necker Hospital for Sick Children, Paris, France</affiliation><affiliation>: Professor Alain Hovnanian, CHU Necker‐Enfants malades, Department of Genetics, Tour Lavoisier, 3 étage, 149 rue de Sèvres, 75743 Paris cedex 15, France: : +33 1 71 19 64 20</affiliation><affiliation>E-mail: alain.hovnanian@inserm.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-06</dateIssued><dateCreated encoding="w3cdtf">2014-03-06</dateCreated><dateCaptured encoding="w3cdtf">2013-08-29</dateCaptured><dateValid encoding="w3cdtf">2013-11-07</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Preserving the integrity of the skin's outermost layer (the epidermis) is vital for humans to thrive in hostile surroundings. Covering the entire body, the epidermis forms a thin but impenetrable cellular cordon that repels external assaults and blocks escape of water and electrolytes from within. This structure exists in a perpetual state of regeneration where the production of new cellular subunits at the base of the epidermis is offset by the release of terminally differentiated corneocytes from the surface. It is becoming increasingly clear that proteases hold vital roles in assembling and maintaining the epidermal barrier. More than 30 proteases are expressed by keratinocytes or infiltrating immune cells and the activity of each must be maintained within narrow limits and confined to the correct time and place. Accordingly, over‐ or under‐exertion of proteolytic activity is a common factor in a multitude of skin disorders that range in severity from relatively mild to life‐threatening. This review explores the current state of knowledge on the involvement of proteases in skin diseases and the latest findings from proteomic and transcriptomic studies focused on uncovering novel (patho)physiological roles for these enzymes.</abstract><note type="funding">French Ministry of Health</note><note type="funding">Agence Nationale de la Recherche - No. ANR‐08‐GENO‐033; </note><subject><genre>keywords</genre><topic>Epidermis</topic><topic>Inflammation</topic><topic>Keratinocyte</topic><topic>Permeability barrier</topic><topic>Therapeutic target</topic></subject><relatedItem type="host"><titleInfo><title>PROTEOMICS – Clinical Applications</title></titleInfo><titleInfo type="abbreviated"><title>Prot. Clin. Appl.</title></titleInfo><name type="personal"><namePart type="given">Oliver</namePart><namePart type="family">Schilling</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Peter</namePart><namePart type="family">Findeisen</namePart><role><roleTerm type="text">editor</roleTerm></role></name><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic></subject><identifier type="ISSN">1862-8346</identifier><identifier type="eISSN">1862-8354</identifier><identifier type="DOI">10.1002/(ISSN)1862-8354</identifier><identifier type="PublisherID">PRCA</identifier><part><date>2014</date><detail type="title"><title>Proteases and Disease</title></detail><detail type="volume"><caption>vol.</caption><number>8</number></detail><detail type="issue"><caption>no.</caption><number>5-6</number></detail><extent unit="pages"><start>389</start><end>402</end><total>14</total></extent></part></relatedItem><identifier type="istex">8F58DCC8457926A416193B4F5E5198A3D1D65D54</identifier><identifier type="ark">ark:/67375/WNG-5SHJ5NDF-C</identifier><identifier type="DOI">10.1002/prca.201300081</identifier><identifier type="ArticleID">PRCA1534</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2014 WILEY‐VCH Verlag GmbH & Co. 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