Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy
Identifieur interne : 001A69 ( Istex/Corpus ); précédent : 001A68; suivant : 001A70Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy
Auteurs : A. D. J. Watson ; Hervé P. Lefebvre ; Didier Concordet ; Valérie Laroute ; Jean-Pierre Ferré ; Jean-Pierre Braun ; Fabrice Conchou ; Pierre-Louis ToutainSource :
- Journal of Veterinary Internal Medicine [ 0891-6640 ] ; 2002-01.
English descriptors
- KwdEn :
- Basal, Beagle, Bolus, Bolus administration, Clearance, Compartmental, Creatine, Creatinine, Creatinine clearance, Endogenous, Endogenous creatinine, Exogenous, Exogenous creatinine, Healthy dogs, Impairment, Inulin, Iothalamate, Lefebvre, Linearity, Linearity study, Ltration, Ltration rate, Nominal dosage, Noncompartmental, Pharmacokinetic, Pharmacokinetic analysis, Plasma, Plasma clearance, Plasma concentration, Plasma creatinine, Plasma creatinine clearance, Plasma creatinine clearance test, Plasma creatinine clearances, Plasma creatinine concentration, Plasma inulin clearance, Plasma iothalamate clearance, Renal, Renal failure, Renal function, Tricompartmental, Urine, Urine clearance, Urine clearances, Urine inulin clearance.
- Teeft :
- Basal, Beagle, Bolus, Bolus administration, Clearance, Compartmental, Creatine, Creatinine, Creatinine clearance, Endogenous, Endogenous creatinine, Exogenous, Exogenous creatinine, Healthy dogs, Impairment, Inulin, Iothalamate, Lefebvre, Linearity, Linearity study, Ltration, Ltration rate, Nominal dosage, Noncompartmental, Pharmacokinetic, Pharmacokinetic analysis, Plasma, Plasma clearance, Plasma concentration, Plasma creatinine, Plasma creatinine clearance, Plasma creatinine clearance test, Plasma creatinine clearances, Plasma creatinine concentration, Plasma inulin clearance, Plasma iothalamate clearance, Renal, Renal failure, Renal function, Tricompartmental, Urine, Urine clearance, Urine clearances, Urine inulin clearance.
Abstract
Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.
Url:
DOI: 10.1111/j.1939-1676.2002.tb01603.x
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ISTEX:8D5234D10922FD831A68F12A4F4EF81386BB838BLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title><author><name sortKey="Watson, A D J" sort="Watson, A D J" uniqKey="Watson A" first="A. D. J." last="Watson">A. D. J. Watson</name><affiliation><mods:affiliation>Veterinary Medicine, The University of Sydney, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: adjw@vetc.usyd.edu.au.</mods:affiliation></affiliation></author><author><name sortKey="Lefebvre, Herve P" sort="Lefebvre, Herve P" uniqKey="Lefebvre H" first="Hervé P." last="Lefebvre">Hervé P. Lefebvre</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Concordet, Didier" sort="Concordet, Didier" uniqKey="Concordet D" first="Didier" last="Concordet">Didier Concordet</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Laroute, Valerie" sort="Laroute, Valerie" uniqKey="Laroute V" first="Valérie" last="Laroute">Valérie Laroute</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Ferre, Jean Ierre" sort="Ferre, Jean Ierre" uniqKey="Ferre J" first="Jean-Pierre" last="Ferré">Jean-Pierre Ferré</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Braun, Jean Ierre" sort="Braun, Jean Ierre" uniqKey="Braun J" first="Jean-Pierre" last="Braun">Jean-Pierre Braun</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Conchou, Fabrice" sort="Conchou, Fabrice" uniqKey="Conchou F" first="Fabrice" last="Conchou">Fabrice Conchou</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Toutain, Pierre Ouis" sort="Toutain, Pierre Ouis" uniqKey="Toutain P" first="Pierre-Louis" last="Toutain">Pierre-Louis Toutain</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8D5234D10922FD831A68F12A4F4EF81386BB838B</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1111/j.1939-1676.2002.tb01603.x</idno><idno type="url">https://api.istex.fr/document/8D5234D10922FD831A68F12A4F4EF81386BB838B/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A69</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A69</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title><author><name sortKey="Watson, A D J" sort="Watson, A D J" uniqKey="Watson A" first="A. D. J." last="Watson">A. D. J. Watson</name><affiliation><mods:affiliation>Veterinary Medicine, The University of Sydney, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: adjw@vetc.usyd.edu.au.</mods:affiliation></affiliation></author><author><name sortKey="Lefebvre, Herve P" sort="Lefebvre, Herve P" uniqKey="Lefebvre H" first="Hervé P." last="Lefebvre">Hervé P. Lefebvre</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Concordet, Didier" sort="Concordet, Didier" uniqKey="Concordet D" first="Didier" last="Concordet">Didier Concordet</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Laroute, Valerie" sort="Laroute, Valerie" uniqKey="Laroute V" first="Valérie" last="Laroute">Valérie Laroute</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Ferre, Jean Ierre" sort="Ferre, Jean Ierre" uniqKey="Ferre J" first="Jean-Pierre" last="Ferré">Jean-Pierre Ferré</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Braun, Jean Ierre" sort="Braun, Jean Ierre" uniqKey="Braun J" first="Jean-Pierre" last="Braun">Jean-Pierre Braun</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Conchou, Fabrice" sort="Conchou, Fabrice" uniqKey="Conchou F" first="Fabrice" last="Conchou">Fabrice Conchou</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author><author><name sortKey="Toutain, Pierre Ouis" sort="Toutain, Pierre Ouis" uniqKey="Toutain P" first="Pierre-Louis" last="Toutain">Pierre-Louis Toutain</name><affiliation><mods:affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Veterinary Internal Medicine</title><title level="j" type="alt">JOURNAL OF VETERINARY INTERNAL MEDICINE</title><idno type="ISSN">0891-6640</idno><idno type="eISSN">1939-1676</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="22">22</biblScope><biblScope unit="page" to="33">33</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-01">2002-01</date></imprint><idno type="ISSN">0891-6640</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0891-6640</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal</term><term>Beagle</term><term>Bolus</term><term>Bolus administration</term><term>Clearance</term><term>Compartmental</term><term>Creatine</term><term>Creatinine</term><term>Creatinine clearance</term><term>Endogenous</term><term>Endogenous creatinine</term><term>Exogenous</term><term>Exogenous creatinine</term><term>Healthy dogs</term><term>Impairment</term><term>Inulin</term><term>Iothalamate</term><term>Lefebvre</term><term>Linearity</term><term>Linearity study</term><term>Ltration</term><term>Ltration rate</term><term>Nominal dosage</term><term>Noncompartmental</term><term>Pharmacokinetic</term><term>Pharmacokinetic analysis</term><term>Plasma</term><term>Plasma clearance</term><term>Plasma concentration</term><term>Plasma creatinine</term><term>Plasma creatinine clearance</term><term>Plasma creatinine clearance test</term><term>Plasma creatinine clearances</term><term>Plasma creatinine concentration</term><term>Plasma inulin clearance</term><term>Plasma iothalamate clearance</term><term>Renal</term><term>Renal failure</term><term>Renal function</term><term>Tricompartmental</term><term>Urine</term><term>Urine clearance</term><term>Urine clearances</term><term>Urine inulin clearance</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Basal</term><term>Beagle</term><term>Bolus</term><term>Bolus administration</term><term>Clearance</term><term>Compartmental</term><term>Creatine</term><term>Creatinine</term><term>Creatinine clearance</term><term>Endogenous</term><term>Endogenous creatinine</term><term>Exogenous</term><term>Exogenous creatinine</term><term>Healthy dogs</term><term>Impairment</term><term>Inulin</term><term>Iothalamate</term><term>Lefebvre</term><term>Linearity</term><term>Linearity study</term><term>Ltration</term><term>Ltration rate</term><term>Nominal dosage</term><term>Noncompartmental</term><term>Pharmacokinetic</term><term>Pharmacokinetic analysis</term><term>Plasma</term><term>Plasma clearance</term><term>Plasma concentration</term><term>Plasma creatinine</term><term>Plasma creatinine clearance</term><term>Plasma creatinine clearance test</term><term>Plasma creatinine clearances</term><term>Plasma creatinine concentration</term><term>Plasma inulin clearance</term><term>Plasma iothalamate clearance</term><term>Renal</term><term>Renal failure</term><term>Renal function</term><term>Tricompartmental</term><term>Urine</term><term>Urine clearance</term><term>Urine clearances</term><term>Urine inulin clearance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>creatinine</json:string><json:string>inulin</json:string><json:string>iothalamate</json:string><json:string>urine</json:string><json:string>plasma creatinine clearance</json:string><json:string>exogenous</json:string><json:string>renal</json:string><json:string>clearance</json:string><json:string>bolus</json:string><json:string>exogenous creatinine</json:string><json:string>plasma clearance</json:string><json:string>renal function</json:string><json:string>renal failure</json:string><json:string>ltration</json:string><json:string>plasma iothalamate clearance</json:string><json:string>plasma creatinine concentration</json:string><json:string>healthy dogs</json:string><json:string>ltration rate</json:string><json:string>noncompartmental</json:string><json:string>pharmacokinetic</json:string><json:string>basal</json:string><json:string>linearity</json:string><json:string>urine inulin clearance</json:string><json:string>nominal dosage</json:string><json:string>plasma creatinine clearances</json:string><json:string>beagle</json:string><json:string>tricompartmental</json:string><json:string>endogenous creatinine</json:string><json:string>urine clearances</json:string><json:string>plasma creatinine</json:string><json:string>linearity study</json:string><json:string>bolus administration</json:string><json:string>compartmental</json:string><json:string>lefebvre</json:string><json:string>creatine</json:string><json:string>urine clearance</json:string><json:string>endogenous</json:string><json:string>plasma</json:string><json:string>plasma concentration</json:string><json:string>plasma creatinine clearance test</json:string><json:string>creatinine clearance</json:string><json:string>pharmacokinetic analysis</json:string><json:string>plasma inulin clearance</json:string><json:string>impairment</json:string><json:string>daily input rate</json:string><json:string>urine creatinine clearance</json:string><json:string>body weight</json:string><json:string>pharmacokinetic variables</json:string><json:string>input rate</json:string><json:string>plasma clearances</json:string><json:string>tubular secretion</json:string><json:string>clearance values</json:string><json:string>compartmental analysis</json:string><json:string>urine gravity</json:string><json:string>trapezoidal rule</json:string><json:string>beagle dogs</json:string><json:string>noncompartmental analysis</json:string><json:string>renal impairment</json:string><json:string>nominal dosages</json:string><json:string>urine clearance procedures</json:string><json:string>rinsing water</json:string><json:string>assay</json:string><json:string>glomerular</json:string><json:string>dosage</json:string><json:string>rinsing cages</json:string><json:string>total volume</json:string><json:string>routine practice</json:string><json:string>dose rates</json:string><json:string>iothalamate clearances</json:string><json:string>reference method</json:string><json:string>sampling strategies</json:string><json:string>central compartment</json:string><json:string>basal plasma creatinine concentration</json:string><json:string>blood sampling</json:string><json:string>plasma creatinine concentrations</json:string><json:string>time curve</json:string><json:string>other clearance values</json:string><json:string>urine inulin</json:string><json:string>blood samples</json:string><json:string>healthy beagle dogs</json:string><json:string>creatinine input rate</json:string><json:string>limited sampling strategy</json:string><json:string>plasma exogenous creatinine clearance test</json:string><json:string>tricompartmental approach</json:string><json:string>creatinine concentrations</json:string><json:string>renal disease</json:string><json:string>dynamic test</json:string><json:string>threshold value</json:string><json:string>basal concentration</json:string></teeft></keywords><author><json:item><name>A.D.J. Watson</name><affiliations><json:string>Veterinary Medicine, The University of Sydney, Australia</json:string><json:string>E-mail: adjw@vetc.usyd.edu.au.</json:string></affiliations></json:item><json:item><name>Hervé P. Lefebvre</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Didier Concordet</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Valérie Laroute</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Jean‐Pierre Ferré</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Jean‐Pierre Braun</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Fabrice Conchou</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item><json:item><name>Pierre‐Louis Toutain</name><affiliations><json:string>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Glomerular fitration rate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Inulin</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Iothalamate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pharmacokinetics</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Urine</value></json:item></subject><articleId><json:string>JVIM22</json:string></articleId><arkIstex>ark:/67375/WNG-48RNH2HP-Z</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P > .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P > .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</abstract><qualityIndicators><score>9.94</score><pdfWordCount>7977</pdfWordCount><pdfCharCount>49232</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>12</pdfPageCount><pdfPageSize>648 x 864 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>245</abstractWordCount><abstractCharCount>1683</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title><pmid><json:string>11826881</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Veterinary Internal Medicine</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1939-1676</json:string></doi><issn><json:string>0891-6640</json:string></issn><eissn><json:string>1939-1676</json:string></eissn><publisherId><json:string>JVIM</json:string></publisherId><volume>16</volume><issue>1</issue><pages><first>22</first><last>33</last><total>12</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2002</json:string></date><geogName></geogName><orgName><json:string>Sigma Chemical Co</json:string><json:string>Ministry of Agriculture</json:string><json:string>University of Sydney</json:string><json:string>American College of Veterinary Internal Medicine</json:string><json:string>Consulting Inc</json:string><json:string>Ektachem</json:string><json:string>France Dog</json:string><json:string>Bio-Tek Instruments</json:string><json:string>Beckman Instruments</json:string><json:string>Committee of the ENVT</json:string><json:string>SPSS Inc, Chicago</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Herve P. Lefebvre</json:string><json:string>Jean-Pierre Gau</json:string><json:string>Didier Concordet</json:string><json:string>Jean-Pierre Ferre</json:string><json:string>Fabrice Conchou</json:string><json:string>A.D.J. Watson</json:string><json:string>Valerie Laroute</json:string><json:string>Joseph Maligoy</json:string><json:string>Jean-Pierre Braun</json:string><json:string>Gisele Costes</json:string><json:string>C. 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e‐mail: adjw@vetc.usyd.edu.au.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Hervé P.</forename><surname>Lefebvre</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Didier</forename><surname>Concordet</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Valérie</forename><surname>Laroute</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Jean‐Pierre</forename><surname>Ferré</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Jean‐Pierre</forename><surname>Braun</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Fabrice</forename><surname>Conchou</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Pierre‐Louis</forename><surname>Toutain</surname></persName><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.<address><country key="FR"></country></address></affiliation></author><idno type="istex">8D5234D10922FD831A68F12A4F4EF81386BB838B</idno><idno type="ark">ark:/67375/WNG-48RNH2HP-Z</idno><idno type="DOI">10.1111/j.1939-1676.2002.tb01603.x</idno><idno type="unit">JVIM22</idno><idno type="toTypesetVersion">file:JVIM.JVIM22.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Veterinary Internal Medicine</title><title level="j" type="alt">JOURNAL OF VETERINARY INTERNAL MEDICINE</title><idno type="pISSN">0891-6640</idno><idno type="eISSN">1939-1676</idno><idno type="book-DOI">10.1111/(ISSN)1939-1676</idno><idno type="book-part-DOI">10.1111/jvim.2002.16.issue-1</idno><idno type="product">JVIM</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="22">22</biblScope><biblScope unit="page" to="33">33</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2002-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of <hi rend="superscript">14</hi>C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (<hi rend="italic">P</hi> < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (<hi rend="italic">P</hi> < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">Glomerular fitration rate</term><term xml:id="k2">Inulin</term><term xml:id="k3">Iothalamate</term><term xml:id="k4">Pharmacokinetics</term><term xml:id="k5">Urine</term></keywords><keywords rend="tocHeading1"><term>Original Article</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/8D5234D10922FD831A68F12A4F4EF81386BB838B/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1939-1676</doi><issn type="print">0891-6640</issn><issn type="electronic">1939-1676</issn><idGroup><id type="product" value="JVIM"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF VETERINARY INTERNAL MEDICINE">Journal of Veterinary Internal Medicine</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/jvim.2002.16.issue-1</doi><numberingGroup><numbering type="journalVolume" number="16">16</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2002-01">January 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0002200" status="forIssue"><doi origin="wiley">10.1111/j.1939-1676.2002.tb01603.x</doi><idGroup><id type="unit" value="JVIM22"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><eventGroup><event type="firstOnline" date="2008-06-28"></event><event type="publishedOnlineFinalForm" date="2008-06-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:HeaderRef result:HeaderRef" date="2010-04-20"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="22">22</numbering><numbering type="pageLast" number="33">33</numbering></numberingGroup><correspondenceTo>
Veterinary Medicine, The University of Sydney, NSW 2006, Australia; e‐mail: <email>adjw@vetc.usyd.edu.au.</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JVIM.JVIM22.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Revised May 3, 2001; Accepted July 26, 2001</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="38"></count><count type="linksCrossRef" number="9"></count></countGroup><titleGroup><title type="main">Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>A.D.J.</givenNames><familyName>Watson</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>Hervé P.</givenNames><familyName>Lefebvre</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a2"><personName><givenNames>Didier</givenNames><familyName>Concordet</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a2"><personName><givenNames>Valérie</givenNames><familyName>Laroute</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>Jean‐Pierre</givenNames><familyName>Ferré</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Jean‐Pierre</givenNames><familyName>Braun</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a2"><personName><givenNames>Fabrice</givenNames><familyName>Conchou</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a2"><personName><givenNames>Pierre‐Louis</givenNames><familyName>Toutain</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="AU"><unparsedAffiliation>Veterinary Medicine, The University of Sydney, Australia</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Glomerular fitration rate</keyword><keyword xml:id="k2">Inulin</keyword><keyword xml:id="k3">Iothalamate</keyword><keyword xml:id="k4">Pharmacokinetics</keyword><keyword xml:id="k5">Urine</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of <sup>14</sup>C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (<i>P</i> < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (<i>P</i> < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="n-fnt-1" numbered="no"><p>Part of this study was presented at the 16th annual ACVIM Forum in San Diego, CA, May 22–25, 1998.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy</title></titleInfo><name type="personal"><namePart type="given">A.D.J.</namePart><namePart type="family">Watson</namePart><affiliation>Veterinary Medicine, The University of Sydney, Australia</affiliation><affiliation>E-mail: adjw@vetc.usyd.edu.au.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hervé P.</namePart><namePart type="family">Lefebvre</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Didier</namePart><namePart type="family">Concordet</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Valérie</namePart><namePart type="family">Laroute</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Pierre</namePart><namePart type="family">Ferré</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐Pierre</namePart><namePart type="family">Braun</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrice</namePart><namePart type="family">Conchou</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre‐Louis</namePart><namePart type="family">Toutain</namePart><affiliation>URA INRA Physiopathologie et Toxicologie Expéri‐mentales, Ecole Nationale Vétérinaire, Toulouse, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2002-01</dateIssued><edition>Revised May 3, 2001; Accepted July 26, 2001</edition><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">38</extent><extent unit="linksCrossRef">9</extent></physicalDescription><abstract lang="en">Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. 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