Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy
Identifieur interne : 001A69 ( Istex/Corpus ); précédent : 001A68; suivant : 001A70Plasma Exogenous Creatinine Clearance Test in Dogs: Comparison with Other Methods and Proposed Limited Sampling Strategy
Auteurs : A. D. J. Watson ; Hervé P. Lefebvre ; Didier Concordet ; Valérie Laroute ; Jean-Pierre Ferré ; Jean-Pierre Braun ; Fabrice Conchou ; Pierre-Louis ToutainSource :
- Journal of Veterinary Internal Medicine [ 0891-6640 ] ; 2002-01.
English descriptors
- KwdEn :
- Basal, Beagle, Bolus, Bolus administration, Clearance, Compartmental, Creatine, Creatinine, Creatinine clearance, Endogenous, Endogenous creatinine, Exogenous, Exogenous creatinine, Healthy dogs, Impairment, Inulin, Iothalamate, Lefebvre, Linearity, Linearity study, Ltration, Ltration rate, Nominal dosage, Noncompartmental, Pharmacokinetic, Pharmacokinetic analysis, Plasma, Plasma clearance, Plasma concentration, Plasma creatinine, Plasma creatinine clearance, Plasma creatinine clearance test, Plasma creatinine clearances, Plasma creatinine concentration, Plasma inulin clearance, Plasma iothalamate clearance, Renal, Renal failure, Renal function, Tricompartmental, Urine, Urine clearance, Urine clearances, Urine inulin clearance.
- Teeft :
- Basal, Beagle, Bolus, Bolus administration, Clearance, Compartmental, Creatine, Creatinine, Creatinine clearance, Endogenous, Endogenous creatinine, Exogenous, Exogenous creatinine, Healthy dogs, Impairment, Inulin, Iothalamate, Lefebvre, Linearity, Linearity study, Ltration, Ltration rate, Nominal dosage, Noncompartmental, Pharmacokinetic, Pharmacokinetic analysis, Plasma, Plasma clearance, Plasma concentration, Plasma creatinine, Plasma creatinine clearance, Plasma creatinine clearance test, Plasma creatinine clearances, Plasma creatinine concentration, Plasma inulin clearance, Plasma iothalamate clearance, Renal, Renal failure, Renal function, Tricompartmental, Urine, Urine clearance, Urine clearances, Urine inulin clearance.
Abstract
Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.
Url:
DOI: 10.1111/j.1939-1676.2002.tb01603.x
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P < .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P < .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</div>
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<abstract>Plasma clearance of creatinine was evaluated for assessment of glomerular nitration rate (GFR) in dogs. In 6 healthy dogs (Experiment 1), we determined 24‐hour urine clearance of endogenous creatinine, plasma, and urine clearances of exogenous creatinine administered at 40, 80, and 160 mg/kg in a crossover design (linearity study), plasma iothalamate clearance, and plasma and urine clearances of 14C‐inulin. In Experiment 2, plasma creatinine and iothalamate clearances were compared, and a linearity study was performed as for Experiment 1 in 6 dogs with surgically induced renal impairment. Experiment 3 compared plasma creatinine clearance with plasma iothalamate clearance before and 3 weeks after induction of moderate renal impairment in 6 dogs. Plasma creatinine clearances were calculated by both noncompartmental and compartmental analyses. In Experiment 1, plasma inulin clearance was higher (P > .001) than other clearance values. Plasma creatinine clearances at the 3 dose rates did not differ from urine inulin clearance and each other. In Experiment 2, plasma creatinine clearances were about 14% lower than plasma iothalamate clearance (P > .05). In Experiment 3, decreases in GFR assessed by plasma clearances of iothalamate and creatinine were similar. Renal failure decreased the daily endogenous input rate of creatinine by 25%. Limiting sampling strategies for optimizing GFR calculation were proposed, allowing an error lower than 6.5% with 4 blood samples. These results suggest that determination of plasma creatinine clearance by a noncompartmental approach offers a reliable, inexpensive, rapid, and convenient means of estimating GFR in routine practice.</abstract>
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