Alpha‐synuclein repeat variants and survival in Parkinson's disease
Identifieur interne : 001869 ( Istex/Corpus ); précédent : 001868; suivant : 001870Alpha‐synuclein repeat variants and survival in Parkinson's disease
Auteurs : Sun Ju Chung ; Joanna M. Biernacka ; Sebastian M. Armasu ; Kari Anderson ; Roberta Frigerio ; Jan O. Aasly ; Grazia Annesi ; Anna Rita Bentivoglio ; Laura Brighina ; Marie-Christine Chartier-Harlin ; Stefano Goldwurm ; Georgios Hadjigeorgiou ; Barbara Jasinska-Myga ; Beom Seok Jeon ; Yun Joong Kim ; Rejko Krüger ; Suzanne Lesage ; Katerina Markopoulou ; George Mellick ; Karen E. Morrison ; Andreas Puschmann ; Eng-King Tan ; David Crosiers ; Jessie Theuns ; Christine Van Broeckhoven ; Karin Wirdefeldt ; Zbigniew K. Wszolek ; Alexis Elbaz ; Demetrius M. MaraganoreSource :
- Movement Disorders [ 0885-3185 ] ; 2014-07.
Abstract
To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).
Url:
DOI: 10.1002/mds.25841
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Alpha‐synuclein repeat variants and survival in Parkinson's disease</title><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation><mods:affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><affiliation><mods:affiliation>Research Institute, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Department of Neurology, Catholic University, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>INSERM UMR837, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Lille Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name><affiliation><mods:affiliation>Faculty of Medicine, University of Thessalia, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><affiliation><mods:affiliation>Seoul National University Hospital, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation><mods:affiliation>Department of Neurology, Hallym University, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR, 7225, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name><affiliation><mods:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, QLD, Nathan, Australia</mods:affiliation></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name><affiliation><mods:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><mods:affiliation>Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Crosiers, David" sort="Crosiers, David" uniqKey="Crosiers D" first="David" last="Crosiers">David Crosiers</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Antwerp University Hospital, Edegem, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health, Villejuif, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Versailles St‐Quentin, UMRS, 1018, Villejuif, France</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dmaraganore@northshore.org</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/mds.25841</idno><idno type="url">https://api.istex.fr/document/82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001869</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001869</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Alpha‐synuclein repeat variants and survival in Parkinson's disease</title><author><name sortKey="Chung, Sun Ju" sort="Chung, Sun Ju" uniqKey="Chung S" first="Sun Ju" last="Chung">Sun Ju Chung</name><affiliation><mods:affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M." last="Biernacka">Joanna M. Biernacka</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Armasu, Sebastian M" sort="Armasu, Sebastian M" uniqKey="Armasu S" first="Sebastian M." last="Armasu">Sebastian M. Armasu</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Anderson, Kari" sort="Anderson, Kari" uniqKey="Anderson K" first="Kari" last="Anderson">Kari Anderson</name><affiliation><mods:affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</mods:affiliation></affiliation></author><author><name sortKey="Frigerio, Roberta" sort="Frigerio, Roberta" uniqKey="Frigerio R" first="Roberta" last="Frigerio">Roberta Frigerio</name><affiliation><mods:affiliation>Research Institute, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Annesi, Grazia" sort="Annesi, Grazia" uniqKey="Annesi G" first="Grazia" last="Annesi">Grazia Annesi</name><affiliation><mods:affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bentivoglio, Anna Rita" sort="Bentivoglio, Anna Rita" uniqKey="Bentivoglio A" first="Anna Rita" last="Bentivoglio">Anna Rita Bentivoglio</name><affiliation><mods:affiliation>Department of Neurology, Catholic University, Rome, Italy</mods:affiliation></affiliation></author><author><name sortKey="Brighina, Laura" sort="Brighina, Laura" uniqKey="Brighina L" first="Laura" last="Brighina">Laura Brighina</name><affiliation><mods:affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy</mods:affiliation></affiliation></author><author><name sortKey="Chartier Arlin, Marie Hristine" sort="Chartier Arlin, Marie Hristine" uniqKey="Chartier Arlin M" first="Marie-Christine" last="Chartier-Harlin">Marie-Christine Chartier-Harlin</name><affiliation><mods:affiliation>INSERM UMR837, Lille, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Lille Nord de France, Lille, France</mods:affiliation></affiliation></author><author><name sortKey="Goldwurm, Stefano" sort="Goldwurm, Stefano" uniqKey="Goldwurm S" first="Stefano" last="Goldwurm">Stefano Goldwurm</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios" sort="Hadjigeorgiou, Georgios" uniqKey="Hadjigeorgiou G" first="Georgios" last="Hadjigeorgiou">Georgios Hadjigeorgiou</name><affiliation><mods:affiliation>Faculty of Medicine, University of Thessalia, Larissa, Greece</mods:affiliation></affiliation></author><author><name sortKey="Jasinska Yga, Barbara" sort="Jasinska Yga, Barbara" uniqKey="Jasinska Yga B" first="Barbara" last="Jasinska-Myga">Barbara Jasinska-Myga</name><affiliation><mods:affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Jeon, Beom Seok" sort="Jeon, Beom Seok" uniqKey="Jeon B" first="Beom Seok" last="Jeon">Beom Seok Jeon</name><affiliation><mods:affiliation>Seoul National University Hospital, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kim, Yun Joong" sort="Kim, Yun Joong" uniqKey="Kim Y" first="Yun Joong" last="Kim">Yun Joong Kim</name><affiliation><mods:affiliation>Department of Neurology, Hallym University, Seoul, Korea</mods:affiliation></affiliation></author><author><name sortKey="Kruger, Rejko" sort="Kruger, Rejko" uniqKey="Kruger R" first="Rejko" last="Krüger">Rejko Krüger</name><affiliation><mods:affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, Tübingen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name><affiliation><mods:affiliation>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR, 7225, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Markopoulou, Katerina" sort="Markopoulou, Katerina" uniqKey="Markopoulou K" first="Katerina" last="Markopoulou">Katerina Markopoulou</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation></author><author><name sortKey="Mellick, George" sort="Mellick, George" uniqKey="Mellick G" first="George" last="Mellick">George Mellick</name><affiliation><mods:affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, QLD, Nathan, Australia</mods:affiliation></affiliation></author><author><name sortKey="Morrison, Karen E" sort="Morrison, Karen E" uniqKey="Morrison K" first="Karen E." last="Morrison">Karen E. Morrison</name><affiliation><mods:affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Puschmann, Andreas" sort="Puschmann, Andreas" uniqKey="Puschmann A" first="Andreas" last="Puschmann">Andreas Puschmann</name><affiliation><mods:affiliation>Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><affiliation><mods:affiliation>Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</mods:affiliation></affiliation></author><author><name sortKey="Crosiers, David" sort="Crosiers, David" uniqKey="Crosiers D" first="David" last="Crosiers">David Crosiers</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Antwerp University Hospital, Edegem, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Theuns, Jessie" sort="Theuns, Jessie" uniqKey="Theuns J" first="Jessie" last="Theuns">Jessie Theuns</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Van Broeckhoven, Christine" sort="Van Broeckhoven, Christine" uniqKey="Van Broeckhoven C" first="Christine" last="Van Broeckhoven">Christine Van Broeckhoven</name><affiliation><mods:affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Wirdefeldt, Karin" sort="Wirdefeldt, Karin" uniqKey="Wirdefeldt K" first="Karin" last="Wirdefeldt">Karin Wirdefeldt</name><affiliation><mods:affiliation>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</mods:affiliation></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation><mods:affiliation>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health, Villejuif, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Université Versailles St‐Quentin, UMRS, 1018, Villejuif, France</mods:affiliation></affiliation></author><author><name sortKey="Maraganore, Demetrius M" sort="Maraganore, Demetrius M" uniqKey="Maraganore D" first="Demetrius M." last="Maraganore">Demetrius M. Maraganore</name><affiliation><mods:affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: dmaraganore@northshore.org</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Movement Disorders</title><title level="j" type="alt">MOVEMENT DISORDERS</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1053">1053</biblScope><biblScope unit="page" to="1057">1057</biblScope><biblScope unit="page-count">6</biblScope><date type="published" when="2014-07">2014-07</date></imprint><idno type="ISSN">0885-3185</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Sun Ju Chung MD, PhD</name><affiliations><json:string>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Joanna M. Biernacka PhD</name><affiliations><json:string>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</json:string></affiliations></json:item><json:item><name>Sebastian M. Armasu MS</name><affiliations><json:string>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</json:string></affiliations></json:item><json:item><name>Kari Anderson MS</name><affiliations><json:string>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</json:string></affiliations></json:item><json:item><name>Roberta Frigerio MD</name><affiliations><json:string>Research Institute, NorthShore University HealthSystem, Illinois, Evanston, USA</json:string></affiliations></json:item><json:item><name>Jan O. Aasly MD</name><affiliations><json:string>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>Grazia Annesi PhD</name><affiliations><json:string>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Italy</json:string></affiliations></json:item><json:item><name>Anna Rita Bentivoglio MD, PhD</name><affiliations><json:string>Department of Neurology, Catholic University, Rome, Italy</json:string></affiliations></json:item><json:item><name>Laura Brighina MD, PhD</name><affiliations><json:string>Department of Neurology, San Gerardo Hospital, Monza, Italy</json:string></affiliations></json:item><json:item><name>Marie‐Christine Chartier‐Harlin PhD</name><affiliations><json:string>INSERM UMR837, Lille, France</json:string><json:string>Université Lille Nord de France, Lille, France</json:string></affiliations></json:item><json:item><name>Stefano Goldwurm MD</name><affiliations><json:string>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Georgios Hadjigeorgiou MD</name><affiliations><json:string>Faculty of Medicine, University of Thessalia, Larissa, Greece</json:string></affiliations></json:item><json:item><name>Barbara Jasinska‐Myga MD, PhD</name><affiliations><json:string>Department of Neurology, Medical University of Silesia, Katowice, Poland</json:string><json:string>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Beom Seok Jeon MD, PhD</name><affiliations><json:string>Seoul National University Hospital, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Yun Joong Kim MD, PhD</name><affiliations><json:string>Department of Neurology, Hallym University, Seoul, Korea</json:string></affiliations></json:item><json:item><name>Rejko Krüger MD</name><affiliations><json:string>Center of Neurology and Hertie‐Institute for Clinical Brain Research, Tübingen, Germany</json:string></affiliations></json:item><json:item><name>Suzanne Lesage PhD</name><affiliations><json:string>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR, 7225, Paris, France</json:string></affiliations></json:item><json:item><name>Katerina Markopoulou MD</name><affiliations><json:string>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</json:string></affiliations></json:item><json:item><name>George Mellick PhD</name><affiliations><json:string>Eskitis Institute for Cell and Molecular Therapies, Griffith University, QLD, Nathan, Australia</json:string></affiliations></json:item><json:item><name>Karen E. Morrison DPhil</name><affiliations><json:string>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK</json:string></affiliations></json:item><json:item><name>Andreas Puschmann MD</name><affiliations><json:string>Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</json:string></affiliations></json:item><json:item><name>Eng‐King Tan MD</name><affiliations><json:string>Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</json:string></affiliations></json:item><json:item><name>David Crosiers MD</name><affiliations><json:string>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</json:string><json:string>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</json:string><json:string>Department of Neurology, Antwerp University Hospital, Edegem, Belgium</json:string></affiliations></json:item><json:item><name>Jessie Theuns PhD</name><affiliations><json:string>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</json:string><json:string>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Christine Van Broeckhoven PhD, DSc</name><affiliations><json:string>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</json:string><json:string>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Karin Wirdefeldt MD</name><affiliations><json:string>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>Zbigniew K. Wszolek MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</json:string></affiliations></json:item><json:item><name>Alexis Elbaz MD, PhD</name><affiliations><json:string>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health, Villejuif, France</json:string><json:string>Université Versailles St‐Quentin, UMRS, 1018, Villejuif, France</json:string></affiliations></json:item><json:item><name>Demetrius M. Maraganore MD</name><affiliations><json:string>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</json:string><json:string>E-mail: dmaraganore@northshore.org</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α‐synuclein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gene</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>survival</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>association</value></json:item></subject><articleId><json:string>MDS25841</json:string></articleId><arkIstex>ark:/67375/WNG-LNDG6P1N-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).</abstract><qualityIndicators><score>5.697</score><pdfWordCount>3505</pdfWordCount><pdfCharCount>24237</pdfCharCount><pdfVersion>1.6</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>612 x 809.972 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>16</abstractWordCount><abstractCharCount>127</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Alpha‐synuclein repeat variants and survival in Parkinson's disease</title><corporate><json:item><name>on behalf of the Genetic Epidemiology of Parkinson's Disease Consortium</name></json:item></corporate><genre><json:string>article</json:string></genre><host><title>Movement Disorders</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi><issn><json:string>0885-3185</json:string></issn><eissn><json:string>1531-8257</json:string></eissn><publisherId><json:string>MDS</json:string></publisherId><volume>29</volume><issue>8</issue><pages><first>1053</first><last>1057</last><total>6</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Brief Report</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-LNDG6P1N-5</json:string></ark><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1002/mds.25841</json:string></doi><id>82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Alpha‐synuclein repeat variants and survival in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2014 International Parkinson and Movement Disorder Society</licence></availability><date type="published" when="2014-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Alpha‐synuclein repeat variants and survival in Parkinson's disease</title><title level="a" type="short">α‐Synuclein and Survival in Parkinson's Disease</title><author xml:id="author-0000"><persName><forename type="first">Sun Ju</forename><surname>Chung</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Department of Neurology, Asan Medical Center</orgName><orgName>University of Ulsan College of Medicine</orgName><address><settlement type="city">Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Joanna M.</forename><surname>Biernacka</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>Department of Health Sciences Research</orgName><orgName>Mayo Clinic</orgName><address><settlement type="city">Rochester</settlement><region>Minnesota</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Sebastian M.</forename><surname>Armasu</surname><roleName type="degree">MS</roleName></persName><affiliation><orgName>Department of Health Sciences Research</orgName><orgName>Mayo Clinic</orgName><address><settlement type="city">Rochester</settlement><region>Minnesota</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Kari</forename><surname>Anderson</surname><roleName type="degree">MS</roleName></persName><affiliation><orgName>Department of Health Sciences Research</orgName><orgName>Mayo Clinic</orgName><address><settlement type="city">Rochester</settlement><region>Minnesota</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Roberta</forename><surname>Frigerio</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Research Institute, NorthShore University HealthSystem</orgName><address><settlement type="city">Evanston</settlement><region>Illinois</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Jan O.</forename><surname>Aasly</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>St. Olav's Hospital</orgName><address><settlement type="city">Trondheim</settlement><country key="NO">Norway</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Grazia</forename><surname>Annesi</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</orgName><address><country key="IT">Italy</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Anna Rita</forename><surname>Bentivoglio</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>Catholic University</orgName><address><settlement type="city">Rome</settlement><country key="IT">Italy</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Laura</forename><surname>Brighina</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>San Gerardo Hospital</orgName><address><settlement type="city">Monza</settlement><country key="IT">Italy</country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Marie‐Christine</forename><surname>Chartier‐Harlin</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>INSERM UMR837</orgName><address><settlement type="city">Lille</settlement><country key="FR">France</country></address></affiliation><affiliation><orgName>Université Lille Nord de France</orgName><address><settlement type="city">Lille</settlement><country key="FR">France</country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Stefano</forename><surname>Goldwurm</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Parkinson Institute, Istituti Clinici di Perfezionamento</orgName><address><settlement type="city">Milan</settlement><country key="IT">Italy</country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Georgios</forename><surname>Hadjigeorgiou</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Faculty of Medicine</orgName><orgName>University of Thessalia</orgName><address><settlement type="city">Larissa</settlement><country key="GR">Greece</country></address></affiliation></author><author xml:id="author-0012"><persName><forename type="first">Barbara</forename><surname>Jasinska‐Myga</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>Medical University of Silesia</orgName><address><settlement type="city">Katowice</settlement><country key="PL">Poland</country></address></affiliation><affiliation><orgName>Department of Neurology</orgName><orgName>Mayo Clinic, Jacksonville</orgName><address><settlement type="city">Florida</settlement><country key="US">USA</country></address></affiliation></author><author xml:id="author-0013"><persName><forename type="first">Beom Seok</forename><surname>Jeon</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Seoul National University Hospital</orgName><address><settlement type="city">Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0014"><persName><forename type="first">Yun Joong</forename><surname>Kim</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>Hallym University</orgName><address><settlement type="city">Seoul</settlement><country>Korea</country></address></affiliation></author><author xml:id="author-0015"><persName><forename type="first">Rejko</forename><surname>Krüger</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Center of Neurology and Hertie‐Institute for Clinical Brain Research</orgName><address><settlement type="city">Tübingen</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0016"><persName><forename type="first">Suzanne</forename><surname>Lesage</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR</orgName><address><settlement type="city">Paris</settlement><postCode>7225</postCode><country key="FR">France</country></address></affiliation></author><author xml:id="author-0017"><persName><forename type="first">Katerina</forename><surname>Markopoulou</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>NorthShore University HealthSystem</orgName><address><settlement type="city">Evanston</settlement><region>Illinois</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0018"><persName><forename type="first">George</forename><surname>Mellick</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>Eskitis Institute for Cell and Molecular Therapies, Griffith University</orgName><address><settlement type="city">Nathan</settlement><region>QLD</region><country key="AU">Australia</country></address></affiliation></author><author xml:id="author-0019"><persName><forename type="first">Karen E.</forename><surname>Morrison</surname><roleName type="degree">DPhil</roleName></persName><affiliation><orgName>School of Clinical and Experimental Medicine</orgName><orgName>College of Medical and Dental Sciences, University of Birmingham</orgName><address><settlement type="city">Birmingham</settlement><country key="GB">UK</country></address></affiliation></author><author xml:id="author-0020"><persName><forename type="first">Andreas</forename><surname>Puschmann</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Section of Neurology, Department of Clinical Sciences</orgName><orgName>Lund University</orgName><address><settlement type="city">Lund</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0021"><persName><forename type="first">Eng‐King</forename><surname>Tan</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Singapore General Hospital, National Neuroscience Institute</orgName><address><settlement type="city">Singapore</settlement><country key="SG">Singapore</country></address></affiliation></author><author xml:id="author-0022"><persName><forename type="first">David</forename><surname>Crosiers</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics</orgName><orgName>VIB</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation><affiliation><orgName>Institute Born‐Bunge, University of Antwerp</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation><affiliation><orgName>Department of Neurology</orgName><orgName>Antwerp University Hospital</orgName><address><settlement type="city">Edegem</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0023"><persName><forename type="first">Jessie</forename><surname>Theuns</surname><roleName type="degree">PhD</roleName></persName><affiliation><orgName>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics</orgName><orgName>VIB</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation><affiliation><orgName>Institute Born‐Bunge, University of Antwerp</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0024"><persName><forename type="first">Christine</forename><surname>Broeckhoven</surname><roleName type="degree">PhD, DSc</roleName></persName><affiliation><orgName>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics</orgName><orgName>VIB</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation><affiliation><orgName>Institute Born‐Bunge, University of Antwerp</orgName><address><settlement type="city">Antwerp</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0025"><persName><forename type="first">Karin</forename><surname>Wirdefeldt</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience</orgName><orgName>Karolinska Institutet</orgName><address><settlement type="city">Stockholm</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0026"><persName><forename type="first">Zbigniew K.</forename><surname>Wszolek</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>Mayo Clinic</orgName><address><settlement type="city">Jacksonville</settlement><region>Florida</region><country key="US">USA</country></address></affiliation></author><author xml:id="author-0027"><persName><forename type="first">Alexis</forename><surname>Elbaz</surname><roleName type="degree">MD, PhD</roleName></persName><affiliation><orgName>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health</orgName><address><settlement type="city">Villejuif</settlement><country key="FR">France</country></address></affiliation><affiliation><orgName>Université Versailles St‐Quentin, UMRS</orgName><address><settlement type="city">Villejuif</settlement><postCode>1018</postCode><country key="FR">France</country></address></affiliation></author><author xml:id="author-0028" role="corresp"><persName><forename type="first">Demetrius M.</forename><surname>Maraganore</surname><roleName type="degree">MD</roleName></persName><affiliation><orgName>Department of Neurology</orgName><orgName>NorthShore University HealthSystem</orgName><address><settlement type="city">Evanston</settlement><region>Illinois</region><country key="US">USA</country></address></affiliation><affiliation>Correspondence to: Dr. Demetrius M. Maraganore, Ruth Cain Ruggles Chairman, Department of Neurology, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, IL 60201, USA; dmaraganore@northshore.org</affiliation></author><author xml:id="author-0029"><author><orgName>on behalf of the Genetic Epidemiology of Parkinson's Disease Consortium</orgName></author></author><idno type="istex">82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8</idno><idno type="ark">ark:/67375/WNG-LNDG6P1N-5</idno><idno type="DOI">10.1002/mds.25841</idno><idno type="unit">MDS25841</idno><idno type="toTypesetVersion">file:MDS.MDS25841.pdf</idno></analytic><monogr><title level="j" type="main">Movement Disorders</title><title level="j" type="alt">MOVEMENT DISORDERS</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="book-DOI">10.1002/(ISSN)1531-8257</idno><idno type="book-part-DOI">10.1002/mds.v29.8</idno><idno type="product">MDS</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1053">1053</biblScope><biblScope unit="page" to="1057">1057</biblScope><biblScope unit="page-count">6</biblScope><date type="published" when="2014-07"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main"><head>ABSTRACT</head>
Objectives
<p>To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).</p>
Methods
<p>Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow‐up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p>
Results
<p>Twenty‐one sites contributed data for 6,154 cases. There was no significant association between α‐synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01‐1.10; <hi rend="italic">P</hi> value = 0.01).</p>
Conclusions
<p>In our large consortium study, α‐synuclein REP1 genotypes were not associated with survival in PD. Further studies of α‐synuclein's role in disease progression and long‐term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society</p></abstract><textClass><keywords><term xml:id="mds25841-kwd-0001">Parkinson's disease</term><term xml:id="mds25841-kwd-0002">α‐synuclein</term><term xml:id="mds25841-kwd-0003">gene</term><term xml:id="mds25841-kwd-0004">survival</term><term xml:id="mds25841-kwd-0005">association</term></keywords><keywords rend="articleCategory"><term>Brief Report</term></keywords><keywords rend="tocHeading1"><term>Brief Reports</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="mds25841"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi>10.1002/mds.v29.8</doi><copyright ownership="thirdParty">© 2014 International Parkinson and Movement Disorder Society</copyright><numberingGroup><numbering type="journalVolume" number="29">29</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2014-07">July 2014</coverDate></publicationMeta><publicationMeta level="unit" position="150" type="article" status="forIssue"><doi>10.1002/mds.25841</doi><idGroup><id type="unit" value="MDS25841"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">© 2014 International Parkinson and Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2013-08-09"></event><event type="manuscriptRevised" date="2014-01-15"></event><event type="manuscriptAccepted" date="2014-01-20"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.5 mode:FullText" date="2014-09-23"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-02-27"></event><event type="publishedOnlineFinalForm" date="2014-07-17"></event><event type="firstOnline" date="2014-02-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">1053</numbering><numbering type="pageLast">1057</numbering></numberingGroup><correspondenceTo><b>Correspondence to:</b> Dr. Demetrius M. Maraganore, Ruth Cain Ruggles Chairman, Department of Neurology, NorthShore University HealthSystem, 2650 Ridge Avenue, Evanston, IL 60201, USA; <email>dmaraganore@northshore.org</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS25841.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Alpha‐synuclein repeat variants and survival in Parkinson's disease</title><title type="short">α‐Synuclein and Survival in Parkinson's Disease</title><title type="shortAuthors">Chung et al</title></titleGroup><creators><creator affiliationRef="#mds25841-aff-0001" creatorRole="author" xml:id="mds25841-cr-0001"><personName><givenNames>Sun Ju</givenNames><familyName>Chung</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0002" creatorRole="author" xml:id="mds25841-cr-0002"><personName><givenNames>Joanna 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xml:id="mds25841-cr-0011"><personName><givenNames>Stefano</givenNames><familyName>Goldwurm</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0011" creatorRole="author" xml:id="mds25841-cr-0012"><personName><givenNames>Georgios</givenNames><familyName>Hadjigeorgiou</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0012 #mds25841-aff-0013" creatorRole="author" xml:id="mds25841-cr-0013"><personName><givenNames>Barbara</givenNames><familyName>Jasinska‐Myga</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0014" creatorRole="author" xml:id="mds25841-cr-0014"><personName><givenNames>Beom Seok</givenNames><familyName>Jeon</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0015" creatorRole="author" xml:id="mds25841-cr-0015"><personName><givenNames>Yun Joong</givenNames><familyName>Kim</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0016" creatorRole="author" xml:id="mds25841-cr-0016"><personName><givenNames>Rejko</givenNames><familyName>Krüger</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0017" creatorRole="author" xml:id="mds25841-cr-0017"><personName><givenNames>Suzanne</givenNames><familyName>Lesage</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0018" creatorRole="author" xml:id="mds25841-cr-0018"><personName><givenNames>Katerina</givenNames><familyName>Markopoulou</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0019" creatorRole="author" xml:id="mds25841-cr-0019"><personName><givenNames>George</givenNames><familyName>Mellick</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0020" creatorRole="author" xml:id="mds25841-cr-0020"><personName><givenNames>Karen E.</givenNames><familyName>Morrison</familyName><degrees>DPhil</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0021" creatorRole="author" xml:id="mds25841-cr-0021"><personName><givenNames>Andreas</givenNames><familyName>Puschmann</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0022" creatorRole="author" xml:id="mds25841-cr-0022"><personName><givenNames>Eng‐King</givenNames><familyName>Tan</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0023 #mds25841-aff-0024 #mds25841-aff-0025" creatorRole="author" xml:id="mds25841-cr-0023"><personName><givenNames>David</givenNames><familyName>Crosiers</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0023 #mds25841-aff-0024" creatorRole="author" xml:id="mds25841-cr-0024"><personName><givenNames>Jessie</givenNames><familyName>Theuns</familyName><degrees>PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0023 #mds25841-aff-0024" creatorRole="author" xml:id="mds25841-cr-0025"><personName><givenNames>Christine</givenNames><familyNamePrefix>Van</familyNamePrefix><familyName>Broeckhoven</familyName><degrees>PhD, DSc</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0026" creatorRole="author" xml:id="mds25841-cr-0026"><personName><givenNames>Karin</givenNames><familyName>Wirdefeldt</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0027" creatorRole="author" xml:id="mds25841-cr-0027"><personName><givenNames>Zbigniew K.</givenNames><familyName>Wszolek</familyName><degrees>MD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0028 #mds25841-aff-0029" creatorRole="author" xml:id="mds25841-cr-0028"><personName><givenNames>Alexis</givenNames><familyName>Elbaz</familyName><degrees>MD, PhD</degrees></personName></creator><creator affiliationRef="#mds25841-aff-0018" corresponding="yes" creatorRole="author" xml:id="mds25841-cr-0029"><personName><givenNames>Demetrius M.</givenNames><familyName>Maraganore</familyName><degrees>MD</degrees></personName></creator><creator creatorRole="author" xml:id="mds25841-cr-0030"><groupName>on behalf of the Genetic Epidemiology of Parkinson's Disease Consortium</groupName></creator></creators><affiliationGroup><affiliation type="organization" xml:id="mds25841-aff-0001"><orgDiv>Department of Neurology, Asan Medical Center</orgDiv><orgName>University of Ulsan College of Medicine</orgName><address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25841-aff-0002"><orgDiv>Department of Health Sciences Research</orgDiv><orgName>Mayo Clinic</orgName><address><city>Rochester</city><countryPart>Minnesota</countryPart><country>USA</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25841-aff-0003"><orgName>Research Institute, NorthShore University HealthSystem</orgName><address><city>Evanston</city><countryPart>Illinois</countryPart><country>USA</country></address></affiliation><affiliation countryCode="NO" type="organization" xml:id="mds25841-aff-0004"><orgName>St. Olav's Hospital</orgName><orgDiv>Department of Neurology</orgDiv><address><city>Trondheim</city><country>Norway</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="mds25841-aff-0005"><orgName>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone</orgName><address><country>Italy</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="mds25841-aff-0006"><orgDiv>Department of Neurology</orgDiv><orgName>Catholic University</orgName><address><city>Rome</city><country>Italy</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="mds25841-aff-0007"><orgDiv>Department of Neurology</orgDiv><orgName>San Gerardo Hospital</orgName><address><city>Monza</city><country>Italy</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="mds25841-aff-0008"><orgName>INSERM UMR837</orgName><address><city>Lille</city><country>France</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="mds25841-aff-0009"><orgName>Université Lille Nord de France</orgName><address><city>Lille</city><country>France</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="mds25841-aff-0010"><orgName>Parkinson Institute, Istituti Clinici di Perfezionamento</orgName><address><city>Milan</city><country>Italy</country></address></affiliation><affiliation countryCode="GR" type="organization" xml:id="mds25841-aff-0011"><orgDiv>Faculty of Medicine</orgDiv><orgName>University of Thessalia</orgName><address><city>Larissa</city><country>Greece</country></address></affiliation><affiliation countryCode="PL" type="organization" xml:id="mds25841-aff-0012"><orgDiv>Department of Neurology</orgDiv><orgName>Medical University of Silesia</orgName><address><city>Katowice</city><country>Poland</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25841-aff-0013"><orgDiv>Department of Neurology</orgDiv><orgName>Mayo Clinic, Jacksonville</orgName><address><city>Florida</city><country>USA</country></address></affiliation><affiliation type="organization" xml:id="mds25841-aff-0014"><orgName>Seoul National University Hospital</orgName><address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation type="organization" xml:id="mds25841-aff-0015"><orgDiv>Department of Neurology</orgDiv><orgName>Hallym University</orgName><address><city>Seoul</city><country>Korea</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="mds25841-aff-0016"><orgName>Center of Neurology and Hertie‐Institute for Clinical Brain Research</orgName><address><city>Tübingen</city><country>Germany</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="mds25841-aff-0017"><orgName>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR</orgName><address><postCode>7225</postCode><city>Paris</city><country>France</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25841-aff-0018"><orgDiv>Department of Neurology</orgDiv><orgName>NorthShore University HealthSystem</orgName><address><city>Evanston</city><countryPart>Illinois</countryPart><country>USA</country></address></affiliation><affiliation countryCode="AU" type="organization" xml:id="mds25841-aff-0019"><orgName>Eskitis Institute for Cell and Molecular Therapies, Griffith University</orgName><address><city>Nathan</city><countryPart>QLD</countryPart><country>Australia</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="mds25841-aff-0020"><orgDiv>School of Clinical and Experimental Medicine</orgDiv><orgName>College of Medical and Dental Sciences, University of Birmingham</orgName><address><city>Birmingham</city><country>UK</country></address></affiliation><affiliation countryCode="SE" type="organization" xml:id="mds25841-aff-0021"><orgDiv>Section of Neurology, Department of Clinical Sciences</orgDiv><orgName>Lund University</orgName><address><city>Lund</city><country>Sweden</country></address></affiliation><affiliation countryCode="SG" type="organization" xml:id="mds25841-aff-0022"><orgName>Singapore General Hospital, National Neuroscience Institute</orgName><address><city>Singapore</city><country>Singapore</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="mds25841-aff-0023"><orgDiv>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics</orgDiv><orgName>VIB</orgName><address><city>Antwerp</city><country>Belgium</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="mds25841-aff-0024"><orgName>Institute Born‐Bunge, University of Antwerp</orgName><address><city>Antwerp</city><country>Belgium</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="mds25841-aff-0025"><orgDiv>Department of Neurology</orgDiv><orgName>Antwerp University Hospital</orgName><address><city>Edegem</city><country>Belgium</country></address></affiliation><affiliation countryCode="SE" type="organization" xml:id="mds25841-aff-0026"><orgDiv>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience</orgDiv><orgName>Karolinska Institutet</orgName><address><city>Stockholm</city><country>Sweden</country></address></affiliation><affiliation countryCode="US" type="organization" xml:id="mds25841-aff-0027"><orgDiv>Department of Neurology</orgDiv><orgName>Mayo Clinic</orgName><address><city>Jacksonville</city><countryPart>Florida</countryPart><country>USA</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="mds25841-aff-0028"><orgName>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health</orgName><address><city>Villejuif</city><country>France</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="mds25841-aff-0029"><orgName>Université Versailles St‐Quentin, UMRS</orgName><address><postCode>1018</postCode><city>Villejuif</city><country>France</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="mds25841-kwd-0001">Parkinson's disease</keyword><keyword xml:id="mds25841-kwd-0002">α‐synuclein</keyword><keyword xml:id="mds25841-kwd-0003">gene</keyword><keyword xml:id="mds25841-kwd-0004">survival</keyword><keyword xml:id="mds25841-kwd-0005">association</keyword></keywordGroup><supportingInformation><p>Additional supporting information may be found in the online version of this article at the publisher's web‐site.</p><supportingInfoItem><mediaResource alt="application/pdf" href="urn-x:wiley:08853185:media:mds25841:mds25841-sup-0001-suppinfo"></mediaResource><caption>Supplementary Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main"><title type="main">ABSTRACT</title><section xml:id="mds25841-sec-0001"><title type="main">Objectives</title><p>To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).</p></section><section xml:id="mds25841-sec-0002"><title type="main">Methods</title><p>Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow‐up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</p></section><section xml:id="mds25841-sec-0003"><title type="main">Results</title><p>Twenty‐one sites contributed data for 6,154 cases. There was no significant association between α‐synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01‐1.10; <i>P</i> value = 0.01).</p></section><section xml:id="mds25841-sec-0004"><title type="main">Conclusions</title><p>In our large consortium study, α‐synuclein REP1 genotypes were not associated with survival in PD. Further studies of α‐synuclein's role in disease progression and long‐term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="mds25841-note-0001"><p><b>Funding agencies:</b> The Goldwurm site acknowledges the funding support of the Italian Telethon Foundation (grant no.: GTB07001) and the “Fondazione Grigioni per il Morbo di Parkinson.” The Maraganore site acknowledges the funding support of the National Institutes of Health (R01 ES10751). The Morrison site acknowledges the funding support of the Medical Research Council UK, Midlands Neuroscience Teaching and Research Fund, and Queen Elizabeth Hospital Birmingham Charity. The Theuns/Van Broeckhoven site acknowledges the funding support of the Interuniversity Attraction Poles program of the Belgian Science Policy Office, the Foundation for Alzheimer Research, the Belgian Parkinson Foundation, the Methusalem Excellence Program of the Flemish Government, the Research Foundation Flanders, the Agency for Innovation by Science and Technology Flanders, and the Special Research Fund of the University of Antwerp, Antwerp, Belgium. The Wszolek site acknowledges the funding support of the National Institutes of Health (P50 NS072187) and the Mayo Clinic Florida Research Committee CR program.</p></note><note xml:id="mds25841-note-0002"><p><b>Relevant conflicts of interest/financial disclosures:</b> Demetrius M. Maraganore, MD has licensed an invention to Alnylam Pharmaceuticals, Inc. regarding a method to treat Parkinson's disease. He has received less than $25,000 in royalties. The remaining authors have nothing to declare.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Alpha‐synuclein repeat variants and survival in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>α‐Synuclein and Survival in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Alpha‐synuclein repeat variants and survival in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Sun Ju</namePart><namePart type="family">Chung</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Joanna M.</namePart><namePart type="family">Biernacka</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sebastian M.</namePart><namePart type="family">Armasu</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kari</namePart><namePart type="family">Anderson</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Health Sciences Research, Mayo Clinic, Minnesota, Rochester, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberta</namePart><namePart type="family">Frigerio</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Research Institute, NorthShore University HealthSystem, Illinois, Evanston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan O.</namePart><namePart type="family">Aasly</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Grazia</namePart><namePart type="family">Annesi</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anna Rita</namePart><namePart type="family">Bentivoglio</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Catholic University, Rome, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Laura</namePart><namePart type="family">Brighina</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, San Gerardo Hospital, Monza, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Christine</namePart><namePart type="family">Chartier‐Harlin</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>INSERM UMR837, Lille, France</affiliation><affiliation>Université Lille Nord de France, Lille, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefano</namePart><namePart type="family">Goldwurm</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georgios</namePart><namePart type="family">Hadjigeorgiou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Faculty of Medicine, University of Thessalia, Larissa, Greece</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara</namePart><namePart type="family">Jasinska‐Myga</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Medical University of Silesia, Katowice, Poland</affiliation><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Beom Seok</namePart><namePart type="family">Jeon</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Seoul National University Hospital, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yun Joong</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Hallym University, Seoul, Korea</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Rejko</namePart><namePart type="family">Krüger</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Center of Neurology and Hertie‐Institute for Clinical Brain Research, Tübingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suzanne</namePart><namePart type="family">Lesage</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Université Pierre et Marie Curie‐Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UMR‐S975; INSERM U975, CNRS, UMR, 7225, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Katerina</namePart><namePart type="family">Markopoulou</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">George</namePart><namePart type="family">Mellick</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Eskitis Institute for Cell and Molecular Therapies, Griffith University, QLD, Nathan, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karen E.</namePart><namePart type="family">Morrison</namePart><namePart type="termsOfAddress">DPhil</namePart><affiliation>School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andreas</namePart><namePart type="family">Puschmann</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eng‐King</namePart><namePart type="family">Tan</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Crosiers</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation><affiliation>Department of Neurology, Antwerp University Hospital, Edegem, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jessie</namePart><namePart type="family">Theuns</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Van Broeckhoven</namePart><namePart type="termsOfAddress">PhD, DSc</namePart><affiliation>Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium</affiliation><affiliation>Institute Born‐Bunge, University of Antwerp, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Karin</namePart><namePart type="family">Wirdefeldt</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Medical Epidemiology and Biostatistics and Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zbigniew K.</namePart><namePart type="family">Wszolek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Florida, Jacksonville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexis</namePart><namePart type="family">Elbaz</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>INSERM, Center for Research in Epidemiology and Population Health, U1018, Social and Occupational Determinants of Health, Villejuif, France</affiliation><affiliation>Université Versailles St‐Quentin, UMRS, 1018, Villejuif, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Demetrius M.</namePart><namePart type="family">Maraganore</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, NorthShore University HealthSystem, Illinois, Evanston, USA</affiliation><affiliation>E-mail: dmaraganore@northshore.org</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="corporate"><namePart>on behalf of the Genetic Epidemiology of Parkinson's Disease Consortium</namePart></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-07</dateIssued><dateCreated encoding="w3cdtf">2014-01-30</dateCreated><dateCaptured encoding="w3cdtf">2013-08-09</dateCaptured><dateValid encoding="w3cdtf">2014-01-20</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>To determine whether α‐synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).</abstract><abstract>Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow‐up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.</abstract><abstract>Twenty‐one sites contributed data for 6,154 cases. There was no significant association between α‐synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01‐1.10; P value = 0.01).</abstract><abstract>In our large consortium study, α‐synuclein REP1 genotypes were not associated with survival in PD. Further studies of α‐synuclein's role in disease progression and long‐term outcomes are needed. © 2014 International Parkinson and Movement Disorder Society</abstract><subject><genre>keywords</genre><topic>Parkinson's disease</topic><topic>α‐synuclein</topic><topic>gene</topic><topic>survival</topic><topic>association</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov Disord.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Additional supporting information may be found in the online version of this article at the publisher's web‐site.Supporting Info Item: Supplementary Information - </note><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1053</start><end>1057</end><total>6</total></extent></part></relatedItem><identifier type="istex">82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8</identifier><identifier type="ark">ark:/67375/WNG-LNDG6P1N-5</identifier><identifier type="DOI">10.1002/mds.25841</identifier><identifier type="ArticleID">MDS25841</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2014 International Parkinson and Movement Disorder Society© 2014 International Parkinson and Movement Disorder Society</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/82BAA12F32685CF8DEAC989A33F9A2E6E192BEB8/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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