The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Identifieur interne : 001486 ( Istex/Corpus ); précédent : 001485; suivant : 001487The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm
Auteurs : H. Razavi ; I. Waked ; C. Sarrazin ; R. P. Myers ; R. Idilman ; F. Calinas ; W. Vogel ; M. C. Mendes Correa ; C. Hézode ; P. Lázaro ; U. Akarca ; S. Aleman ; Bal K ; T. Berg ; F. Bihl ; M. Bilodeau ; A. J. Blasco ; C. E. Brandão Mello ; P. Bruggmann ; M. Buti ; J. L. Calleja ; H. Cheinquer ; P. B. Christensen ; M. Clausen ; H. S. M. Coelho ; M. E. Cramp ; G. J. Dore ; W. Doss ; A. S. Duberg ; M. H. El-Sayed ; G. Ergör ; G. Esmat ; K. Falconer ; J. Félix ; M. L. G. Ferraz ; P. R. Ferreira ; S. Frankova ; J. García-Samaniego ; J. Gerstoft ; J. A. Giria ; F. L. Gonçales Jr ; E. Gower ; M. Gschwantler ; M. Guimarães Pessôa ; S. J. Hindman ; H. Hofer ; P. Husa ; M. K Berg ; K. D. E. Kaita ; A. Kautz ; S. Kaymakoglu ; M. Krajden ; H. Krarup ; W. Laleman ; D. Lavanchy ; R. T. Marinho ; P. Marotta ; S. Mauss ; C. Moreno ; K. Murphy ; F. Negro ; V. Nemecek ; N. Örmeci ; A. L. H. Vrehus ; J. Parkes ; K. Pasini ; K. M. Peltekian ; A. Ramji ; N. Reis ; S. K. Roberts ; W. M. Rosenberg ; F. Roudot-Thoraval ; S. D. Ryder ; R. Sarmento-Castro ; D. Semela ; M. Sherman ; G. E. Shiha ; W. Sievert ; J. Sperl ; P. St Rkel ; R. E. Stauber ; A. J. Thompson ; P. Urbanek ; P. Van Damme ; I. Van Thiel ; H. Van Vlierberghe ; D. Vandijck ; H. Wedemeyer ; N. Weis ; J. Wiegand ; A. Yosry ; A. Zekry ; M. Cornberg ; B. Müllhaupt ; C. EstesSource :
- Journal of Viral Hepatitis [ 1352-0504 ] ; 2014-05.
Abstract
The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver‐related deaths from increasing.
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DOI: 10.1111/jvh.12248
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Waked</name><affiliation><mods:affiliation>National Liver Institute, Menoufiya, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Sarrazin, C" sort="Sarrazin, C" uniqKey="Sarrazin C" first="C." last="Sarrazin">C. Sarrazin</name><affiliation><mods:affiliation>J.W. Goethe University Hospital, Frankfurt, Germany</mods:affiliation></affiliation></author><author><name sortKey="Myers, R P" sort="Myers, R P" uniqKey="Myers R" first="R. P." last="Myers">R. P. Myers</name><affiliation><mods:affiliation>Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, AB, Calgary, Canada</mods:affiliation></affiliation></author><author><name sortKey="Idilman, R" sort="Idilman, R" uniqKey="Idilman R" first="R." last="Idilman">R. Idilman</name><affiliation><mods:affiliation>Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Calinas, F" sort="Calinas, F" uniqKey="Calinas F" first="F." last="Calinas">F. Calinas</name><affiliation><mods:affiliation>Gastroenterology Department, Centro Hospitalar de Lisboa Central – Hospital Santo António Capuchos, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Vogel, W" sort="Vogel, W" uniqKey="Vogel W" first="W." last="Vogel">W. Vogel</name><affiliation><mods:affiliation>Innsbruck Medical University, Innsbruck, Austria</mods:affiliation></affiliation></author><author><name sortKey="Mendes Correa, M C" sort="Mendes Correa, M C" uniqKey="Mendes Correa M" first="M. C." last="Mendes Correa">M. C. Mendes Correa</name><affiliation><mods:affiliation>School of Medicine‐ Universidade de São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Hezode, C" sort="Hezode, C" uniqKey="Hezode C" first="C." last="Hézode">C. Hézode</name><affiliation><mods:affiliation>Service d' Hépato‐Gastroentérologie, Hôpital Henri Mondor, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Lazaro, P" sort="Lazaro, P" uniqKey="Lazaro P" first="P." last="Lázaro">P. Lázaro</name><affiliation><mods:affiliation>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Akarca, U" sort="Akarca, U" uniqKey="Akarca U" first="U." last="Akarca">U. Akarca</name><affiliation><mods:affiliation>Gastroenterology, Ege University, Izmir, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Aleman, S" sort="Aleman, S" uniqKey="Aleman S" first="S." last="Aleman">S. Aleman</name><affiliation><mods:affiliation>Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Gastroenterology and Hepatology/Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Bal K, " sort="Bal K, " uniqKey="Bal K " first="" last="Bal K"> Bal K</name><affiliation><mods:affiliation>Infectious Diseases, Ankara University, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Berg, T" sort="Berg, T" uniqKey="Berg T" first="T." last="Berg">T. Berg</name><affiliation><mods:affiliation>University of Leipzig, Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bihl, F" sort="Bihl, F" uniqKey="Bihl F" first="F." last="Bihl">F. Bihl</name><affiliation><mods:affiliation>Gastroenterology Department, Ospedale Cantonale, Bellinzona, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Bilodeau, M" sort="Bilodeau, M" uniqKey="Bilodeau M" first="M." last="Bilodeau">M. Bilodeau</name><affiliation><mods:affiliation>Liver Unit, Department of Medicine, Université de Montréal, QC, Montréal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Blasco, A J" sort="Blasco, A J" uniqKey="Blasco A" first="A. J." last="Blasco">A. J. Blasco</name><affiliation><mods:affiliation>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Brandao Mello, C E" sort="Brandao Mello, C E" uniqKey="Brandao Mello C" first="C. E." last="Brandão Mello">C. E. Brandão Mello</name><affiliation><mods:affiliation>Department of Gastroenterology, Federal University of the State of Rio de Janeiro, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Bruggmann, P" sort="Bruggmann, P" uniqKey="Bruggmann P" first="P." last="Bruggmann">P. Bruggmann</name><affiliation><mods:affiliation>Arud Centres for Addiction Medicine, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Buti, M" sort="Buti, M" uniqKey="Buti M" first="M." last="Buti">M. Buti</name><affiliation><mods:affiliation>Hospital Vall d'Hebron, CIBERehd, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Calleja, J L" sort="Calleja, J L" uniqKey="Calleja J" first="J. L." last="Calleja">J. L. 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Clausen</name><affiliation><mods:affiliation>Region Hospital Hovedstaden, Copenhagen, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Coelho, H S M" sort="Coelho, H S M" uniqKey="Coelho H" first="H. S. M." last="Coelho">H. S. M. Coelho</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Cramp, M E" sort="Cramp, M E" uniqKey="Cramp M" first="M. E." last="Cramp">M. E. Cramp</name><affiliation><mods:affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK</mods:affiliation></affiliation></author><author><name sortKey="Dore, G J" sort="Dore, G J" uniqKey="Dore G" first="G. J." last="Dore">G. J. Dore</name><affiliation><mods:affiliation>Kirby Institute, University of New South Wales, NSW, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Doss, W" sort="Doss, W" uniqKey="Doss W" first="W." last="Doss">W. Doss</name><affiliation><mods:affiliation>Cairo University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Duberg, A S" sort="Duberg, A S" uniqKey="Duberg A" first="A. S." last="Duberg">A. S. Duberg</name><affiliation><mods:affiliation>Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Health and Medical Sciences, Örebro University, Örebro, Sweden</mods:affiliation></affiliation></author><author><name sortKey="El Ayed, M H" sort="El Ayed, M H" uniqKey="El Ayed M" first="M. H." last="El-Sayed">M. H. El-Sayed</name><affiliation><mods:affiliation>Ain Shams University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Ergor, G" sort="Ergor, G" uniqKey="Ergor G" first="G." last="Ergör">G. Ergör</name><affiliation><mods:affiliation>Public Health and Epidemiology, Dokuz Eylul University, Izmir, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Esmat, G" sort="Esmat, G" uniqKey="Esmat G" first="G." last="Esmat">G. Esmat</name><affiliation><mods:affiliation>Cairo University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Falconer, K" sort="Falconer, K" uniqKey="Falconer K" first="K." last="Falconer">K. Falconer</name><affiliation><mods:affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Felix, J" sort="Felix, J" uniqKey="Felix J" first="J." last="Félix">J. Félix</name><affiliation><mods:affiliation>Exigo Consultores, Alhos Vedros, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Ferraz, M L G" sort="Ferraz, M L G" uniqKey="Ferraz M" first="M. L. G." last="Ferraz">M. L. G. Ferraz</name><affiliation><mods:affiliation>Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ferreira, P R" sort="Ferreira, P R" uniqKey="Ferreira P" first="P. R." last="Ferreira">P. R. Ferreira</name><affiliation><mods:affiliation>Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Frankova, S" sort="Frankova, S" uniqKey="Frankova S" first="S." last="Frankova">S. Frankova</name><affiliation><mods:affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Garcia Amaniego, J" sort="Garcia Amaniego, J" uniqKey="Garcia Amaniego J" first="J." last="García-Samaniego">J. García-Samaniego</name><affiliation><mods:affiliation>Hospital Carlos III, CIBERehd, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gerstoft, J" sort="Gerstoft, J" uniqKey="Gerstoft J" first="J." last="Gerstoft">J. Gerstoft</name><affiliation><mods:affiliation>University of Copenhagen, Copenhagen, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Giria, J A" sort="Giria, J A" uniqKey="Giria J" first="J. A." last="Giria">J. A. Giria</name><affiliation><mods:affiliation>Direcção‐Geral da Saúde, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Goncales Jr, F L" sort="Goncales Jr, F L" uniqKey="Goncales Jr F" first="F. L." last="Gonçales Jr">F. L. Gonçales Jr</name><affiliation><mods:affiliation>Grupo de Estudo das Hepatites, Disciplina de Doenças Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Gower, E" sort="Gower, E" uniqKey="Gower E" first="E." last="Gower">E. Gower</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Gschwantler, M" sort="Gschwantler, M" uniqKey="Gschwantler M" first="M." last="Gschwantler">M. Gschwantler</name><affiliation><mods:affiliation>Department of Internal Medicine IV, Wilhelminenspital, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Guimaraes Pessoa, M" sort="Guimaraes Pessoa, M" uniqKey="Guimaraes Pessoa M" first="M." last="Guimarães Pessôa">M. Guimarães Pessôa</name><affiliation><mods:affiliation>Division of Gastroenterology and Hepatology, University of São Paulo School of Medicine, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Hindman, S J" sort="Hindman, S J" uniqKey="Hindman S" first="S. J." last="Hindman">S. J. 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K Berg</name><affiliation><mods:affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Kaita, K D E" sort="Kaita, K D E" uniqKey="Kaita K" first="K. D. E." last="Kaita">K. D. E. Kaita</name><affiliation><mods:affiliation>Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Viral Hepatitis Investigative Unit, Health Sciences Centre, MB, Winnipeg, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kautz, A" sort="Kautz, A" uniqKey="Kautz A" first="A." last="Kautz">A. Kautz</name><affiliation><mods:affiliation>European Liver Patients Association, Sint‐Truiden, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Kaymakoglu, S" sort="Kaymakoglu, S" uniqKey="Kaymakoglu S" first="S." last="Kaymakoglu">S. Kaymakoglu</name><affiliation><mods:affiliation>Gastroenterology, Istanbul University, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Krajden, M" sort="Krajden, M" uniqKey="Krajden M" first="M." last="Krajden">M. Krajden</name><affiliation><mods:affiliation>British Columbia Centre for Disease Control, University of British Columbia, BC, Vancouver, Canada</mods:affiliation></affiliation></author><author><name sortKey="Krarup, H" sort="Krarup, H" uniqKey="Krarup H" first="H." last="Krarup">H. Krarup</name><affiliation><mods:affiliation>Department of Medical Gastroenterology and Section of Molecular Diagnostics, Cinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Laleman, W" sort="Laleman, W" uniqKey="Laleman W" first="W." last="Laleman">W. Laleman</name><affiliation><mods:affiliation>University Hospitals Leuven, KU Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Lavanchy, D" sort="Lavanchy, D" uniqKey="Lavanchy D" first="D." last="Lavanchy">D. Lavanchy</name><affiliation><mods:affiliation>Independent Consultant, Denges, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Marinho, R T" sort="Marinho, R T" uniqKey="Marinho R" first="R. T." last="Marinho">R. T. Marinho</name><affiliation><mods:affiliation>Gastroenterology Department, Centro Hospitalar de Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Marotta, P" sort="Marotta, P" uniqKey="Marotta P" first="P." last="Marotta">P. Marotta</name><affiliation><mods:affiliation>Division of Gastroenterology, University of Western Ontario, ON, London, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mauss, S" sort="Mauss, S" uniqKey="Mauss S" first="S." last="Mauss">S. Mauss</name><affiliation><mods:affiliation>Heinrich‐Heine University in Duesseldorf, Dusseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Moreno, C" sort="Moreno, C" uniqKey="Moreno C" first="C." last="Moreno">C. Moreno</name><affiliation><mods:affiliation>Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Murphy, K" sort="Murphy, K" uniqKey="Murphy K" first="K." last="Murphy">K. Murphy</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F." last="Negro">F. Negro</name><affiliation><mods:affiliation>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Genève, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Nemecek, V" sort="Nemecek, V" uniqKey="Nemecek V" first="V." last="Nemecek">V. Nemecek</name><affiliation><mods:affiliation>National Reference Laboratory for Hepatitis, National Institute of Public Health, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Ormeci, N" sort="Ormeci, N" uniqKey="Ormeci N" first="N." last="Örmeci">N. Örmeci</name><affiliation><mods:affiliation>Gastroenterology, Ankara University, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey=" Vrehus, A L H" sort=" Vrehus, A L H" uniqKey=" Vrehus A" first="A. L. H." last=" Vrehus">A. L. H. Vrehus</name><affiliation><mods:affiliation>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Parkes, J" sort="Parkes, J" uniqKey="Parkes J" first="J." last="Parkes">J. Parkes</name><affiliation><mods:affiliation>University of Southhampton, Southhampton, UK</mods:affiliation></affiliation></author><author><name sortKey="Pasini, K" sort="Pasini, K" uniqKey="Pasini K" first="K." last="Pasini">K. Pasini</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Peltekian, K M" sort="Peltekian, K M" uniqKey="Peltekian K" first="K. M." last="Peltekian">K. M. Peltekian</name><affiliation><mods:affiliation>Departments of Medicine and Surgery, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University and Hepatology Services, NS, Halifax, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ramji, A" sort="Ramji, A" uniqKey="Ramji A" first="A." last="Ramji">A. Ramji</name><affiliation><mods:affiliation>Department of Gastroenterology, University of British Columbia, BC, Vancouver, Canada</mods:affiliation></affiliation></author><author><name sortKey="Reis, N" sort="Reis, N" uniqKey="Reis N" first="N." last="Reis">N. Reis</name><affiliation><mods:affiliation>Assembleia da República, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Roberts, S K" sort="Roberts, S K" uniqKey="Roberts S" first="S. K." last="Roberts">S. K. Roberts</name><affiliation><mods:affiliation>The Alfred Hospital and Monash University, Vic., Melbourne, Australia</mods:affiliation></affiliation></author><author><name sortKey="Rosenberg, W M" sort="Rosenberg, W M" uniqKey="Rosenberg W" first="W. M." last="Rosenberg">W. M. Rosenberg</name><affiliation><mods:affiliation>Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Roudot Horaval, F" sort="Roudot Horaval, F" uniqKey="Roudot Horaval F" first="F." last="Roudot-Thoraval">F. Roudot-Thoraval</name><affiliation><mods:affiliation>Département Santé Publique, Hôpital Henri Mondor, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Ryder, S D" sort="Ryder, S D" uniqKey="Ryder S" first="S. D." last="Ryder">S. D. Ryder</name><affiliation><mods:affiliation>Nottingham University Hospitals NHS Trust and Biomedical Research Unit, Nottingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Sarmento Astro, R" sort="Sarmento Astro, R" uniqKey="Sarmento Astro R" first="R." last="Sarmento-Castro">R. Sarmento-Castro</name><affiliation><mods:affiliation>Infectious Diseases Department, Centro Hospitalar do Porto, Porto, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Semela, D" sort="Semela, D" uniqKey="Semela D" first="D." last="Semela">D. Semela</name><affiliation><mods:affiliation>Division of Gastroenterology & Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Sherman, M" sort="Sherman, M" uniqKey="Sherman M" first="M." last="Sherman">M. Sherman</name><affiliation><mods:affiliation>Toronto General Hospital, University Health Network/University of Toronto, ON, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shiha, G E" sort="Shiha, G E" uniqKey="Shiha G" first="G. E." last="Shiha">G. E. Shiha</name><affiliation><mods:affiliation>Egyptian Liver Research Institute And Hospital, Dakahliah, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Sievert, W" sort="Sievert, W" uniqKey="Sievert W" first="W." last="Sievert">W. Sievert</name><affiliation><mods:affiliation>Monash University and Monash Health, Vic., Melbourne, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sperl, J" sort="Sperl, J" uniqKey="Sperl J" first="J." last="Sperl">J. Sperl</name><affiliation><mods:affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="St Rkel, P" sort="St Rkel, P" uniqKey="St Rkel P" first="P." last="St Rkel">P. 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Aleman</name><affiliation><mods:affiliation>Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Gastroenterology and Hepatology/Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Bal K, " sort="Bal K, " uniqKey="Bal K " first="" last="Bal K"> Bal K</name><affiliation><mods:affiliation>Infectious Diseases, Ankara University, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Berg, T" sort="Berg, T" uniqKey="Berg T" first="T." last="Berg">T. Berg</name><affiliation><mods:affiliation>University of Leipzig, Leipzig, Germany</mods:affiliation></affiliation></author><author><name sortKey="Bihl, F" sort="Bihl, F" uniqKey="Bihl F" first="F." last="Bihl">F. Bihl</name><affiliation><mods:affiliation>Gastroenterology Department, Ospedale Cantonale, Bellinzona, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Bilodeau, M" sort="Bilodeau, M" uniqKey="Bilodeau M" first="M." last="Bilodeau">M. Bilodeau</name><affiliation><mods:affiliation>Liver Unit, Department of Medicine, Université de Montréal, QC, Montréal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Blasco, A J" sort="Blasco, A J" uniqKey="Blasco A" first="A. J." last="Blasco">A. J. Blasco</name><affiliation><mods:affiliation>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Brandao Mello, C E" sort="Brandao Mello, C E" uniqKey="Brandao Mello C" first="C. E." last="Brandão Mello">C. E. Brandão Mello</name><affiliation><mods:affiliation>Department of Gastroenterology, Federal University of the State of Rio de Janeiro, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Bruggmann, P" sort="Bruggmann, P" uniqKey="Bruggmann P" first="P." last="Bruggmann">P. Bruggmann</name><affiliation><mods:affiliation>Arud Centres for Addiction Medicine, Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Buti, M" sort="Buti, M" uniqKey="Buti M" first="M." last="Buti">M. Buti</name><affiliation><mods:affiliation>Hospital Vall d'Hebron, CIBERehd, Barcelona, Spain</mods:affiliation></affiliation></author><author><name sortKey="Calleja, J L" sort="Calleja, J L" uniqKey="Calleja J" first="J. L." last="Calleja">J. L. Calleja</name><affiliation><mods:affiliation>Hospital Puerta de Hierro, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Cheinquer, H" sort="Cheinquer, H" uniqKey="Cheinquer H" first="H." last="Cheinquer">H. Cheinquer</name><affiliation><mods:affiliation>Hospital das Clínicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Christensen, P B" sort="Christensen, P B" uniqKey="Christensen P" first="P. B." last="Christensen">P. B. Christensen</name><affiliation><mods:affiliation>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Clausen, M" sort="Clausen, M" uniqKey="Clausen M" first="M." last="Clausen">M. Clausen</name><affiliation><mods:affiliation>Region Hospital Hovedstaden, Copenhagen, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Coelho, H S M" sort="Coelho, H S M" uniqKey="Coelho H" first="H. S. M." last="Coelho">H. S. M. Coelho</name><affiliation><mods:affiliation>Department of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Cramp, M E" sort="Cramp, M E" uniqKey="Cramp M" first="M. E." last="Cramp">M. E. Cramp</name><affiliation><mods:affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK</mods:affiliation></affiliation></author><author><name sortKey="Dore, G J" sort="Dore, G J" uniqKey="Dore G" first="G. J." last="Dore">G. J. Dore</name><affiliation><mods:affiliation>Kirby Institute, University of New South Wales, NSW, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Doss, W" sort="Doss, W" uniqKey="Doss W" first="W." last="Doss">W. Doss</name><affiliation><mods:affiliation>Cairo University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Duberg, A S" sort="Duberg, A S" uniqKey="Duberg A" first="A. S." last="Duberg">A. S. Duberg</name><affiliation><mods:affiliation>Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>School of Health and Medical Sciences, Örebro University, Örebro, Sweden</mods:affiliation></affiliation></author><author><name sortKey="El Ayed, M H" sort="El Ayed, M H" uniqKey="El Ayed M" first="M. H." last="El-Sayed">M. H. El-Sayed</name><affiliation><mods:affiliation>Ain Shams University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Ergor, G" sort="Ergor, G" uniqKey="Ergor G" first="G." last="Ergör">G. Ergör</name><affiliation><mods:affiliation>Public Health and Epidemiology, Dokuz Eylul University, Izmir, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Esmat, G" sort="Esmat, G" uniqKey="Esmat G" first="G." last="Esmat">G. Esmat</name><affiliation><mods:affiliation>Cairo University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Falconer, K" sort="Falconer, K" uniqKey="Falconer K" first="K." last="Falconer">K. Falconer</name><affiliation><mods:affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Felix, J" sort="Felix, J" uniqKey="Felix J" first="J." last="Félix">J. Félix</name><affiliation><mods:affiliation>Exigo Consultores, Alhos Vedros, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Ferraz, M L G" sort="Ferraz, M L G" uniqKey="Ferraz M" first="M. L. G." last="Ferraz">M. L. G. Ferraz</name><affiliation><mods:affiliation>Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Ferreira, P R" sort="Ferreira, P R" uniqKey="Ferreira P" first="P. R." last="Ferreira">P. R. Ferreira</name><affiliation><mods:affiliation>Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Frankova, S" sort="Frankova, S" uniqKey="Frankova S" first="S." last="Frankova">S. Frankova</name><affiliation><mods:affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Garcia Amaniego, J" sort="Garcia Amaniego, J" uniqKey="Garcia Amaniego J" first="J." last="García-Samaniego">J. García-Samaniego</name><affiliation><mods:affiliation>Hospital Carlos III, CIBERehd, Madrid, Spain</mods:affiliation></affiliation></author><author><name sortKey="Gerstoft, J" sort="Gerstoft, J" uniqKey="Gerstoft J" first="J." last="Gerstoft">J. Gerstoft</name><affiliation><mods:affiliation>University of Copenhagen, Copenhagen, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Giria, J A" sort="Giria, J A" uniqKey="Giria J" first="J. A." last="Giria">J. A. Giria</name><affiliation><mods:affiliation>Direcção‐Geral da Saúde, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Goncales Jr, F L" sort="Goncales Jr, F L" uniqKey="Goncales Jr F" first="F. L." last="Gonçales Jr">F. L. Gonçales Jr</name><affiliation><mods:affiliation>Grupo de Estudo das Hepatites, Disciplina de Doenças Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Gower, E" sort="Gower, E" uniqKey="Gower E" first="E." last="Gower">E. Gower</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Gschwantler, M" sort="Gschwantler, M" uniqKey="Gschwantler M" first="M." last="Gschwantler">M. Gschwantler</name><affiliation><mods:affiliation>Department of Internal Medicine IV, Wilhelminenspital, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Guimaraes Pessoa, M" sort="Guimaraes Pessoa, M" uniqKey="Guimaraes Pessoa M" first="M." last="Guimarães Pessôa">M. Guimarães Pessôa</name><affiliation><mods:affiliation>Division of Gastroenterology and Hepatology, University of São Paulo School of Medicine, São Paulo, Brazil</mods:affiliation></affiliation></author><author><name sortKey="Hindman, S J" sort="Hindman, S J" uniqKey="Hindman S" first="S. J." last="Hindman">S. J. Hindman</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Hofer, H" sort="Hofer, H" uniqKey="Hofer H" first="H." last="Hofer">H. Hofer</name><affiliation><mods:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria</mods:affiliation></affiliation></author><author><name sortKey="Husa, P" sort="Husa, P" uniqKey="Husa P" first="P." last="Husa">P. Husa</name><affiliation><mods:affiliation>Clinic of Infectious Diseases of the University Hospital Brno, Masaryk University Brno, Brno, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="K Berg, M" sort="K Berg, M" uniqKey="K Berg M" first="M." last="K Berg">M. K Berg</name><affiliation><mods:affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Kaita, K D E" sort="Kaita, K D E" uniqKey="Kaita K" first="K. D. E." last="Kaita">K. D. E. Kaita</name><affiliation><mods:affiliation>Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada</mods:affiliation></affiliation><affiliation><mods:affiliation>Viral Hepatitis Investigative Unit, Health Sciences Centre, MB, Winnipeg, Canada</mods:affiliation></affiliation></author><author><name sortKey="Kautz, A" sort="Kautz, A" uniqKey="Kautz A" first="A." last="Kautz">A. Kautz</name><affiliation><mods:affiliation>European Liver Patients Association, Sint‐Truiden, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Kaymakoglu, S" sort="Kaymakoglu, S" uniqKey="Kaymakoglu S" first="S." last="Kaymakoglu">S. Kaymakoglu</name><affiliation><mods:affiliation>Gastroenterology, Istanbul University, Istanbul, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Krajden, M" sort="Krajden, M" uniqKey="Krajden M" first="M." last="Krajden">M. Krajden</name><affiliation><mods:affiliation>British Columbia Centre for Disease Control, University of British Columbia, BC, Vancouver, Canada</mods:affiliation></affiliation></author><author><name sortKey="Krarup, H" sort="Krarup, H" uniqKey="Krarup H" first="H." last="Krarup">H. Krarup</name><affiliation><mods:affiliation>Department of Medical Gastroenterology and Section of Molecular Diagnostics, Cinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Laleman, W" sort="Laleman, W" uniqKey="Laleman W" first="W." last="Laleman">W. Laleman</name><affiliation><mods:affiliation>University Hospitals Leuven, KU Leuven, Leuven, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Lavanchy, D" sort="Lavanchy, D" uniqKey="Lavanchy D" first="D." last="Lavanchy">D. Lavanchy</name><affiliation><mods:affiliation>Independent Consultant, Denges, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Marinho, R T" sort="Marinho, R T" uniqKey="Marinho R" first="R. T." last="Marinho">R. T. Marinho</name><affiliation><mods:affiliation>Gastroenterology Department, Centro Hospitalar de Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Marotta, P" sort="Marotta, P" uniqKey="Marotta P" first="P." last="Marotta">P. Marotta</name><affiliation><mods:affiliation>Division of Gastroenterology, University of Western Ontario, ON, London, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mauss, S" sort="Mauss, S" uniqKey="Mauss S" first="S." last="Mauss">S. Mauss</name><affiliation><mods:affiliation>Heinrich‐Heine University in Duesseldorf, Dusseldorf, Germany</mods:affiliation></affiliation></author><author><name sortKey="Moreno, C" sort="Moreno, C" uniqKey="Moreno C" first="C." last="Moreno">C. Moreno</name><affiliation><mods:affiliation>Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Murphy, K" sort="Murphy, K" uniqKey="Murphy K" first="K." last="Murphy">K. Murphy</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Negro, F" sort="Negro, F" uniqKey="Negro F" first="F." last="Negro">F. Negro</name><affiliation><mods:affiliation>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Genève, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Nemecek, V" sort="Nemecek, V" uniqKey="Nemecek V" first="V." last="Nemecek">V. Nemecek</name><affiliation><mods:affiliation>National Reference Laboratory for Hepatitis, National Institute of Public Health, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Ormeci, N" sort="Ormeci, N" uniqKey="Ormeci N" first="N." last="Örmeci">N. Örmeci</name><affiliation><mods:affiliation>Gastroenterology, Ankara University, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey=" Vrehus, A L H" sort=" Vrehus, A L H" uniqKey=" Vrehus A" first="A. L. H." last=" Vrehus">A. L. H. Vrehus</name><affiliation><mods:affiliation>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Parkes, J" sort="Parkes, J" uniqKey="Parkes J" first="J." last="Parkes">J. Parkes</name><affiliation><mods:affiliation>University of Southhampton, Southhampton, UK</mods:affiliation></affiliation></author><author><name sortKey="Pasini, K" sort="Pasini, K" uniqKey="Pasini K" first="K." last="Pasini">K. Pasini</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author><author><name sortKey="Peltekian, K M" sort="Peltekian, K M" uniqKey="Peltekian K" first="K. M." last="Peltekian">K. M. Peltekian</name><affiliation><mods:affiliation>Departments of Medicine and Surgery, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University and Hepatology Services, NS, Halifax, Canada</mods:affiliation></affiliation></author><author><name sortKey="Ramji, A" sort="Ramji, A" uniqKey="Ramji A" first="A." last="Ramji">A. Ramji</name><affiliation><mods:affiliation>Department of Gastroenterology, University of British Columbia, BC, Vancouver, Canada</mods:affiliation></affiliation></author><author><name sortKey="Reis, N" sort="Reis, N" uniqKey="Reis N" first="N." last="Reis">N. Reis</name><affiliation><mods:affiliation>Assembleia da República, Lisboa, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Roberts, S K" sort="Roberts, S K" uniqKey="Roberts S" first="S. K." last="Roberts">S. K. Roberts</name><affiliation><mods:affiliation>The Alfred Hospital and Monash University, Vic., Melbourne, Australia</mods:affiliation></affiliation></author><author><name sortKey="Rosenberg, W M" sort="Rosenberg, W M" uniqKey="Rosenberg W" first="W. M." last="Rosenberg">W. M. Rosenberg</name><affiliation><mods:affiliation>Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Roudot Horaval, F" sort="Roudot Horaval, F" uniqKey="Roudot Horaval F" first="F." last="Roudot-Thoraval">F. Roudot-Thoraval</name><affiliation><mods:affiliation>Département Santé Publique, Hôpital Henri Mondor, Créteil, France</mods:affiliation></affiliation></author><author><name sortKey="Ryder, S D" sort="Ryder, S D" uniqKey="Ryder S" first="S. D." last="Ryder">S. D. Ryder</name><affiliation><mods:affiliation>Nottingham University Hospitals NHS Trust and Biomedical Research Unit, Nottingham, UK</mods:affiliation></affiliation></author><author><name sortKey="Sarmento Astro, R" sort="Sarmento Astro, R" uniqKey="Sarmento Astro R" first="R." last="Sarmento-Castro">R. Sarmento-Castro</name><affiliation><mods:affiliation>Infectious Diseases Department, Centro Hospitalar do Porto, Porto, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Semela, D" sort="Semela, D" uniqKey="Semela D" first="D." last="Semela">D. Semela</name><affiliation><mods:affiliation>Division of Gastroenterology & Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Sherman, M" sort="Sherman, M" uniqKey="Sherman M" first="M." last="Sherman">M. Sherman</name><affiliation><mods:affiliation>Toronto General Hospital, University Health Network/University of Toronto, ON, Toronto, Canada</mods:affiliation></affiliation></author><author><name sortKey="Shiha, G E" sort="Shiha, G E" uniqKey="Shiha G" first="G. E." last="Shiha">G. E. Shiha</name><affiliation><mods:affiliation>Egyptian Liver Research Institute And Hospital, Dakahliah, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Sievert, W" sort="Sievert, W" uniqKey="Sievert W" first="W." last="Sievert">W. Sievert</name><affiliation><mods:affiliation>Monash University and Monash Health, Vic., Melbourne, Australia</mods:affiliation></affiliation></author><author><name sortKey="Sperl, J" sort="Sperl, J" uniqKey="Sperl J" first="J." last="Sperl">J. Sperl</name><affiliation><mods:affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="St Rkel, P" sort="St Rkel, P" uniqKey="St Rkel P" first="P." last="St Rkel">P. St Rkel</name><affiliation><mods:affiliation>Cliniques Universitaires Saint‐Luc, Université Catholique de Louvain, Brussel, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Stauber, R E" sort="Stauber, R E" uniqKey="Stauber R" first="R. E." last="Stauber">R. E. Stauber</name><affiliation><mods:affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria</mods:affiliation></affiliation></author><author><name sortKey="Thompson, A J" sort="Thompson, A J" uniqKey="Thompson A" first="A. J." last="Thompson">A. J. Thompson</name><affiliation><mods:affiliation>Department of Gastroenterology, St Vincent's Hospital and the University of Melbourne, Vic., Melbourne, Australia</mods:affiliation></affiliation></author><author><name sortKey="Urbanek, P" sort="Urbanek, P" uniqKey="Urbanek P" first="P." last="Urbanek">P. Urbanek</name><affiliation><mods:affiliation>Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague and Central Military Hospital, Prague, Czech Republic</mods:affiliation></affiliation></author><author><name sortKey="Van Damme, P" sort="Van Damme, P" uniqKey="Van Damme P" first="P." last="Van Damme">P. Van Damme</name><affiliation><mods:affiliation>Universiteit Antwerpen, Antwerpen, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Van Thiel, I" sort="Van Thiel, I" uniqKey="Van Thiel I" first="I." last="Van Thiel">I. Van Thiel</name><affiliation><mods:affiliation>European Liver Patients Association, Sint‐Truiden, Belgium</mods:affiliation></affiliation><affiliation><mods:affiliation>Deutsche Leberhilfe e.V., Cologne, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van Vlierberghe, H" sort="Van Vlierberghe, H" uniqKey="Van Vlierberghe H" first="H." last="Van Vlierberghe">H. Van Vlierberghe</name><affiliation><mods:affiliation>Ghent University Hospital, Ghent, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Vandijck, D" sort="Vandijck, D" uniqKey="Vandijck D" first="D." last="Vandijck">D. Vandijck</name><affiliation><mods:affiliation>Department of Health Economics & Patient Safety, Ghent University, Belgium Hasselt University, Diepenbeek, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Wedemeyer, H" sort="Wedemeyer, H" uniqKey="Wedemeyer H" first="H." last="Wedemeyer">H. Wedemeyer</name><affiliation><mods:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weis, N" sort="Weis, N" uniqKey="Weis N" first="N." last="Weis">N. Weis</name><affiliation><mods:affiliation>Copenhagen University Hospital, Hvidovre, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Wiegand, J" sort="Wiegand, J" uniqKey="Wiegand J" first="J." last="Wiegand">J. Wiegand</name><affiliation><mods:affiliation>Infectious Diseases, Ankara University, Ankara, Turkey</mods:affiliation></affiliation></author><author><name sortKey="Yosry, A" sort="Yosry, A" uniqKey="Yosry A" first="A." last="Yosry">A. Yosry</name><affiliation><mods:affiliation>Cairo University, Cairo, Egypt</mods:affiliation></affiliation></author><author><name sortKey="Zekry, A" sort="Zekry, A" uniqKey="Zekry A" first="A." last="Zekry">A. Zekry</name><affiliation><mods:affiliation>St George Hospital Clinical School of Medicine and School of Medical Science, University of New South Wales, NSW, Sydney, Australia</mods:affiliation></affiliation></author><author><name sortKey="Cornberg, M" sort="Cornberg, M" uniqKey="Cornberg M" first="M." last="Cornberg">M. Cornberg</name><affiliation><mods:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mullhaupt, B" sort="Mullhaupt, B" uniqKey="Mullhaupt B" first="B." last="Müllhaupt">B. Müllhaupt</name><affiliation><mods:affiliation>Swiss HPB (Hepato‐Pancreato‐Biliary) Center and Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Estes, C" sort="Estes, C" uniqKey="Estes C" first="C." last="Estes">C. Estes</name><affiliation><mods:affiliation>Center for Disease Analysis, Colorado, Louisville, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Viral Hepatitis</title><title level="j" type="sub">Hepatitis C Disease Burden & Strategies to Manage the Burden</title><title level="j" type="alt">JOURNAL OF VIRAL HEPATITIS</title><idno type="ISSN">1352-0504</idno><idno type="eISSN">1365-2893</idno><imprint><biblScope unit="vol">21</biblScope><biblScope unit="page" from="34">34</biblScope><biblScope unit="page" to="59">59</biblScope><biblScope unit="page-count">26</biblScope><date type="published" when="2014-05">2014-05</date></imprint><idno type="ISSN">1352-0504</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1352-0504</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver‐related deaths from increasing.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>H. Razavi</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string><json:string>Correspondence: Homie A. Razavi, Center for Disease Analysis, 901 Front Street, Suite 291, Louisville, CO 80027, USA.E‐mail:</json:string><json:string>E-mail: homie.razavi@centerforda.com</json:string></affiliations></json:item><json:item><name>I. Waked</name><affiliations><json:string>National Liver Institute, Menoufiya, Egypt</json:string></affiliations></json:item><json:item><name>C. Sarrazin</name><affiliations><json:string>J.W. Goethe University Hospital, Frankfurt, Germany</json:string></affiliations></json:item><json:item><name>R. P. Myers</name><affiliations><json:string>Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, AB, Calgary, Canada</json:string></affiliations></json:item><json:item><name>R. Idilman</name><affiliations><json:string>Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey</json:string></affiliations></json:item><json:item><name>F. Calinas</name><affiliations><json:string>Gastroenterology Department, Centro Hospitalar de Lisboa Central – Hospital Santo António Capuchos, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>W. Vogel</name><affiliations><json:string>Innsbruck Medical University, Innsbruck, Austria</json:string></affiliations></json:item><json:item><name>M. C. Mendes Correa</name><affiliations><json:string>School of Medicine‐ Universidade de São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>C. Hézode</name><affiliations><json:string>Service d' Hépato‐Gastroentérologie, Hôpital Henri Mondor, Créteil, France</json:string></affiliations></json:item><json:item><name>P. Lázaro</name><affiliations><json:string>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</json:string></affiliations></json:item><json:item><name>U. Akarca</name><affiliations><json:string>Gastroenterology, Ege University, Izmir, Turkey</json:string></affiliations></json:item><json:item><name>S. Aleman</name><affiliations><json:string>Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden</json:string><json:string>Department of Gastroenterology and Hepatology/Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>İ. Balık</name><affiliations><json:string>Infectious Diseases, Ankara University, Ankara, Turkey</json:string></affiliations></json:item><json:item><name>T. Berg</name><affiliations><json:string>University of Leipzig, Leipzig, Germany</json:string></affiliations></json:item><json:item><name>F. Bihl</name><affiliations><json:string>Gastroenterology Department, Ospedale Cantonale, Bellinzona, Switzerland</json:string></affiliations></json:item><json:item><name>M. Bilodeau</name><affiliations><json:string>Liver Unit, Department of Medicine, Université de Montréal, QC, Montréal, Canada</json:string></affiliations></json:item><json:item><name>A. J. Blasco</name><affiliations><json:string>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</json:string></affiliations></json:item><json:item><name>C. E. Brandão Mello</name><affiliations><json:string>Department of Gastroenterology, Federal University of the State of Rio de Janeiro, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>P. Bruggmann</name><affiliations><json:string>Arud Centres for Addiction Medicine, Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>M. Buti</name><affiliations><json:string>Hospital Vall d'Hebron, CIBERehd, Barcelona, Spain</json:string></affiliations></json:item><json:item><name>J. L. Calleja</name><affiliations><json:string>Hospital Puerta de Hierro, Madrid, Spain</json:string></affiliations></json:item><json:item><name>H. Cheinquer</name><affiliations><json:string>Hospital das Clínicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil</json:string></affiliations></json:item><json:item><name>P. B. Christensen</name><affiliations><json:string>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</json:string></affiliations></json:item><json:item><name>M. Clausen</name><affiliations><json:string>Region Hospital Hovedstaden, Copenhagen, Denmark</json:string></affiliations></json:item><json:item><name>H. S. M. Coelho</name><affiliations><json:string>Department of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil</json:string></affiliations></json:item><json:item><name>M. E. Cramp</name><affiliations><json:string>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK</json:string></affiliations></json:item><json:item><name>G. J. Dore</name><affiliations><json:string>Kirby Institute, University of New South Wales, NSW, Sydney, Australia</json:string></affiliations></json:item><json:item><name>W. Doss</name><affiliations><json:string>Cairo University, Cairo, Egypt</json:string></affiliations></json:item><json:item><name>A. S. Duberg</name><affiliations><json:string>Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden</json:string><json:string>School of Health and Medical Sciences, Örebro University, Örebro, Sweden</json:string></affiliations></json:item><json:item><name>M. H. El‐Sayed</name><affiliations><json:string>Ain Shams University, Cairo, Egypt</json:string></affiliations></json:item><json:item><name>G. Ergör</name><affiliations><json:string>Public Health and Epidemiology, Dokuz Eylul University, Izmir, Turkey</json:string></affiliations></json:item><json:item><name>G. Esmat</name><affiliations><json:string>Cairo University, Cairo, Egypt</json:string></affiliations></json:item><json:item><name>K. Falconer</name><affiliations><json:string>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>J. Félix</name><affiliations><json:string>Exigo Consultores, Alhos Vedros, Portugal</json:string></affiliations></json:item><json:item><name>M. L. G. Ferraz</name><affiliations><json:string>Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>P. R. Ferreira</name><affiliations><json:string>Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>S. Frankova</name><affiliations><json:string>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</json:string></affiliations></json:item><json:item><name>J. García‐Samaniego</name><affiliations><json:string>Hospital Carlos III, CIBERehd, Madrid, Spain</json:string></affiliations></json:item><json:item><name>J. Gerstoft</name><affiliations><json:string>University of Copenhagen, Copenhagen, Denmark</json:string></affiliations></json:item><json:item><name>J. A. Giria</name><affiliations><json:string>Direcção‐Geral da Saúde, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>F. L. Gonçales Jr</name><affiliations><json:string>Grupo de Estudo das Hepatites, Disciplina de Doenças Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>E. Gower</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string></affiliations></json:item><json:item><name>M. Gschwantler</name><affiliations><json:string>Department of Internal Medicine IV, Wilhelminenspital, Vienna, Austria</json:string></affiliations></json:item><json:item><name>M. Guimarães Pessôa</name><affiliations><json:string>Division of Gastroenterology and Hepatology, University of São Paulo School of Medicine, São Paulo, Brazil</json:string></affiliations></json:item><json:item><name>S. J. Hindman</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string></affiliations></json:item><json:item><name>H. Hofer</name><affiliations><json:string>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria</json:string></affiliations></json:item><json:item><name>P. Husa</name><affiliations><json:string>Clinic of Infectious Diseases of the University Hospital Brno, Masaryk University Brno, Brno, Czech Republic</json:string></affiliations></json:item><json:item><name>M. Kåberg</name><affiliations><json:string>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</json:string></affiliations></json:item><json:item><name>K. D. E. Kaita</name><affiliations><json:string>Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada</json:string><json:string>Viral Hepatitis Investigative Unit, Health Sciences Centre, MB, Winnipeg, Canada</json:string></affiliations></json:item><json:item><name>A. Kautz</name><affiliations><json:string>European Liver Patients Association, Sint‐Truiden, Belgium</json:string></affiliations></json:item><json:item><name>S. Kaymakoglu</name><affiliations><json:string>Gastroenterology, Istanbul University, Istanbul, Turkey</json:string></affiliations></json:item><json:item><name>M. Krajden</name><affiliations><json:string>British Columbia Centre for Disease Control, University of British Columbia, BC, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>H. Krarup</name><affiliations><json:string>Department of Medical Gastroenterology and Section of Molecular Diagnostics, Cinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</json:string></affiliations></json:item><json:item><name>W. Laleman</name><affiliations><json:string>University Hospitals Leuven, KU Leuven, Leuven, Belgium</json:string></affiliations></json:item><json:item><name>D. Lavanchy</name><affiliations><json:string>Independent Consultant, Denges, Switzerland</json:string></affiliations></json:item><json:item><name>R. T. Marinho</name><affiliations><json:string>Gastroenterology Department, Centro Hospitalar de Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>P. Marotta</name><affiliations><json:string>Division of Gastroenterology, University of Western Ontario, ON, London, Canada</json:string></affiliations></json:item><json:item><name>S. Mauss</name><affiliations><json:string>Heinrich‐Heine University in Duesseldorf, Dusseldorf, Germany</json:string></affiliations></json:item><json:item><name>C. Moreno</name><affiliations><json:string>Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium</json:string></affiliations></json:item><json:item><name>K. Murphy</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string></affiliations></json:item><json:item><name>F. Negro</name><affiliations><json:string>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Genève, Switzerland</json:string></affiliations></json:item><json:item><name>V. Nemecek</name><affiliations><json:string>National Reference Laboratory for Hepatitis, National Institute of Public Health, Prague, Czech Republic</json:string></affiliations></json:item><json:item><name>N. Örmeci</name><affiliations><json:string>Gastroenterology, Ankara University, Ankara, Turkey</json:string></affiliations></json:item><json:item><name>A. L. H. Øvrehus</name><affiliations><json:string>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</json:string></affiliations></json:item><json:item><name>J. Parkes</name><affiliations><json:string>University of Southhampton, Southhampton, UK</json:string></affiliations></json:item><json:item><name>K. Pasini</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string></affiliations></json:item><json:item><name>K. M. Peltekian</name><affiliations><json:string>Departments of Medicine and Surgery, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University and Hepatology Services, NS, Halifax, Canada</json:string></affiliations></json:item><json:item><name>A. Ramji</name><affiliations><json:string>Department of Gastroenterology, University of British Columbia, BC, Vancouver, Canada</json:string></affiliations></json:item><json:item><name>N. Reis</name><affiliations><json:string>Assembleia da República, Lisboa, Portugal</json:string></affiliations></json:item><json:item><name>S. K. Roberts</name><affiliations><json:string>The Alfred Hospital and Monash University, Vic., Melbourne, Australia</json:string></affiliations></json:item><json:item><name>W. M. Rosenberg</name><affiliations><json:string>Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK</json:string></affiliations></json:item><json:item><name>F. Roudot‐Thoraval</name><affiliations><json:string>Département Santé Publique, Hôpital Henri Mondor, Créteil, France</json:string></affiliations></json:item><json:item><name>S. D. Ryder</name><affiliations><json:string>Nottingham University Hospitals NHS Trust and Biomedical Research Unit, Nottingham, UK</json:string></affiliations></json:item><json:item><name>R. Sarmento‐Castro</name><affiliations><json:string>Infectious Diseases Department, Centro Hospitalar do Porto, Porto, Portugal</json:string></affiliations></json:item><json:item><name>D. Semela</name><affiliations><json:string>Division of Gastroenterology & Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland</json:string></affiliations></json:item><json:item><name>M. Sherman</name><affiliations><json:string>Toronto General Hospital, University Health Network/University of Toronto, ON, Toronto, Canada</json:string></affiliations></json:item><json:item><name>G. E. Shiha</name><affiliations><json:string>Egyptian Liver Research Institute And Hospital, Dakahliah, Egypt</json:string></affiliations></json:item><json:item><name>W. Sievert</name><affiliations><json:string>Monash University and Monash Health, Vic., Melbourne, Australia</json:string></affiliations></json:item><json:item><name>J. Sperl</name><affiliations><json:string>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</json:string></affiliations></json:item><json:item><name>P. Stärkel</name><affiliations><json:string>Cliniques Universitaires Saint‐Luc, Université Catholique de Louvain, Brussel, Belgium</json:string></affiliations></json:item><json:item><name>R. E. Stauber</name><affiliations><json:string>Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria</json:string></affiliations></json:item><json:item><name>A. J. Thompson</name><affiliations><json:string>Department of Gastroenterology, St Vincent's Hospital and the University of Melbourne, Vic., Melbourne, Australia</json:string></affiliations></json:item><json:item><name>P. Urbanek</name><affiliations><json:string>Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague and Central Military Hospital, Prague, Czech Republic</json:string></affiliations></json:item><json:item><name>P. Van Damme</name><affiliations><json:string>Universiteit Antwerpen, Antwerpen, Belgium</json:string></affiliations></json:item><json:item><name>I. van Thiel</name><affiliations><json:string>European Liver Patients Association, Sint‐Truiden, Belgium</json:string><json:string>Deutsche Leberhilfe e.V., Cologne, Germany</json:string></affiliations></json:item><json:item><name>H. Van Vlierberghe</name><affiliations><json:string>Ghent University Hospital, Ghent, Belgium</json:string></affiliations></json:item><json:item><name>D. Vandijck</name><affiliations><json:string>Department of Health Economics & Patient Safety, Ghent University, Belgium Hasselt University, Diepenbeek, Belgium</json:string></affiliations></json:item><json:item><name>H. Wedemeyer</name><affiliations><json:string>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</json:string></affiliations></json:item><json:item><name>N. Weis</name><affiliations><json:string>Copenhagen University Hospital, Hvidovre, Denmark</json:string></affiliations></json:item><json:item><name>J. Wiegand</name><affiliations><json:string>Infectious Diseases, Ankara University, Ankara, Turkey</json:string></affiliations></json:item><json:item><name>A. Yosry</name><affiliations><json:string>Cairo University, Cairo, Egypt</json:string></affiliations></json:item><json:item><name>A. Zekry</name><affiliations><json:string>St George Hospital Clinical School of Medicine and School of Medical Science, University of New South Wales, NSW, Sydney, Australia</json:string></affiliations></json:item><json:item><name>M. Cornberg</name><affiliations><json:string>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</json:string></affiliations></json:item><json:item><name>B. Müllhaupt</name><affiliations><json:string>Swiss HPB (Hepato‐Pancreato‐Biliary) Center and Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland</json:string></affiliations></json:item><json:item><name>C. Estes</name><affiliations><json:string>Center for Disease Analysis, Colorado, Louisville, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>diagnosis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>disease burden</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HCV</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatitis C</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>incidence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mortality</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>prevalence</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>treatment</value></json:item></subject><articleId><json:string>JVH12248</json:string></articleId><arkIstex>ark:/67375/WNG-085BKGWQ-5</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver‐related deaths from increasing.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>155</abstractWordCount><abstractCharCount>996</abstractCharCount><keywordCount>9</keywordCount><score>8.86</score><pdfWordCount>12963</pdfWordCount><pdfCharCount>81305</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>26</pdfPageCount><pdfPageSize>595.276 x 796.535 pts</pdfPageSize></qualityIndicators><title>The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title><genre><json:string>article</json:string></genre><host><title>Journal of Viral Hepatitis</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1365-2893</json:string></doi><issn><json:string>1352-0504</json:string></issn><eissn><json:string>1365-2893</json:string></eissn><publisherId><json:string>JVH</json:string></publisherId><volume>21</volume><pages><first>34</first><last>59</last><total>26</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-085BKGWQ-5</json:string></ark><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1111/jvh.12248</json:string></doi><id>6F5499030B2D47269785C4D57593C4C552FA1B5F</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6F5499030B2D47269785C4D57593C4C552FA1B5F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/6F5499030B2D47269785C4D57593C4C552FA1B5F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6F5499030B2D47269785C4D57593C4C552FA1B5F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Publishing Ltd</publisher><availability><licence>© 2014 John Wiley & Sons Ltd</licence></availability><date type="published" when="2014-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">H.</forename><surname>Razavi</surname></persName><affiliation><orgName>Center for Disease Analysis</orgName><address><settlement type="city">Louisville</settlement><region>Colorado</region><country key="US">USA</country></address></affiliation><note type="foot"></note><affiliation>Correspondence: Homie A. Razavi, Center for Disease Analysis, 901 Front Street, Suite 291, Louisville, CO 80027, USA. E‐mail: homie.razavi@centerforda.com</affiliation></author><author xml:id="author-0001"><persName><forename type="first">I.</forename><surname>Waked</surname></persName><affiliation><orgName>National Liver Institute</orgName><address><settlement type="city">Menoufiya</settlement><country key="EG">Egypt</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0002"><persName><forename type="first">C.</forename><surname>Sarrazin</surname></persName><affiliation><orgName>J.W. Goethe University Hospital</orgName><address><settlement type="city">Frankfurt</settlement><country key="DE">Germany</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0003"><persName><forename type="first">R. 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B.</forename><surname>Christensen</surname></persName><affiliation><orgName>Department of Infectious Diseases</orgName><orgName>Odense University Hospital</orgName><address><settlement type="city">Odense</settlement><country key="DK">Denmark</country></address></affiliation></author><author xml:id="author-0023"><persName><forename type="first">M.</forename><surname>Clausen</surname></persName><affiliation><orgName>Region Hospital Hovedstaden</orgName><address><settlement type="city">Copenhagen</settlement><country key="DK">Denmark</country></address></affiliation></author><author xml:id="author-0024"><persName><forename type="first">H. S. M.</forename><surname>Coelho</surname></persName><affiliation><orgName>Department of Clinical Medicine</orgName><orgName>Federal University of Rio de Janeiro</orgName><address><settlement type="city">Rio de Janeiro</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0025"><persName><forename type="first">M. E.</forename><surname>Cramp</surname></persName><affiliation><orgName>Plymouth University Peninsula Schools of Medicine and Dentistry</orgName><address><settlement type="city">Plymouth</settlement><country key="GB">UK</country></address></affiliation></author><author xml:id="author-0026"><persName><forename type="first">G. J.</forename><surname>Dore</surname></persName><affiliation><orgName>Kirby Institute</orgName><orgName>University of New South Wales</orgName><address><settlement type="city">Sydney</settlement><region>NSW</region><country key="AU">Australia</country></address></affiliation></author><author xml:id="author-0027"><persName><forename type="first">W.</forename><surname>Doss</surname></persName><affiliation><orgName>Cairo University</orgName><address><settlement type="city">Cairo</settlement><country key="EG">Egypt</country></address></affiliation></author><author xml:id="author-0028"><persName><forename type="first">A. S.</forename><surname>Duberg</surname></persName><affiliation><orgName>Department of Infectious Diseases</orgName><orgName>Örebro University Hospital</orgName><address><settlement type="city">Örebro</settlement><country key="SE">Sweden</country></address></affiliation><affiliation><orgName>School of Health and Medical Sciences</orgName><orgName>Örebro University</orgName><address><settlement type="city">Örebro</settlement><country key="SE">Sweden</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0029"><persName><forename type="first">M. H.</forename><surname>El‐Sayed</surname></persName><affiliation><orgName>Ain Shams University</orgName><address><settlement type="city">Cairo</settlement><country key="EG">Egypt</country></address></affiliation></author><author xml:id="author-0030"><persName><forename type="first">G.</forename><surname>Ergör</surname></persName><affiliation><orgName>Public Health and Epidemiology</orgName><orgName>Dokuz Eylul University</orgName><address><settlement type="city">Izmir</settlement><country key="TR">Turkey</country></address></affiliation></author><author xml:id="author-0031"><persName><forename type="first">G.</forename><surname>Esmat</surname></persName><affiliation><orgName>Cairo University</orgName><address><settlement type="city">Cairo</settlement><country key="EG">Egypt</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0032"><persName><forename type="first">K.</forename><surname>Falconer</surname></persName><affiliation><orgName>Unit of Infectious Diseases</orgName><orgName>Department of Medicine Huddinge</orgName><orgName>Karolinska Institutet</orgName><orgName>Karolinska University Hospital</orgName><address><settlement type="city">Stockholm</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0033"><persName><forename type="first">J.</forename><surname>Félix</surname></persName><affiliation><orgName>Exigo Consultores</orgName><address><settlement type="city">Alhos Vedros</settlement><country key="PT">Portugal</country></address></affiliation></author><author xml:id="author-0034"><persName><forename type="first">M. L. G.</forename><surname>Ferraz</surname></persName><affiliation><orgName>Division of Gastroenterology</orgName><orgName>Federal University of São Paulo</orgName><address><settlement type="city">São Paulo</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0035"><persName><forename type="first">P. R.</forename><surname>Ferreira</surname></persName><affiliation><orgName>Division of Infectious Disease</orgName><orgName>Federal University of São Paulo</orgName><address><settlement type="city">São Paulo</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0036"><persName><forename type="first">S.</forename><surname>Frankova</surname></persName><affiliation><orgName>Department of Hepatogastroenterology</orgName><orgName>Institute for Clinical and Experimental Medicine</orgName><address><settlement type="city">Prague</settlement><country key="CZ">Czech Republic</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0037"><persName><forename type="first">J.</forename><surname>García‐Samaniego</surname></persName><affiliation><orgName>Hospital Carlos III</orgName><orgName>CIBERehd</orgName><address><settlement type="city">Madrid</settlement><country key="ES">Spain</country></address></affiliation></author><author xml:id="author-0038"><persName><forename type="first">J.</forename><surname>Gerstoft</surname></persName><affiliation><orgName>University of Copenhagen</orgName><address><settlement type="city">Copenhagen</settlement><country key="DK">Denmark</country></address></affiliation></author><author xml:id="author-0039"><persName><forename type="first">J. A.</forename><surname>Giria</surname></persName><affiliation><orgName>Direcção‐Geral da Saúde</orgName><address><settlement type="city">Lisboa</settlement><country key="PT">Portugal</country></address></affiliation></author><author xml:id="author-0040"><persName><genName>Jr</genName><forename type="first">F. L.</forename><surname>Gonçales</surname></persName><affiliation><orgName>Grupo de Estudo das Hepatites</orgName><orgName>Disciplina de Doenças Infecciosas</orgName><orgName>Departamento de Clínica Médica</orgName><orgName>Faculdade de Ciências Médicas</orgName><orgName>Universidade Estadual de Campinas</orgName><orgName>UNICAMP</orgName><address><settlement type="city">São Paulo</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0041"><persName><forename type="first">E.</forename><surname>Gower</surname></persName><affiliation><orgName>Center for Disease Analysis</orgName><address><settlement type="city">Louisville</settlement><region>Colorado</region><country key="US">USA</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0042"><persName><forename type="first">M.</forename><surname>Gschwantler</surname></persName><affiliation><orgName>Department of Internal Medicine IV</orgName><orgName>Wilhelminenspital</orgName><address><settlement type="city">Vienna</settlement><country key="AT">Austria</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0043"><persName><forename type="first">M.</forename><surname>Guimarães Pessôa</surname></persName><affiliation><orgName>Division of Gastroenterology and Hepatology</orgName><orgName>University of São Paulo School of Medicine</orgName><address><settlement type="city">São Paulo</settlement><country key="BR">Brazil</country></address></affiliation></author><author xml:id="author-0044"><persName><forename type="first">S. J.</forename><surname>Hindman</surname></persName><affiliation><orgName>Center for Disease Analysis</orgName><address><settlement type="city">Louisville</settlement><region>Colorado</region><country key="US">USA</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0045"><persName><forename type="first">H.</forename><surname>Hofer</surname></persName><affiliation><orgName>Division of Gastroenterology and Hepatology</orgName><orgName>Department of Internal Medicine III</orgName><orgName>Medical University of Vienna</orgName><address><settlement type="city">Vienna</settlement><country key="AT">Austria</country></address></affiliation></author><author xml:id="author-0046"><persName><forename type="first">P.</forename><surname>Husa</surname></persName><affiliation><orgName>Clinic of Infectious Diseases of the University Hospital Brno</orgName><orgName>Masaryk University Brno</orgName><address><settlement type="city">Brno</settlement><country key="CZ">Czech Republic</country></address></affiliation></author><author xml:id="author-0047"><persName><forename type="first">M.</forename><surname>Kåberg</surname></persName><affiliation><orgName>Unit of Infectious Diseases</orgName><orgName>Department of Medicine Huddinge</orgName><orgName>Karolinska Institutet</orgName><orgName>Karolinska University Hospital</orgName><address><settlement type="city">Stockholm</settlement><country key="SE">Sweden</country></address></affiliation></author><author xml:id="author-0048"><persName><forename type="first">K. D. 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M.</forename><surname>Peltekian</surname></persName><affiliation><orgName>Departments of Medicine and Surgery</orgName><orgName>Queen Elizabeth II Health Sciences Centre</orgName><orgName>Capital District Health Authority</orgName><orgName>Dalhousie University and Hepatology Services</orgName><address><settlement type="city">Halifax</settlement><region>NS</region><country key="CA">Canada</country></address></affiliation></author><author xml:id="author-0067"><persName><forename type="first">A.</forename><surname>Ramji</surname></persName><affiliation><orgName>Department of Gastroenterology</orgName><orgName>University of British Columbia</orgName><address><settlement type="city">Vancouver</settlement><region>BC</region><country key="CA">Canada</country></address></affiliation></author><author xml:id="author-0068"><persName><forename type="first">N.</forename><surname>Reis</surname></persName><affiliation><orgName>Assembleia da República</orgName><address><settlement type="city">Lisboa</settlement><country key="PT">Portugal</country></address></affiliation></author><author xml:id="author-0069"><persName><forename type="first">S. K.</forename><surname>Roberts</surname></persName><affiliation><orgName>The Alfred Hospital and Monash University</orgName><address><settlement type="city">Melbourne</settlement><region>Vic.</region><country key="AU">Australia</country></address></affiliation></author><author xml:id="author-0070"><persName><forename type="first">W. M.</forename><surname>Rosenberg</surname></persName><affiliation><orgName>Division of Medicine</orgName><orgName>UCL Institute for Liver and Digestive Health</orgName><orgName>University College London</orgName><address><settlement type="city">London</settlement><country key="GB">UK</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0071"><persName><forename type="first">F.</forename><surname>Roudot‐Thoraval</surname></persName><affiliation><orgName>Département Santé Publique</orgName><orgName>Hôpital Henri Mondor</orgName><address><settlement type="city">Créteil</settlement><country key="FR">France</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0072"><persName><forename type="first">S. D.</forename><surname>Ryder</surname></persName><affiliation><orgName>Nottingham University Hospitals NHS Trust and Biomedical Research Unit</orgName><address><settlement type="city">Nottingham</settlement><country key="GB">UK</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0073"><persName><forename type="first">R.</forename><surname>Sarmento‐Castro</surname></persName><affiliation><orgName>Infectious Diseases Department</orgName><orgName>Centro Hospitalar do Porto</orgName><address><settlement type="city">Porto</settlement><country key="PT">Portugal</country></address></affiliation></author><author xml:id="author-0074"><persName><forename type="first">D.</forename><surname>Semela</surname></persName><affiliation><orgName>Division of Gastroenterology & Hepatology</orgName><orgName>Cantonal Hospital St. Gallen</orgName><address><settlement type="city">St. Gallen</settlement><country key="CH">Switzerland</country></address></affiliation></author><author xml:id="author-0075"><persName><forename type="first">M.</forename><surname>Sherman</surname></persName><affiliation><orgName>Toronto General Hospital</orgName><orgName>University Health Network/University of Toronto</orgName><address><settlement type="city">Toronto</settlement><region>ON</region><country key="CA">Canada</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0076"><persName><forename type="first">G. E.</forename><surname>Shiha</surname></persName><affiliation><orgName>Egyptian Liver Research Institute And Hospital</orgName><address><settlement type="city">Dakahliah</settlement><country key="EG">Egypt</country></address></affiliation></author><author xml:id="author-0077"><persName><forename type="first">W.</forename><surname>Sievert</surname></persName><affiliation><orgName>Monash University and Monash Health</orgName><address><settlement type="city">Melbourne</settlement><region>Vic.</region><country key="AU">Australia</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0078"><persName><forename type="first">J.</forename><surname>Sperl</surname></persName><affiliation><orgName>Department of Hepatogastroenterology</orgName><orgName>Institute for Clinical and Experimental Medicine</orgName><address><settlement type="city">Prague</settlement><country key="CZ">Czech Republic</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0079"><persName><forename type="first">P.</forename><surname>Stärkel</surname></persName><affiliation><orgName>Cliniques Universitaires Saint‐Luc</orgName><orgName>Université Catholique de Louvain</orgName><address><settlement type="city">Brussel</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0080"><persName><forename type="first">R. E.</forename><surname>Stauber</surname></persName><affiliation><orgName>Division of Gastroenterology and Hepatology</orgName><orgName>Department of Internal Medicine</orgName><orgName>Medical University of Graz</orgName><address><settlement type="city">Graz</settlement><country key="AT">Austria</country></address></affiliation></author><author xml:id="author-0081"><persName><forename type="first">A. J.</forename><surname>Thompson</surname></persName><affiliation><orgName>Department of Gastroenterology</orgName><orgName>St Vincent's Hospital and the University of Melbourne</orgName><address><settlement type="city">Melbourne</settlement><region>Vic.</region><country key="AU">Australia</country></address></affiliation></author><author xml:id="author-0082"><persName><forename type="first">P.</forename><surname>Urbanek</surname></persName><affiliation><orgName>Department of Internal Medicine</orgName><orgName>1st Faculty of Medicine</orgName><orgName>Charles University in Prague and Central Military Hospital</orgName><address><settlement type="city">Prague</settlement><country key="CZ">Czech Republic</country></address></affiliation></author><author xml:id="author-0083"><persName><forename type="first">P.</forename><surname>Damme</surname></persName><affiliation><orgName>Universiteit Antwerpen</orgName><address><settlement type="city">Antwerpen</settlement><country key="BE">Belgium</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0084"><persName><forename type="first">I.</forename><surname>Thiel</surname></persName><affiliation><orgName>European Liver Patients Association</orgName><address><settlement type="city">Sint‐Truiden</settlement><country key="BE">Belgium</country></address></affiliation><affiliation><orgName>Deutsche Leberhilfe e.V.</orgName><address><settlement type="city">Cologne</settlement><country key="DE">Germany</country></address></affiliation></author><author xml:id="author-0085"><persName><forename type="first">H.</forename><surname>Vlierberghe</surname></persName><affiliation><orgName>Ghent University Hospital</orgName><address><settlement type="city">Ghent</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0086"><persName><forename type="first">D.</forename><surname>Vandijck</surname></persName><affiliation><orgName>Department of Health Economics & Patient Safety</orgName><orgName>Ghent University</orgName><orgName>Belgium Hasselt University</orgName><address><settlement type="city">Diepenbeek</settlement><country key="BE">Belgium</country></address></affiliation></author><author xml:id="author-0087"><persName><forename type="first">H.</forename><surname>Wedemeyer</surname></persName><affiliation><orgName>Department of Gastroenterology, Hepatology and Endocrinology</orgName><orgName>Hannover Medical School</orgName><address><settlement type="city">Hannover</settlement><country key="DE">Germany</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0088"><persName><forename type="first">N.</forename><surname>Weis</surname></persName><affiliation><orgName>Copenhagen University Hospital</orgName><address><settlement type="city">Hvidovre</settlement><country key="DK">Denmark</country></address></affiliation></author><author xml:id="author-0089"><persName><forename type="first">J.</forename><surname>Wiegand</surname></persName><affiliation><orgName>Infectious Diseases</orgName><orgName>Ankara University</orgName><address><settlement type="city">Ankara</settlement><country key="TR">Turkey</country></address></affiliation></author><author xml:id="author-0090"><persName><forename type="first">A.</forename><surname>Yosry</surname></persName><affiliation><orgName>Cairo University</orgName><address><settlement type="city">Cairo</settlement><country key="EG">Egypt</country></address></affiliation></author><author xml:id="author-0091"><persName><forename type="first">A.</forename><surname>Zekry</surname></persName><affiliation><orgName>St George Hospital Clinical School of Medicine and School of Medical Science</orgName><orgName>University of New South Wales</orgName><address><settlement type="city">Sydney</settlement><region>NSW</region><country key="AU">Australia</country></address></affiliation></author><author xml:id="author-0092"><persName><forename type="first">M.</forename><surname>Cornberg</surname></persName><affiliation><orgName>Department of Gastroenterology, Hepatology and Endocrinology</orgName><orgName>Hannover Medical School</orgName><address><settlement type="city">Hannover</settlement><country key="DE">Germany</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0093"><persName><forename type="first">B.</forename><surname>Müllhaupt</surname></persName><affiliation><orgName>Swiss HPB (Hepato‐Pancreato‐Biliary) Center and Department of Gastroenterology and Hepatology</orgName><orgName>University Hospital Zürich</orgName><address><settlement type="city">Zürich</settlement><country key="CH">Switzerland</country></address></affiliation><note type="foot"></note></author><author xml:id="author-0094"><persName><forename type="first">C.</forename><surname>Estes</surname></persName><affiliation><orgName>Center for Disease Analysis</orgName><address><settlement type="city">Louisville</settlement><region>Colorado</region><country key="US">USA</country></address></affiliation><note type="foot"></note></author><idno type="istex">6F5499030B2D47269785C4D57593C4C552FA1B5F</idno><idno type="ark">ark:/67375/WNG-085BKGWQ-5</idno><idno type="DOI">10.1111/jvh.12248</idno><idno type="unit">JVH12248</idno><idno type="toTypesetVersion">file:JVH.JVH12248.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Viral Hepatitis</title><title level="j" type="sub">Hepatitis C Disease Burden & Strategies to Manage the Burden</title><title level="j" type="alt">JOURNAL OF VIRAL HEPATITIS</title><idno type="pISSN">1352-0504</idno><idno type="eISSN">1365-2893</idno><idno type="book-DOI">10.1111/(ISSN)1365-2893</idno><idno type="book-part-DOI">10.1111/jvh.2014.21.issue-s1</idno><idno type="product">JVH</idno><imprint><biblScope unit="vol">21</biblScope><biblScope unit="page" from="34">34</biblScope><biblScope unit="page" to="59">59</biblScope><biblScope unit="page-count">26</biblScope><date type="published" when="2014-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract style="main" xml:id="jvh12248-abs-0001"><head>Summary</head><p>The disease burden of hepatitis <hi rend="fc">C</hi> virus (<hi rend="fc">HCV</hi>) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of <hi rend="fc">HCV</hi> infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of <hi rend="fc">HCV</hi> infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of <hi rend="fc">HCV</hi>. Thus, alternative strategies are required to keep the number of <hi rend="fc">HCV</hi> individuals with advanced liver disease and liver‐related deaths from increasing.</p></abstract><textClass><keywords><term xml:id="jvh12248-kwd-0001">diagnosis</term><term xml:id="jvh12248-kwd-0002">disease burden</term><term xml:id="jvh12248-kwd-0003">epidemiology</term><term xml:id="jvh12248-kwd-0004"><hi rend="fc">HCV</hi></term><term xml:id="jvh12248-kwd-0005">hepatitis C</term><term xml:id="jvh12248-kwd-0006">incidence</term><term xml:id="jvh12248-kwd-0007">mortality</term><term xml:id="jvh12248-kwd-0008">prevalence</term><term xml:id="jvh12248-kwd-0009">treatment</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Publication of this supplement is made possible by Center for Disease Analysis and support from Gilead Sciences.</term></keywords><keywords rend="tocHeading2"><term>Original Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="jvh12248" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1365-2893</doi><issn type="print">1352-0504</issn><issn type="electronic">1365-2893</issn><idGroup><id type="product" value="JVH"></id></idGroup><titleGroup><title sort="JOURNAL OF VIRAL HEPATITIS" type="main">Journal of Viral Hepatitis</title><title type="short">J Viral Hepat</title></titleGroup></publicationMeta><publicationMeta level="part" position="45"><doi origin="wiley">10.1111/jvh.2014.21.issue-s1</doi><titleGroup><title type="specialIssueTitle">Hepatitis C Disease Burden & Strategies to Manage the Burden</title></titleGroup><copyright ownership="publisher">Copyright © 2014 John Wiley & Sons Ltd</copyright><numberingGroup><numbering number="21" type="journalVolume">21</numbering><numbering type="supplement">s1</numbering></numberingGroup><coverDate startDate="2014-05">May 2014</coverDate></publicationMeta><publicationMeta level="unit" position="30" status="forIssue" type="article"><doi>10.1111/jvh.12248</doi><idGroup><id type="unit" value="JVH12248"></id></idGroup><countGroup><count number="26" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Publication of this supplement is made possible by Center for Disease Analysis and support from Gilead Sciences.</title><title type="tocHeading2">Original Articles</title></titleGroup><copyright ownership="publisher">© 2014 John Wiley & Sons Ltd</copyright><eventGroup><event agent="SPS" date="2014-03-14" type="xmlCreated"></event><event type="publishedOnlineFinalForm" date="2014-04-08"></event><event type="firstOnline" date="2014-04-08"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-06"></event></eventGroup><numberingGroup><numbering type="pageFirst">34</numbering><numbering type="pageLast">59</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence: Homie A. Razavi, Center for Disease Analysis, 901 Front Street, Suite 291, Louisville, CO 80027, USA.</line><line>E‐mail: <email>homie.razavi@centerforda.com</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JVH.JVH12248.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title><title type="shortAuthors"><i>H. 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type="organization" xml:id="jvh12248-aff-0039"><orgName>University of Copenhagen</orgName> <address><city>Copenhagen</city> <country>Denmark</country></address></affiliation><affiliation countryCode="PT" type="organization" xml:id="jvh12248-aff-0040"><orgName>Direcção‐Geral da Saúde</orgName> <address><city>Lisboa</city> <country>Portugal</country></address></affiliation><affiliation countryCode="BR" type="organization" xml:id="jvh12248-aff-0041"><orgDiv>Grupo de Estudo das Hepatites</orgDiv> <orgDiv>Disciplina de Doenças Infecciosas</orgDiv> <orgDiv>Departamento de Clínica Médica</orgDiv> <orgDiv>Faculdade de Ciências Médicas</orgDiv> <orgName>Universidade Estadual de Campinas</orgName> <orgName>UNICAMP</orgName> <address><city>São Paulo</city> <country>Brazil</country></address></affiliation><affiliation countryCode="AT" type="organization" xml:id="jvh12248-aff-0042"><orgDiv>Department of Internal Medicine IV</orgDiv> <orgName>Wilhelminenspital</orgName> <address><city>Vienna</city> <country>Austria</country></address></affiliation><affiliation countryCode="BR" type="organization" xml:id="jvh12248-aff-0043"><orgDiv>Division of Gastroenterology and Hepatology</orgDiv> <orgName>University of São Paulo School of Medicine</orgName> <address><city>São Paulo</city> <country>Brazil</country></address></affiliation><affiliation countryCode="AT" type="organization" xml:id="jvh12248-aff-0044"><orgDiv>Division of Gastroenterology and Hepatology</orgDiv> <orgDiv>Department of Internal Medicine III</orgDiv> <orgName>Medical University of Vienna</orgName> <address><city>Vienna</city> <country>Austria</country></address></affiliation><affiliation countryCode="CZ" type="organization" xml:id="jvh12248-aff-0045"><orgName>Clinic of Infectious Diseases of the University Hospital Brno</orgName> <orgName>Masaryk University Brno</orgName> <address><city>Brno</city> <country>Czech Republic</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0046"><orgDiv>Section of Hepatology</orgDiv> <orgDiv>Department of Internal Medicine</orgDiv> <orgName>University of Manitoba</orgName> <address><city>Winnipeg</city> <countryPart>MB</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0047"><orgDiv>Viral Hepatitis Investigative Unit</orgDiv> <orgName>Health Sciences Centre</orgName> <address><city>Winnipeg</city> <countryPart>MB</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0048"><orgName>European Liver Patients Association</orgName> <address><city>Sint‐Truiden</city> <country>Belgium</country></address></affiliation><affiliation countryCode="TR" type="organization" xml:id="jvh12248-aff-0049"><orgDiv>Gastroenterology</orgDiv> <orgName>Istanbul University</orgName> <address><city>Istanbul</city> <country>Turkey</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0050"><orgDiv>British Columbia Centre for Disease Control</orgDiv> <orgName>University of British Columbia</orgName> <address><city>Vancouver</city> <countryPart>BC</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="DK" type="organization" xml:id="jvh12248-aff-0051"><orgDiv>Department of Medical Gastroenterology and Section of Molecular Diagnostics</orgDiv> <orgDiv>Cinical Biochemistry</orgDiv> <orgName>Aalborg University Hospital</orgName> <address><city>Aalborg</city> <country>Denmark</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0052"><orgName>University Hospitals Leuven</orgName> <orgName>KU Leuven</orgName> <address><city>Leuven</city> <country>Belgium</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="jvh12248-aff-0053"><orgName>Independent Consultant</orgName> <address><city>Denges</city> <country>Switzerland</country></address></affiliation><affiliation countryCode="PT" type="organization" xml:id="jvh12248-aff-0054"><orgDiv>Gastroenterology Department</orgDiv> <orgName>Centro Hospitalar de Lisboa Norte</orgName> <orgName>Hospital Santa Maria</orgName> <address><city>Lisboa</city> <country>Portugal</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0055"><orgDiv>Division of Gastroenterology</orgDiv> <orgName>University of Western Ontario</orgName> <address><city>London</city> <countryPart>ON</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jvh12248-aff-0056"><orgName>Heinrich‐Heine University in Duesseldorf</orgName> <address><city>Dusseldorf</city> <country>Germany</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0057"><orgName>Erasme University Hospital</orgName> <orgName>Université Libre de Bruxelles</orgName> <address><city>Brussels</city> <country>Belgium</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="jvh12248-aff-0058"><orgDiv>Divisions of Gastroenterology and Hepatology and of Clinical Pathology</orgDiv> <orgName>University Hospital</orgName> <address><city>Genève</city> <country>Switzerland</country></address></affiliation><affiliation countryCode="CZ" type="organization" xml:id="jvh12248-aff-0059"><orgDiv>National Reference Laboratory for Hepatitis</orgDiv> <orgName>National Institute of Public Health</orgName> <address><city>Prague</city> <country>Czech Republic</country></address></affiliation><affiliation countryCode="TR" type="organization" xml:id="jvh12248-aff-0060"><orgDiv>Gastroenterology</orgDiv> <orgName>Ankara University</orgName> <address><city>Ankara</city> <country>Turkey</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="jvh12248-aff-0061"><orgName>University of Southhampton</orgName> <address><city>Southhampton</city> <country>UK</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0062"><orgDiv>Departments of Medicine and Surgery</orgDiv> <orgDiv>Queen Elizabeth II Health Sciences Centre</orgDiv> <orgDiv>Capital District Health Authority</orgDiv> <orgName>Dalhousie University and Hepatology Services</orgName> <address><city>Halifax</city> <countryPart>NS</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0063"><orgDiv>Department of Gastroenterology</orgDiv> <orgName>University of British Columbia</orgName> <address><city>Vancouver</city> <countryPart>BC</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="PT" type="organization" xml:id="jvh12248-aff-0064"><orgName>Assembleia da República</orgName> <address><city>Lisboa</city> <country>Portugal</country></address></affiliation><affiliation countryCode="AU" type="organization" xml:id="jvh12248-aff-0065"><orgName>The Alfred Hospital and Monash University</orgName> <address><city>Melbourne</city> <countryPart>Vic.</countryPart> <country>Australia</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="jvh12248-aff-0066"><orgDiv>Division of Medicine</orgDiv> <orgName>UCL Institute for Liver and Digestive Health</orgName> <orgName>University College London</orgName> <address><city>London</city> <country>UK</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="jvh12248-aff-0067"><orgDiv>Département Santé Publique</orgDiv> <orgName>Hôpital Henri Mondor</orgName> <address><city>Créteil</city> <country>France</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="jvh12248-aff-0068"><orgName>Nottingham University Hospitals NHS Trust and Biomedical Research Unit</orgName> <address><city>Nottingham</city> <country>UK</country></address></affiliation><affiliation countryCode="PT" type="organization" xml:id="jvh12248-aff-0069"><orgDiv>Infectious Diseases Department</orgDiv> <orgName>Centro Hospitalar do Porto</orgName> <address><city>Porto</city> <country>Portugal</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="jvh12248-aff-0070"><orgDiv>Division of Gastroenterology & Hepatology</orgDiv> <orgName>Cantonal Hospital St. Gallen</orgName> <address><city>St. Gallen</city> <country>Switzerland</country></address></affiliation><affiliation countryCode="CA" type="organization" xml:id="jvh12248-aff-0071"><orgName>Toronto General Hospital</orgName> <orgName>University Health Network/University of Toronto</orgName> <address><city>Toronto</city> <countryPart>ON</countryPart> <country>Canada</country></address></affiliation><affiliation countryCode="EG" type="organization" xml:id="jvh12248-aff-0072"><orgName>Egyptian Liver Research Institute And Hospital</orgName> <address><city>Dakahliah</city> <country>Egypt</country></address></affiliation><affiliation countryCode="AU" type="organization" xml:id="jvh12248-aff-0073"><orgName>Monash University and Monash Health</orgName> <address><city>Melbourne</city> <countryPart>Vic.</countryPart> <country>Australia</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0074"><orgDiv>Cliniques Universitaires Saint‐Luc</orgDiv> <orgName>Université Catholique de Louvain</orgName> <address><city>Brussel</city> <country>Belgium</country></address></affiliation><affiliation countryCode="AT" type="organization" xml:id="jvh12248-aff-0075"><orgDiv>Division of Gastroenterology and Hepatology</orgDiv> <orgDiv>Department of Internal Medicine</orgDiv> <orgName>Medical University of Graz</orgName> <address><city>Graz</city> <country>Austria</country></address></affiliation><affiliation countryCode="AU" type="organization" xml:id="jvh12248-aff-0076"><orgDiv>Department of Gastroenterology</orgDiv> <orgName>St Vincent's Hospital and the University of Melbourne</orgName> <address><city>Melbourne</city> <countryPart>Vic.</countryPart> <country>Australia</country></address></affiliation><affiliation countryCode="CZ" type="organization" xml:id="jvh12248-aff-0077"><orgDiv>Department of Internal Medicine</orgDiv> <orgDiv>1st Faculty of Medicine</orgDiv> <orgName>Charles University in Prague and Central Military Hospital</orgName> <address><city>Prague</city> <country>Czech Republic</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0078"><orgName>Universiteit Antwerpen</orgName> <address><city>Antwerpen</city> <country>Belgium</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jvh12248-aff-0079"><orgName>Deutsche Leberhilfe e.V.</orgName> <address><city>Cologne</city> <country>Germany</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0080"><orgName>Ghent University Hospital</orgName> <address><city>Ghent</city> <country>Belgium</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="jvh12248-aff-0081"><orgDiv>Department of Health Economics & Patient Safety</orgDiv> <orgName>Ghent University</orgName> <orgName>Belgium Hasselt University</orgName> <address><city>Diepenbeek</city> <country>Belgium</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="jvh12248-aff-0082"><orgDiv>Department of Gastroenterology, Hepatology and Endocrinology</orgDiv> <orgName>Hannover Medical School</orgName> <address><city>Hannover</city> <country>Germany</country></address></affiliation><affiliation countryCode="DK" type="organization" xml:id="jvh12248-aff-0083"><orgName>Copenhagen University Hospital</orgName> <address><city>Hvidovre</city> <country>Denmark</country></address></affiliation><affiliation countryCode="AU" type="organization" xml:id="jvh12248-aff-0084"><orgName>St George Hospital Clinical School of Medicine and School of Medical Science</orgName> <orgName>University of New South Wales</orgName> <address><city>Sydney</city> <countryPart>NSW</countryPart> <country>Australia</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="jvh12248-aff-0085"><orgDiv>Swiss HPB (Hepato‐Pancreato‐Biliary) Center and Department of Gastroenterology and Hepatology</orgDiv> <orgName>University Hospital Zürich</orgName> <address><city>Zürich</city> <country>Switzerland</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="jvh12248-kwd-0001">diagnosis</keyword><keyword xml:id="jvh12248-kwd-0002">disease burden</keyword><keyword xml:id="jvh12248-kwd-0003">epidemiology</keyword><keyword xml:id="jvh12248-kwd-0004"><fc>HCV</fc></keyword><keyword xml:id="jvh12248-kwd-0005">hepatitis C</keyword><keyword xml:id="jvh12248-kwd-0006">incidence</keyword><keyword xml:id="jvh12248-kwd-0007">mortality</keyword><keyword xml:id="jvh12248-kwd-0008">prevalence</keyword><keyword xml:id="jvh12248-kwd-0009">treatment</keyword></keywordGroup><fundingInfo><fundingAgency>Gilead Sciences</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:id="jvh12248-abs-0001"><title type="main">Summary</title><p>The disease burden of hepatitis <fc>C</fc> virus (<fc>HCV</fc>) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of <fc>HCV</fc> infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of <fc>HCV</fc> infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of <fc>HCV</fc>. Thus, alternative strategies are required to keep the number of <fc>HCV</fc> individuals with advanced liver disease and liver‐related deaths from increasing.</p></abstract></abstractGroup></contentMeta><noteGroup xml:id="jvh12248-ntgp-0001"><note xml:id="jvh12248-note-0001">Denotes senior authors.</note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Razavi</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><description>Denotes senior authors.</description><affiliation>Correspondence: Homie A. Razavi, Center for Disease Analysis, 901 Front Street, Suite 291, Louisville, CO 80027, USA.E‐mail:</affiliation><affiliation>E-mail: homie.razavi@centerforda.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Waked</namePart><affiliation>National Liver Institute, Menoufiya, Egypt</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sarrazin</namePart><affiliation>J.W. Goethe University Hospital, Frankfurt, Germany</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. P.</namePart><namePart type="family">Myers</namePart><affiliation>Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, AB, Calgary, Canada</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Idilman</namePart><affiliation>Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Calinas</namePart><affiliation>Gastroenterology Department, Centro Hospitalar de Lisboa Central – Hospital Santo António Capuchos, Lisboa, Portugal</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Vogel</namePart><affiliation>Innsbruck Medical University, Innsbruck, Austria</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. C.</namePart><namePart type="family">Mendes Correa</namePart><affiliation>School of Medicine‐ Universidade de São Paulo, São Paulo, Brazil</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Hézode</namePart><affiliation>Service d' Hépato‐Gastroentérologie, Hôpital Henri Mondor, Créteil, France</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Lázaro</namePart><affiliation>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Akarca</namePart><affiliation>Gastroenterology, Ege University, Izmir, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Aleman</namePart><affiliation>Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden</affiliation><affiliation>Department of Gastroenterology and Hepatology/Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">İ.</namePart><namePart type="family">Balık</namePart><affiliation>Infectious Diseases, Ankara University, Ankara, Turkey</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Berg</namePart><affiliation>University of Leipzig, Leipzig, Germany</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Bihl</namePart><affiliation>Gastroenterology Department, Ospedale Cantonale, Bellinzona, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Bilodeau</namePart><affiliation>Liver Unit, Department of Medicine, Université de Montréal, QC, Montréal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Blasco</namePart><affiliation>Advanced Techniques in Health Services Research (TAISS), Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. E.</namePart><namePart type="family">Brandão Mello</namePart><affiliation>Department of Gastroenterology, Federal University of the State of Rio de Janeiro, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Bruggmann</namePart><affiliation>Arud Centres for Addiction Medicine, Zurich, Switzerland</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Buti</namePart><affiliation>Hospital Vall d'Hebron, CIBERehd, Barcelona, Spain</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Calleja</namePart><affiliation>Hospital Puerta de Hierro, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Cheinquer</namePart><affiliation>Hospital das Clínicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. B.</namePart><namePart type="family">Christensen</namePart><affiliation>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Clausen</namePart><affiliation>Region Hospital Hovedstaden, Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. S. M.</namePart><namePart type="family">Coelho</namePart><affiliation>Department of Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. E.</namePart><namePart type="family">Cramp</namePart><affiliation>Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Dore</namePart><affiliation>Kirby Institute, University of New South Wales, NSW, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Doss</namePart><affiliation>Cairo University, Cairo, Egypt</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Duberg</namePart><affiliation>Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden</affiliation><affiliation>School of Health and Medical Sciences, Örebro University, Örebro, Sweden</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. H.</namePart><namePart type="family">El‐Sayed</namePart><affiliation>Ain Shams University, Cairo, Egypt</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Ergör</namePart><affiliation>Public Health and Epidemiology, Dokuz Eylul University, Izmir, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Esmat</namePart><affiliation>Cairo University, Cairo, Egypt</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Falconer</namePart><affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Félix</namePart><affiliation>Exigo Consultores, Alhos Vedros, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L. G.</namePart><namePart type="family">Ferraz</namePart><affiliation>Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. R.</namePart><namePart type="family">Ferreira</namePart><affiliation>Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Frankova</namePart><affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">García‐Samaniego</namePart><affiliation>Hospital Carlos III, CIBERehd, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Gerstoft</namePart><affiliation>University of Copenhagen, Copenhagen, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Giria</namePart><affiliation>Direcção‐Geral da Saúde, Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. L.</namePart><namePart type="family">Gonçales Jr</namePart><affiliation>Grupo de Estudo das Hepatites, Disciplina de Doenças Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, UNICAMP, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Gower</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Gschwantler</namePart><affiliation>Department of Internal Medicine IV, Wilhelminenspital, Vienna, Austria</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Guimarães Pessôa</namePart><affiliation>Division of Gastroenterology and Hepatology, University of São Paulo School of Medicine, São Paulo, Brazil</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. J.</namePart><namePart type="family">Hindman</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Hofer</namePart><affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Husa</namePart><affiliation>Clinic of Infectious Diseases of the University Hospital Brno, Masaryk University Brno, Brno, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kåberg</namePart><affiliation>Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. D. E.</namePart><namePart type="family">Kaita</namePart><affiliation>Section of Hepatology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada</affiliation><affiliation>Viral Hepatitis Investigative Unit, Health Sciences Centre, MB, Winnipeg, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kautz</namePart><affiliation>European Liver Patients Association, Sint‐Truiden, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kaymakoglu</namePart><affiliation>Gastroenterology, Istanbul University, Istanbul, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Krajden</namePart><affiliation>British Columbia Centre for Disease Control, University of British Columbia, BC, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Krarup</namePart><affiliation>Department of Medical Gastroenterology and Section of Molecular Diagnostics, Cinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Laleman</namePart><affiliation>University Hospitals Leuven, KU Leuven, Leuven, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Lavanchy</namePart><affiliation>Independent Consultant, Denges, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. T.</namePart><namePart type="family">Marinho</namePart><affiliation>Gastroenterology Department, Centro Hospitalar de Lisboa Norte, Hospital Santa Maria, Lisboa, Portugal</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Marotta</namePart><affiliation>Division of Gastroenterology, University of Western Ontario, ON, London, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Mauss</namePart><affiliation>Heinrich‐Heine University in Duesseldorf, Dusseldorf, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Moreno</namePart><affiliation>Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Murphy</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Negro</namePart><affiliation>Divisions of Gastroenterology and Hepatology and of Clinical Pathology, University Hospital, Genève, Switzerland</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Nemecek</namePart><affiliation>National Reference Laboratory for Hepatitis, National Institute of Public Health, Prague, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Örmeci</namePart><affiliation>Gastroenterology, Ankara University, Ankara, Turkey</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L. H.</namePart><namePart type="family">Øvrehus</namePart><affiliation>Department of Infectious Diseases, Odense University Hospital, Odense, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Parkes</namePart><affiliation>University of Southhampton, Southhampton, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Pasini</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Peltekian</namePart><affiliation>Departments of Medicine and Surgery, Queen Elizabeth II Health Sciences Centre, Capital District Health Authority, Dalhousie University and Hepatology Services, NS, Halifax, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ramji</namePart><affiliation>Department of Gastroenterology, University of British Columbia, BC, Vancouver, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Reis</namePart><affiliation>Assembleia da República, Lisboa, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Roberts</namePart><affiliation>The Alfred Hospital and Monash University, Vic., Melbourne, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. M.</namePart><namePart type="family">Rosenberg</namePart><affiliation>Division of Medicine, UCL Institute for Liver and Digestive Health, University College London, London, UK</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Roudot‐Thoraval</namePart><affiliation>Département Santé Publique, Hôpital Henri Mondor, Créteil, France</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Ryder</namePart><affiliation>Nottingham University Hospitals NHS Trust and Biomedical Research Unit, Nottingham, UK</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Sarmento‐Castro</namePart><affiliation>Infectious Diseases Department, Centro Hospitalar do Porto, Porto, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Semela</namePart><affiliation>Division of Gastroenterology & Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sherman</namePart><affiliation>Toronto General Hospital, University Health Network/University of Toronto, ON, Toronto, Canada</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. E.</namePart><namePart type="family">Shiha</namePart><affiliation>Egyptian Liver Research Institute And Hospital, Dakahliah, Egypt</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Sievert</namePart><affiliation>Monash University and Monash Health, Vic., Melbourne, Australia</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Sperl</namePart><affiliation>Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Stärkel</namePart><affiliation>Cliniques Universitaires Saint‐Luc, Université Catholique de Louvain, Brussel, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. E.</namePart><namePart type="family">Stauber</namePart><affiliation>Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Thompson</namePart><affiliation>Department of Gastroenterology, St Vincent's Hospital and the University of Melbourne, Vic., Melbourne, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Urbanek</namePart><affiliation>Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague and Central Military Hospital, Prague, Czech Republic</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Van Damme</namePart><affiliation>Universiteit Antwerpen, Antwerpen, Belgium</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">van Thiel</namePart><affiliation>European Liver Patients Association, Sint‐Truiden, Belgium</affiliation><affiliation>Deutsche Leberhilfe e.V., Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Van Vlierberghe</namePart><affiliation>Ghent University Hospital, Ghent, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Vandijck</namePart><affiliation>Department of Health Economics & Patient Safety, Ghent University, Belgium Hasselt University, Diepenbeek, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Wedemeyer</namePart><affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Weis</namePart><affiliation>Copenhagen University Hospital, Hvidovre, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wiegand</namePart><affiliation>Infectious Diseases, Ankara University, Ankara, Turkey</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Yosry</namePart><affiliation>Cairo University, Cairo, Egypt</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Zekry</namePart><affiliation>St George Hospital Clinical School of Medicine and School of Medical Science, University of New South Wales, NSW, Sydney, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Cornberg</namePart><affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Müllhaupt</namePart><affiliation>Swiss HPB (Hepato‐Pancreato‐Biliary) Center and Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Estes</namePart><affiliation>Center for Disease Analysis, Colorado, Louisville, USA</affiliation><description>Denotes senior authors.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-05</dateIssued><dateCreated encoding="w3cdtf">2014-03-14</dateCreated><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013–2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late‐stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver‐related deaths from increasing.</abstract><note type="funding">Gilead Sciences</note><subject><genre>keywords</genre><topic>diagnosis</topic><topic>disease burden</topic><topic>epidemiology</topic><topic>HCV</topic><topic>hepatitis C</topic><topic>incidence</topic><topic>mortality</topic><topic>prevalence</topic><topic>treatment</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Viral Hepatitis</title></titleInfo><titleInfo type="abbreviated"><title>J Viral Hepat</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">1352-0504</identifier><identifier type="eISSN">1365-2893</identifier><identifier type="DOI">10.1111/(ISSN)1365-2893</identifier><identifier type="PublisherID">JVH</identifier><part><date>2014</date><detail type="title"><title>Hepatitis C Disease Burden & Strategies to Manage the Burden</title></detail><detail type="volume"><caption>vol.</caption><number>21</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s1</number></detail><extent unit="pages"><start>34</start><end>59</end><total>26</total></extent></part></relatedItem><identifier type="istex">6F5499030B2D47269785C4D57593C4C552FA1B5F</identifier><identifier type="ark">ark:/67375/WNG-085BKGWQ-5</identifier><identifier type="DOI">10.1111/jvh.12248</identifier><identifier type="ArticleID">JVH12248</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2014 John Wiley & Sons Ltd© 2014 John Wiley & Sons Ltd</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/6F5499030B2D47269785C4D57593C4C552FA1B5F/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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