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Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study

Identifieur interne : 000F75 ( Istex/Corpus ); précédent : 000F74; suivant : 000F76

Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study

Auteurs : Thomas Behrens ; Benjamin Kendzia ; Tabea Treppmann ; Ann Olsson ; Karl-Heinz Jöckel ; Per Gustavsson ; Hermann Pohlabeln ; Wolfgang Ahrens ; Irene Brüske ; Hans-Erich Wichmann ; Franco Merletti ; Dario Mirabelli ; Lorenzo Richiardi ; Lorenzo Simonato ; David Zaridze ; Neonila Szeszenia-Dabrowska ; Peter Rudnai ; Jolanta Lissowska ; Eleonora Fabianova ; Adonina Tard N ; John Field ; Rodica Stanescu Dumitru ; Vladimir Bencko ; Lenka Foretova ; Vladimir Janout ; Jack Siemiatycki ; Marie-Elise Parent ; John Mclaughlin ; Paul Demers ; Maria Teresa Landi ; Neil Caporaso ; Hans Kromhout ; Roel Vermeulen ; Susan Peters ; Simone Benhamou ; Isabelle Stücker ; Florence Guida ; Dario Consonni ; Bas Bueno-De-Mesquita ; Andrea Mannetje ; Neil Pearce ; Lap Ah Tse ; Ignatius Tak-Sun Yu ; Nils Plato ; Paolo Boffetta ; Kurt Straif ; Joachim Schüz ; Beate Pesch ; Thomas Brüning

Source :

RBID : ISTEX:5371352228E9E973C0249D4E73BBFF99BBA284DB

English descriptors

Abstract

Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.

Url:
DOI: 10.1136/oemed-2013-101469

Links to Exploration step

ISTEX:5371352228E9E973C0249D4E73BBFF99BBA284DB

Le document en format XML

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<name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name>
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<name sortKey="Demers, Paul" sort="Demers, Paul" uniqKey="Demers P" first="Paul" last="Demers">Paul Demers</name>
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<name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
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<name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name>
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<name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name>
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<name sortKey="Consonni, Dario" sort="Consonni, Dario" uniqKey="Consonni D" first="Dario" last="Consonni">Dario Consonni</name>
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<name sortKey="Bueno De Mesquita, Bas" sort="Bueno De Mesquita, Bas" uniqKey="Bueno De Mesquita B" first="Bas" last="Bueno-De-Mesquita">Bas Bueno-De-Mesquita</name>
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<mods:affiliation>The National Institute for Public Health and Environmental Protection, Center for Nutrition and Health, Bilthoven, The Netherlands</mods:affiliation>
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<name sortKey=" Mannetje, Andrea" sort=" Mannetje, Andrea" uniqKey=" Mannetje A" first="Andrea" last=" Mannetje">Andrea Mannetje</name>
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<name sortKey="Pearce, Neil" sort="Pearce, Neil" uniqKey="Pearce N" first="Neil" last="Pearce">Neil Pearce</name>
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<name sortKey="Tse, Lap Ah" sort="Tse, Lap Ah" uniqKey="Tse L" first="Lap Ah" last="Tse">Lap Ah Tse</name>
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<mods:affiliation>Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China</mods:affiliation>
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<name sortKey="Yu, Ignatius Tak Sun" sort="Yu, Ignatius Tak Sun" uniqKey="Yu I" first="Ignatius Tak-Sun" last="Yu">Ignatius Tak-Sun Yu</name>
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<name sortKey="Plato, Nils" sort="Plato, Nils" uniqKey="Plato N" first="Nils" last="Plato">Nils Plato</name>
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<name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name>
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<mods:affiliation>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</mods:affiliation>
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<name sortKey="Straif, Kurt" sort="Straif, Kurt" uniqKey="Straif K" first="Kurt" last="Straif">Kurt Straif</name>
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<name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
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<title level="a">Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study</title>
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<name sortKey="Olsson, Ann" sort="Olsson, Ann" uniqKey="Olsson A" first="Ann" last="Olsson">Ann Olsson</name>
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<name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name>
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<mods:affiliation>Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany</mods:affiliation>
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<name sortKey="Gustavsson, Per" sort="Gustavsson, Per" uniqKey="Gustavsson P" first="Per" last="Gustavsson">Per Gustavsson</name>
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<mods:affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</mods:affiliation>
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<name sortKey="Pohlabeln, Hermann" sort="Pohlabeln, Hermann" uniqKey="Pohlabeln H" first="Hermann" last="Pohlabeln">Hermann Pohlabeln</name>
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<name sortKey="Ahrens, Wolfgang" sort="Ahrens, Wolfgang" uniqKey="Ahrens W" first="Wolfgang" last="Ahrens">Wolfgang Ahrens</name>
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<mods:affiliation>Leibniz-Institute for Prevention Research and Epidemiology - BIPS GmbH, Bremen, Germany</mods:affiliation>
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<affiliation>
<mods:affiliation>Institute for Statistics, University of Bremen, Bremen, Germany</mods:affiliation>
</affiliation>
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<name sortKey="Bruske, Irene" sort="Bruske, Irene" uniqKey="Bruske I" first="Irene" last="Brüske">Irene Brüske</name>
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<mods:affiliation>Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany</mods:affiliation>
</affiliation>
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<name sortKey="Wichmann, Hans Erich" sort="Wichmann, Hans Erich" uniqKey="Wichmann H" first="Hans-Erich" last="Wichmann">Hans-Erich Wichmann</name>
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<mods:affiliation>Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany</mods:affiliation>
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<name sortKey="Merletti, Franco" sort="Merletti, Franco" uniqKey="Merletti F" first="Franco" last="Merletti">Franco Merletti</name>
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<name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name>
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<name sortKey="Field, John" sort="Field, John" uniqKey="Field J" first="John" last="Field">John Field</name>
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<author>
<name sortKey="Stanescu Dumitru, Rodica" sort="Stanescu Dumitru, Rodica" uniqKey="Stanescu Dumitru R" first="Rodica" last="Stanescu Dumitru">Rodica Stanescu Dumitru</name>
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<author>
<name sortKey="Bencko, Vladimir" sort="Bencko, Vladimir" uniqKey="Bencko V" first="Vladimir" last="Bencko">Vladimir Bencko</name>
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</affiliation>
</author>
<author>
<name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimir" last="Janout">Vladimir Janout</name>
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<mods:affiliation>Faculty of Medicine, Palacky University, Olomouc, Czech Republic</mods:affiliation>
</affiliation>
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<mods:affiliation>University of Montreal, Hospital Research Center (CRCHUM) and School of Public Health, Montreal, Canada</mods:affiliation>
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<name sortKey="Mclaughlin, John" sort="Mclaughlin, John" uniqKey="Mclaughlin J" first="John" last="Mclaughlin">John Mclaughlin</name>
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<name sortKey="Demers, Paul" sort="Demers, Paul" uniqKey="Demers P" first="Paul" last="Demers">Paul Demers</name>
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<name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
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<author>
<name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name>
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<mods:affiliation>Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands</mods:affiliation>
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</author>
<author>
<name sortKey="Vermeulen, Roel" sort="Vermeulen, Roel" uniqKey="Vermeulen R" first="Roel" last="Vermeulen">Roel Vermeulen</name>
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<mods:affiliation>Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands</mods:affiliation>
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</author>
<author>
<name sortKey="Peters, Susan" sort="Peters, Susan" uniqKey="Peters S" first="Susan" last="Peters">Susan Peters</name>
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<mods:affiliation>Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Benhamou, Simone" sort="Benhamou, Simone" uniqKey="Benhamou S" first="Simone" last="Benhamou">Simone Benhamou</name>
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<mods:affiliation>INSERM U 946, Paris, France</mods:affiliation>
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</author>
<author>
<name sortKey="Stucker, Isabelle" sort="Stucker, Isabelle" uniqKey="Stucker I" first="Isabelle" last="Stücker">Isabelle Stücker</name>
<affiliation>
<mods:affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>University Paris-Sud, UMRS 1018, F-94807, Villejuif, France</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name>
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<mods:affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>University Paris-Sud, UMRS 1018, F-94807, Villejuif, France</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Consonni, Dario" sort="Consonni, Dario" uniqKey="Consonni D" first="Dario" last="Consonni">Dario Consonni</name>
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<mods:affiliation>Unit of Epidemiology, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bueno De Mesquita, Bas" sort="Bueno De Mesquita, Bas" uniqKey="Bueno De Mesquita B" first="Bas" last="Bueno-De-Mesquita">Bas Bueno-De-Mesquita</name>
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<mods:affiliation>The National Institute for Public Health and Environmental Protection, Center for Nutrition and Health, Bilthoven, The Netherlands</mods:affiliation>
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</author>
<author>
<name sortKey=" Mannetje, Andrea" sort=" Mannetje, Andrea" uniqKey=" Mannetje A" first="Andrea" last=" Mannetje">Andrea Mannetje</name>
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<mods:affiliation>Centre for Public Health Research, Massey University, Wellington, New Zealand</mods:affiliation>
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</author>
<author>
<name sortKey="Pearce, Neil" sort="Pearce, Neil" uniqKey="Pearce N" first="Neil" last="Pearce">Neil Pearce</name>
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<mods:affiliation>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Tse, Lap Ah" sort="Tse, Lap Ah" uniqKey="Tse L" first="Lap Ah" last="Tse">Lap Ah Tse</name>
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<mods:affiliation>Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Yu, Ignatius Tak Sun" sort="Yu, Ignatius Tak Sun" uniqKey="Yu I" first="Ignatius Tak-Sun" last="Yu">Ignatius Tak-Sun Yu</name>
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<mods:affiliation>Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China</mods:affiliation>
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</author>
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<name sortKey="Plato, Nils" sort="Plato, Nils" uniqKey="Plato N" first="Nils" last="Plato">Nils Plato</name>
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</author>
<author>
<name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name>
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<mods:affiliation>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</mods:affiliation>
</affiliation>
<affiliation>
<mods:affiliation>The International Prevention Research Institute, Lyon, France</mods:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Straif, Kurt" sort="Straif, Kurt" uniqKey="Straif K" first="Kurt" last="Straif">Kurt Straif</name>
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<author>
<name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
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<mods:affiliation>International Agency for Research on Cancer (IARC), Lyon, France</mods:affiliation>
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</author>
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<name sortKey="Pesch, Beate" sort="Pesch, Beate" uniqKey="Pesch B" first="Beate" last="Pesch">Beate Pesch</name>
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<mods:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bochum, Germany</mods:affiliation>
</affiliation>
</author>
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<name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
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<mods:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bochum, Germany</mods:affiliation>
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<title level="j">Occupational and Environmental Medicine</title>
<title level="j" type="abbrev">Occup Environ Med</title>
<idno type="ISSN">1351-0711</idno>
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<date type="published" when="2013-11">2013-11</date>
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<term>Accident insurance</term>
<term>Baking</term>
<term>Baking process</term>
<term>Behrens</term>
<term>Cancer epidemiology</term>
<term>Carcinogen</term>
<term>Centre</term>
<term>Cigarette smoking</term>
<term>Confectionary</term>
<term>Confectionary makers</term>
<term>Control subjects</term>
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<term>Female bakers</term>
<term>Healthy worker effect</term>
<term>Histological</term>
<term>Histological subtype</term>
<term>Hong kong</term>
<term>Individual studies</term>
<term>Italian eagle study</term>
<term>Lung cancer</term>
<term>Lung cancer risk</term>
<term>Lung cancer risks</term>
<term>National institute</term>
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<term>Occup</term>
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<front>
<div type="abstract">Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.</div>
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<abstract>Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.</abstract>
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<forename type="first">John</forename>
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<forename type="first">Rodica</forename>
<surname>Stanescu Dumitru</surname>
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<forename type="first">Vladimir</forename>
<surname>Bencko</surname>
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<forename type="first">Vladimir</forename>
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<forename type="first">Jack</forename>
<surname>Siemiatycki</surname>
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<forename type="first">Marie-Elise</forename>
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<affiliation>INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada</affiliation>
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<forename type="first">John</forename>
<surname>McLaughlin</surname>
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<forename type="first">Paul</forename>
<surname>Demers</surname>
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<forename type="first">Maria Teresa</forename>
<surname>Landi</surname>
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<affiliation>National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, USA</affiliation>
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<forename type="first">Neil</forename>
<surname>Caporaso</surname>
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<affiliation>National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, USA</affiliation>
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<forename type="first">Hans</forename>
<surname>Kromhout</surname>
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<forename type="first">Roel</forename>
<surname>Vermeulen</surname>
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<affiliation>Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands</affiliation>
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<forename type="first">Susan</forename>
<surname>Peters</surname>
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<affiliation>Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands</affiliation>
<affiliation>Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia, Australia</affiliation>
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<persName>
<forename type="first">Simone</forename>
<surname>Benhamou</surname>
</persName>
<affiliation>INSERM U 946, Paris, France</affiliation>
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<persName>
<forename type="first">Isabelle</forename>
<surname>Stücker</surname>
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<affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France</affiliation>
<affiliation>University Paris-Sud, UMRS 1018, F-94807, Villejuif, France</affiliation>
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<persName>
<forename type="first">Florence</forename>
<surname>Guida</surname>
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<affiliation>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807, Villejuif, France</affiliation>
<affiliation>University Paris-Sud, UMRS 1018, F-94807, Villejuif, France</affiliation>
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<persName>
<forename type="first">Dario</forename>
<surname>Consonni</surname>
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<affiliation>Unit of Epidemiology, Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy</affiliation>
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<forename type="first">Bas</forename>
<surname>Bueno-de-Mesquita</surname>
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<affiliation>The National Institute for Public Health and Environmental Protection, Center for Nutrition and Health, Bilthoven, The Netherlands</affiliation>
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<persName>
<forename type="first">Andrea</forename>
<surname>‘t Mannetje</surname>
</persName>
<affiliation>Centre for Public Health Research, Massey University, Wellington, New Zealand</affiliation>
</author>
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<persName>
<forename type="first">Neil</forename>
<surname>Pearce</surname>
</persName>
<affiliation>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK</affiliation>
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<persName>
<forename type="first">Lap Ah</forename>
<surname>Tse</surname>
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<affiliation>Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China</affiliation>
</author>
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<persName>
<forename type="first">Ignatius Tak-sun</forename>
<surname>Yu</surname>
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<affiliation>Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China</affiliation>
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<forename type="first">Nils</forename>
<surname>Plato</surname>
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<affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden</affiliation>
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<persName>
<forename type="first">Paolo</forename>
<surname>Boffetta</surname>
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<affiliation>The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, USA</affiliation>
<affiliation>The International Prevention Research Institute, Lyon, France</affiliation>
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<persName>
<forename type="first">Kurt</forename>
<surname>Straif</surname>
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<forename type="first">Joachim</forename>
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<persName>
<forename type="first">Beate</forename>
<surname>Pesch</surname>
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<affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bochum, Germany</affiliation>
</author>
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<persName>
<forename type="first">Thomas</forename>
<surname>Brüning</surname>
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<affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bochum, Germany</affiliation>
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<title level="j">Occupational and Environmental Medicine</title>
<title level="j" type="abbrev">Occup Environ Med</title>
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<p>Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.</p>
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<journal-title>Occupational and Environmental Medicine</journal-title>
<abbrev-journal-title abbrev-type="publisher">Occup Environ Med</abbrev-journal-title>
<abbrev-journal-title>Occup Environ Med</abbrev-journal-title>
<issn pub-type="ppub">1351-0711</issn>
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<subject>Workplace</subject>
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<series-title>Original article</series-title>
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<title-group>
<article-title>Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study</article-title>
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<contrib contrib-type="author">
<name>
<surname>Behrens</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kendzia</surname>
<given-names>Benjamin</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Treppmann</surname>
<given-names>Tabea</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Olsson</surname>
<given-names>Ann</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jöckel</surname>
<given-names>Karl-Heinz</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gustavsson</surname>
<given-names>Per</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pohlabeln</surname>
<given-names>Hermann</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
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<name>
<surname>Ahrens</surname>
<given-names>Wolfgang</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
<xref ref-type="aff" rid="af6">6</xref>
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<contrib contrib-type="author">
<name>
<surname>Brüske</surname>
<given-names>Irene</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wichmann</surname>
<given-names>Hans-Erich</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
</contrib>
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<name>
<surname>Merletti</surname>
<given-names>Franco</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
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<name>
<surname>Mirabelli</surname>
<given-names>Dario</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Richiardi</surname>
<given-names>Lorenzo</given-names>
</name>
<xref ref-type="aff" rid="af8">8</xref>
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<contrib contrib-type="author">
<name>
<surname>Simonato</surname>
<given-names>Lorenzo</given-names>
</name>
<xref ref-type="aff" rid="af9">9</xref>
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<name>
<surname>Zaridze</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="af10">10</xref>
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<name>
<surname>Szeszenia-Dabrowska</surname>
<given-names>Neonila</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
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<contrib contrib-type="author">
<name>
<surname>Rudnai</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
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<name>
<surname>Lissowska</surname>
<given-names>Jolanta</given-names>
</name>
<xref ref-type="aff" rid="af13">13</xref>
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<name>
<surname>Fabianova</surname>
<given-names>Eleonora</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
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<name>
<surname>Tardón</surname>
<given-names>Adonina</given-names>
</name>
<xref ref-type="aff" rid="af15">15</xref>
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<contrib contrib-type="author">
<name>
<surname>Field</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="af16">16</xref>
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<name>
<surname>Stanescu Dumitru</surname>
<given-names>Rodica</given-names>
</name>
<xref ref-type="aff" rid="af17">17</xref>
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<name>
<surname>Bencko</surname>
<given-names>Vladimir</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
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<name>
<surname>Foretova</surname>
<given-names>Lenka</given-names>
</name>
<xref ref-type="aff" rid="af19">19</xref>
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<contrib contrib-type="author">
<name>
<surname>Janout</surname>
<given-names>Vladimir</given-names>
</name>
<xref ref-type="aff" rid="af20">20</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Siemiatycki</surname>
<given-names>Jack</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Parent</surname>
<given-names>Marie-Elise</given-names>
</name>
<xref ref-type="aff" rid="af22">22</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McLaughlin</surname>
<given-names>John</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
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<contrib contrib-type="author">
<name>
<surname>Demers</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Landi</surname>
<given-names>Maria Teresa</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Caporaso</surname>
<given-names>Neil</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Kromhout</surname>
<given-names>Hans</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Vermeulen</surname>
<given-names>Roel</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Peters</surname>
<given-names>Susan</given-names>
</name>
<xref ref-type="aff" rid="af25">25</xref>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Benhamou</surname>
<given-names>Simone</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Stücker</surname>
<given-names>Isabelle</given-names>
</name>
<xref ref-type="aff" rid="af28">28</xref>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Guida</surname>
<given-names>Florence</given-names>
</name>
<xref ref-type="aff" rid="af28">28</xref>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Consonni</surname>
<given-names>Dario</given-names>
</name>
<xref ref-type="aff" rid="af30">30</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Bueno-de-Mesquita</surname>
<given-names>Bas</given-names>
</name>
<xref ref-type="aff" rid="af31">31</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>‘t Mannetje</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="af32">32</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pearce</surname>
<given-names>Neil</given-names>
</name>
<xref ref-type="aff" rid="af33">33</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tse</surname>
<given-names>Lap Ah</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Ignatius Tak-sun</given-names>
</name>
<xref ref-type="aff" rid="af34">34</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Plato</surname>
<given-names>Nils</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Boffetta</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="af35">35</xref>
<xref ref-type="aff" rid="af36">36</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Straif</surname>
<given-names>Kurt</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schüz</surname>
<given-names>Joachim</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Pesch</surname>
<given-names>Beate</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brüning</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
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<addr-line>Bochum</addr-line>
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<country>Germany</country>
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<label>2</label>
<institution>International Agency for Research on Cancer (IARC)</institution>
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<addr-line>Lyon</addr-line>
,
<country>France</country>
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<aff id="af3">
<label>3</label>
<institution>Institute of Environmental Medicine, Karolinska Institutet</institution>
,
<addr-line>Stockholm</addr-line>
,
<country>Sweden</country>
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<aff id="af4">
<label>4</label>
<institution>Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen</institution>
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<addr-line>Essen</addr-line>
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<country>Germany</country>
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<aff id="af5">
<label>5</label>
<institution>Leibniz-Institute for Prevention Research and Epidemiology - BIPS GmbH</institution>
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<addr-line>Bremen</addr-line>
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<country>Germany</country>
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<aff id="af6">
<label>6</label>
<institution>Institute for Statistics, University of Bremen</institution>
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<addr-line>Bremen</addr-line>
,
<country>Germany</country>
</aff>
<aff id="af7">
<label>7</label>
<institution>Institute of Epidemiology I, Helmholtz Zentrum München</institution>
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<addr-line>Neuherberg</addr-line>
,
<country>Germany</country>
</aff>
<aff id="af8">
<label>8</label>
<addr-line>Cancer Epidemiology Unit</addr-line>
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<institution>CPO-Piemonte and University of Turin</institution>
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<addr-line>Turin</addr-line>
,
<country>Italy</country>
</aff>
<aff id="af9">
<label>9</label>
<addr-line>Department of Environmental Medicine and Public Health</addr-line>
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<institution>University of Padova</institution>
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<addr-line>Padova</addr-line>
,
<country>Italy</country>
</aff>
<aff id="af10">
<label>10</label>
<institution>Institute of Carcinogenesis, Russian Cancer Research Centre</institution>
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<addr-line>Moscow</addr-line>
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<country>Russia</country>
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<aff id="af11">
<label>11</label>
<institution>The Nofer Institute of Occupational Medicine</institution>
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<addr-line>Lodz</addr-line>
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<country>Poland</country>
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<aff id="af12">
<label>12</label>
<institution>National Institute of Environmental Health</institution>
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<addr-line>Budapest</addr-line>
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<country>Hungary</country>
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<aff id="af13">
<label>13</label>
<institution>The M Sklodowska-Curie Cancer Center and Institute of Oncology</institution>
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<addr-line>Warsaw</addr-line>
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<country>Poland</country>
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<aff id="af14">
<label>14</label>
<institution>Regional Authority of Public Health, Preventive Occupational Medicine</institution>
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<addr-line>Banska Bystrica</addr-line>
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<country>Slovakia</country>
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<aff id="af15">
<label>15</label>
<addr-line>Molecular Epidemiology of Cancer Unit</addr-line>
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<institution>University of Oviedo-Ciber de Epidemiologia, CIBERESP</institution>
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<addr-line>Oviedo</addr-line>
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<country>Spain</country>
</aff>
<aff id="af16">
<label>16</label>
<institution>Roy Castle Lung Cancer Research Programme, Cancer Research Centre</institution>
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<institution>University of Liverpool</institution>
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<addr-line>Liverpool</addr-line>
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<country>UK</country>
</aff>
<aff id="af17">
<label>17</label>
<institution>National Institute of Public Health</institution>
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<addr-line>Bucharest</addr-line>
,
<country>Romania</country>
</aff>
<aff id="af18">
<label>18</label>
<institution>Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University</institution>
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<addr-line>Prague</addr-line>
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<country>Czech Republic</country>
</aff>
<aff id="af19">
<label>19</label>
<addr-line>Department of Cancer Epidemiology and Genetics</addr-line>
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<institution>Masaryk Memorial Cancer Institute</institution>
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<addr-line>Brno</addr-line>
,
<country>Czech Republic</country>
</aff>
<aff id="af20">
<label>20</label>
<addr-line>Faculty of Medicine</addr-line>
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<institution>Palacky University</institution>
,
<addr-line>Olomouc</addr-line>
,
<country>Czech Republic</country>
</aff>
<aff id="af21">
<label>21</label>
<institution>University of Montreal, Hospital Research Center (CRCHUM) and School of Public Health</institution>
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<addr-line>Montreal</addr-line>
,
<country>Canada</country>
</aff>
<aff id="af22">
<label>22</label>
<institution>INRS-Institut Armand-Frappier, Université du Québec</institution>
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<addr-line>Laval, Québec</addr-line>
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<country>Canada</country>
</aff>
<aff id="af23">
<label>23</label>
<institution>Cancer Care Ontario, Occupational Cancer Research Centre</institution>
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<addr-line>Toronto</addr-line>
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<country>Canada</country>
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<aff id="af24">
<label>24</label>
<institution>National Cancer Institute, Division of Cancer Epidemiology and Genetics</institution>
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<addr-line>Bethesda</addr-line>
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<country>USA</country>
</aff>
<aff id="af25">
<label>25</label>
<addr-line>Environmental Epidemiology Division</addr-line>
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<institution>Institute for Risk Assessment Sciences, Utrecht University</institution>
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<addr-line>Utrecht</addr-line>
,
<country>The Netherlands</country>
</aff>
<aff id="af26">
<label>26</label>
<institution>Western Australian Institute for Medical Research, University of Western Australia</institution>
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<addr-line>Perth, Western Australia</addr-line>
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<country>Australia</country>
</aff>
<aff id="af27">
<label>27</label>
<institution>INSERM U 946</institution>
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<addr-line>Paris</addr-line>
,
<country>France</country>
</aff>
<aff id="af28">
<label>28</label>
<institution>Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Environmental Epidemiology of Cancer Team, F-94807</institution>
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<addr-line>Villejuif</addr-line>
,
<country>France</country>
</aff>
<aff id="af29">
<label>29</label>
<institution>University Paris-Sud, UMRS 1018, F-94807</institution>
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<addr-line>Villejuif</addr-line>
,
<country>France</country>
</aff>
<aff id="af30">
<label>30</label>
<addr-line>Unit of Epidemiology</addr-line>
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<institution>Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico</institution>
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<addr-line>Milan</addr-line>
,
<country>Italy</country>
</aff>
<aff id="af31">
<label>31</label>
<institution>The National Institute for Public Health and Environmental Protection, Center for Nutrition and Health</institution>
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<addr-line>Bilthoven</addr-line>
,
<country>The Netherlands</country>
</aff>
<aff id="af32">
<label>32</label>
<institution>Centre for Public Health Research</institution>
,
<institution>Massey University</institution>
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<addr-line>Wellington</addr-line>
,
<country>New Zealand</country>
</aff>
<aff id="af33">
<label>33</label>
<addr-line>Faculty of Epidemiology and Population Health</addr-line>
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<institution>London School of Hygiene and Tropical Medicine</institution>
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<addr-line>London</addr-line>
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<country>UK</country>
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<aff id="af34">
<label>34</label>
<addr-line>Division of Occupational and Environmental Health</addr-line>
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<institution>JC School of Public Health and Primary Care, The Chinese University of Hong Kong</institution>
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<addr-line>Hong Kong</addr-line>
,
<country>China</country>
</aff>
<aff id="af35">
<label>35</label>
<institution>The Tisch Cancer Institute, Mount Sinai School of Medicine</institution>
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<addr-line>New York</addr-line>
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<country>USA</country>
</aff>
<aff id="af36">
<label>36</label>
<institution>The International Prevention Research Institute</institution>
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<addr-line>Lyon</addr-line>
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<country>France</country>
</aff>
<author-notes>
<corresp>
<label>Correspondence to</label>
Professor Thomas Behrens, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, Bochum 44789, Germany;
<email>behrens@ipa-dguv.de</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub-original">
<day>2</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>2</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>70</volume>
<volume-id pub-id-type="other">70</volume-id>
<volume-id pub-id-type="other">70</volume-id>
<issue>11</issue>
<issue-id pub-id-type="other">oemed;70/11</issue-id>
<issue-id pub-id-type="other">11</issue-id>
<issue-id pub-id-type="other">70/11</issue-id>
<fpage>810</fpage>
<history>
<date date-type="received">
<day>21</day>
<month>2</month>
<year>2013</year>
</date>
<date date-type="rev-recd">
<day>18</day>
<month>6</month>
<year>2013</year>
</date>
<date date-type="accepted">
<day>11</day>
<month>7</month>
<year>2013</year>
</date>
</history>
<permissions>
<copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-70-810.pdf"></self-uri>
<abstract>
<sec>
<title>Introduction</title>
<p>Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries.</p>
</sec>
<sec>
<title>Methods</title>
<p>Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status.</p>
</sec>
<sec>
<title>Results</title>
<p>19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared.</p>
</sec>
<sec>
<title>Discussion</title>
<p>The findings from this study do not suggest increased lung cancer risks in baking-related professions.</p>
</sec>
</abstract>
</article-meta>
</front>
</article>
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<title>Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study</title>
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<title>Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study</title>
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<name type="personal">
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<name type="personal">
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<namePart type="given">Jolanta</namePart>
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<name type="personal">
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<name type="personal">
<namePart type="given">Adonina</namePart>
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<roleTerm type="text">author</roleTerm>
</role>
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<name type="personal">
<namePart type="given">John</namePart>
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<roleTerm type="text">author</roleTerm>
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<name type="personal">
<namePart type="given">Rodica</namePart>
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<name type="personal">
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<namePart type="given">Jack</namePart>
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<name type="personal">
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<roleTerm type="text">author</roleTerm>
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<name type="personal">
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<name type="personal">
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<affiliation>The National Institute for Public Health and Environmental Protection, Center for Nutrition and Health, Bilthoven, The Netherlands</affiliation>
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<namePart type="given">Paolo</namePart>
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<affiliation>The International Prevention Research Institute, Lyon, France</affiliation>
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<namePart type="given">Kurt</namePart>
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<namePart type="given">Beate</namePart>
<namePart type="family">Pesch</namePart>
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<roleTerm type="text">author</roleTerm>
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<name type="personal">
<namePart type="given">Thomas</namePart>
<namePart type="family">Brüning</namePart>
<affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA) Institute of the Ruhr-Universität Bochum, Bochum, Germany</affiliation>
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<abstract>Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.</abstract>
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<identifier type="ISSN">1351-0711</identifier>
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<identifier type="DOI">10.1136/oemed-2013-101469</identifier>
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<identifier type="PMID">23911873</identifier>
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