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Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols

Identifieur interne : 002B48 ( Istex/Checkpoint ); précédent : 002B47; suivant : 002B49

Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols

Auteurs : R. Saracci [France] ; M. Kogevinas [France] ; R. Winkelmann [France] ; P. A. Bertazzi [Italie] ; B. H. Bueno De Mesquita [Pays-Bas] ; D. Coggon [Royaume-Uni] ; L. M. Green [Canada] ; T. Kauppinen [Finlande] ; K. A. L'Abbé [Canada] ; M. Littorin [Suède] ; E. Lynge [Danemark] ; J. D. Mathews [Australie] ; M. Neuberger [Autriche] ; J. Osman [Royaume-Uni] ; N. Pearce [Nouvelle-Zélande]

Source :

RBID : ISTEX:481A6B8A0824861EEFDD00CD5ACEBD85A92AD276

Descripteurs français

English descriptors

Abstract

Abstract: Epidemiological studies have revealed an increased risk of cancer, notably soft-tissue sarcomas and non-Hodgkin's lymphomas, in people occupationally exposed to chlorophenoxy herbicides, including those contaminated by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). We report here a historical cohort study of mortality in an international register of 18 910 production workers or sprayers from ten countries. Exposure was reconstructed through questionnaires, factory or spraying records, and job histories. Cause-specific national death rates were used as reference. No excess was observed in all-cause mortality, for all neoplasms, for the most common epithelial cancers, or for lymphomas. A statistically non-significant two-fold excess risk, based on 4 observed deaths, was noted for soft-tissue sarcoma with a standardised mortality ratio (SMR) of 196 and 95% confidence interval (CI) 53-502; this was concentrated as a six-fold statistically significant excess, occurring 10-19 years from first exposure in the cohort as a whole (SMR=606 [165-1552]) and, for the same time period, as a nine-fold excess among sprayers (SMR=882 [182-2579]). Risks appeared to be increased for cancers of the testicle, thyroid, other endocrine glands, and nose and nasal cavity, based on small numbers of deaths. The excess of soft-tissue sarcomas among sprayers is compatible with a causal role of chlorophenoxy herbicides but the excess does not seem to be specifically associated with those herbicides probably contaminated by TCDD.

Url:
DOI: 10.1016/0140-6736(91)91898-5


Affiliations:


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ISTEX:481A6B8A0824861EEFDD00CD5ACEBD85A92AD276

Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: Epidemiological studies have revealed an increased risk of cancer, notably soft-tissue sarcomas and non-Hodgkin's lymphomas, in people occupationally exposed to chlorophenoxy herbicides, including those contaminated by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). We report here a historical cohort study of mortality in an international register of 18 910 production workers or sprayers from ten countries. Exposure was reconstructed through questionnaires, factory or spraying records, and job histories. Cause-specific national death rates were used as reference. No excess was observed in all-cause mortality, for all neoplasms, for the most common epithelial cancers, or for lymphomas. A statistically non-significant two-fold excess risk, based on 4 observed deaths, was noted for soft-tissue sarcoma with a standardised mortality ratio (SMR) of 196 and 95% confidence interval (CI) 53-502; this was concentrated as a six-fold statistically significant excess, occurring 10-19 years from first exposure in the cohort as a whole (SMR=606 [165-1552]) and, for the same time period, as a nine-fold excess among sprayers (SMR=882 [182-2579]). Risks appeared to be increased for cancers of the testicle, thyroid, other endocrine glands, and nose and nasal cavity, based on small numbers of deaths. The excess of soft-tissue sarcomas among sprayers is compatible with a causal role of chlorophenoxy herbicides but the excess does not seem to be specifically associated with those herbicides probably contaminated by TCDD.</div>
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