AustralieFrV1, Istex, Checkpoint, bibRecord, 002A70

Detection of Human Immunodeficiency Virus Type 2 in Brain Tissue

Identifieur interne : 002A70 ( Istex/Checkpoint ); précédent : 002A69; suivant : 002A71

Detection of Human Immunodeficiency Virus Type 2 in Brain Tissue

Auteurs : Dominic E. Dwyer [France, Australie] ; Sophie Matheron [France] ; Serge Bakchine [France] ; Jean-Marie Bechet [France] ; Luc Montagnier [France] ; Rosemay Vazeux [France]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1992-10.

RBID : ISTEX:9D048CA91246DF06E3AF14C9E50D1CCA467FD3AA

Abstract

Infection due to human immunodeficiency virus (HIV) type 2 is believed to cause a clinical picture similar to that of HIV-1, although extensive data are not available. In 2 patients with West African exposure and neurologic symptoms, HIV-2 was detected in the central nervous system using DNA and RNA polymerase chain reaction, in situ hybridization, and immunohistology. In the first patient, the neurologic disease was most likely due to productive infection with HIV-2. In the second, a combination of neuropathologic abnormalities (including the presence of HIV-2) explained the clinical features. Thus HIV-2, like HIV-1, can be readily detected in brain tissue in patients with neurologic abnormalities, although the exact role of HIV-2 in pathogenesis of AIDS-associated neurologic disease requires further study.

Url:

https://api.istex.fr/document/9D048CA91246DF06E3AF14C9E50D1CCA467FD3AA/fulltext/pdf

DOI: 10.1093/infdis/166.4.888

Affiliations:

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ISTEX:9D048CA91246DF06E3AF14C9E50D1CCA467FD3AA

Le document en format XML

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<author><name sortKey="Matheron, Sophie" sort="Matheron, Sophie" uniqKey="Matheron S" first="Sophie" last="Matheron">Sophie Matheron</name>
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<author><name sortKey="Bakchine, Serge" sort="Bakchine, Serge" uniqKey="Bakchine S" first="Serge" last="Bakchine">Serge Bakchine</name>
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<author><name sortKey="Bechet, Jean Marie" sort="Bechet, Jean Marie" uniqKey="Bechet J" first="Jean-Marie" last="Bechet">Jean-Marie Bechet</name>
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<author><name sortKey="Montagnier, Luc" sort="Montagnier, Luc" uniqKey="Montagnier L" first="Luc" last="Montagnier">Luc Montagnier</name>
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<front><div type="abstract">Infection due to human immunodeficiency virus (HIV) type 2 is believed to cause a clinical picture similar to that of HIV-1, although extensive data are not available. In 2 patients with West African exposure and neurologic symptoms, HIV-2 was detected in the central nervous system using DNA and RNA polymerase chain reaction, in situ hybridization, and immunohistology. In the first patient, the neurologic disease was most likely due to productive infection with HIV-2. In the second, a combination of neuropathologic abnormalities (including the presence of HIV-2) explained the clinical features. Thus HIV-2, like HIV-1, can be readily detected in brain tissue in patients with neurologic abnormalities, although the exact role of HIV-2 in pathogenesis of AIDS-associated neurologic disease requires further study.</div>
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Detection of Human Immunodeficiency Virus Type 2 in Brain Tissue

Detection of Human Immunodeficiency Virus Type 2 in Brain Tissue

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Abstract

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