AustralieFrV1, Istex, Checkpoint, bibRecord, 001031

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Identifieur interne : 001031 ( Istex/Checkpoint ); précédent : 001030; suivant : 001032

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Auteurs : Hui Hong [Royaume-Uni] ; Caroline Demangel [France] ; Sacha J. Pidot [Australie] ; Peter F. Leadlay [Royaume-Uni] ; Tim Stinear [Australie]

Source :

Natural Product Reports [ 0265-0568 ] ; 2008.

RBID : ISTEX:281E26302FB7F74EA29F9733A11FDED0EF3E4202

English descriptors

Abstract

Covering: up to January 2008 Mycolactones are a family of highly related macrocyclic polyketides that exhibit immunosuppressive and cytotoxic properties. First discovered in 1999, they are the primary virulence factors produced by the environmental human pathogen Mycobacterium ulcerans, the causative agent of Buruli ulcer, and by some closely-related aquatic mycobacteria that cause disease in fish and frogs. Mycolactones are characterized by a common 12-membered lactone core to which is appended an unsaturated fatty acyl side-chain of variable length and oxidation state. This Highlight summarizes recent progress in understanding the structural diversity of the mycolactones, their biological activity and mode of action in mammalian cells, and the genetics, evolution, and enzymology of their biosynthesis.

Url:

https://api.istex.fr/document/281E26302FB7F74EA29F9733A11FDED0EF3E4202/fulltext/pdf

DOI: 10.1039/b803101k

Affiliations:

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ISTEX:281E26302FB7F74EA29F9733A11FDED0EF3E4202

Le document en format XML

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<author wicri:is="90%"><name sortKey="Pidot, Sacha J" sort="Pidot, Sacha J" uniqKey="Pidot S" first="Sacha J." last="Pidot">Sacha J. Pidot</name>
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<author wicri:is="90%"><name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
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<series><title level="j">Natural Product Reports</title>
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<term>Buruli ulcer</term>
<term>Cell extracts</term>
<term>Chem</term>
<term>Chinese strain</term>
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<term>Structural features</term>
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<front><div type="abstract">Covering: up to January 2008 Mycolactones are a family of highly related macrocyclic polyketides that exhibit immunosuppressive and cytotoxic properties. First discovered in 1999, they are the primary virulence factors produced by the environmental human pathogen Mycobacterium ulcerans, the causative agent of Buruli ulcer, and by some closely-related aquatic mycobacteria that cause disease in fish and frogs. Mycolactones are characterized by a common 12-membered lactone core to which is appended an unsaturated fatty acyl side-chain of variable length and oxidation state. This Highlight summarizes recent progress in understanding the structural diversity of the mycolactones, their biological activity and mode of action in mammalian cells, and the genetics, evolution, and enzymology of their biosynthesis.</div>
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Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri