The complexity of managing systemic sclerosis: screening and diagnosis
Identifieur interne : 000D03 ( Istex/Checkpoint ); précédent : 000D02; suivant : 000D04The complexity of managing systemic sclerosis: screening and diagnosis
Auteurs : M. Matucci-Cerinic [France, Italie] ; V. Steen [France] ; P. Nash [France] ; E. Hachulla [France]Source :
- Rheumatology [ 1462-0324 ] ; 2009-06.
Abstract
The difficulties inherent in diagnosing, screening and treating SSc are reflected by the complex pathology of the disease, which involves the development of severe organ-based complications that reduce both quality of life and overall survival. Early detection and prompt treatment of such complications depend upon a successful and timely screening strategy, which, in turn, requires cooperation between disciplines and good collaborative links at all stages of the disease. Establishment of a disease registry for SSc may also be of benefit, as such registries facilitate longitudinal observation of trends in disease presentation, management and outcome. They may also help to determine potential risk factors and identify those patient subgroups that face the highest risk of developing disease. In patients with known or suspected SSc, a panel of disease-specific markers—such as autoantibodies, cell activation markers and markers of organ involvement—may help to establish the diagnosis and assess prognosis; however, changes in serum levels of such markers throughout the course of SSc should be interpreted with caution, as they may not always correlate with disease activity. Nail-fold capillaroscopy is a promising tool for SSc assessment and may provide useful diagnostic and prognostic information, although further research is required to clarify its role in evaluating disease evolution.
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DOI: 10.1093/rheumatology/ken482
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Hachulla</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F1243A2583736C36FEEB3B3F206119E7D8DAC925</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1093/rheumatology/ken482</idno><idno type="url">https://api.istex.fr/document/F1243A2583736C36FEEB3B3F206119E7D8DAC925/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002D44</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002D44</idno><idno type="wicri:Area/Istex/Curation">002D44</idno><idno type="wicri:Area/Istex/Checkpoint">000D03</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The complexity of managing systemic sclerosis: screening and diagnosis</title><author><name sortKey="Matucci Cerinic, M" sort="Matucci Cerinic, M" uniqKey="Matucci Cerinic M" first="M." last="Matucci-Cerinic">M. Matucci-Cerinic</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biomedicine, Centre DenoThe, Division of Rheumatology, AOUC University of Florence, Florence, Italy, Department of Medicine, Georgetown University, Washington DC, USA, Rheumatology Research Unit, Sunshine Coast Queensland Department of Medicine, University of Queensland, Queensland, Australia and Hôpital Claude-Huriez, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Steen, V" sort="Steen, V" uniqKey="Steen V" first="V." last="Steen">V. Steen</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biomedicine, Centre DenoThe, Division of Rheumatology, AOUC University of Florence, Florence, Italy, Department of Medicine, Georgetown University, Washington DC, USA, Rheumatology Research Unit, Sunshine Coast Queensland Department of Medicine, University of Queensland, Queensland, Australia and Hôpital Claude-Huriez, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Nash, P" sort="Nash, P" uniqKey="Nash P" first="P." last="Nash">P. Nash</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biomedicine, Centre DenoThe, Division of Rheumatology, AOUC University of Florence, Florence, Italy, Department of Medicine, Georgetown University, Washington DC, USA, Rheumatology Research Unit, Sunshine Coast Queensland Department of Medicine, University of Queensland, Queensland, Australia and Hôpital Claude-Huriez, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Hachulla, E" sort="Hachulla, E" uniqKey="Hachulla E" first="E." last="Hachulla">E. Hachulla</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Biomedicine, Centre DenoThe, Division of Rheumatology, AOUC University of Florence, Florence, Italy, Department of Medicine, Georgetown University, Washington DC, USA, Rheumatology Research Unit, Sunshine Coast Queensland Department of Medicine, University of Queensland, Queensland, Australia and Hôpital Claude-Huriez, University of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-06">2009-06</date><biblScope unit="volume">48</biblScope><biblScope unit="supplement">suppl_3</biblScope><biblScope unit="page" from="8">iii8</biblScope><biblScope unit="page" to="13">iii13</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The difficulties inherent in diagnosing, screening and treating SSc are reflected by the complex pathology of the disease, which involves the development of severe organ-based complications that reduce both quality of life and overall survival. Early detection and prompt treatment of such complications depend upon a successful and timely screening strategy, which, in turn, requires cooperation between disciplines and good collaborative links at all stages of the disease. Establishment of a disease registry for SSc may also be of benefit, as such registries facilitate longitudinal observation of trends in disease presentation, management and outcome. They may also help to determine potential risk factors and identify those patient subgroups that face the highest risk of developing disease. In patients with known or suspected SSc, a panel of disease-specific markers—such as autoantibodies, cell activation markers and markers of organ involvement—may help to establish the diagnosis and assess prognosis; however, changes in serum levels of such markers throughout the course of SSc should be interpreted with caution, as they may not always correlate with disease activity. Nail-fold capillaroscopy is a promising tool for SSc assessment and may provide useful diagnostic and prognostic information, although further research is required to clarify its role in evaluating disease evolution.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Matucci Cerinic, M" sort="Matucci Cerinic, M" uniqKey="Matucci Cerinic M" first="M." last="Matucci-Cerinic">M. Matucci-Cerinic</name></region><name sortKey="Hachulla, E" sort="Hachulla, E" uniqKey="Hachulla E" first="E." last="Hachulla">E. Hachulla</name><name sortKey="Nash, P" sort="Nash, P" uniqKey="Nash P" first="P." last="Nash">P. Nash</name><name sortKey="Steen, V" sort="Steen, V" uniqKey="Steen V" first="V." last="Steen">V. Steen</name></country><country name="Italie"><noRegion><name sortKey="Matucci Cerinic, M" sort="Matucci Cerinic, M" uniqKey="Matucci Cerinic M" first="M." last="Matucci-Cerinic">M. Matucci-Cerinic</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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