Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England.
Identifieur interne : 000727 ( PubMed/Checkpoint ); précédent : 000726; suivant : 000728Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England.
Auteurs : S. Mays [Royaume-Uni] ; G M Taylor ; A J Legge ; D B Young ; G. Turner-WalkerSource :
- American journal of physical anthropology [ 0002-9483 ] ; 2001.
English descriptors
- KwdEn :
- Adult, Amidohydrolases (chemistry), Amidohydrolases (genetics), Bacterial Proteins (chemistry), Bacterial Proteins (genetics), Bone and Bones (chemistry), Bone and Bones (microbiology), Bone and Bones (ultrastructure), DNA, Bacterial, DNA-Binding Proteins, England, Female, History, Medieval, Housing (history), Humans, Male, Microscopy, Electron, Scanning, Middle Aged, Mycobacterium tuberculosis (genetics), Paleopathology, Polymerase Chain Reaction, Repressor Proteins (chemistry), Repressor Proteins (genetics), Transcription Factors (chemistry), Transcription Factors (genetics), Tuberculosis (history), Tuberculosis (microbiology), Type C Phospholipases.
- MESH :
- chemical , chemistry : Amidohydrolases, Bacterial Proteins, Repressor Proteins, Transcription Factors.
- chemical , genetics : Amidohydrolases, Bacterial Proteins, Repressor Proteins, Transcription Factors.
- geographic : England, Type C Phospholipases.
- chemistry : Bone and Bones.
- genetics : Mycobacterium tuberculosis.
- history : Housing, Tuberculosis.
- microbiology : Bone and Bones, Tuberculosis.
- ultrastructure : Bone and Bones.
- Adult, DNA, Bacterial, DNA-Binding Proteins, Female, History, Medieval, Humans, Male, Microscopy, Electron, Scanning, Middle Aged, Paleopathology, Polymerase Chain Reaction.
Abstract
Nine human skeletons of medieval date from a rural English burial site show signs of skeletal tuberculosis. They were subject to polymerase chain reaction (PCR) assays aimed at detecting traces of DNA from infecting mycobacteria, with the purpose both of confirming the paleopathological diagnosis of tuberculosis and determining in individual cases whether disease was due to M. tuberculosis or M. bovis. In all nine cases, evidence for M. tuberculosis complex DNA was found, and in all instances it appeared that disease was due to M. tuberculosis rather than M. bovis. The significance of the findings for understanding tuberculous infection in rural agrarian communities in medieval England is discussed.
DOI: 10.1002/ajpa.1042
PubMed: 11275959
Affiliations:
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Mays</name><affiliation wicri:level="1"><nlm:affiliation>Ancient Monuments Laboratory, English Heritage, Fort Cumberland, Eastney, Portsmouth PO4 9LD, UK. simon.mays@english-heritage.org.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ancient Monuments Laboratory, English Heritage, Fort Cumberland, Eastney, Portsmouth PO4 9LD</wicri:regionArea><wicri:noRegion>Portsmouth PO4 9LD</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, G M" sort="Taylor, G M" uniqKey="Taylor G" first="G M" last="Taylor">G M Taylor</name></author><author><name sortKey="Legge, A J" sort="Legge, A J" uniqKey="Legge A" first="A J" last="Legge">A J Legge</name></author><author><name sortKey="Young, D B" sort="Young, D B" uniqKey="Young D" first="D B" last="Young">D B Young</name></author><author><name sortKey="Turner Walker, G" sort="Turner Walker, G" uniqKey="Turner Walker G" first="G" last="Turner-Walker">G. 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Mays</name><affiliation wicri:level="1"><nlm:affiliation>Ancient Monuments Laboratory, English Heritage, Fort Cumberland, Eastney, Portsmouth PO4 9LD, UK. simon.mays@english-heritage.org.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Ancient Monuments Laboratory, English Heritage, Fort Cumberland, Eastney, Portsmouth PO4 9LD</wicri:regionArea><wicri:noRegion>Portsmouth PO4 9LD</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, G M" sort="Taylor, G M" uniqKey="Taylor G" first="G M" last="Taylor">G M Taylor</name></author><author><name sortKey="Legge, A J" sort="Legge, A J" uniqKey="Legge A" first="A J" last="Legge">A J Legge</name></author><author><name sortKey="Young, D B" sort="Young, D B" uniqKey="Young D" first="D B" last="Young">D B Young</name></author><author><name sortKey="Turner Walker, G" sort="Turner Walker, G" uniqKey="Turner Walker G" first="G" last="Turner-Walker">G. Turner-Walker</name></author></analytic><series><title level="j">American journal of physical anthropology</title><idno type="ISSN">0002-9483</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Amidohydrolases (chemistry)</term><term>Amidohydrolases (genetics)</term><term>Bacterial Proteins (chemistry)</term><term>Bacterial Proteins (genetics)</term><term>Bone and Bones (chemistry)</term><term>Bone and Bones (microbiology)</term><term>Bone and Bones (ultrastructure)</term><term>DNA, Bacterial</term><term>DNA-Binding Proteins</term><term>England</term><term>Female</term><term>History, Medieval</term><term>Housing (history)</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Scanning</term><term>Middle Aged</term><term>Mycobacterium tuberculosis (genetics)</term><term>Paleopathology</term><term>Polymerase Chain Reaction</term><term>Repressor Proteins (chemistry)</term><term>Repressor Proteins (genetics)</term><term>Transcription Factors (chemistry)</term><term>Transcription Factors (genetics)</term><term>Tuberculosis (history)</term><term>Tuberculosis (microbiology)</term><term>Type C Phospholipases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Amidohydrolases</term><term>Bacterial Proteins</term><term>Repressor Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Amidohydrolases</term><term>Bacterial Proteins</term><term>Repressor Proteins</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>England</term><term>Type C Phospholipases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Housing</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bone and Bones</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Bone and Bones</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>DNA, Bacterial</term><term>DNA-Binding Proteins</term><term>Female</term><term>History, Medieval</term><term>Humans</term><term>Male</term><term>Microscopy, Electron, Scanning</term><term>Middle Aged</term><term>Paleopathology</term><term>Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nine human skeletons of medieval date from a rural English burial site show signs of skeletal tuberculosis. They were subject to polymerase chain reaction (PCR) assays aimed at detecting traces of DNA from infecting mycobacteria, with the purpose both of confirming the paleopathological diagnosis of tuberculosis and determining in individual cases whether disease was due to M. tuberculosis or M. bovis. In all nine cases, evidence for M. tuberculosis complex DNA was found, and in all instances it appeared that disease was due to M. tuberculosis rather than M. bovis. The significance of the findings for understanding tuberculous infection in rural agrarian communities in medieval England is discussed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11275959</PMID><DateCreated><Year>2001</Year><Month>03</Month><Day>29</Day></DateCreated><DateCompleted><Year>2001</Year><Month>06</Month><Day>28</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9483</ISSN><JournalIssue CitedMedium="Print"><Volume>114</Volume><Issue>4</Issue><PubDate><Year>2001</Year><Month>Apr</Month></PubDate></JournalIssue><Title>American journal of physical anthropology</Title><ISOAbbreviation>Am. J. Phys. Anthropol.</ISOAbbreviation></Journal><ArticleTitle>Paleopathological and biomolecular study of tuberculosis in a medieval skeletal collection from England.</ArticleTitle><Pagination><MedlinePgn>298-311</MedlinePgn></Pagination><Abstract><AbstractText>Nine human skeletons of medieval date from a rural English burial site show signs of skeletal tuberculosis. They were subject to polymerase chain reaction (PCR) assays aimed at detecting traces of DNA from infecting mycobacteria, with the purpose both of confirming the paleopathological diagnosis of tuberculosis and determining in individual cases whether disease was due to M. tuberculosis or M. bovis. In all nine cases, evidence for M. tuberculosis complex DNA was found, and in all instances it appeared that disease was due to M. tuberculosis rather than M. bovis. 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Legge</name><name sortKey="Taylor, G M" sort="Taylor, G M" uniqKey="Taylor G" first="G M" last="Taylor">G M Taylor</name><name sortKey="Turner Walker, G" sort="Turner Walker, G" uniqKey="Turner Walker G" first="G" last="Turner-Walker">G. Turner-Walker</name><name sortKey="Young, D B" sort="Young, D B" uniqKey="Young D" first="D B" last="Young">D B Young</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Mays, S" sort="Mays, S" uniqKey="Mays S" first="S" last="Mays">S. Mays</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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