Direct action of radiation on mummified cells: modeling of computed tomography by Monte Carlo algorithms.
Identifieur interne : 000328 ( Main/Merge ); précédent : 000327; suivant : 000329Direct action of radiation on mummified cells: modeling of computed tomography by Monte Carlo algorithms.
Auteurs : Johann Wanek [Suisse] ; Robert Speller ; Frank Jakobus RühliSource :
- Radiation and environmental biophysics [ 1432-2099 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- cytology : Bone and Bones.
- instrumentation : Tomography, X-Ray Computed.
- radiation effects : Cell Nucleus.
- Algorithms, Models, Theoretical, Monte Carlo Method, Mummies, Phantoms, Imaging, Radiation.
Abstract
X-ray imaging is a nondestructive and preferred method in paleopathology to reconstruct the history of ancient diseases. Sophisticated imaging technologies such as computed tomography (CT) have become common for the investigation of skeletal disorders in human remains. Researchers have investigated the impact of ionizing radiation on living cells, but never on ancient cells in dry tissue. The effects of CT exposure on ancient cells have not been examined in the past and may be important for subsequent genetic analysis. To remedy this shortcoming, we developed different Monte Carlo models to simulate X-ray irradiation on ancient cells. Effects of mummification were considered by using two sizes of cells and three different phantom tissues, which enclosed the investigated cell cluster. This cluster was positioned at the isocenter of a CT scanner model, where the cell hit probabilities P(0,1,…, n) were calculated according to the Poisson distribution. To study the impact of the dominant physics process, CT scans for X-ray spectra of 80 and 120 kVp were simulated. Comparison between normal and dry tissue phantoms revealed that the probability of unaffected cells increased by 21 % following cell shrinkage for 80 kVp, while for 120 kVp, a further increase of unaffected cells of 23 % was observed. Consequently, cell shrinkage caused by dehydration decreased the impact of X-ray radiation on mummified cells significantly. Moreover, backscattered electrons in cortical bone protected deeper-lying ancient cells from radiation damage at 80 kVp X-rays.
DOI: 10.1007/s00411-013-0471-z
PubMed: 23616199
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000217
- to stream PubMed, to step Curation: 000217
- to stream PubMed, to step Checkpoint: 000217
- to stream Ncbi, to step Merge: 000C61
- to stream Ncbi, to step Curation: 000C61
- to stream Ncbi, to step Checkpoint: 000C61
Links to Exploration step
pubmed:23616199Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Direct action of radiation on mummified cells: modeling of computed tomography by Monte Carlo algorithms.</title>
<author><name sortKey="Wanek, Johann" sort="Wanek, Johann" uniqKey="Wanek J" first="Johann" last="Wanek">Johann Wanek</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. johann.wanek@anatom.uzh.ch</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, 8057 Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Speller, Robert" sort="Speller, Robert" uniqKey="Speller R" first="Robert" last="Speller">Robert Speller</name>
</author>
<author><name sortKey="Ruhli, Frank Jakobus" sort="Ruhli, Frank Jakobus" uniqKey="Ruhli F" first="Frank Jakobus" last="Rühli">Frank Jakobus Rühli</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23616199</idno>
<idno type="pmid">23616199</idno>
<idno type="doi">10.1007/s00411-013-0471-z</idno>
<idno type="wicri:Area/PubMed/Corpus">000217</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000217</idno>
<idno type="wicri:Area/PubMed/Curation">000217</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000217</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000217</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000217</idno>
<idno type="wicri:Area/Ncbi/Merge">000C61</idno>
<idno type="wicri:Area/Ncbi/Curation">000C61</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000C61</idno>
<idno type="wicri:Area/Main/Merge">000328</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Direct action of radiation on mummified cells: modeling of computed tomography by Monte Carlo algorithms.</title>
<author><name sortKey="Wanek, Johann" sort="Wanek, Johann" uniqKey="Wanek J" first="Johann" last="Wanek">Johann Wanek</name>
<affiliation wicri:level="4"><nlm:affiliation>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. johann.wanek@anatom.uzh.ch</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Winterthurerstrasse 190, 8057 Zurich</wicri:regionArea>
<orgName type="university">Université de Zurich</orgName>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Speller, Robert" sort="Speller, Robert" uniqKey="Speller R" first="Robert" last="Speller">Robert Speller</name>
</author>
<author><name sortKey="Ruhli, Frank Jakobus" sort="Ruhli, Frank Jakobus" uniqKey="Ruhli F" first="Frank Jakobus" last="Rühli">Frank Jakobus Rühli</name>
</author>
</analytic>
<series><title level="j">Radiation and environmental biophysics</title>
<idno type="eISSN">1432-2099</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term>
<term>Bone and Bones (cytology)</term>
<term>Cell Nucleus (radiation effects)</term>
<term>Models, Theoretical</term>
<term>Monte Carlo Method</term>
<term>Mummies</term>
<term>Phantoms, Imaging</term>
<term>Radiation</term>
<term>Tomography, X-Ray Computed (instrumentation)</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Bone and Bones</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Tomography, X-Ray Computed</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Cell Nucleus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Algorithms</term>
<term>Models, Theoretical</term>
<term>Monte Carlo Method</term>
<term>Mummies</term>
<term>Phantoms, Imaging</term>
<term>Radiation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">X-ray imaging is a nondestructive and preferred method in paleopathology to reconstruct the history of ancient diseases. Sophisticated imaging technologies such as computed tomography (CT) have become common for the investigation of skeletal disorders in human remains. Researchers have investigated the impact of ionizing radiation on living cells, but never on ancient cells in dry tissue. The effects of CT exposure on ancient cells have not been examined in the past and may be important for subsequent genetic analysis. To remedy this shortcoming, we developed different Monte Carlo models to simulate X-ray irradiation on ancient cells. Effects of mummification were considered by using two sizes of cells and three different phantom tissues, which enclosed the investigated cell cluster. This cluster was positioned at the isocenter of a CT scanner model, where the cell hit probabilities P(0,1,…, n) were calculated according to the Poisson distribution. To study the impact of the dominant physics process, CT scans for X-ray spectra of 80 and 120 kVp were simulated. Comparison between normal and dry tissue phantoms revealed that the probability of unaffected cells increased by 21 % following cell shrinkage for 80 kVp, while for 120 kVp, a further increase of unaffected cells of 23 % was observed. Consequently, cell shrinkage caused by dehydration decreased the impact of X-ray radiation on mummified cells significantly. Moreover, backscattered electrons in cortical bone protected deeper-lying ancient cells from radiation damage at 80 kVp X-rays.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Archeologie/explor/PaleopathV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000328 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000328 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Archeologie |area= PaleopathV1 |flux= Main |étape= Merge |type= RBID |clé= pubmed:23616199 |texte= Direct action of radiation on mummified cells: modeling of computed tomography by Monte Carlo algorithms. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:23616199" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PaleopathV1
![]() | This area was generated with Dilib version V0.6.27. | ![]() |