Unusual spinal tuberculosis in an Avar Age skeleton (Csongrád-Felgyő, Ürmös-tanya, Hungary): A morphological and biomolecular study.
Identifieur interne : 000085 ( Main/Exploration ); précédent : 000084; suivant : 000086Unusual spinal tuberculosis in an Avar Age skeleton (Csongrád-Felgyő, Ürmös-tanya, Hungary): A morphological and biomolecular study.
Auteurs : G. Pálfi [Hongrie] ; F. Maixner [Italie] ; M. Maczel [Hongrie] ; E. Molnár [Hongrie] ; A. P Sa [Hongrie] ; L A Krist F [Hongrie] ; A. Marcsik [Hongrie] ; J. Balázs [Hongrie] ; M. Masson [Hongrie] ; L. Paja [Hongrie] ; A. Palk [Hongrie] ; R. Szentgyörgyi [Autriche] ; A. Nerlich [Allemagne] ; A. Zink [Italie] ; Olivier Dutour [Canada]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Hongrie.
English descriptors
- KwdEn :
- Adult, DNA, Bacterial (genetics), Female, History, Ancient, Humans, Hungary, Mycobacterium tuberculosis (genetics), Nucleic Acid Amplification Techniques, Paleopathology, Tomography, X-Ray Computed, Tuberculosis, Spinal (genetics), Tuberculosis, Spinal (history), Tuberculosis, Spinal (pathology), Young Adult.
- MESH :
- chemical , genetics : DNA, Bacterial.
- geographic : Hungary.
- genetics : Mycobacterium tuberculosis, Tuberculosis, Spinal.
- history : Tuberculosis, Spinal.
- pathology : Tuberculosis, Spinal.
- Adult, Female, History, Ancient, Humans, Nucleic Acid Amplification Techniques, Paleopathology, Tomography, X-Ray Computed, Young Adult.
Abstract
The paleopathological analysis of a well-preserved young adult female skeleton from the AD 7-8th century (Avar Age) in Hungary revealed multiple lytic lesions in all of the thoracic and lumbar vertebral bodies. The lesions were characterized by smooth marginal zones and space-occupying mass appearance. The considerable loss of spongy bone in the thoracolumbar vertebrae resulted in angular deformity and fusion, characteristic of the healing stage of TB. Osteolytic lesions were also observed on the vertebral processes, ribs and sternum. On the endocranial surface, abnormal blood vessel impressions were revealed, indicating some kind of meningitis. The X-ray and CT analysis of the affected bones detected abnormal structures and cystic zones of destruction. The lesions were however not always bordered by areas of increased density, which is typical in cystic TB. Vertebral remains were also subjected to biomolecular analysis in two different laboratories, which attested the presence of Mycobacterium tuberculosis complex (MTBC) DNA and supported the paleopathological diagnosis of TB. Spoligotyping analysis confirmed the presence of MTBC DNA and more specifically an infection caused by bacteria belonging to the M. tuberculosis lineage. This case study provides new data for the paleoepidemiology of TB in this geographical area and historical period, and draws attention to the great variability of TB lesions in the human skeleton.
DOI: 10.1016/j.tube.2015.02.033
PubMed: 25840822
Affiliations:
- Allemagne, Autriche, Canada, Hongrie, Italie
- Aquitaine, Bavière, District de Haute-Bavière, Provence-Alpes-Côte d'Azur, Vienne (Autriche)
- Bordeaux, Marseille, Munich, Vienne (Autriche)
- Université d'Aix-Marseille, Université de Bordeaux
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Le document en format XML
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Pálfi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary. Electronic address: palfigy@bio.u-szeged.hu.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Maixner, F" sort="Maixner, F" uniqKey="Maixner F" first="F" last="Maixner">F. Maixner</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Mummies and the Iceman, EURAC European Academy, Bolzano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Mummies and the Iceman, EURAC European Academy, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Maczel, M" sort="Maczel, M" uniqKey="Maczel M" first="M" last="Maczel">M. Maczel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Molnar, E" sort="Molnar, E" uniqKey="Molnar E" first="E" last="Molnár">E. Molnár</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="P Sa, A" sort="P Sa, A" uniqKey="P Sa A" first="A" last="P Sa">A. P Sa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Krist F, L A" sort="Krist F, L A" uniqKey="Krist F L" first="L A" last="Krist F">L A Krist F</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Marcsik, A" sort="Marcsik, A" uniqKey="Marcsik A" first="A" last="Marcsik">A. Marcsik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Balazs, J" sort="Balazs, J" uniqKey="Balazs J" first="J" last="Balázs">J. Balázs</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Masson, M" sort="Masson, M" uniqKey="Masson M" first="M" last="Masson">M. Masson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Paja, L" sort="Paja, L" uniqKey="Paja L" first="L" last="Paja">L. Paja</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Hungary; National Heritage Protection Centre, Hungarian National Museum, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Hungary; National Heritage Protection Centre, Hungarian National Museum, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Palk, A" sort="Palk, A" uniqKey="Palk A" first="A" last="Palk">A. Palk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, University of Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Radiology, University of Szeged</wicri:regionArea><wicri:noRegion>University of Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Szentgyorgyi, R" sort="Szentgyorgyi, R" uniqKey="Szentgyorgyi R" first="R" last="Szentgyörgyi">R. Szentgyörgyi</name><affiliation wicri:level="3"><nlm:affiliation>Privatklinik Döbling, Department of Diagnostic Imaging and Interventional Radiology, Vienna, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Privatklinik Döbling, Department of Diagnostic Imaging and Interventional Radiology, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Nerlich, A" sort="Nerlich, A" uniqKey="Nerlich A" first="A" last="Nerlich">A. Nerlich</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Academic Hospital Munich-Bogenhausen, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Academic Hospital Munich-Bogenhausen, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Zink, A" sort="Zink, A" uniqKey="Zink A" first="A" last="Zink">A. Zink</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Mummies and the Iceman, EURAC European Academy, Bolzano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute for Mummies and the Iceman, EURAC European Academy, Bolzano</wicri:regionArea><wicri:noRegion>Bolzano</wicri:noRegion></affiliation></author><author><name sortKey="Dutour, O" sort="Dutour, O" uniqKey="Dutour O" first="O" last="Dutour">Olivier Dutour</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire d'anthropologie biologique Paul Broca de l'EPHE (Ecole Pratique des Hautes Etudes), UMR 5199 PACEA, Université de Bordeaux, Pessac, France; Department of Anthropology, University of Western Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratoire d'anthropologie biologique Paul Broca de l'EPHE (Ecole Pratique des Hautes Etudes), UMR 5199 PACEA, Université de Bordeaux, Pessac, France; Department of Anthropology, University of Western Ontario</wicri:regionArea><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName><placeName><settlement type="city">Marseille</settlement><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region></placeName><orgName type="university" n="3">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>DNA, Bacterial (genetics)</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Hungary</term><term>Mycobacterium tuberculosis (genetics)</term><term>Nucleic Acid Amplification Techniques</term><term>Paleopathology</term><term>Tomography, X-Ray Computed</term><term>Tuberculosis, Spinal (genetics)</term><term>Tuberculosis, Spinal (history)</term><term>Tuberculosis, Spinal (pathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Bacterial</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hungary</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mycobacterium tuberculosis</term><term>Tuberculosis, Spinal</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Tuberculosis, Spinal</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Tuberculosis, Spinal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Nucleic Acid Amplification Techniques</term><term>Paleopathology</term><term>Tomography, X-Ray Computed</term><term>Young Adult</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Hongrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The paleopathological analysis of a well-preserved young adult female skeleton from the AD 7-8th century (Avar Age) in Hungary revealed multiple lytic lesions in all of the thoracic and lumbar vertebral bodies. The lesions were characterized by smooth marginal zones and space-occupying mass appearance. The considerable loss of spongy bone in the thoracolumbar vertebrae resulted in angular deformity and fusion, characteristic of the healing stage of TB. Osteolytic lesions were also observed on the vertebral processes, ribs and sternum. On the endocranial surface, abnormal blood vessel impressions were revealed, indicating some kind of meningitis. The X-ray and CT analysis of the affected bones detected abnormal structures and cystic zones of destruction. The lesions were however not always bordered by areas of increased density, which is typical in cystic TB. Vertebral remains were also subjected to biomolecular analysis in two different laboratories, which attested the presence of Mycobacterium tuberculosis complex (MTBC) DNA and supported the paleopathological diagnosis of TB. Spoligotyping analysis confirmed the presence of MTBC DNA and more specifically an infection caused by bacteria belonging to the M. tuberculosis lineage. This case study provides new data for the paleoepidemiology of TB in this geographical area and historical period, and draws attention to the great variability of TB lesions in the human skeleton.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>Hongrie</li><li>Italie</li></country><region><li>Aquitaine</li><li>Bavière</li><li>District de Haute-Bavière</li><li>Provence-Alpes-Côte d'Azur</li><li>Vienne (Autriche)</li></region><settlement><li>Bordeaux</li><li>Marseille</li><li>Munich</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université d'Aix-Marseille</li><li>Université de Bordeaux</li></orgName></list><tree><country name="Hongrie"><noRegion><name sortKey="Palfi, G" sort="Palfi, G" uniqKey="Palfi G" first="G" last="Pálfi">G. Pálfi</name></noRegion><name sortKey="Balazs, J" sort="Balazs, J" uniqKey="Balazs J" first="J" last="Balázs">J. Balázs</name><name sortKey="Krist F, L A" sort="Krist F, L A" uniqKey="Krist F L" first="L A" last="Krist F">L A Krist F</name><name sortKey="Maczel, M" sort="Maczel, M" uniqKey="Maczel M" first="M" last="Maczel">M. Maczel</name><name sortKey="Marcsik, A" sort="Marcsik, A" uniqKey="Marcsik A" first="A" last="Marcsik">A. Marcsik</name><name sortKey="Masson, M" sort="Masson, M" uniqKey="Masson M" first="M" last="Masson">M. Masson</name><name sortKey="Molnar, E" sort="Molnar, E" uniqKey="Molnar E" first="E" last="Molnár">E. Molnár</name><name sortKey="P Sa, A" sort="P Sa, A" uniqKey="P Sa A" first="A" last="P Sa">A. P Sa</name><name sortKey="Paja, L" sort="Paja, L" uniqKey="Paja L" first="L" last="Paja">L. Paja</name><name sortKey="Palk, A" sort="Palk, A" uniqKey="Palk A" first="A" last="Palk">A. Palk</name></country><country name="Italie"><noRegion><name sortKey="Maixner, F" sort="Maixner, F" uniqKey="Maixner F" first="F" last="Maixner">F. Maixner</name></noRegion><name sortKey="Zink, A" sort="Zink, A" uniqKey="Zink A" first="A" last="Zink">A. Zink</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Szentgyorgyi, R" sort="Szentgyorgyi, R" uniqKey="Szentgyorgyi R" first="R" last="Szentgyörgyi">R. Szentgyörgyi</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Nerlich, A" sort="Nerlich, A" uniqKey="Nerlich A" first="A" last="Nerlich">A. Nerlich</name></region></country><country name="Canada"><region name="Aquitaine"><name sortKey="Dutour, O" sort="Dutour, O" uniqKey="Dutour O" first="O" last="Dutour">Olivier Dutour</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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