Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)
Identifieur interne : 001832 ( Istex/Corpus ); précédent : 001831; suivant : 001833Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)
Auteurs : Carina Marques ; Ana Luísa Santos ; Eugénia CunhaSource :
- International Journal of Osteoarchaeology [ 1047-482X ] ; 2013-11.
Abstract
The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. Copyright © 2011 John Wiley & Sons, Ltd.
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DOI: 10.1002/oa.1294
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title><author><name sortKey="Marques, Carina" sort="Marques, Carina" uniqKey="Marques C" first="Carina" last="Marques">Carina Marques</name><affiliation><mods:affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: anac@ci.uc.pt</mods:affiliation></affiliation></author><author><name sortKey="Santos, Ana Luisa" sort="Santos, Ana Luisa" uniqKey="Santos A" first="Ana Luísa" last="Santos">Ana Luísa Santos</name><affiliation><mods:affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Cunha, Eugenia" sort="Cunha, Eugenia" uniqKey="Cunha E" first="Eugénia" last="Cunha">Eugénia Cunha</name><affiliation><mods:affiliation>Department of Life Sciences, University of Coimbra and Centro de Ciências Forenses, Portugal</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/oa.1294</idno><idno type="url">https://api.istex.fr/document/83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001832</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001832</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title><author><name sortKey="Marques, Carina" sort="Marques, Carina" uniqKey="Marques C" first="Carina" last="Marques">Carina Marques</name><affiliation><mods:affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: anac@ci.uc.pt</mods:affiliation></affiliation></author><author><name sortKey="Santos, Ana Luisa" sort="Santos, Ana Luisa" uniqKey="Santos A" first="Ana Luísa" last="Santos">Ana Luísa Santos</name><affiliation><mods:affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</mods:affiliation></affiliation></author><author><name sortKey="Cunha, Eugenia" sort="Cunha, Eugenia" uniqKey="Cunha E" first="Eugénia" last="Cunha">Eugénia Cunha</name><affiliation><mods:affiliation>Department of Life Sciences, University of Coimbra and Centro de Ciências Forenses, Portugal</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Osteoarchaeology</title><title level="j" type="abbrev">Int. J. Osteoarchaeol.</title><idno type="ISSN">1047-482X</idno><idno type="eISSN">1099-1212</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-11">2013-11</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="664">664</biblScope><biblScope unit="page" to="675">675</biblScope></imprint><idno type="ISSN">1047-482X</idno></series><idno type="istex">83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F</idno><idno type="DOI">10.1002/oa.1294</idno><idno type="ArticleID">OA1294</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1047-482X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. Copyright © 2011 John Wiley & Sons, Ltd.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Carina Marques</name><affiliations><json:string>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</json:string><json:string>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.e‐mail:</json:string><json:string>E-mail: anac@ci.uc.pt</json:string></affiliations></json:item><json:item><name>Ana Luísa Santos</name><affiliations><json:string>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</json:string></affiliations></json:item><json:item><name>Eugénia Cunha</name><affiliations><json:string>Department of Life Sciences, University of Coimbra and Centro de Ciências Forenses, Portugal</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>carcinoma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>identified skeletal collection</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>metastases</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>multiple myeloma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteolytic</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>paleopathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tumour</value></json:item></subject><articleId><json:string>OA1294</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. 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Praeger: New York.</title></host></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>23</volume><publisherId><json:string>OA</json:string></publisherId><pages><total>12</total><last>675</last><first>664</first></pages><issn><json:string>1047-482X</json:string></issn><issue>6</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1099-1212</json:string></eissn><title>International Journal of Osteoarchaeology</title><doi><json:string>10.1002/(ISSN)1099-1212</json:string></doi></host><categories><wos><json:string>social science</json:string><json:string>anthropology</json:string></wos><scienceMetrix><json:string>arts & humanities</json:string><json:string>historical studies</json:string><json:string>archaeology</json:string></scienceMetrix></categories><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1002/oa.1294</json:string></doi><id>83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F</id><score>0.41639653</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><availability><p>Copyright © 2013 John Wiley & Sons, Ltd.Copyright © 2011 John Wiley & Sons, Ltd.</p></availability><date>2011-10-07</date></publicationStmt><notesStmt><note>Fundação para a Ciência e a Tecnologia - No. SFRH/BD/30038/2006;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title><author xml:id="author-1"><persName><forename type="first">Carina</forename><surname>Marques</surname></persName><email>anac@ci.uc.pt</email><affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</affiliation><affiliation>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.e‐mail:</affiliation></author><author xml:id="author-2"><persName><forename type="first">Ana Luísa</forename><surname>Santos</surname></persName><affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</affiliation></author><author xml:id="author-3"><persName><forename type="first">Eugénia</forename><surname>Cunha</surname></persName><affiliation>Department of Life Sciences, University of Coimbra and Centro de Ciências Forenses, Portugal</affiliation></author></analytic><monogr><title level="j">International Journal of Osteoarchaeology</title><title level="j" type="abbrev">Int. J. Osteoarchaeol.</title><idno type="pISSN">1047-482X</idno><idno type="eISSN">1099-1212</idno><idno type="DOI">10.1002/(ISSN)1099-1212</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><date type="published" when="2013-11"></date><biblScope unit="volume">23</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="664">664</biblScope><biblScope unit="page" to="675">675</biblScope></imprint></monogr><idno type="istex">83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F</idno><idno type="DOI">10.1002/oa.1294</idno><idno type="ArticleID">OA1294</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2011-10-07</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. Copyright © 2011 John Wiley & Sons, Ltd.</p></abstract><textClass><keywords scheme="keyword"><list><head>keywords</head><item><term>carcinoma</term></item><item><term>identified skeletal collection</term></item><item><term>metastases</term></item><item><term>multiple myeloma</term></item><item><term>osteolytic</term></item><item><term>paleopathology</term></item><item><term>tumour</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2010-05-14">Received</change><change when="2011-09-11">Registration</change><change when="2011-10-07">Created</change><change when="2013-11">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:lang="en" xml:id="oa1294"><header><publicationMeta level="product"><doi>10.1002/(ISSN)1099-1212</doi><issn type="print">1047-482X</issn><issn type="electronic">1099-1212</issn><idGroup><id type="product" value="OA"></id></idGroup><titleGroup><title type="main" sort="INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY">International Journal of Osteoarchaeology</title><title type="short">Int. 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Osteoarchaeol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi>10.1002/oa.v23.6</doi><copyright ownership="publisher">Copyright © 2013 John Wiley & Sons, Ltd.</copyright><numberingGroup><numbering type="journalVolume" number="23">23</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2013-11">November/December 2013</coverDate></publicationMeta><publicationMeta level="unit" position="40" type="article" status="forIssue"><doi>10.1002/oa.1294</doi><idGroup><id type="unit" value="OA1294"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2011 John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptReceived" date="2010-05-14"></event><event type="manuscriptRevised" date="2011-08-31"></event><event type="manuscriptAccepted" date="2011-09-11"></event><event type="xmlCreated" agent="SPi Global" date="2011-10-07"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-11-28"></event><event type="firstOnline" date="2011-11-28"></event><event type="publishedOnlineFinalForm" date="2013-12-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">664</numbering><numbering type="pageLast">675</numbering></numberingGroup><correspondenceTo><lineatedText><line>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.</line><line>e‐mail: <email>anac@ci.uc.pt</email></line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:OA.OA1294.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title><title type="shortAuthors">C. Marques et al.</title><title type="short">Palaeopathological Differential Diagnosis in a Neoplastic Condition</title></titleGroup><creators><creator creatorRole="author" xml:id="oa1294-cr-0001" affiliationRef="#oa1294-aff-0001" corresponding="yes"><personName><givenNames>Carina</givenNames><familyName>Marques</familyName></personName></creator><creator creatorRole="author" xml:id="oa1294-cr-0002" affiliationRef="#oa1294-aff-0001"><personName><givenNames>Ana Luísa</givenNames><familyName>Santos</familyName></personName></creator><creator creatorRole="author" xml:id="oa1294-cr-0003" affiliationRef="#oa1294-aff-0002"><personName><givenNames>Eugénia</givenNames><familyName>Cunha</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="oa1294-aff-0001" countryCode="PT" type="organization"><orgDiv>Centro de Investigação em Antropologia e Saúde (CIAS)</orgDiv><orgDiv>Department of Life Sciences</orgDiv><orgName>University of Coimbra</orgName><address><country>Portugal</country></address></affiliation><affiliation xml:id="oa1294-aff-0002" countryCode="PT" type="organization"><orgDiv>Department of Life Sciences</orgDiv><orgName>University of Coimbra and Centro de Ciências Forenses</orgName><address><country>Portugal</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="oa1294-kwd-0001">carcinoma</keyword><keyword xml:id="oa1294-kwd-0002">identified skeletal collection</keyword><keyword xml:id="oa1294-kwd-0003">metastases</keyword><keyword xml:id="oa1294-kwd-0004">multiple myeloma</keyword><keyword xml:id="oa1294-kwd-0005">osteolytic</keyword><keyword xml:id="oa1294-kwd-0006">paleopathology</keyword><keyword xml:id="oa1294-kwd-0007">tumour</keyword></keywordGroup><fundingInfo><fundingAgency>Fundação para a Ciência e a Tecnologia</fundingAgency><fundingNumber>SFRH/BD/30038/2006</fundingNumber></fundingInfo><abstractGroup><abstract type="main"><title type="main">ABSTRACT</title><p>The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. Copyright © 2011 John Wiley & Sons, Ltd.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Palaeopathological Differential Diagnosis in a Neoplastic Condition</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Better a Broader Diagnosis Than a Misdiagnosis: The Study of a Neoplastic Condition in a Male Individual who Died in Early 20th Century (Coimbra, Portugal)</title></titleInfo><name type="personal"><namePart type="given">Carina</namePart><namePart type="family">Marques</namePart><affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</affiliation><affiliation>Correspondence to: Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Apartado 3046, P‐ 3001 401 Coimbra, Portugal.e‐mail:</affiliation><affiliation>E-mail: anac@ci.uc.pt</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ana Luísa</namePart><namePart type="family">Santos</namePart><affiliation>Centro de Investigação em Antropologia e Saúde (CIAS), Department of Life Sciences, University of Coimbra, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eugénia</namePart><namePart type="family">Cunha</namePart><affiliation>Department of Life Sciences, University of Coimbra and Centro de Ciências Forenses, Portugal</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2013-11</dateIssued><dateCreated encoding="w3cdtf">2011-10-07</dateCreated><dateCaptured encoding="w3cdtf">2010-05-14</dateCaptured><dateValid encoding="w3cdtf">2011-09-11</dateValid><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>The paleopathological record of neoplastic conditions in the past is considered scarce. The detection of tumours in ancient populations is hindered by the quality and quantity of signs visible on the skeleton, the methodological approach, the preservation of remains, and by difficulties of differential diagnosis. The aims of this paper are to report the extensive and multiple osteolytic lesions observed in an adult male and to discuss the possible etiology of these lesions. The individual, a 71‐year‐old male who died in 1932, is part of the Coimbra Identified Skeletal Collection. Records indicate that he died of a ‘heart lesion’. The present study used macroscopic, radiological, and computerized tomography examinations to analyse the skeletal remains of the individual number 439. The type and pattern of the lesions detected, which were most prominent on the skull, were compared with both clinical and paleopathological diagnostic criteria for different nosologic groups. The differential diagnosis addresses problems expressed both in clinical and in paleopathological literature with regard to the difficulties in distinguishing metastatic tumours from multiple myeloma. The nature of the lesions represented by this individual precludes an exact diagnosis. Therefore, we employed a broader category, neoplastic condition, instead of choosing a more specific diagnosis that would likely have resulted in a misdiagnosis due to overlapping features on this individual's condition. Further investigations are necessary to establish more replicable indicators and to improve confidence in retrospective diagnosis of these types of conditions. Copyright © 2011 John Wiley & Sons, Ltd.</abstract><note type="funding">Fundação para a Ciência e a Tecnologia - No. SFRH/BD/30038/2006; </note><subject><genre>keywords</genre><topic>carcinoma</topic><topic>identified skeletal collection</topic><topic>metastases</topic><topic>multiple myeloma</topic><topic>osteolytic</topic><topic>paleopathology</topic><topic>tumour</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Osteoarchaeology</title></titleInfo><titleInfo type="abbreviated"><title>Int. J. Osteoarchaeol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">1047-482X</identifier><identifier type="eISSN">1099-1212</identifier><identifier type="DOI">10.1002/(ISSN)1099-1212</identifier><identifier type="PublisherID">OA</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>664</start><end>675</end><total>12</total></extent></part></relatedItem><identifier type="istex">83D310C3B36D3A3E3398DF3D7FC922DA2DC21C2F</identifier><identifier type="DOI">10.1002/oa.1294</identifier><identifier type="ArticleID">OA1294</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons, Ltd.Copyright © 2011 John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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