Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies
Identifieur interne : 001799 ( Istex/Corpus ); précédent : 001798; suivant : 001800Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies
Auteurs : F. J. Rühli ; G. Kuhn ; R. Evison ; R. Müller ; M. SchultzSource :
- American Journal of Physical Anthropology [ 0002-9483 ] ; 2007-08.
English descriptors
- KwdEn :
Abstract
Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajpa.20611
Links to Exploration step
ISTEX:C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title><author><name sortKey="Ruhli, F J" sort="Ruhli, F J" uniqKey="Ruhli F" first="F. J." last="Rühli">F. J. Rühli</name><affiliation><mods:affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Kuhn, G" sort="Kuhn, G" uniqKey="Kuhn G" first="G." last="Kuhn">G. Kuhn</name><affiliation><mods:affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Evison, R" sort="Evison, R" uniqKey="Evison R" first="R." last="Evison">R. Evison</name><affiliation><mods:affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Muller, R" sort="Muller, R" uniqKey="Muller R" first="R." last="Müller">R. Müller</name><affiliation><mods:affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Schultz, M" sort="Schultz, M" uniqKey="Schultz M" first="M." last="Schultz">M. Schultz</name><affiliation><mods:affiliation>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1002/ajpa.20611</idno><idno type="url">https://api.istex.fr/document/C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001799</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001799</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title><author><name sortKey="Ruhli, F J" sort="Ruhli, F J" uniqKey="Ruhli F" first="F. J." last="Rühli">F. J. Rühli</name><affiliation><mods:affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Kuhn, G" sort="Kuhn, G" uniqKey="Kuhn G" first="G." last="Kuhn">G. Kuhn</name><affiliation><mods:affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Evison, R" sort="Evison, R" uniqKey="Evison R" first="R." last="Evison">R. Evison</name><affiliation><mods:affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Muller, R" sort="Muller, R" uniqKey="Muller R" first="R." last="Müller">R. Müller</name><affiliation><mods:affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Schultz, M" sort="Schultz, M" uniqKey="Schultz M" first="M." last="Schultz">M. Schultz</name><affiliation><mods:affiliation>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Physical Anthropology</title><title level="j" type="abbrev">Am. J. Phys. Anthropol.</title><idno type="ISSN">0002-9483</idno><idno type="eISSN">1096-8644</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08">2007-08</date><biblScope unit="volume">133</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1099">1099</biblScope><biblScope unit="page" to="1111">1111</biblScope></imprint><idno type="ISSN">0002-9483</idno></series><idno type="istex">C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8</idno><idno type="DOI">10.1002/ajpa.20611</idno><idno type="ArticleID">AJPA20611</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9483</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>hyperostosis frontalis interna</term><term>hyperparathyroidism</term><term>osteomyelitis</term><term>paleopathology</term><term>syphilis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>F.J. Rühli</name><affiliations><json:string>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>G. Kuhn</name><affiliations><json:string>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>R. Evison</name><affiliations><json:string>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>R. Müller</name><affiliations><json:string>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>M. Schultz</name><affiliations><json:string>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</json:string><json:string>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>paleopathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>osteomyelitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>syphilis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hyperostosis frontalis interna</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hyperparathyroidism</value></json:item></subject><articleId><json:string>AJPA20611</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1956</abstractCharCount><pdfWordCount>7956</pdfWordCount><pdfCharCount>49429</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>289</abstractWordCount></qualityIndicators><title>Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title><refBibs><json:item><host><author></author><title>Die Gallersche Knochensammlung</title></host></json:item><json:item><author><json:item><name>P Beauchesne</name></json:item><json:item><name>S Saunders</name></json:item></author><host><volume>16</volume><pages><last>87</last><first>82</first></pages><author></author><title>Int J Osteoarchaeol</title></host><title>A test of the revised Frost's ‘rapid manual method’ for the preparation of bone thin sections</title></json:item><json:item><author><json:item><name>X Bosch</name></json:item></author><host><volume>355</volume><pages><first>1248</first></pages><author></author><title>Lancet</title></host><title>Look to the bones for clues to human disease</title></json:item><json:item><author><json:item><name>KA Buckwalter</name></json:item><json:item><name>J Rydberg</name></json:item><json:item><name>KK Kopecky</name></json:item><json:item><name>K Crow</name></json:item><json:item><name>EL Yang</name></json:item></author><host><volume>176</volume><pages><last>986</last><first>979</first></pages><author></author><title>Am J Roentgenol</title></host><title>Musculoskeletal imaging with Multislice CT</title></json:item><json:item><author><json:item><name>F Cesarani</name></json:item><json:item><name>MC Martina</name></json:item><json:item><name>A Ferraris</name></json:item><json:item><name>R Grilletto</name></json:item><json:item><name>R Boano</name></json:item><json:item><name>EF Marochetti</name></json:item><json:item><name>AM Donadoni</name></json:item><json:item><name>G Gandini</name></json:item></author><host><volume>180</volume><pages><last>606</last><first>597</first></pages><author></author><title>Am J Roentgenol</title></host><title>Whole‐body three‐dimensional multidetector CT of 13 Egyptian human mummies</title></json:item><json:item><author><json:item><name>N Chege</name></json:item><json:item><name>DJ Sartoris</name></json:item><json:item><name>R Tyson</name></json:item><json:item><name>D Resnick</name></json:item></author><host><volume>6</volume><pages><last>258</last><first>249</first></pages><author></author><title>Int J Osteoarcheol</title></host><title>Imaging evaluation of skull trepanation using radiography and CT</title></json:item><json:item><author><json:item><name>F Di Raimondo</name></json:item><json:item><name>MP Azzaro</name></json:item><json:item><name>GA Palumbo</name></json:item><json:item><name>S Bagnato</name></json:item><json:item><name>F Stagno</name></json:item><json:item><name>GM Giustolisi</name></json:item><json:item><name>E Cacciola</name></json:item><json:item><name>G Sortino</name></json:item><json:item><name>P Guglielmo</name></json:item><json:item><name>R Giustolisi</name></json:item></author><host><volume>15</volume><pages><last>80</last><first>976</first></pages><author></author><title>Leukemia</title></host><title>Elevated vascular endothelial growth factor (VEGF) serum levels in idiopathic myelofibrosis</title></json:item><json:item><author><json:item><name>K Engelke</name></json:item><json:item><name>W Graeff</name></json:item><json:item><name>L Meiss</name></json:item><json:item><name>M Hahn</name></json:item><json:item><name>G Delling</name></json:item></author><host><volume>28</volume><pages><last>349</last><first>341</first></pages><author></author><title>Invest Radiol</title></host><title>High spatial resolution imaging of bone mineral using computed microtomography. Comparison with microradiography and undecalcified histologic sections</title></json:item><json:item><author><json:item><name>RJ Fajardo</name></json:item><json:item><name>R Müller</name></json:item></author><host><volume>115</volume><pages><last>336</last><first>327</first></pages><author></author><title>Am J Phys Anthropol</title></host><title>Three‐dimensional analysis of nonhuman primate trabecular architecture using micro‐computed tomography</title></json:item><json:item><author><json:item><name>LA Feldkamp</name></json:item><json:item><name>SA Goldstein</name></json:item><json:item><name>AM Parfitt</name></json:item><json:item><name>G Jesion</name></json:item><json:item><name>M Kleerekoper</name></json:item></author><host><volume>4</volume><pages><last>11</last><first>3</first></pages><author></author><title>J Bone Miner Res</title></host><title>The direct examination of three‐dimensional bone architecture in vitro by computed tomography</title></json:item><json:item><host><author></author><title>Galanski M,Prokop M (1998)Ganzkörper‐Computertomographie.Stuttgart, New York:Thieme.</title></host></json:item><json:item><author><json:item><name>CJ Hackett</name></json:item></author><host><volume>368</volume><pages><last>241</last><first>229</first></pages><author></author><title>Virchows Arch A Pathol Anat Histol</title></host><title>An introduction to diagnostic criteria of syphilis, treponarid and yaws (treponematoses) in dry bones, and some implications</title></json:item><json:item><author><json:item><name>CW Hayes</name></json:item><json:item><name>WF Conway</name></json:item></author><host><volume>29</volume><pages><last>96</last><first>85</first></pages><author></author><title>Radiol Clin North Am</title></host><title>Hyperparathyroidism</title></json:item><json:item><author><json:item><name>I Hershkovitz</name></json:item><json:item><name>C Greenwald</name></json:item><json:item><name>BM Rothschild</name></json:item><json:item><name>B Latimer</name></json:item><json:item><name>O Dutour</name></json:item><json:item><name>LM Jellema</name></json:item><json:item><name>S Wish‐Baratz</name></json:item></author><host><volume>109</volume><pages><last>325</last><first>303</first></pages><author></author><title>Am J Phys Anthropol</title></host><title>Hyperostosis frontalis interna: an anthropological perspective</title></json:item><json:item><author><json:item><name>G Heuck</name></json:item></author><host><volume>78</volume><pages><last>496</last><first>475</first></pages><author></author><title>Virchows Arch Path Anat</title></host><title>Zwei Fälle von Leukämie mit eigentümlichem Blut‐ resp. Knochenmarksbefund</title></json:item><json:item><author><json:item><name>GN Hounsfield</name></json:item></author><host><volume>45</volume><pages><last>1022</last><first>1016</first></pages><author></author><title>Br J Radiol</title></host><title>Computerized transverse axial scanning (tomography), Part 1: Description of system</title></json:item><json:item><author><json:item><name>H Hu</name></json:item></author><host><volume>26</volume><pages><last>18</last><first>5</first></pages><author></author><title>Med Phys</title></host><title>Multi‐slice helical CT: scan and reconstruction</title></json:item><json:item><author><json:item><name>RJ Jansen</name></json:item><json:item><name>M Poulus</name></json:item><json:item><name>W Taconis</name></json:item><json:item><name>J Stoker</name></json:item></author><host><volume>26</volume><pages><last>216</last><first>211</first></pages><author></author><title>Comput Med Imaging Graph</title></host><title>High‐resolution spiral computed tomography with multiplanar reformatting, 3D surface‐ and volume rendering: a non‐destructive method to visualize ancient Egyptian mummification techniques</title></json:item><json:item><author><json:item><name>G Kuhn</name></json:item><json:item><name>M Schultz</name></json:item><json:item><name>R Müller</name></json:item><json:item><name>FJ Rühli</name></json:item></author><host><author></author><title>J Comp Hum Biol.</title></host><title>Diagnostic value of micro CT in comparison with histology in the qualitative assessment of historic human postcranial bone pathologies</title></json:item><json:item><author><json:item><name>M Lachmann</name></json:item><json:item><name>ME Kricun</name></json:item><json:item><name>EE Schwartz</name></json:item></author><host><volume>13</volume><pages><last>252</last><first>248</first></pages><author></author><title>Skeletal Radiol</title></host><title>Case report 310. diagnosis: primary hyperparathyroidism (HPR), with patchy diffuse osteosclerosis at multiple skeletal sites</title></json:item><json:item><author><json:item><name>GJR Maat</name></json:item><json:item><name>RPM Van den Bos</name></json:item><json:item><name>MJ Aarents</name></json:item></author><host><volume>11</volume><pages><last>374</last><first>366</first></pages><author></author><title>Int J Osteoarchaeol</title></host><title>Manual preparation of ground sections for the microscopy of natural bone tissue: update and modification of Frost's ‘rapid manual method’</title></json:item><json:item><author><json:item><name>R Macchiarelli</name></json:item><json:item><name>L Bondioli</name></json:item><json:item><name>V Galichon</name></json:item><json:item><name>PV Tobias</name></json:item></author><host><volume>36</volume><pages><last>232</last><first>211</first></pages><author></author><title>J Hum Evol</title></host><title>Hip bone trabecular architecture shows uniquely distinctive locomotor behaviour in South African australopithecines</title></json:item><json:item><author><json:item><name>CH McCollough</name></json:item><json:item><name>FE Zink</name></json:item></author><host><volume>26</volume><pages><last>2230</last><first>2223</first></pages><author></author><title>Med Phys</title></host><title>Performance evaluation of a multi‐slice CT system</title></json:item><json:item><author><json:item><name>DD McErlain</name></json:item><json:item><name>RK Chhem</name></json:item><json:item><name>RN Bohay</name></json:item><json:item><name>DW Holdsworth</name></json:item></author><host><volume>55</volume><pages><last>5</last><first>242</first></pages><author></author><title>Can Assoc Radiol J</title></host><title>Micro‐computed tomography of a 500‐year‐old tooth: technical note</title></json:item><json:item><host><author></author><title>Morgagni GB.1719.Adversaria anatomica VI. Animadversio LXXIV.Padua:Vulporius.</title></host></json:item><json:item><author><json:item><name>R Müller</name></json:item></author><host><volume>14</volume><pages><last>99</last><first>89</first></pages><author></author><title>Osteoporosis Int</title></host><title>Bone microarchitecture assessment ‐ current and future trends</title></json:item><json:item><author><json:item><name>R Müller</name></json:item><json:item><name>H Van Campenhout</name></json:item><json:item><name>B Van Damme</name></json:item><json:item><name>G Van Der Perre</name></json:item><json:item><name>J Dequeker</name></json:item><json:item><name>T Hildebrand</name></json:item><json:item><name>P Rüegsegger</name></json:item></author><host><volume>23</volume><pages><last>66</last><first>59</first></pages><author></author><title>Bone</title></host><title>Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro‐computed tomography</title></json:item><json:item><author><json:item><name>E Picano</name></json:item></author><host><volume>328</volume><pages><last>580</last><first>578</first></pages><author></author><title>BMJ</title></host><title>Sustainability of medical imaging</title></json:item><json:item><author><json:item><name>JT Reilly</name></json:item></author><host><volume>11</volume><pages><last>242</last><first>233</first></pages><author></author><title>Blood Rev</title></host><title>Idiopathic myelofibrosis: pathogenesis, natural history and management</title></json:item><json:item><host><author></author><title>Resnick D,Pettersson H.1992Skeletal radiology.London:Merit Communications.</title></host></json:item><json:item><author><json:item><name>ML Richardson</name></json:item><json:item><name>RS Pozzi‐Mucelli</name></json:item><json:item><name>AS Kanter</name></json:item><json:item><name>FO Kolb</name></json:item><json:item><name>B Ettinger</name></json:item><json:item><name>HK Genant</name></json:item></author><host><volume>15</volume><pages><last>95</last><first>85</first></pages><author></author><title>Skeletal Radiol</title></host><title>Bone mineral changes in primary hyperparathyroidism</title></json:item><json:item><author><json:item><name>EL Ritman</name></json:item></author><host><volume>6</volume><pages><last>208</last><first>185</first></pages><author></author><title>Annual Rev Biomed Eng</title></host><title>Micro‐computed tomography‐current status and developments</title></json:item><json:item><host><author></author><title>Über eine neue Art von Strahlen</title></host></json:item><json:item><author><json:item><name>P Rüegsegger</name></json:item><json:item><name>B Koller</name></json:item><json:item><name>R Müller</name></json:item></author><host><volume>58</volume><pages><last>9</last><first>24</first></pages><author></author><title>Calcified Tissue International</title></host><title>A microtomographic system for the nondestructive evaluation of bone architecture</title></json:item><json:item><author><json:item><name>FJ Rühli</name></json:item><json:item><name>G Hotz</name></json:item><json:item><name>T Böni</name></json:item></author><host><volume>121</volume><pages><last>18</last><first>15</first></pages><author></author><title>Am J Phys Anthropol</title></host><title>Brief communication: the Galler Collection: a little‐known historic Swiss bone pathology reference series</title></json:item><json:item><author><json:item><name>FJ Rühli</name></json:item><json:item><name>C Lanz</name></json:item><json:item><name>S Ulrich‐Bochsler</name></json:item></author><host><volume>6</volume><pages><last>26</last><first>23</first></pages><author></author><title>Bull Soc Suisse d'Anthropol</title></host><title>Darstellung schweizerischer mittelalterlicher Knochenläsionen mittels Multislice ‐ CT</title></json:item><json:item><author><json:item><name>FJ Rühli</name></json:item><json:item><name>C Lanz</name></json:item><json:item><name>S Ulrich‐Bochsler</name></json:item><json:item><name>KW Alt</name></json:item></author><host><volume>12</volume><pages><last>379</last><first>372</first></pages><author></author><title>Int J Osteoarcheol</title></host><title>State‐of‐the‐art imaging in paleopathology: value of multislice computed tomography to visualize doubtful cranial lesions</title></json:item><json:item><host><author></author><title>Erste Ergebnisse bei der Darstellung paläopathologischer Knochenläsionen mittels Multislice‐CT. 4</title></host></json:item><json:item><author><json:item><name>FJ Rühli</name></json:item><json:item><name>C Lanz</name></json:item><json:item><name>S Ulrich‐Bochsler</name></json:item><json:item><name>M Schultz</name></json:item><json:item><name>A von Smekal</name></json:item></author><host><volume>51</volume><pages><first>105</first></pages><issue>Suppl</issue><author></author><title>Homo</title></host><title>Vergleichende Morphologie von Knochenpathologien im Multislice‐CT und in der Histologie</title></json:item><json:item><author><json:item><name>J Rydberg</name></json:item><json:item><name>KA Buckwalter</name></json:item><json:item><name>KS Caldemeyer</name></json:item><json:item><name>MD Phillips</name></json:item><json:item><name>DJ Conces Jr</name></json:item><json:item><name>AM Aisen</name></json:item><json:item><name>SA Persohn</name></json:item><json:item><name>KK Kopecky</name></json:item></author><host><volume>20</volume><pages><last>806</last><first>1787</first></pages><author></author><title>Radiographics</title></host><title>Multisection CT: scanning techniques and clinical applications</title></json:item><json:item><host><author></author><title>Die Gallersche Knochensammlung</title></host></json:item><json:item><host><author></author><title>Die mikroskopische Untersuchung prähistorischer Skelettfunde</title></host></json:item><json:item><author><json:item><name>M Schultz</name></json:item></author><host><pages><last>730</last><first>608</first></pages><author></author><title>Anthropologie. Handbuch der vergleichenden Biologe des Menschen 1</title></host><title>Methoden der Licht‐ und Elektronenmikroskopie</title></json:item><json:item><author><json:item><name>M Schultz</name></json:item></author><host><pages><last>67</last><first>63</first></pages><author></author><title>L'origine de la syphilis en Europe</title></host><title>Comparative histopathology of syphilitic lesions in prehistoric and historic human bones</title></json:item><json:item><author><json:item><name>M Schultz</name></json:item></author><host><pages><last>222</last><first>201</first></pages><author></author><title>Forensic taphonomy. The postmortem fate of human remains</title></host><title>Microscopic investigation of excavated skeletal remains: A contribution to paleopathology and forensic medicine</title></json:item><json:item><author><json:item><name>M Schultz</name></json:item></author><host><volume>44</volume><pages><last>147</last><first>106</first></pages><author></author><title>Yrbk Phys Anthropol</title></host><title>Paleohistopathology of bone: a new approach to the study of ancient diseases</title></json:item><json:item><author><json:item><name>M Schultz</name></json:item></author><host><pages><last>107</last><first>73</first></pages><author></author><title>Identification of pathological conditions in human skeletal remains</title></host><title>Light microscopic analysis in skeletal paleopathology</title></json:item><json:item><author><json:item><name>M Schultz</name></json:item><json:item><name>R Drommer</name></json:item></author><host><pages><last>97</last><first>95</first></pages><author></author><title>Experimentelle Mund‐Kiefer‐Gesichtschirurgie: mikrochirurgische Eingriffe</title></host><title>Möglichkeiten der Präparateherstellung aus dem Gesichtsschädelbereich für die makroskopische und mikroskopische Untersuchung unter Verwendung neuer Kunststofftechniken</title></json:item><json:item><author><json:item><name>H Seyle</name></json:item></author><host><volume>14</volume><pages><first>60</first></pages><author></author><title>Arch Pathol</title></host><title>Action of parathyroid hormone on the epiphyseal junction of the young rat</title></json:item><json:item><host><author></author><title>von Recklinghausen FD.1891.Die fibröse und deformirende Ostitis, die Osteomalacie und die osteoplastische Carcinose in ihren gegenseitigen Beziehungen.: Festschrift Rudolf Virchow zu seinem 71. Geburtstag.Berlin:Reimer.</title></host></json:item><json:item><author><json:item><name>JC Wang</name></json:item><json:item><name>K Hemavathy</name></json:item><json:item><name>W Charles</name></json:item><json:item><name>H Zhang</name></json:item><json:item><name>PK Dua</name></json:item><json:item><name>AD Novetsky</name></json:item><json:item><name>T Chang</name></json:item><json:item><name>C Wong</name></json:item><json:item><name>M Jabara</name></json:item></author><host><volume>32</volume><pages><last>910</last><first>905</first></pages><author></author><title>Exp Hematol</title></host><title>Osteosclerosis in idiopathic myelofibrosis is related to the overproduction of osteoprotegerin (OPG)</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>133</volume><publisherId><json:string>AJPA</json:string></publisherId><pages><total>13</total><last>1111</last><first>1099</first></pages><issn><json:string>0002-9483</json:string></issn><issue>4</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1096-8644</json:string></eissn><title>American Journal of Physical Anthropology</title><doi><json:string>10.1002/(ISSN)1096-8644</json:string></doi></host><categories><wos><json:string>social science</json:string><json:string>anthropology</json:string><json:string>science</json:string><json:string>evolutionary biology</json:string></wos><scienceMetrix><json:string>arts & humanities</json:string><json:string>historical studies</json:string><json:string>anthropology</json:string></scienceMetrix></categories><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/ajpa.20611</json:string></doi><id>C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8</id><score>0.20805815</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>Copyright © 2007 Wiley‐Liss, Inc.</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title><author xml:id="author-1"><persName><forename type="first">F.J.</forename><surname>Rühli</surname></persName><affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</affiliation></author><author xml:id="author-2"><persName><forename type="first">G.</forename><surname>Kuhn</surname></persName><affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</affiliation></author><author xml:id="author-3"><persName><forename type="first">R.</forename><surname>Evison</surname></persName><affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</affiliation></author><author xml:id="author-4"><persName><forename type="first">R.</forename><surname>Müller</surname></persName><affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</affiliation></author><author xml:id="author-5"><persName><forename type="first">M.</forename><surname>Schultz</surname></persName><affiliation>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</affiliation><affiliation>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</affiliation></author></analytic><monogr><title level="j">American Journal of Physical Anthropology</title><title level="j" type="abbrev">Am. J. Phys. Anthropol.</title><idno type="pISSN">0002-9483</idno><idno type="eISSN">1096-8644</idno><idno type="DOI">10.1002/(ISSN)1096-8644</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-08"></date><biblScope unit="volume">133</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1099">1099</biblScope><biblScope unit="page" to="1111">1111</biblScope></imprint></monogr><idno type="istex">C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8</idno><idno type="DOI">10.1002/ajpa.20611</idno><idno type="ArticleID">AJPA20611</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>paleopathology</term></item><item><term>osteomyelitis</term></item><item><term>syphilis</term></item><item><term>hyperostosis frontalis interna</term></item><item><term>hyperparathyroidism</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-02-03">Received</change><change when="2007-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1096-8644</doi><issn type="print">0002-9483</issn><issn type="electronic">1096-8644</issn><idGroup><id type="product" value="AJPA"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY">American Journal of Physical Anthropology</title><title type="short">Am. J. Phys. Anthropol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi origin="wiley" registered="yes">10.1002/ajpa.v133:4</doi><numberingGroup><numbering type="journalVolume" number="133">133</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2007-08">August 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/ajpa.20611</doi><idGroup><id type="unit" value="AJPA20611"></id></idGroup><countGroup><count type="pageTotal" number="13"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2007 Wiley‐Liss, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2006-02-03"></event><event type="publishedOnlineEarlyUnpaginated" date="2007-05-25"></event><event type="firstOnline" date="2007-05-25"></event><event type="publishedOnlineFinalForm" date="2007-07-20"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.18.1 mode:FullText source:HeaderRef result:HeaderRef" date="2010-09-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst">1099</numbering><numbering type="pageLast">1111</numbering></numberingGroup><correspondenceTo>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:AJPA.AJPA20611.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="9"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="51"></count><count type="wordTotal" number="1221"></count></countGroup><titleGroup><title type="main" xml:lang="en">Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title><title type="short" xml:lang="en">Micro‐CT of Historical Skull Bones</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>F.J.</givenNames><familyName>Rühli</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>G.</givenNames><familyName>Kuhn</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>R.</givenNames><familyName>Evison</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>R.</givenNames><familyName>Müller</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af3" corresponding="yes"><personName><givenNames>M.</givenNames><familyName>Schultz</familyName></personName><contactDetails><email>mschult1@gwdg.de</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="CH" type="organization"><unparsedAffiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="CH" type="organization"><unparsedAffiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="DE" type="organization"><unparsedAffiliation>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">paleopathology</keyword><keyword xml:id="kwd2">osteomyelitis</keyword><keyword xml:id="kwd3">syphilis</keyword><keyword xml:id="kwd4">hyperostosis frontalis interna</keyword><keyword xml:id="kwd5">hyperparathyroidism</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Micro‐CT of Historical Skull Bones</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies</title></titleInfo><name type="personal"><namePart type="given">F.J.</namePart><namePart type="family">Rühli</namePart><affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Kuhn</namePart><affiliation>Institute of Anatomy, University of Zurich, CH‐8057 Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Evison</namePart><affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Müller</namePart><affiliation>Institute for Biomedical Engineering, University and ETH Zurich, CH‐8044 Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Schultz</namePart><affiliation>Department of Anatomy, Georg‐August‐University of Göttingen, D‐37075 Goettingen, Germany</affiliation><affiliation>Zentrum Anatomie der Georg‐August‐Universität, Kreuzbergring 36, D‐37075 Göttingen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-08</dateIssued><dateCaptured encoding="w3cdtf">2006-02-03</dateCaptured><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">9</extent><extent unit="tables">1</extent><extent unit="references">51</extent><extent unit="words">1221</extent></physicalDescription><abstract lang="en">Cases of pathologically changed bone might constitute a diagnostic pitfall and frequently need histological methods to be etiologically properly evaluated. With micro‐computed tomography (μCT), a new epoch of 2D and 3D imaging has been launched. We evaluated the diagnostic investigation of this analytical method versus well established histological investigations of historical human bone. Pathological changes due to various etiologies (infectious, traumatic, endocrinological, neoplasia) observed in autopsy‐based macerated human skulls (Galler Collection, Natural History Museum Basel, Switzerland) were investigated by μCT and compared with histological thin ground sections using polarized light. Micro‐CT images visualize the architecture of the bone with high spatial resolution without preparation or destruction of the sample in the area to be sectioned. Changes in the bone surfaces as well as alterations of the diploë can be assessed. However, morphological patterns caused by reactive response, such as typical arrangements of collagen fibers, can only be visualized by the microscopic investigation of thin ground sections using polarized light. A great advantage of μCT is the high number of slices obtained so that spatial differences within the areas of the specimen become visible. Micro‐CT is a valuable tool for the diagnosis of vestiges of skull bone diseases. Its advantages over histology are the fast, automated image acquisition and the fact that the specimen is not completely destroyed. Only excision of the area to be scanned is necessary, if the specimen is too large to be scanned as a whole. Further, the 3D visualization of the micro‐architecture allows an easy orientation within the sample, for example, for the choice of the location of the histological slices. However, the need to differentiate woven from lamellar bone still makes histology an indispensable method. Am J Phys Anthropol, 2007. © 2007 Wiley‐Liss, Inc.</abstract><subject lang="en"><genre>keywords</genre><topic>paleopathology</topic><topic>osteomyelitis</topic><topic>syphilis</topic><topic>hyperostosis frontalis interna</topic><topic>hyperparathyroidism</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Physical Anthropology</title></titleInfo><titleInfo type="abbreviated"><title>Am. J. Phys. Anthropol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0002-9483</identifier><identifier type="eISSN">1096-8644</identifier><identifier type="DOI">10.1002/(ISSN)1096-8644</identifier><identifier type="PublisherID">AJPA</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>133</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>1099</start><end>1111</end><total>13</total></extent></part></relatedItem><identifier type="istex">C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8</identifier><identifier type="DOI">10.1002/ajpa.20611</identifier><identifier type="ArticleID">AJPA20611</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Wiley‐Liss, Inc.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Archeologie/explor/PaleopathV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001799 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001799 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Archeologie
|area= PaleopathV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:C2E6DAE8EF7AA34845AB011AAD19652BA8A61AF8
|texte= Diagnostic value of micro‐CT in comparison with histology in the qualitative assessment of historical human skull bone pathologies
}}
| This area was generated with Dilib version V0.6.27. |  |