Presence of drugs in different tissues of an egyptian mummy
Identifieur interne : 000960 ( Istex/Corpus ); précédent : 000959; suivant : 000961Presence of drugs in different tissues of an egyptian mummy
Auteurs : Franz Parsche ; Andreas NerlichSource :
- Fresenius' Journal of Analytical Chemistry [ 0937-0633 ] ; 1995-01-01.
Abstract
Abstract: Data are presented on the biochemical findings in several intermal organs from an Egyptian mummy with a 14C-dating of approximately 950 B.C. By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.
Url:
DOI: 10.1007/BF00322236
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ISTEX:04240CA489D9EDC2F4FBFF68C55F689F3E5F4D88Le document en format XML
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By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>Franz Parsche</name><affiliations><json:string>Institut für Anthropologie und Humangenetik der Universität München, Richard-Wagner-Strasse 36, D-80333, München, Germany</json:string></affiliations></json:item><json:item><name>Andreas Nerlich</name><affiliations><json:string>Pathologisches Institut der Universität München, Thalkirchnerstrasse 36, D-80337, München, Germany</json:string></affiliations></json:item></author><articleId><json:string>BF00322236</json:string><json:string>Art12</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Data are presented on the biochemical findings in several intermal organs from an Egyptian mummy with a 14C-dating of approximately 950 B.C. By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. 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Bar-Ziv</name></json:item><json:item><name>Gm Goldberg</name></json:item></author><host><volume>29</volume><pages><last>126</last><first>121</first></pages><author></author><title>Arch Env Health</title><publicationDate>1974</publicationDate></host><publicationDate>1974</publicationDate></json:item><json:item><author><json:item><name>A Policart</name></json:item><json:item><name>A Collet</name></json:item></author><host><volume>5</volume><pages><last>534</last><first>527</first></pages><author></author><title>Arch Ind Hyg Occup Med</title><publicationDate>1952</publicationDate></host><publicationDate>1952</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>352</volume><pages><last>384</last><first>380</first></pages><issn><json:string>0937-0633</json:string></issn><issue>3-4</issue><subject><json:item><value>Analytical Chemistry</value></json:item><json:item><value>Food Science</value></json:item><json:item><value>Inorganic 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GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1995</p></availability><date>1994-10-01</date></publicationStmt><notesStmt><note>Original Papers/Archeometric Analysis</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Presence of drugs in different tissues of an egyptian mummy</title><author xml:id="author-1"><persName><forename type="first">Franz</forename><surname>Parsche</surname></persName><affiliation>Institut für Anthropologie und Humangenetik der Universität München, Richard-Wagner-Strasse 36, D-80333, München, Germany</affiliation></author><author xml:id="author-2" corresp="yes"><persName><forename type="first">Andreas</forename><surname>Nerlich</surname></persName><affiliation>Pathologisches Institut der Universität München, Thalkirchnerstrasse 36, D-80337, München, Germany</affiliation></author></analytic><monogr><title level="j">Fresenius' Journal of Analytical Chemistry</title><title level="j" type="abbrev">Fresenius J Anal Chem</title><idno type="journal-ID">216</idno><idno type="pISSN">0937-0633</idno><idno type="eISSN">1432-1130</idno><idno type="issue-article-count">21</idno><idno type="volume-issue-count">8</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1995-01-01"></date><biblScope unit="volume">352</biblScope><biblScope unit="issue">3-4</biblScope><biblScope unit="page" from="380">380</biblScope><biblScope unit="page" to="384">384</biblScope></imprint></monogr><idno type="istex">04240CA489D9EDC2F4FBFF68C55F689F3E5F4D88</idno><idno 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By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Chemistry</head><item><term>Analytical Chemistry</term></item><item><term>Food Science</term></item><item><term>Inorganic Chemistry</term></item><item><term>Physical Chemistry</term></item><item><term>Monitoring/Environmental Analysis/Environmental Ecotoxicology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-10-01">Created</change><change when="1995-01-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-22">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-21">References 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Analysis</ArticleSubCategory><ArticleFirstPage>380</ArticleFirstPage><ArticleLastPage>384</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>8</Month><Day>27</Day></RegistrationDate><Received><Year>1994</Year><Month>10</Month><Day>1</Day></Received><Revised><Year>1994</Year><Month>12</Month><Day>21</Day></Revised><Accepted><Year>1994</Year><Month>12</Month><Day>23</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1995</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>216</JournalID><VolumeIDStart>352</VolumeIDStart><VolumeIDEnd>352</VolumeIDEnd><IssueIDStart>3</IssueIDStart><IssueIDEnd>4</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Franz</GivenName><FamilyName>Parsche</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff2" CorrespondingAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>Andreas</GivenName><FamilyName>Nerlich</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Institut für Anthropologie und Humangenetik der Universität München</OrgName><OrgAddress><Street>Richard-Wagner-Strasse 36</Street><Postcode>D-80333</Postcode><City>München</City><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Pathologisches Institut der Universität München</OrgName><OrgAddress><Street>Thalkirchnerstrasse 36</Street><Postcode>D-80337</Postcode><City>München</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Data are presented on the biochemical findings in several intermal organs from an Egyptian mummy with a <Superscript>14</Superscript>C-dating of approximately 950 B.C. By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Presence of drugs in different tissues of an egyptian mummy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Presence of drugs in different tissues of an egyptian mummy</title></titleInfo><name type="personal"><namePart type="given">Franz</namePart><namePart type="family">Parsche</namePart><affiliation>Institut für Anthropologie und Humangenetik der Universität München, Richard-Wagner-Strasse 36, D-80333, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Andreas</namePart><namePart type="family">Nerlich</namePart><affiliation>Pathologisches Institut der Universität München, Thalkirchnerstrasse 36, D-80337, München, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1994-10-01</dateCreated><dateIssued encoding="w3cdtf">1995-01-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Data are presented on the biochemical findings in several intermal organs from an Egyptian mummy with a 14C-dating of approximately 950 B.C. By use of radio immunoassay systems and gas chromatography/mass spectrometry, significant amounts of various drugs were detected in internal organs (lung, liver, stomach, intestines) as well as in hair, bone, skin/muscle and tendon. These analyses revealed a significant deposition of tetrahydrocannabinol (THC), nicotine (and its metabolite cotinine) and cocaine in the tissue from the mummy. The concentration profiles additionally provide evidence for the preferential ways of consumption: Thus, the highest levels of THC in lung specimens point to an inhalation of this drug — as it has been assumed from known ritual smoking ceremonies —, while nicotine and cocaine containing drugs showed their highest concentrations in the intestines and liver, so that they seem to have been consumed perorally. Furthermore, a histopathological examination of the internal organ tissues revealed some evidence for the underlying disease and the probable cause of death. Thus, a severe and presumably recurrent intravital pulmonary bleeding, most obviously due to a parasitosis affecting the lung, was observed.</abstract><note>Original Papers/Archeometric Analysis</note><relatedItem type="host"><titleInfo><title>Fresenius' Journal of Analytical Chemistry</title></titleInfo><titleInfo type="abbreviated"><title>Fresenius J Anal Chem</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1995-01-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><subject><genre>Chemistry</genre><topic>Analytical Chemistry</topic><topic>Food Science</topic><topic>Inorganic Chemistry</topic><topic>Physical Chemistry</topic><topic>Monitoring/Environmental Analysis/Environmental Ecotoxicology</topic></subject><identifier type="ISSN">0937-0633</identifier><identifier type="eISSN">1432-1130</identifier><identifier type="JournalID">216</identifier><identifier type="IssueArticleCount">21</identifier><identifier type="VolumeIssueCount">8</identifier><part><date>1995</date><detail type="volume"><number>352</number><caption>vol.</caption></detail><detail type="issue"><number>3-4</number><caption>no.</caption></detail><extent unit="pages"><start>380</start><end>384</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></relatedItem><identifier type="istex">04240CA489D9EDC2F4FBFF68C55F689F3E5F4D88</identifier><identifier type="DOI">10.1007/BF00322236</identifier><identifier type="ArticleID">BF00322236</identifier><identifier type="ArticleID">Art12</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1995</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1995</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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