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Biologic scaffold for CNS repair.

Identifieur interne : 002E82 ( PubMed/Curation ); précédent : 002E81; suivant : 002E83

Biologic scaffold for CNS repair.

Auteurs : Fanwei Meng [États-Unis] ; Michel Modo ; Stephen F. Badylak

Source :

Regenerative medicine [ 1746-076X ] ; 2014.

RBID : pubmed:24935046

Descripteurs français

KwdFr :
- Dure-mère (anatomopathologie), Dure-mère (métabolisme), Humains, Matrice extracellulaire (), Médecine régénérative (), Médecine régénérative (tendances), Régénération nerveuse (physiologie), Structures d'échafaudage tissulaires (), Structures d'échafaudage tissulaires (tendances), Système nerveux central (traumatismes).
MESH :
- anatomopathologie : Dure-mère.
- métabolisme : Dure-mère.
- physiologie : Régénération nerveuse.
- tendances : Médecine régénérative, Structures d'échafaudage tissulaires.
- traumatismes : Système nerveux central.
- Humains, Matrice extracellulaire, Médecine régénérative, Structures d'échafaudage tissulaires.

English descriptors

KwdEn :
- Central Nervous System (injuries), Dura Mater (metabolism), Dura Mater (pathology), Extracellular Matrix (chemistry), Humans, Nerve Regeneration (physiology), Regenerative Medicine (methods), Regenerative Medicine (trends), Tissue Scaffolds (chemistry), Tissue Scaffolds (trends).
MESH :
- chemistry : Extracellular Matrix, Tissue Scaffolds.
- injuries : Central Nervous System.
- metabolism : Dura Mater.
- methods : Regenerative Medicine.
- pathology : Dura Mater.
- physiology : Nerve Regeneration.
- trends : Regenerative Medicine, Tissue Scaffolds.
- Humans.

Abstract

Injury to the CNS typically results in significant morbidity and endogenous repair mechanisms are limited in their ability to restore fully functional CNS tissue. Biologic scaffolds composed of individual purified components have been shown to facilitate functional tissue reconstruction following CNS injury. Extracellular matrix scaffolds derived from mammalian tissues retain a number of bioactive molecules and their ability for CNS repair has recently been recognized. In addition, novel biomaterials for dural mater repairs are of clinical interest as the dura provides barrier function and maintains homeostasis to CNS. The present article describes the application of regenerative medicine principles to the CNS tissues and dural mater repair. While many approaches have been exploring the use of cells and/or therapeutic molecules, the strategies described herein focus upon the use of extracellular matrix scaffolds derived from mammalian tissues that are free of cells and exogenous factors.

DOI: 10.2217/rme.14.9
PubMed: 24935046

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Le document en format XML

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<term>Extracellular Matrix (chemistry)</term>
<term>Humans</term>
<term>Nerve Regeneration (physiology)</term>
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<term>Dure-mère (métabolisme)</term>
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<term>Matrice extracellulaire ()</term>
<term>Médecine régénérative ()</term>
<term>Médecine régénérative (tendances)</term>
<term>Régénération nerveuse (physiologie)</term>
<term>Structures d'échafaudage tissulaires ()</term>
<term>Structures d'échafaudage tissulaires (tendances)</term>
<term>Système nerveux central (traumatismes)</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Dure-mère</term>
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<term>Tissue Scaffolds</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Régénération nerveuse</term>
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<term>Structures d'échafaudage tissulaires</term>
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<term>Tissue Scaffolds</term>
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<front><div type="abstract" xml:lang="en">Injury to the CNS typically results in significant morbidity and endogenous repair mechanisms are limited in their ability to restore fully functional CNS tissue. Biologic scaffolds composed of individual purified components have been shown to facilitate functional tissue reconstruction following CNS injury. Extracellular matrix scaffolds derived from mammalian tissues retain a number of bioactive molecules and their ability for CNS repair has recently been recognized. In addition, novel biomaterials for dural mater repairs are of clinical interest as the dura provides barrier function and maintains homeostasis to CNS. The present article describes the application of regenerative medicine principles to the CNS tissues and dural mater repair. While many approaches have been exploring the use of cells and/or therapeutic molecules, the strategies described herein focus upon the use of extracellular matrix scaffolds derived from mammalian tissues that are free of cells and exogenous factors.</div>
</front>
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<Title>Regenerative medicine</Title>
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Biologic scaffold for CNS repair.

Biologic scaffold for CNS repair.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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