Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.
Identifieur interne : 002B69 ( PubMed/Curation ); précédent : 002B68; suivant : 002B70Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.
Auteurs : Venkat R R. Mantha [États-Unis] ; Harsha K. Nair ; Raman Venkataramanan ; Yuan Yue Gao ; Krzysztof Matyjaszewski ; Hongchen Dong ; Wenwen Li ; Doug Landsittel ; Elan Cohen ; William R. LariviereSource :
- Anesthesia and analgesia [ 1526-7598 ] ; 2014.
Descripteurs français
- KwdFr :
- Aire sous la courbe, Amides (administration et posologie), Amides (pharmacocinétique), Anesthésie (), Anesthésiques locaux (administration et posologie), Anesthésiques locaux (pharmacocinétique), Animaux, Bloc nerveux (), Magnétisme, Membre pelvien, Mâle, Nanoparticules, Préparation de médicament, Période, Rat Sprague-Dawley, Rats.
- MESH :
- administration et posologie : Amides, Anesthésiques locaux.
- pharmacocinétique : Amides, Anesthésiques locaux.
- Aire sous la courbe, Anesthésie, Animaux, Bloc nerveux, Magnétisme, Membre pelvien, Mâle, Nanoparticules, Préparation de médicament, Période, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- Amides (administration & dosage), Amides (pharmacokinetics), Anesthesia (methods), Anesthetics, Local (administration & dosage), Anesthetics, Local (pharmacokinetics), Animals, Area Under Curve, Drug Compounding, Half-Life, Hindlimb, Magnetics, Male, Nanoparticles, Nerve Block (methods), Rats, Rats, Sprague-Dawley.
- MESH :
- chemical , administration & dosage : Amides, Anesthetics, Local.
- chemical , pharmacokinetics : Amides, Anesthetics, Local.
- methods : Anesthesia, Nerve Block.
- Animals, Area Under Curve, Drug Compounding, Half-Life, Hindlimb, Magnetics, Male, Nanoparticles, Rats, Rats, Sprague-Dawley.
Abstract
As an alternative to current methods of local nerve block, we studied the feasibility of producing ankle block in the rat with IV injection of magnetic nanoparticles (MNPs) associated with ropivacaine and application of a magnet at the ankle.
DOI: 10.1213/ANE.0000000000000175
PubMed: 24722259
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Mantha</name><affiliation wicri:level="2"><nlm:affiliation>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nair, Harsha K" sort="Nair, Harsha K" uniqKey="Nair H" first="Harsha K" last="Nair">Harsha K. 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Mantha</name><affiliation wicri:level="2"><nlm:affiliation>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Nair, Harsha K" sort="Nair, Harsha K" uniqKey="Nair H" first="Harsha K" last="Nair">Harsha K. Nair</name></author><author><name sortKey="Venkataramanan, Raman" sort="Venkataramanan, Raman" uniqKey="Venkataramanan R" first="Raman" last="Venkataramanan">Raman Venkataramanan</name></author><author><name sortKey="Gao, Yuan Yue" sort="Gao, Yuan Yue" uniqKey="Gao Y" first="Yuan Yue" last="Gao">Yuan Yue Gao</name></author><author><name sortKey="Matyjaszewski, Krzysztof" sort="Matyjaszewski, Krzysztof" uniqKey="Matyjaszewski K" first="Krzysztof" last="Matyjaszewski">Krzysztof Matyjaszewski</name></author><author><name sortKey="Dong, Hongchen" sort="Dong, Hongchen" uniqKey="Dong H" first="Hongchen" last="Dong">Hongchen Dong</name></author><author><name sortKey="Li, Wenwen" sort="Li, Wenwen" uniqKey="Li W" first="Wenwen" last="Li">Wenwen Li</name></author><author><name sortKey="Landsittel, Doug" sort="Landsittel, Doug" uniqKey="Landsittel D" first="Doug" last="Landsittel">Doug Landsittel</name></author><author><name sortKey="Cohen, Elan" sort="Cohen, Elan" uniqKey="Cohen E" first="Elan" last="Cohen">Elan Cohen</name></author><author><name sortKey="Lariviere, William R" sort="Lariviere, William R" uniqKey="Lariviere W" first="William R" last="Lariviere">William R. Lariviere</name></author></analytic><series><title level="j">Anesthesia and analgesia</title><idno type="eISSN">1526-7598</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amides (administration & dosage)</term><term>Amides (pharmacokinetics)</term><term>Anesthesia (methods)</term><term>Anesthetics, Local (administration & dosage)</term><term>Anesthetics, Local (pharmacokinetics)</term><term>Animals</term><term>Area Under Curve</term><term>Drug Compounding</term><term>Half-Life</term><term>Hindlimb</term><term>Magnetics</term><term>Male</term><term>Nanoparticles</term><term>Nerve Block (methods)</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aire sous la courbe</term><term>Amides (administration et posologie)</term><term>Amides (pharmacocinétique)</term><term>Anesthésie ()</term><term>Anesthésiques locaux (administration et posologie)</term><term>Anesthésiques locaux (pharmacocinétique)</term><term>Animaux</term><term>Bloc nerveux ()</term><term>Magnétisme</term><term>Membre pelvien</term><term>Mâle</term><term>Nanoparticules</term><term>Préparation de médicament</term><term>Période</term><term>Rat Sprague-Dawley</term><term>Rats</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Amides</term><term>Anesthetics, Local</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Amides</term><term>Anesthetics, Local</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Amides</term><term>Anesthésiques locaux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Anesthesia</term><term>Nerve Block</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Amides</term><term>Anesthésiques locaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Area Under Curve</term><term>Drug Compounding</term><term>Half-Life</term><term>Hindlimb</term><term>Magnetics</term><term>Male</term><term>Nanoparticles</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aire sous la courbe</term><term>Anesthésie</term><term>Animaux</term><term>Bloc nerveux</term><term>Magnétisme</term><term>Membre pelvien</term><term>Mâle</term><term>Nanoparticules</term><term>Préparation de médicament</term><term>Période</term><term>Rat Sprague-Dawley</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As an alternative to current methods of local nerve block, we studied the feasibility of producing ankle block in the rat with IV injection of magnetic nanoparticles (MNPs) associated with ropivacaine and application of a magnet at the ankle.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24722259</PMID><DateCreated><Year>2014</Year><Month>05</Month><Day>20</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>10</Day></DateCompleted><DateRevised><Year>2014</Year><Month>05</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-7598</ISSN><JournalIssue CitedMedium="Internet"><Volume>118</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Anesthesia and analgesia</Title><ISOAbbreviation>Anesth. Analg.</ISOAbbreviation></Journal><ArticleTitle>Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles.</ArticleTitle><Pagination><MedlinePgn>1355-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1213/ANE.0000000000000175</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">As an alternative to current methods of local nerve block, we studied the feasibility of producing ankle block in the rat with IV injection of magnetic nanoparticles (MNPs) associated with ropivacaine and application of a magnet at the ankle.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The anesthetic effect of magnet-directed ropivacaine-associated MNPs (MNP/Ropiv) was tested in the rat using paw withdrawal latencies from thermal stimuli applied to the hindpaw. The MNP/Ropiv complexes consisted of 0.7% w/v ropivacaine and 0.8% w/v MNPs containing 12% w/w magnetite (F₃O₄). The effect of IV injection of MNP/Ropiv with 15, 30, and 60-minute magnet application to the right ankle was compared with the effect without magnet application on the left hindpaw, to conventional ankle block with 0.1% or 0.2% ropivacaine, and to IV injection of MNPs alone with 30-minute magnet application to the right ankle. In addition, the pharmacokinetics of the MNP/Ropiv complexes were determined.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">IV injection of MNP/Ropiv with magnet application at the ankle significantly increased paw withdrawal latencies from thermal stimuli compared with pretreatment baselines in the same paw (P < 0.0001) and compared with the contralateral paw without magnet application (P < 0.0001). IV injection of MNPs alone had no significant effect on paw withdrawal latency. Absolute ropivacaine concentrations in ankle tissue, and ankle tissue-to-plasma concentration ratios were higher in the MNP/Ropiv group with 30-minute magnet application compared with MNP/Ropiv group without magnet application (mean ± SEM, 150 ± 10 ng/g vs 105 ± 15 ng/g, respectively, and 6.1 ± 0.8 vs 4.2 ± 0.7, respectively).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The current study establishes proof of principle that it is possible to produce ankle block in the rat by IV injection of MNP/Ropiv complexes and magnet application at the ankle. The results indicate that further study of this approach is warranted.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mantha</LastName><ForeName>Venkat R R</ForeName><Initials>VR</Initials><AffiliationInfo><Affiliation>From the *Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; †Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania; ‡Center for Macromolecular Engineering, Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania; §Data Center, Center for Research on Health Care, and ‖Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nair</LastName><ForeName>Harsha K</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Venkataramanan</LastName><ForeName>Raman</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Yuan Yue</ForeName><Initials>YY</Initials></Author><Author ValidYN="Y"><LastName>Matyjaszewski</LastName><ForeName>Krzysztof</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Hongchen</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Wenwen</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Landsittel</LastName><ForeName>Doug</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Elan</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lariviere</LastName><ForeName>William R</ForeName><Initials>WR</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Anesth Analg</MedlineTA><NlmUniqueID>1310650</NlmUniqueID><ISSNLinking>0003-2999</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000577">Amides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000779">Anesthetics, Local</NameOfSubstance></Chemical><Chemical><RegistryNumber>7IO5LYA57N</RegistryNumber><NameOfSubstance UI="C037663">ropivacaine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000577" MajorTopicYN="N">Amides</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000758" MajorTopicYN="N">Anesthesia</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000779" MajorTopicYN="N">Anesthetics, Local</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004339" MajorTopicYN="N">Drug Compounding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006207" MajorTopicYN="N">Half-Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006614" MajorTopicYN="Y">Hindlimb</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008280" MajorTopicYN="Y">Magnetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="Y">Nanoparticles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009407" MajorTopicYN="N">Nerve Block</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24722259</ArticleId><ArticleId IdType="doi">10.1213/ANE.0000000000000175</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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