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Evidence for the role of EPHX2 gene variants in anorexia nervosa.

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Evidence for the role of EPHX2 gene variants in anorexia nervosa.

Auteurs : A A Scott-Van Zeeland [États-Unis] ; C S Bloss [États-Unis] ; R. Tewhey [États-Unis] ; V. Bansal [États-Unis] ; A. Torkamani [États-Unis] ; O. Libiger [États-Unis] ; V. Duvvuri [États-Unis] ; N. Wineinger [États-Unis] ; L. Galvez [États-Unis] ; B F Darst [États-Unis] ; E N Smith [États-Unis] ; A. Carson [États-Unis] ; P. Pham [États-Unis] ; T. Phillips [États-Unis] ; N. Villarasa [États-Unis] ; R. Tisch [États-Unis] ; G. Zhang [États-Unis] ; S. Levy [États-Unis] ; S. Murray [États-Unis] ; W. Chen [États-Unis] ; S. Srinivasan [États-Unis] ; G. Berenson [États-Unis] ; H. Brandt [États-Unis] ; S. Crawford [États-Unis] ; S. Crow [États-Unis] ; M M Fichter [Allemagne] ; K A Halmi [États-Unis] ; C. Johnson [États-Unis] ; A S Kaplan [Canada] ; M. La Via [États-Unis] ; J E Mitchell [États-Unis] ; M. Strober [États-Unis] ; A. Rotondo [Italie] ; J. Treasure [Royaume-Uni] ; D B Woodside [États-Unis] ; C M Bulik [États-Unis] ; P. Keel [États-Unis] ; K L Klump [États-Unis] ; L. Lilenfeld [États-Unis] ; K. Plotnicov [États-Unis] ; E J Topol [États-Unis] ; P B Shih [États-Unis] ; P. Magistretti [Suisse] ; A W Bergen [États-Unis] ; W. Berrettini [États-Unis] ; W. Kaye [États-Unis] ; N J Schork [États-Unis]

Source :

Molecular psychiatry [ 1476-5578 ] ; 2014.

RBID : pubmed:23999524

Descripteurs français

English descriptors

KwdEn :
- Adult, Anorexia Nervosa (genetics), Anorexia Nervosa (metabolism), Body Mass Index, Case-Control Studies, Cholesterol (metabolism), Cohort Studies, Epoxide Hydrolases (genetics), European Continental Ancestry Group (genetics), Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Longitudinal Studies, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychometrics, Young Adult.
MESH :
- chemical , genetics : Epoxide Hydrolases.
- chemical , metabolism : Cholesterol.
- genetics : Anorexia Nervosa, European Continental Ancestry Group.
- metabolism : Anorexia Nervosa.
- Adult, Body Mass Index, Case-Control Studies, Cohort Studies, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Longitudinal Studies, Male, Middle Aged, Polymorphism, Single Nucleotide, Psychometrics, Young Adult.

Abstract

Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.

DOI: 10.1038/mp.2013.91
PubMed: 23999524

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<author><name sortKey="Galvez, L" sort="Galvez, L" uniqKey="Galvez L" first="L" last="Galvez">L. Galvez</name>
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<author><name sortKey="Smith, E N" sort="Smith, E N" uniqKey="Smith E" first="E N" last="Smith">E N Smith</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Carson, A" sort="Carson, A" uniqKey="Carson A" first="A" last="Carson">A. Carson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Phillips, T" sort="Phillips, T" uniqKey="Phillips T" first="T" last="Phillips">T. Phillips</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Villarasa, N" sort="Villarasa, N" uniqKey="Villarasa N" first="N" last="Villarasa">N. Villarasa</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Tisch, R" sort="Tisch, R" uniqKey="Tisch R" first="R" last="Tisch">R. Tisch</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Zhang, G" sort="Zhang, G" uniqKey="Zhang G" first="G" last="Zhang">G. Zhang</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
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<author><name sortKey="Levy, S" sort="Levy, S" uniqKey="Levy S" first="S" last="Levy">S. Levy</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Murray, S" sort="Murray, S" uniqKey="Murray S" first="S" last="Murray">S. Murray</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W" last="Chen">W. Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
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<author><name sortKey="Srinivasan, S" sort="Srinivasan, S" uniqKey="Srinivasan S" first="S" last="Srinivasan">S. Srinivasan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
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<author><name sortKey="Berenson, G" sort="Berenson, G" uniqKey="Berenson G" first="G" last="Berenson">G. Berenson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brandt, H" sort="Brandt, H" uniqKey="Brandt H" first="H" last="Brandt">H. Brandt</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crawford, S" sort="Crawford, S" uniqKey="Crawford S" first="S" last="Crawford">S. Crawford</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crow, S" sort="Crow, S" uniqKey="Crow S" first="S" last="Crow">S. Crow</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Minnesota, Minneapolis, MN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fichter, M M" sort="Fichter, M M" uniqKey="Fichter M" first="M M" last="Fichter">M M Fichter</name>
<affiliation wicri:level="1"><nlm:affiliation>Roseneck Hospital for Behavioral Medicine, Prien, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Roseneck Hospital for Behavioral Medicine, Prien</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Halmi, K A" sort="Halmi, K A" uniqKey="Halmi K" first="K A" last="Halmi">K A Halmi</name>
<affiliation wicri:level="1"><nlm:affiliation>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C" last="Johnson">C. Johnson</name>
<affiliation wicri:level="1"><nlm:affiliation>Eating Recovery Center, Denver, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Eating Recovery Center, Denver, CO</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaplan, A S" sort="Kaplan, A S" uniqKey="Kaplan A" first="A S" last="Kaplan">A S Kaplan</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="La Via, M" sort="La Via, M" uniqKey="La Via M" first="M" last="La Via">M. La Via</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, J E" sort="Mitchell, J E" uniqKey="Mitchell J" first="J E" last="Mitchell">J E Mitchell</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Strober, M" sort="Strober, M" uniqKey="Strober M" first="M" last="Strober">M. Strober</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rotondo, A" sort="Rotondo, A" uniqKey="Rotondo A" first="A" last="Rotondo">A. Rotondo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Treasure, J" sort="Treasure, J" uniqKey="Treasure J" first="J" last="Treasure">J. Treasure</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woodside, D B" sort="Woodside, D B" uniqKey="Woodside D" first="D B" last="Woodside">D B Woodside</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bulik, C M" sort="Bulik, C M" uniqKey="Bulik C" first="C M" last="Bulik">C M Bulik</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Keel, P" sort="Keel, P" uniqKey="Keel P" first="P" last="Keel">P. Keel</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Klump, K L" sort="Klump, K L" uniqKey="Klump K" first="K L" last="Klump">K L Klump</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Michigan State University, East Lansing, MI, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, Michigan State University, East Lansing, MI</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lilenfeld, L" sort="Lilenfeld, L" uniqKey="Lilenfeld L" first="L" last="Lilenfeld">L. Lilenfeld</name>
<affiliation wicri:level="1"><nlm:affiliation>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Clinical Psychology Program, American School of Professional Psychology at Argosy University, Washington, DC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Plotnicov, K" sort="Plotnicov, K" uniqKey="Plotnicov K" first="K" last="Plotnicov">K. Plotnicov</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Topol, E J" sort="Topol, E J" uniqKey="Topol E" first="E J" last="Topol">E J Topol</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shih, P B" sort="Shih, P B" uniqKey="Shih P" first="P B" last="Shih">P B Shih</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Magistretti, P" sort="Magistretti, P" uniqKey="Magistretti P" first="P" last="Magistretti">P. Magistretti</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Laboratory of Neuroenergetics and Cellular Dynamics, The University of Lausanne, Lausanne</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bergen, A W" sort="Bergen, A W" uniqKey="Bergen A" first="A W" last="Bergen">A W Bergen</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Health Sciences, SRI International, Menlo Park, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Health Sciences, SRI International, Menlo Park, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berrettini, W" sort="Berrettini, W" uniqKey="Berrettini W" first="W" last="Berrettini">W. Berrettini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaye, W" sort="Kaye, W" uniqKey="Kaye W" first="W" last="Kaye">W. Kaye</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schork, N J" sort="Schork, N J" uniqKey="Schork N" first="N J" last="Schork">N J Schork</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
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<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2014">2014</date>
<idno type="RBID">pubmed:23999524</idno>
<idno type="pmid">23999524</idno>
<idno type="doi">10.1038/mp.2013.91</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence for the role of EPHX2 gene variants in anorexia nervosa.</title>
<author><name sortKey="Scott Van Zeeland, A A" sort="Scott Van Zeeland, A A" uniqKey="Scott Van Zeeland A" first="A A" last="Scott-Van Zeeland">A A Scott-Van Zeeland</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bloss, C S" sort="Bloss, C S" uniqKey="Bloss C" first="C S" last="Bloss">C S Bloss</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tewhey, R" sort="Tewhey, R" uniqKey="Tewhey R" first="R" last="Tewhey">R. Tewhey</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bansal, V" sort="Bansal, V" uniqKey="Bansal V" first="V" last="Bansal">V. Bansal</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Torkamani, A" sort="Torkamani, A" uniqKey="Torkamani A" first="A" last="Torkamani">A. Torkamani</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Libiger, O" sort="Libiger, O" uniqKey="Libiger O" first="O" last="Libiger">O. Libiger</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Duvvuri, V" sort="Duvvuri, V" uniqKey="Duvvuri V" first="V" last="Duvvuri">V. Duvvuri</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wineinger, N" sort="Wineinger, N" uniqKey="Wineinger N" first="N" last="Wineinger">N. Wineinger</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Galvez, L" sort="Galvez, L" uniqKey="Galvez L" first="L" last="Galvez">L. Galvez</name>
<affiliation wicri:level="1"><nlm:affiliation>The Scripps Translational Science Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Scripps Translational Science Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Darst, B F" sort="Darst, B F" uniqKey="Darst B" first="B F" last="Darst">B F Darst</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, E N" sort="Smith, E N" uniqKey="Smith E" first="E N" last="Smith">E N Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, The University of California, San Diego, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carson, A" sort="Carson, A" uniqKey="Carson A" first="A" last="Carson">A. Carson</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pham, P" sort="Pham, P" uniqKey="Pham P" first="P" last="Pham">P. Pham</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Phillips, T" sort="Phillips, T" uniqKey="Phillips T" first="T" last="Phillips">T. Phillips</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Villarasa, N" sort="Villarasa, N" uniqKey="Villarasa N" first="N" last="Villarasa">N. Villarasa</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tisch, R" sort="Tisch, R" uniqKey="Tisch R" first="R" last="Tisch">R. Tisch</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhang, G" sort="Zhang, G" uniqKey="Zhang G" first="G" last="Zhang">G. Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levy, S" sort="Levy, S" uniqKey="Levy S" first="S" last="Levy">S. Levy</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murray, S" sort="Murray, S" uniqKey="Murray S" first="S" last="Murray">S. Murray</name>
<affiliation wicri:level="1"><nlm:affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, W" sort="Chen, W" uniqKey="Chen W" first="W" last="Chen">W. Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Srinivasan, S" sort="Srinivasan, S" uniqKey="Srinivasan S" first="S" last="Srinivasan">S. Srinivasan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berenson, G" sort="Berenson, G" uniqKey="Berenson G" first="G" last="Berenson">G. Berenson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Brandt, H" sort="Brandt, H" uniqKey="Brandt H" first="H" last="Brandt">H. Brandt</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crawford, S" sort="Crawford, S" uniqKey="Crawford S" first="S" last="Crawford">S. Crawford</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crow, S" sort="Crow, S" uniqKey="Crow S" first="S" last="Crow">S. Crow</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Minnesota, Minneapolis, MN</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fichter, M M" sort="Fichter, M M" uniqKey="Fichter M" first="M M" last="Fichter">M M Fichter</name>
<affiliation wicri:level="1"><nlm:affiliation>Roseneck Hospital for Behavioral Medicine, Prien, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Roseneck Hospital for Behavioral Medicine, Prien</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Halmi, K A" sort="Halmi, K A" uniqKey="Halmi K" first="K A" last="Halmi">K A Halmi</name>
<affiliation wicri:level="1"><nlm:affiliation>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Eating Disorder Research Program Weill Cornell Medical College, White Plains, NY</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnson, C" sort="Johnson, C" uniqKey="Johnson C" first="C" last="Johnson">C. Johnson</name>
<affiliation wicri:level="1"><nlm:affiliation>Eating Recovery Center, Denver, CO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Eating Recovery Center, Denver, CO</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kaplan, A S" sort="Kaplan, A S" uniqKey="Kaplan A" first="A S" last="Kaplan">A S Kaplan</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="La Via, M" sort="La Via, M" uniqKey="La Via M" first="M" last="La Via">M. La Via</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, J E" sort="Mitchell, J E" uniqKey="Mitchell J" first="J E" last="Mitchell">J E Mitchell</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Strober, M" sort="Strober, M" uniqKey="Strober M" first="M" last="Strober">M. Strober</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rotondo, A" sort="Rotondo, A" uniqKey="Rotondo A" first="A" last="Rotondo">A. Rotondo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Treasure, J" sort="Treasure, J" uniqKey="Treasure J" first="J" last="Treasure">J. Treasure</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Woodside, D B" sort="Woodside, D B" uniqKey="Woodside D" first="D B" last="Woodside">D B Woodside</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bulik, C M" sort="Bulik, C M" uniqKey="Bulik C" first="C M" last="Bulik">C M Bulik</name>
<affiliation wicri:level="1"><nlm:affiliation>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC</wicri:regionArea>
</affiliation>
</author>
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<series><title level="j">Molecular psychiatry</title>
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<term>Anorexia Nervosa (metabolism)</term>
<term>Body Mass Index</term>
<term>Case-Control Studies</term>
<term>Cholesterol (metabolism)</term>
<term>Cohort Studies</term>
<term>Epoxide Hydrolases (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Psychometrics</term>
<term>Young Adult</term>
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<term>Adulte d'âge moyen</term>
<term>Anorexie mentale (génétique)</term>
<term>Anorexie mentale (métabolisme)</term>
<term>Cholestérol (métabolisme)</term>
<term>Epoxide hydrolase (génétique)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Psychométrie</term>
<term>Variation génétique</term>
<term>Études cas-témoins</term>
<term>Études de cohortes</term>
<term>Études longitudinales</term>
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<term>Cholestérol</term>
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<term>Body Mass Index</term>
<term>Case-Control Studies</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Psychometrics</term>
<term>Young Adult</term>
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<front><div type="abstract" xml:lang="en">Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.</div>
</front>
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<DateCreated><Year>2014</Year>
<Month>05</Month>
<Day>22</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>04</Month>
<Day>18</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>6</Issue>
<PubDate><Year>2014</Year>
<Month>Jun</Month>
</PubDate>
</JournalIssue>
<Title>Molecular psychiatry</Title>
<ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation>
</Journal>
<ArticleTitle>Evidence for the role of EPHX2 gene variants in anorexia nervosa.</ArticleTitle>
<Pagination><MedlinePgn>724-32</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2013.91</ELocationID>
<Abstract><AbstractText>Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-ß (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Scott-Van Zeeland</LastName>
<ForeName>A A</ForeName>
<Initials>AA</Initials>
<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<ForeName>C S</ForeName>
<Initials>CS</Initials>
<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Tewhey</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>1] Scripps Health, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</Affiliation>
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<ForeName>V</ForeName>
<Initials>V</Initials>
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<ForeName>N</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<Initials>L</Initials>
<AffiliationInfo><Affiliation>The Scripps Translational Science Institute, La Jolla, CA, USA.</Affiliation>
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<Initials>BF</Initials>
<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>E N</ForeName>
<Initials>EN</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, The University of California, San Diego, La Jolla, CA, USA.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Carson</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] The Scripps Translational Science Institute, La Jolla, CA, USA [2] Scripps Health, La Jolla, CA, USA [3] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Chen</LastName>
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<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Srinivasan</LastName>
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<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Tulane University, New Orleans, LA, USA.</Affiliation>
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<Author ValidYN="Y"><LastName>Berenson</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
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<ForeName>H</ForeName>
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<AffiliationInfo><Affiliation>Roseneck Hospital for Behavioral Medicine, Prien, Germany.</Affiliation>
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<AffiliationInfo><Affiliation>1] Center for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [3] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation>
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<AffiliationInfo><Affiliation>1] Neuropsychiatric Research Institute, Fargo, ND, USA [2] Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.</Affiliation>
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<Initials>M</Initials>
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<Author ValidYN="Y"><LastName>Rotondo</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnology, University of Pisa, Pisa, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Treasure</LastName>
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<AffiliationInfo><Affiliation>Department of Academic Psychiatry, Bermondsey Wing Guys Hospital, University of London, London, UK.</Affiliation>
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<ForeName>D B</ForeName>
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<AffiliationInfo><Affiliation>1] Department of Psychiatry, Toronto General Hospital, University Health Network, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada [3] Department of Psychology, Florida State University, Tallahassee, FL, USA.</Affiliation>
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<AffiliationInfo><Affiliation>1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Psychology, Michigan State University, East Lansing, MI, USA.</Affiliation>
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{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    PubMed
   |étape=   Curation
   |type=    RBID
   |clé=     pubmed:23999524
   |texte=   Evidence for the role of EPHX2 gene variants in anorexia nervosa.
}}

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       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
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Serveur d'exploration sur Pittsburgh

Evidence for the role of EPHX2 gene variants in anorexia nervosa.

Evidence for the role of EPHX2 gene variants in anorexia nervosa.

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