Serum D-dimer concentrations are increased after pediatric traumatic brain injury.
Identifieur interne : 000718 ( PubMed/Curation ); précédent : 000717; suivant : 000719Serum D-dimer concentrations are increased after pediatric traumatic brain injury.
Auteurs : Rachel P. Berger [États-Unis] ; Janet Fromkin [États-Unis] ; Pam Rubin [États-Unis] ; John Snyder [États-Unis] ; Rudolph Richichi [États-Unis] ; Patrick Kochanek [États-Unis]Source :
- The Journal of pediatrics [ 1097-6833 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Produits de dégradation de la fibrine et du fibrinogène.
- diagnostic : Maltraitance des enfants.
- sang : Lésions encéphaliques.
- étiologie : Lésions encéphaliques.
- Femelle, Humains, Mâle, Nourrisson, Études cas-témoins, Études prospectives, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Fibrin Fibrinogen Degradation Products.
- blood : Brain Injuries.
- diagnosis : Child Abuse.
- etiology : Brain Injuries.
- Case-Control Studies, Female, Humans, Infant, Male, Prospective Studies, Retrospective Studies.
Abstract
To determine whether D-dimer would be increased in children with traumatic brain injury (TBI), specifically mild abusive head trauma.
DOI: 10.1016/j.jpeds.2014.10.036
PubMed: 25454315
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pubmed:25454315Le document en format XML
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Berger</name><affiliation wicri:level="2"><nlm:affiliation>Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA; Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh, PA. Electronic address: rachel.berger@chp.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA; Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Fromkin, Janet" sort="Fromkin, Janet" uniqKey="Fromkin J" first="Janet" last="Fromkin">Janet Fromkin</name><affiliation wicri:level="2"><nlm:affiliation>Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, 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Resuscitation Research, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author></analytic><series><title level="j">The Journal of pediatrics</title><idno type="eISSN">1097-6833</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain Injuries (blood)</term><term>Brain Injuries (etiology)</term><term>Case-Control Studies</term><term>Child Abuse (diagnosis)</term><term>Female</term><term>Fibrin Fibrinogen Degradation Products (analysis)</term><term>Humans</term><term>Infant</term><term>Male</term><term>Prospective Studies</term><term>Retrospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Lésions encéphaliques (sang)</term><term>Lésions encéphaliques (étiologie)</term><term>Maltraitance des enfants (diagnostic)</term><term>Mâle</term><term>Nourrisson</term><term>Produits de dégradation de la fibrine et du fibrinogène (analyse)</term><term>Études cas-témoins</term><term>Études prospectives</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Produits de dégradation de la fibrine et du fibrinogène</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Child Abuse</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maltraitance des enfants</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lésions encéphaliques</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lésions encéphaliques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Prospective Studies</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Études cas-témoins</term><term>Études prospectives</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether D-dimer would be increased in children with traumatic brain injury (TBI), specifically mild abusive head trauma.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25454315</PMID><DateCreated><Year>2015</Year><Month>01</Month><Day>27</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6833</ISSN><JournalIssue CitedMedium="Internet"><Volume>166</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of pediatrics</Title><ISOAbbreviation>J. Pediatr.</ISOAbbreviation></Journal><ArticleTitle>Serum D-dimer concentrations are increased after pediatric traumatic brain injury.</ArticleTitle><Pagination><MedlinePgn>383-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jpeds.2014.10.036</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0022-3476(14)01003-8</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether D-dimer would be increased in children with traumatic brain injury (TBI), specifically mild abusive head trauma.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">D-dimer was measured using multiplex bead technology in 195 children <4 years old (n = 93 controls without TBI, n = 102 cases with TBI) using previously collected serum. D-dimer was then measured prospectively in a clinical setting in 44 children (n = 24 controls, n = 20 cases). Receiver operator curves were generated for prospective data.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In both the retrospective and prospective cohorts, median (25th-75th percentile) D-dimer was significantly higher in cases vs controls. A receiver operator curve demonstrated an area under the curve of 0.91 (95% CI 0.83-0.99) in the prospective cohort. At a cut-off of 0.59 μg/L, the sensitivity and specificity for identification of a case was 90% and 75%, respectively.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data suggest that serum D-dimer may be able to be used to identify which young children at risk for abusive head trauma might benefit from a head computed tomography or other additional evaluation. Additional data are needed to better identify the clinical scenarios that may result in false positive or false negative D-dimer concentrations.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>Rachel P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA; Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh, PA. Electronic address: rachel.berger@chp.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fromkin</LastName><ForeName>Janet</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubin</LastName><ForeName>Pam</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snyder</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>UPMC Hillman Cancer Center, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richichi</LastName><ForeName>Rudolph</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Statistical Analysis and Measurement Consultants, Inc, Lanexa, VA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochanek</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HD055986</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1K23HD43843</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HD055986</GrantID><Acronym>HD</Acronym><Agency>NICHD NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Pediatr</MedlineTA><NlmUniqueID>0375410</NlmUniqueID><ISSNLinking>0022-3476</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Pediatrics. 2013 Apr;131(4):701-7</RefSource><PMID 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Version="1">10029123</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Blood. 1986 Jul;68(1):317-9</RefSource><PMID Version="1">3719103</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001930" MajorTopicYN="N">Brain Injuries</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002649" MajorTopicYN="N">Child Abuse</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName><QualifierName UI="Q000032" 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