Recent insights into the mode of action of memantine and ketamine.
Identifieur interne : 000714 ( PubMed/Curation ); précédent : 000713; suivant : 000715Recent insights into the mode of action of memantine and ketamine.
Auteurs : Jon W. Johnson [États-Unis] ; Nathan G. Glasgow [États-Unis] ; Nadezhda V. Povysheva [États-Unis]Source :
- Current opinion in pharmacology [ 1471-4973 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- antagonistes et inhibiteurs : Récepteurs du N-méthyl-D-aspartate.
- pharmacologie : Antagonistes des acides aminés excitateurs, Kétamine, Mémantine.
- Animaux, Conception de médicament, Humains, Thérapie moléculaire ciblée.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Receptors, N-Methyl-D-Aspartate.
- chemical , pharmacology : Excitatory Amino Acid Antagonists, Ketamine, Memantine.
- Animals, Drug Design, Humans, Molecular Targeted Therapy.
Abstract
The clinical benefits of the glutamate receptor antagonists memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targets for development of therapeutic drugs. Both memantine and ketamine antagonize N-methyl-D-aspartate receptors (NMDARs), a glutamate receptor subfamily, by blocking the receptor-associated ion channel. Although many of the basic characteristics of NMDAR inhibition by memantine and ketamine appear similar, their effects on humans and to a lesser extent on rodents are strongly divergent. Some recent research suggests that preferential inhibition by memantine and ketamine of distinct NMDAR subpopulations may contribute to the drugs' differential clinical effects. Here we review studies that shed light on possible explanations for differences between the effects of memantine and ketamine.
DOI: 10.1016/j.coph.2014.11.006
PubMed: 25462293
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pubmed:25462293Le document en format XML
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<front><div type="abstract" xml:lang="en">The clinical benefits of the glutamate receptor antagonists memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targets for development of therapeutic drugs. Both memantine and ketamine antagonize N-methyl-D-aspartate receptors (NMDARs), a glutamate receptor subfamily, by blocking the receptor-associated ion channel. Although many of the basic characteristics of NMDAR inhibition by memantine and ketamine appear similar, their effects on humans and to a lesser extent on rodents are strongly divergent. Some recent research suggests that preferential inhibition by memantine and ketamine of distinct NMDAR subpopulations may contribute to the drugs' differential clinical effects. Here we review studies that shed light on possible explanations for differences between the effects of memantine and ketamine.</div>
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